Attenuated processing of proglucagon and glucagon-like peptide-1 in carboxypeptidase E-deficient mice

Journal of Endocrinology

Volumn 169, Issue 3, 2001, Pages 595-602

  Friis Hansen, L ^a   Lacourse, K A ^a   Samuelson, L C ^a   Holst, J J ^a  

^a International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOXYPEPTIDASE H; FAT; FURIN; GLUCAGON LIKE PEPTIDE 1; PEPTIDE HORMONE; PROGLUCAGON;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; ENDOCRINE DISEASE; INTESTINE; MATURATION; MOUSE; NONHUMAN; OBESITY; PANCREAS; PHENOTYPE; PRIORITY JOURNAL; PROTEIN PROCESSING;

ANIMALS; CARBOXYPEPTIDASE H; CARBOXYPEPTIDASES; CHROMATOGRAPHY, GEL; DIABETES MELLITUS, EXPERIMENTAL; FURIN; GLUCAGON; GLUCAGON-LIKE PEPTIDE 1; INTESTINES; MICE; MICE, MUTANT STRAINS; OBESITY; PANCREAS; PEPTIDE FRAGMENTS; PROGLUCAGON; PROTEIN PRECURSORS; SUBTILISINS; TISSUE EXTRACTS;

EID: 0034965257     PISSN: 00220795     EISSN: None     Source Type: Journal    
DOI: 10.1677/joe.0.1690595     Document Type: Article

References (31)

1. Glicentin 1-61 probably represents a major fraction of glucagon related peptides in plasma of anaesthetized uraemic pigs
2. fat mice: A regional difference in the involvement of carboxypeptidase E (CPE) in pro-CCK processing
3. fat mice
4. Carboxypeptidase D is a potential candidate to carry out redundant processing functions of carboxypeptidase E based on comparative distribution studies in rat central nervous system
5. Induction of intestinal epithelial proliferation by glucagon-like peptide 2
6. Defective prohormone processing and altered pancreatic islet morphology in mice lacking active SPC2
7. Evidence that enteroglucagon (II) is identical with the C-terminal sequence (residues 33-39) of glicentin
8. Posttranslational processing of proglucagon and post-secretory fate of proglucagon products
9. Disturbed progastrin processing in the carboxypeptidase E deficient fat mouse
10. Altered processing of procholecystokin processing in carboxypeptidase E-deficient fat mice: Differential synthesis in neurons and endocrine cells
11. A simple salting out procedure for extracting DNA from human nucleated cells
12. Hyperproinsulinaemia in obese fat/fat mice associated with a carboxypeptidase E mutation which reduces enzyme activity
13. Depletion of carboxypeptidase E, a regulated secretory pathway sorting receptor, causes misrouting and constitutive secretion of proinsulin and proenkephalin, but not chromogranin A
14. Proglucagon products in plasma of non-insulin dependent diabetics and non-diabetic controls in the fasting state and following oral glucose and intravenous arginine
15. Biological effects and metabolic rates of glucagonlike peptide-1 7-36 amide and glucagonlike peptide-1 7-37 in healthy subjects are indistinguishable
16. Tissue and plasma concentrations of amidated and glycine-extended glucagon-like peptide I in humans
17. fat mice
18. Carboxypeptidase E, a peripheral membrane protein implicated in the targeting of hormones to secretory granules, co-aggregates with granule content proteins at acidic pH
19. Differential processing of proglucagon by the subtilisin-like prohormone convertases PC2 and PC3 to generate either glucagon or glucagon-like peptide
20. Role of the prohormone convertase PC3 in the processing of proglucagon to glucagon-like peptide 1
21. Impaired processing of brain proneurotensin and promelanin-concentrating hormone in obese fat/fat mice
22. Glucose intolerance but normal satiety in mice with a null mutation in the glucagon-like peptide 1 receptor
23. Central administration of GLP-1-(7-36) amide inhibits food and water intake in rats
24. A role for glucagon-like peptide-1 in the central regulation of feeding
25. Effect of carboxypeptidase E deficiency on progastrin processing and gastrin messenger ribonucleic acid expression in mice with the fat mutation
26. fat mice are defective in carboxypeptidase E and proinsulin processing
27. Localization of metallocarboxypeptidase D in AtT-20 cells. Potential role in prohormone processing
28. Biosynthesis and packaging of carboxypeptidase D in nascent secretory granules in pituitary cell lines
29. The neuroendocrine protein 7B2 is required for peptide hormone processing in vivo and provides a novel mechanism for pituitary Cushing's disease
30. Amidated and non amidated gluagon like peptide-1 (GLP-1): Non pancreatic effects (cephalic phase acid secretion) and stability in human plasma
31. Internal cleavage of the inhibitory 7B2 carboxyl-terminal peptide by PC2: A potential mechanism for its inactivation