Crimean-Congo Hemorrhagic Fever in Humanized Mice Reveals Glial Cells as Primary Targets of Neurological Infection

Journal of Infectious Diseases

Volumn 216, Issue 11, 2017, Pages 1386-1397

  Spengler, Jessica R ^a   Keating, M Kelly ^a   McElroy, Anita K ^a   Zivcec, Marko ^a   Coleman McCray, JoAnn D ^a   Harmon, Jessica R ^a   Bollweg, Brigid C ^a   Goldsmith, Cynthia S ^a   Bergeron, Éric ^a   Keck, James G ^b   Zaki, Sherif R ^a   Nichol, Stuart T ^a   Spiropoulou, Christina F ^a  

^a EMORY UNIVERSITY   (United States)

^b JACKSON LABORATORY   (United States)

Author keywords

Crimean Congo hemorrhagic fever; glial cell; meningitis; neuropathology; NSG SGM3 humanized mice

Indexed keywords

CD34 ANTIGEN; RECEPTOR TYPE TYROSINE PROTEIN PHOSPHATASE C; VIRUS ANTIBODY;

BRAIN; CD8+ T LYMPHOCYTE; CENTRAL NERVOUS SYSTEM; CENTRAL NERVOUS SYSTEM DISEASE; CENTRAL NERVOUS SYSTEM INFECTION; CONFERENCE PAPER; CONTROLLED STUDY; CRIMEAN CONGO HEMORRHAGIC FEVER; CRIMEAN-CONGO HEMORRHAGIC FEVER VIRUS; DYSPNEA; FEMALE; FLOW CYTOMETRY; GAMMA IRRADIATION; GLIA CELL; GLIOSIS; HEART; HUMAN; HUMAN TISSUE; IMMUNOREACTIVITY; LUNG; MENINGITIS; MENINGOENCEPHALITIS; MOUSE; NEUROLOGIC DISEASE; NEUROPATHOLOGY; NONHUMAN; SPLEEN; VIRUS ISOLATION; VIRUS LOAD; VIRUS REPLICATION; ANIMAL; CELL LINE; CHLOROCEBUS AETHIOPS; GLIA; HEMATOPOIETIC STEM CELL TRANSPLANTATION; LIVER; PATHOGENICITY; PATHOLOGY; TICK BORNE DISEASE; VERO CELL LINE; VIROLOGY;

ANIMALS; ANTIBODIES, VIRAL; BRAIN; CELL LINE; CENTRAL NERVOUS SYSTEM; CERCOPITHECUS AETHIOPS; FEMALE; GLIOSIS; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HEMORRHAGIC FEVER VIRUS, CRIMEAN-CONGO; HEMORRHAGIC FEVER, CRIMEAN; HUMANS; LIVER; MENINGITIS; MENINGOENCEPHALITIS; MICE; NEUROGLIA; TICK-BORNE DISEASES; VERO CELLS;

EID: 85028510003     PISSN: 00221899     EISSN: 15376613     Source Type: Journal    
DOI: 10.1093/INFDIS/JIX215     Document Type: Conference Paper

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