Effect of maternal high dosages of folic acid supplements on neurocognitive development in children at 4-5 y of age: The prospective birth cohort Infancia y Medio Ambiente (INMA) study

American Journal of Clinical Nutrition

Volumn 106, Issue 3, 2017, Pages 878-887

  Valera Gran, Desirée ^a,b   Navarrete Muñoz, Eva M ^a,b   De La Hera, Manuela Garcia ^a,b   Fernández Somoano, Ana ^b,c   Tardón, Adonina ^b,c   Ibarluzea, Jesús ^b,d   Balluerka, Nekane ^b,e   Murcia, Mario ^b,f   González Safont, Llúcia ^b,f   Romaguera, Dora ^g,h,i   Julvez, Jordi ^b,h   Vioque, Jesús ^a,b  

^a MIGUEL HERNÁNDEZ UNIVERSITY   (Spain)

^b CIBER EPIDEMIOLOGÍA Y SALUD PÚBLICA CIBERESP   (Spain)

^c UNIVERSITY OF OVIEDO   (Spain)

^d BIODONOSTIA HEALTH RESEARCH INSTITUTE   (Spain)

^e UNIVERSITY OF THE BASQUE COUNTRY UPV EHU   (Spain)

^f UNIVERSITAT JAUME I   (Spain)

^g HEALTH RESEARCH INSTITUTE OF THE BALEARIC ISLANDS IDISBA   (Spain)

^h CENTRE FOR RESEARCH IN ENVIRONMENTAL EPIDEMIOLOGY CREAL   (Spain)

ⁱ Instituto de Salud Carlos III   (Spain)

Author keywords

Child neurocognitive development; Folate; Folic acid supplements; Periconception period; Pregnancy

Indexed keywords

FOLIC ACID; VITAMIN B COMPLEX;

ADULT; ARTICLE; CHILD; CHILD DEVELOPMENT; COGNITION; COGNITIVE DEVELOPMENT; COHORT ANALYSIS; COMMUNICATION SKILL; DRUG MEGADOSE; EXECUTIVE FUNCTION; FEMALE; GESTATIONAL AGE; HUMAN; INTERVIEW; MAJOR CLINICAL STUDY; MALE; MATERNAL TREATMENT; MCCARTHY SCALES OF CHILDREN'S ABILITIES; MOTOR PERFORMANCE; MULTICENTER STUDY; NERVOUS SYSTEM DEVELOPMENT; PREGNANCY; PREGNANT WOMAN; PRESCHOOL CHILD; PROSPECTIVE STUDY; SPAIN; VERBAL MEMORY; VISION; VITAMIN SUPPLEMENTATION; ADVERSE EFFECTS; BRAIN; CLINICAL TRIAL; DIET; DIETARY SUPPLEMENT; DRUG EFFECTS; MATERNAL NUTRITION; MEMORY; PRENATAL EXPOSURE;

ADULT; BRAIN; CHILD DEVELOPMENT; CHILD, PRESCHOOL; COGNITION; DIET; DIET SURVEYS; DIETARY SUPPLEMENTS; FEMALE; FOLIC ACID; HUMANS; MALE; MEMORY; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; PRENATAL NUTRITIONAL PHYSIOLOGICAL PHENOMENA; PROSPECTIVE STUDIES; SPAIN; VITAMIN B COMPLEX;

EID: 85028691216     PISSN: 00029165     EISSN: 19383207     Source Type: Journal    
DOI: 10.3945/ajcn.117.152769     Document Type: Article

References (42)

1. MRC Vitamin Study Research Group. Prevention of neural tube defects: results of the Medical Research Council Vitamin Study. Lancet 1991;338:131-7.
2. Gomes S, Lopes C, Pinto E. Folate and folic acid in the periconceptional period: recommendations from official health organizations in thirty-six countries worldwide and WHO. Public Health Nutr 2016;19:176-89.
3. Institute of Medicine Standing Committee on the Scientific Evaluation of Dietary Reference Intakes and its Panel on Folate, Other B Vitamins, and Choline. Dietary Reference Intakes for thiamin, riboflavin, niacin, vitamin B6, folate, vitamin B12, pantothenic acid, biotin, and choline [Internet]. Washington (DC): National Academies Press; 1998 [cited 2016 May 8]. Available from: http://www.ncbi.nlm.nih.gov/books/ NBK114310/.
4. Valera-Gran D, García de la Hera M, Navarrete-Munoz EM, Fernandez-Somoano A, Tardón A, Julvez J, Forns J, Lertxundi N, Ibarluzea J, Murcia M, et al. Folic acid supplements during pregnancy and child psychomotor development after the first year of life. JAMA Pediatr 2014;168:e142611.
5. Pastor-Valero M, Navarrete-Munoz EM, Rebagliato M, Iniguez C, Murcia M, Marco A, Ballester F, Vioque J. Periconceptional folic acid supplementation and anthropometric measures at birth in a cohort of pregnant women in Valencia, Spain. Br J Nutr 2011;105:1352-60.
6. Takimoto H, Hayashi F, Kusama K, Kato N, Yoshiike N, Toba M, Ishibashi T, Miyasaka N, Kubota T. Elevated maternal serum folate in the third trimester and reduced fetal growth: a longitudinal study. J Nutr Sci Vitaminol (Tokyo) 2011;57:130-7.
7. Mikael LG, Deng L, Paul L, Selhub J, Rozen R. Moderately high intake of folic acid has a negative impact on mouse embryonic development. Birth Defects Res A Clin Mol Teratol 2013;97:47-52.
8. Pickell L, Brown K, Li D, Wang XL, Deng L, Wu Q, Selhub J, Luo L, Jerome-Majewska L, Rozen R. High intake of folic acid disrupts embryonic development in mice. Birth Defects Res A Clin Mol Teratol 2011;91:8-19.
9. Barua S, Chadman KK, Kuizon S, Buenaventura D, Stapley NW, Ruocco F, Begum U, Guariglia SR, Brown WT, Junaid MA. Increasing maternal or post-weaning folic acid alters gene expression and moderately changes behavior in the offspring. PLoS One 2014;9:e101674.
10. Barua S, Kuizon S, Ted Brown W, Junaid MA. High gestational folic acid supplementation alters expression of imprinted and candidate autism susceptibility genes in a sex-specific manner in mouse offspring. J Mol Neurosci 2016;58:277-86.
11. Barua S, Kuizon S, Chadman K, Brown W, Junaid M. Microarray analysis reveals higher gestational folic acid alters expression of genes in the cerebellum of mice offspring - a pilot study. Brain Sci 2015;5:14-31.
12. Reynolds E. Vitamin B12, folic acid, and the nervous system. Lancet Neurol 2006;5:949-60.
13. Wehby GL, Murray JC. The effects of prenatal use of folic acid and other dietary supplements on early child development. Matern Child Health J 2008;12:180-7.
14. Julvez J, Fortuny J, Mendez M, Torrent M, Ribas-Fitó N, Sunyer J. Maternal use of folic acid supplements during pregnancy and fouryear- old neurodevelopment in a population-based birth cohort. Paediatr Perinat Epidemiol 2009;23:199-206.
15. Roth C, Magnus P, Schjølberg S, Stoltenberg C, Surén P, McKeague IW, Davey Smith G, Reichborn-Kjennerud T, Susser E. Folic acid supplements in pregnancy and severe language delay in children. JAMA 2011;306:1566-73.
16. Chatzi L, Papadopoulou E, Koutra K, Roumeliotaki T, Georgiou V, Stratakis N, Lebentakou V, Karachaliou M, Vassilaki M, Kogevinas M. Effect of high doses of folic acid supplementation in early pregnancy on child neurodevelopment at 18 months of age: the mother-child cohort 'Rhea' study in Crete, Greece. Public Health Nutr 2012;15:1728-36.
17. Schmidt RJ, Tancredi DJ, Ozonoff S, Hansen RL, Hartiala J, Allayee H, Schmidt LC, Tassone F, Hertz-Picciotto I. Maternal periconceptional folic acid intake and risk of autism spectrum disorders and developmental delay in the CHARGE (CHildhood Autism Risks from Genetics and Environment) case-control study. Am J Clin Nutr 2012;96:80-9.
18. Villamor E, Rifas-Shiman SL, Gillman MW, Oken E. Maternal intake of methyl-donor nutrients and child cognition at 3 years of age. Paediatr Perinat Epidemiol 2012;26:328-35.
19. Surén P, Roth C, Bresnahan M, Haugen M, Hornig M, Hirtz D, Lie KK, Lipkin WI, Magnus P, Reichborn-Kjennerud T, et al. Association between maternal use of folic acid supplements and risk of autism spectrum disorders in children. JAMA 2013;309:570-7.
20. Roza SJ, van Batenburg-Eddes T, Steegers EA, Jaddoe VW, Mackenbach JP, Hofman A, Verhulst FC, Tiemeier H. Maternal folic acid supplement use in early pregnancy and child behavioural problems: the Generation R Study. Br J Nutr 2010;103:445-52.
21. SchlotzW, Jones A, Phillips DI, Gale CR, Robinson SM, Godfrey KM. Lower maternal folate status in early pregnancy is associated with childhood hyperactivity and peer problems in offspring. J Child Psychol Psychiatry 2010;51:594-602.
22. Steenweg-de Graaff J, Roza SJ, Steegers EA, Hofman A, Verhulst FC, Jaddoe VW, Tiemeier H. Maternal folate status in early pregnancy and child emotional and behavioral problems: the Generation R Study. Am J Clin Nutr 2012;95:1413-21.
23. Navarrete-Muñoz EM, Valera-Gran D, García de la Hera M, Gimenez-Monzo D, Morales E, Julvez J, Riaño I, Tardón A, Ibarluzea J, Santa-Marina L, et al. Use of high doses of folic acid supplements in pregnant women in Spain: an INMA cohort study. BMJ Open 2015;5: e009202.
24. Guxens M, Ballester F, Espada M, Fernández MF, Grimalt JO, Ibarluzea J, Olea N, Rebagliato M, Tardón A, Torrent M, et al. Cohort profile: the INMA-INfancia y Medio Ambiente-(Environment and Childhood) Project. Int J Epidemiol 2012;41:930-40.
25. Vioque J, Navarrete-Muñoz E-M, Gimenez-Monzó D, García-de-la- Hera M, Granado F, Young IS, Ramón R, Ballester F, Murcia M, Rebagliato M, et al. Reproducibility and validity of a food frequency questionnaire among pregnant women in a Mediterranean area. Nutr J 2013;12:26.
26. USDA, Agricultural Research Service. USDA national nutrient database for standard reference, release 27. Washington (DC): USDA; 2015.
27. Palma I, Farran A, Cantós D. Tablas de Composición de Alimentos por Medidas Caseras de Consumo Habitual en Espana. Madrid: McGraw-Hill, Interamericana de Espana; 2008.
28. McCarthy D. Manual for the McCarthy Scales of Children's Abilities. Madrid: TEA Ediciones; 2009. [Spanish adaptation].
29. Julvez J, Forns M, Ribas-Fitó N, Torrent M, Sunyer J. Attention behavior and hyperactivity and concurrent neurocognitive and social competence functioning in 4-year-olds from two population-based birth cohorts. Eur Psychiatry 2011;26:381-9.
30. Becker G. Creating comparability among reliability coefficients: the case of Cronbach alpha and Cohen kappa. Psychol Rep 2000;87:1171-82.
31. Higgins JP, Thompson SG, Deeks JJ, Altman DG. Measuring inconsistency in meta-analyses. BMJ 2003;327:557-60.
32. Murcia M, Rebagliato M, Espada M, Vioque J, Santa Marina L, Alvarez-Pedrerol M, Lopez-Espinosa MJ, León G, Iniguez C, Basterrechea M, et al. Iodine intake in a population of pregnant women: INMA mother and child cohort study, Spain. J Epidemiol Community Health 2010;64:1094-9.
33. Wechsler D, Kaufman A. Escala de inteligencia de Wechsler para adultos (III). Madrid: TEA Ediciones; 2001.
34. Vioque J, Gimenez-Monzo D, Navarrete-Munoz EM, Garcia-de-la- Hera M, Gonzalez-Palacios S, Rebagliato M, Ballester F, Murcia M, Iniguez C, Granado F. Reproducibility and validity of a food frequency questionnaire designed to assess diet in children aged 4-5 years. PLoS One 2016;11:e0167338.
35. Fernández-Barrés S, Romaguera D, Valvi D, Martínez D, Vioque J, Navarrete-Munoz EM, Amiano P, Gonzalez-Palacios S, Guxens M, Pereda E, et al. Mediterranean dietary pattern in pregnant women and offspring risk of overweight and abdominal obesity in early childhood: the INMA birth cohort study. Pediatr Obes 2016;11:491-9.
36. Bayley N. Escalas Bayley de desarrollo infantil. Madrid: TEA Ediciones; 1977.
37. Benton D. Vitamins and neural and cognitive developmental outcomes in children. Proc Nutr Soc 2012;71:14-26.
38. Kwan KY. Transcriptional dysregulation of neocortical circuit assembly in ASD. Int Rev Neurobiol 2013;113:167-205.
39. del Río Garcia C, Torres-Sánchez L, Chen J, Schnaas L, Hernández C, Osorio E, Portillo MG, López-Carrillo L. Maternal MTHFR 677C.T genotype and dietary intake of folate and vitamin B(12): their impact on child neurodevelopment. Nutr Neurosci 2009;12:13-20.
40. Obeid R, Holzgreve W, Pietrzik K. Is 5-methyltetrahydrofolate an alternative to folic acid for the prevention of neural tube defects? J Perinat Med 2013;41:469-83.
41. Morris MS, Jacques PF, Rosenberg IH, Selhub J. Circulating unmetabolized folic acid and 5-methyltetrahydrofolate in relation to anemia, macrocytosis, and cognitive test performance in American seniors. Am J Clin Nutr 2010;91:1733-44.
42. Sauer J, Mason JB, Choi SW. Too much folate: a risk factor for cancer and cardiovascular disease? Curr Opin Clin Nutr Metab Care 2009;12:30-6.