Evaluation of transmission risks associated with in vivo replication of several high containment pathogens in a biosafety level 4 laboratory

Scientific Reports

Volumn 4, Issue , 2014, Pages

  Alimonti, Judie ^a   Leung, Anders ^a   Jones, Shane ^a   Gren, Jason ^a   Qiu, Xiangguo ^a   Fernando, Lisa ^a   Balcewich, Brittany ^a   Wong, Gary ^a,b   Ströher, Ute ^a,d   Grolla, Allen ^a   Strong, James ^a,b   Kobinger, Gary ^a,b,c  

^a PUBLIC HEALTH AGENCY OF CANADA   (Canada)

^b UNIVERSITY OF MANITOBA   (Canada)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

^d CENTERS FOR DISEASE CONTROL AND PREVENTION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

VIRUS ANTIGEN; VIRUS RNA;

AIR FILTER; ANIMAL; ARENAVIRUS; BUNYAVIRIDAE; EBOLAVIRUS; ENZYME LINKED IMMUNOSORBENT ASSAY; EVALUATION STUDY; HAZARDOUS WASTE; HENIPAVIRUS; LABORATORY; MEDICAL DEVICE CONTAMINATION; MICROBUBBLE; PHYSIOLOGY; REAL TIME POLYMERASE CHAIN REACTION; RISK; STANDARDS; TRANSMISSION; VIROLOGY; VIRUS HEMORRHAGIC FEVER; VIRUS LOAD; VIRUS REPLICATION;

AIR FILTERS; ANIMALS; ANTIGENS, VIRAL; ARENAVIRUS; BUNYAVIRIDAE; CONTAINMENT OF BIOHAZARDS; EBOLAVIRUS; ENZYME-LINKED IMMUNOSORBENT ASSAY; EQUIPMENT CONTAMINATION; HEMORRHAGIC FEVERS, VIRAL; HENIPAVIRUS; LABORATORIES; MICROBUBBLES; REAL-TIME POLYMERASE CHAIN REACTION; RISK; RNA, VIRAL; VIRAL LOAD; VIRUS REPLICATION;

EID: 84916607036     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep05824     Document Type: Article

References (41)

1. Madani, T. A. et al. Rift Valley fever epidemic in Saudi Arabia: epidemiological, clinical, and laboratory characteristics. Clin. Infect. Dis. 37, 1084-1092 (2003).
2. Laughlin, L. W., Meegan, J. M., Strausbaugh, L. J., Morens, D. M. & Watten, R. H. Epidemic Rift Valley fever in Egypt: observations of the spectrum of human illness. Trans. R. Soc. Trop. Med. Hyg. 73, 630-633 (1979).
3. McIntosh, B. M., Russell, D., dos Santos, I. & Gear, J. H. Rift Valley fever in humans in South Africa. S. Afr. Med. J. 58, 803-806 (1980).
4. Bente, D. A. et al. Crimean-Congo hemorrhagic fever: History, epidemiology, pathogenesis, clinical syndrome and genetic diversity. Antiviral Res. 100, 159-189 (2013).
5. Mertens, M., Schmidt, K., Ozkul, A. & Groschup, M. H. The impact of Crimean-Congo hemorrhagic fever virus on public health. Antiviral Res. 98, 248-260 (2013).
6. Hartman, A. L. et al. Aerosolized Rift Valley Fever virus causes fatal encephalitis in African green monkeys and common marmosets. J. Virol. 88, 2235-2245 (2013).
7. Grant, A. et al. Junin virus pathogenesis and virus replication. Viruses 4, 2317-2339 (2012).
8. Radoshitzky, S. R., Kuhn, J. H., de Kok-Mercado, F., Jahrling, P. B. & Bavari, S. Drug discovery technologies and strategies for Machupo virus and other New World arenaviruses. Expert Opin. Drug Discov. 7, 613-632 (2012).
9. Charrel, R. N. & de Lamballerie, X. Arenaviruses other than Lassa virus. Antiviral Res. 57, 89-100 (2003).
10. Charrel, R. N. & de Lamballerie, X. Zoonotic aspects of arenavirus infections. Vet. Microbiol. 140, 213-220 (2010).
11. Charrel, R. N. et al. Arenaviruses and hantaviruses: from epidemiology and genomics to antivirals. Antiviral Res. 90, 102-114 (2011).
12. Eddy, G. A., Scott, S. K., Wagner, F. S. & Brand, O. M. Pathogenesis of Machupo virus infection in primates. Bull. World Health Organ. 52, 517-521 (1975).
13. Wagner, F. S., Eddy, G. A. & Brand, O. M. The African green monkey as an alternate primate host for studying Machupo virus infection. Am. J. Trop. Med. Hyg. 26, 159-162 (1977).
14. Weissenbacher, M. C., Calello, M. A., Colillas, O. J., Rondinone, S. N. & Frigerio, M. J. Argentine hemorrhagic fever: a primate model. Intervirology 11, 363-365 (1979).
15. Webb, P. A., Johnson, K. M., Mackenzie, R. B. & Kuns, M. L. Some characteristics of Machupo virus, causative agent of Bolivian hemorrhagic fever. Am. J. Trop. Med. Hyg. 16, 531-538 (1967).
16. Goh, K. J. et al. Clinical features of Nipah virus encephalitis among pig farmers in Malaysia. N. Engl. J. Med. 342, 1229-1235 (2000).
17. Hossain, M. J. et al. Clinical presentation of nipah virus infection in Bangladesh. Clin. Infect. Dis. 46, 977-984 (2008).
18. Tan, C. T. & Wong, K. T. Nipah encephalitis outbreak in Malaysia. Ann. Acad. Med. Singapore 32, 112-117 (2003).
19. Geisbert, T. W., Feldmann, H. & Broder, C. C. Animal challenge models of henipavirus infection and pathogenesis. Curr. Top. Microbiol. Immunol. 359, 153-177 (2012).
20. Chua, K. B. et al. The presence of Nipah virus in respiratory secretions and urine of patients during an outbreak of Nipah virus encephalitis in Malaysia. J. Infect. 42, 40-43 (2001).
21. Escaffre, O., Borisevich, V. & Rockx, B. Pathogenesis of Hendra and Nipah virus infection in humans. J. Infect. Dev. Ctries 7, 308-311 (2013).
22. Luby, S. P., Gurley, E. S. & Hossain, M. J. Transmission of human infection with Nipah virus. Clin. Infect. Dis. 49, 1743-1748 (2009).
23. de Wit, E. et al. Foodborne transmission of nipah virus in Syrian hamsters. PLoS Pathog. 10, e1004001 (2014).
24. Geisbert, T. W. et al. Vesicular stomatitis virus-based vaccines protect nonhuman primates against aerosol challenge with Ebola and Marburg viruses. Vaccine 26, 6894-6900 (2008).
25. Johnson, E., Jaax, N., White, J. & Jahrling, P. Lethal experimental infections of rhesus monkeys by aerosolized Ebola virus. Int. J. Exp. Pathol. 76, 227-236 (1995).
26. Jaax, N. K. et al. Lethal experimental infection of rhesus monkeys with Ebola-Zaire (Mayinga) virus by the oral and conjunctival route of exposure. Arch. Pathol. Lab. Med. 120, 140-155 (1996).
27. Weingartl, H. M. et al. Transmission of Ebola virus from pigs to non-human primates. Sci. Rep. 2, 811 (2012).
28. Sanchez, A., Geisbert, T. W. & Feldmann, H. in Fields Virology (ed Knipe, D. M. et al.) 1409-1448 (Lippincott, Williams & Wilkins, 2007).
29. Williamson, M. M. & Torres-Velez, F. J. Henipavirus: a review of laboratory animal pathology. Vet. Pathol. 47, 871-880 (2010).
30. Rolin, A. I., Berrang-Ford, Lea & Kulkarni, M. A. The risk of Rift Valley fever virus introduction and establishment in the United States and European Union. Emerg. Micro. and Inf. 2, e81 (2013).
31. Qiu, X. et al. Mucosal immunization of cynomolgus macaques with the VSVDeltaG/ZEBOVGP vaccine stimulates strong ebola GP-specific immune responses. PLoS One 4, e5547 (2009).
32. Strong, J. E., Grolla, A., Jahrling, J. B. & Feldmann, H. in Manual of Microbiology and Clinical Immunology Laboratory (eds Detrick, B., Hamilton, R. G. & Folds, J. D.) 774-790 (American Society for Microbiology, Washington, 2006).
33. Gurley, E. S. et al. Person-to-person transmission of Nipah virus in a Bangladeshi community. Emerg. Infect. Dis. 13, 1031-1037 (2007).
34. Homaira, N. et al. Nipah virus outbreak with person-to-person transmission in a district of Bangladesh, 2007. Epidemiol. Infect. 138, 1630-1636 (2010).
35. Kobinger, G. P. et al. Replication, pathogenicity, shedding, and transmission of Zaire ebolavirus in pigs. J. Infect. Dis. 204, 200-208 (2011).
36. Burt, F. J., Paweska, J. T., Ashkettle, B. & Swanepoel, R. Genetic relationship in southern African Crimean-Congo haemorrhagic fever virus isolates: evidence for occurrence of reassortment. Epidemiol. Infect. 137, 1302-1308 (2009).
37. Lukashevich, I. S. Generation of reassortants between African arenaviruses. Virology 188, 600-605 (1992).
38. Briese, T., Calisher, C. H. & Higgs, S. Viruses of the family Bunyaviridae: are all available isolates reassortants? Virology 446, 207-216 (2013).
39. Kerber, R. et al. Cross-species analysis of the replication complex of Old World arenaviruses reveals two nucleoprotein sites involved in L protein function. J. Virol. 85, 12518-12528 (2011).
40. Zapata, J. C. & Salvato, M. S. Arenavirus variations due to host-specific adaptation. Viruses 5, 241-278 (2013).
41. Wolfel, R. et al. Virus detection and monitoring of viral load in Crimean-Congo hemorrhagic fever virus patients. Emerg. Infect. Dis. 13, 1097-1100 (2007).