Perforin competent CD8 T cells are sufficient to cause immune-mediated blood-brain barrier disruption

PLoS ONE

Volumn 9, Issue 10, 2014, Pages

  Johnson, Holly L ^a,b   Willenbring, Robin C ^a,b   Jin, Fang ^b   Manhart, Whitney A ^b   La France, Stephanie J ^b   Pirko, Istvan ^a   Johnson, Aaron J ^a,b  

^a MAYO CLINIC   (United States)

^b MAYO GRADUATE SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CLAUDIN 5; GREEN FLUORESCENT PROTEIN; OCCLUDIN; PERFORIN; FLUORESCENT DYE; GLIAL FIBRILLARY ASTROCYTIC PROTEIN, MOUSE; NERVE PROTEIN; TIGHT JUNCTION PROTEIN;

ADOPTIVE TRANSFER; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; BLOOD BRAIN BARRIER; BLOOD BRAIN BARRIER DISRUPTION; BLOOD VESSEL PERMEABILITY; C57BL 6 MOUSE; CD8+ T LYMPHOCYTE; CELL ACTIVATION; CELL ISOLATION; CELL TYPE; CENTRAL NERVOUS SYSTEM; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DISEASE SEVERITY; FLOW CYTOMETRY; IMAGE ANALYSIS; IMMUNOCOMPETENT CELL; MALE; MOUSE; MULTIPLE SCLEROSIS; MURINE ENCEPHALOMYELITIS VIRUS; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PROTEIN EXPRESSION; ANIMAL; CAPILLARY PERMEABILITY; DIFFUSION; GENE EXPRESSION; GENETICS; IMMUNOLOGY; KNOCKOUT MOUSE; METABOLISM; PATHOLOGY;

ADOPTIVE TRANSFER; ANIMALS; ASTROCYTES; BLOOD-BRAIN BARRIER; CAPILLARY PERMEABILITY; CD8-POSITIVE T-LYMPHOCYTES; DIFFUSION; FLUORESCENT DYES; GENE EXPRESSION; MAGNETIC RESONANCE IMAGING; MALE; MICE; MICE, KNOCKOUT; MODELS, ANIMAL; NERVE TISSUE PROTEINS; PERFORIN; TIGHT JUNCTION PROTEINS;

EID: 84908426102     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0111401     Document Type: Article

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