Exposure to traffic-related air pollution and risk of development of childhood asthma: A systematic review and meta-analysis

Environment International

Volumn 100, Issue , 2017, Pages 1-31

  Khreis, Haneen ^a   Kelly, Charlotte ^a,b   Tate, James ^a   Parslow, Roger ^b   Lucas, Karen ^a   Nieuwenhuijsen, Mark ^c,d,e  

^a UNIVERSITY OF LEEDS   (United Kingdom)

^b UNIVERSITY OF LEEDS   (United Kingdom)

^c CENTRE FOR RESEARCH IN ENVIRONMENTAL EPIDEMIOLOGY CREAL   (Spain)

^d UNIVERSITAT POMPEU FABRA   (Spain)

^e CIBER EPIDEMIOLOGÍA Y SALUD PÚBLICA CIBERESP   (Spain)

Author keywords

Asthma; Black carbon; Childhood; Meta analysis; Traffic related air pollution; Transport policy

Indexed keywords

AIR POLLUTION; ATMOSPHERIC MOVEMENTS; DISEASES; NITROGEN OXIDES; RANDOM PROCESSES; SENSITIVITY ANALYSIS;

ASTHMA; BLACK CARBON; CHILDHOOD; META ANALYSIS; TRAFFIC-RELATED AIR POLLUTION; TRANSPORT POLICY;

RISK ASSESSMENT;

BLACK CARBON; NITROGEN DIOXIDE; NITROGEN OXIDE;

ASTHMA; ATMOSPHERIC POLLUTION; BLACK CARBON; META-ANALYSIS; PARTICULATE MATTER; POLLUTION EXPOSURE; RISK FACTOR; TRANSPORTATION POLICY; YOUNG POPULATION;

AIR POLLUTION; ASTHMA; CHILD; ENVIRONMENTAL EXPOSURE; HUMAN; PARTICULATE MATTER; REVIEW; RISK; SENSITIVITY ANALYSIS; SYSTEMATIC REVIEW; TRAFFIC; TRAFFIC RELATED AIR POLLUTION; ADOLESCENT; AIR POLLUTANT; ANALYSIS; CHEMICALLY INDUCED; EXHAUST GAS; FEMALE; INCIDENCE; INFANT; MALE; META ANALYSIS; NEWBORN; PRESCHOOL CHILD; PREVALENCE; RISK FACTOR;

ADOLESCENT; AIR POLLUTANTS; AIR POLLUTION; ASTHMA; CHILD; CHILD, PRESCHOOL; ENVIRONMENTAL EXPOSURE; FEMALE; HUMANS; INCIDENCE; INFANT; INFANT, NEWBORN; MALE; PREVALENCE; RISK FACTORS; VEHICLE EMISSIONS;

EID: 85028274653     PISSN: 01604120     EISSN: 18736750     Source Type: Journal    
DOI: 10.1016/j.envint.2016.11.012     Document Type: Review

References (125)

1. Akers, J., Aguiar-Ibáñez, R., Baba-Akbari Sari, A., CRD's Guidance for Undertaking Reviews in Health Care. 2009, University of York Centre for Reviews and Dissemination (CRD), York (UK).
2. Anandan, C., et al. Is the prevalence of asthma declining? Systematic review of epidemiological studies. Allergy 65:2 (2010), 152–167.
3. Anderson, H.R., Air pollution and trends in asthma. The Rising Trends in Asthma, 1997, Wiley Chichester, 190–203.
4. Anderson, H.R., et al. 50 years of asthma: UK trends from 1955 to 2004. Thorax 62:1 (2007), 85–90.
5. Anderson, H.R., Favarato, G., Atkinson, R.W., Long-term exposure to air pollution and the incidence of asthma: meta-analysis of cohort studies. Air Qual. Atmos. Health 6:1 (2013), 47–56.
6. Asher, M.I., Urbanisation, asthma and allergies. Thorax 66:12 (2011), 1025–1026.
7. Basagaña, X., et al. Measurement error in epidemiologic studies of air pollution based on land-use regression models. Am. J. Epidemiol. 178:8 (2013), 1342–1346.
8. Bateson, T.F., Schwartz, J., Children's response to air pollutants. J. Toxic. Environ. Health A 71:3 (2007), 238–243.
9. Beelen, R., et al. Development of NO2and NOxland use regression models for estimating air pollution exposure in 36 study areas in Europe–the ESCAPE project. Atmos. Environ. 72 (2013), 10–23.
10. Bennett, W.D., Zeman, K.L., Jarabek, A.M., Nasal contribution to breathing and fine particle deposition in children versus adults. J. Toxic. Environ. Health A 71:3 (2007), 227–237.
11. Bousquet, J., et al. MeDALL (mechanisms of the development of ALLergy): an integrated approach from phenotypes to systems medicine. Allergy 66:5 (2011), 596–604.
12. Bowatte, G., et al. The Influence of Childhood Traffic-Related Air Pollution Exposure on Asthma, Allergy and Sensitization: A Systematic Review and a Meta-Analysis of Birth Cohort Studies. Allergy, 2014.
13. Braback, L., Forsberg, B., Does traffic exhaust contribute to the development of asthma and allergic sensitization in children: findings from recent cohort studies. Environ. Health, 8(1), 2009, 17.
14. Braman, S.S., The global burden of asthma. Chest Journal 130:1_suppl (2006), 4S–12S.
15. Brauer, M., et al. Air pollution from traffic and the development of respiratory infections and asthmatic and allergic symptoms in children. Am. J. Respir. Crit. Care Med. 166:8 (2002), 1092–1098.
16. Brauer, M., et al. Air pollution and development of asthma, allergy and infections in a birth cohort. Eur. Respir. J. 29:5 (2007), 879–888.
17. Brunekreef, B., Holgate, S.T., Air pollution and health. Lancet 360:9341 (2002), 1233–1242.
18. Brunst, K.J., et al. Timing and duration of traffic-related air pollution exposure and the risk for childhood wheeze and asthma. Am. J. Respir. Crit. Care Med. 192:4 (2015), 421–427.
19. Carlsten, C., et al. Traffic-related air pollution and incident asthma in a high-risk birth cohort. Occup. Environ. Med., 2010, oem-2010.
20. Chen, Y., Wong, G.W., Li, J., Environmental exposure and genetic predisposition as risk factors for asthma in China. Allergy, Asthma Immunol. Res. 8:2 (2016), 92–100.
21. Clark, N.A., et al. Effect of early life exposure to air pollution on development of childhood asthma. Environ. Health Perspect., 118(2), 2010, 284.
22. Critical Appraisal Skills Programme, C.A.S.P. CASP Checklists. 2014 (2nd February 2015; Available from: http://www.casp-uk.net/#!casp-tools-checklists/c18f8).
23. Crouse, D.L., Goldberg, M.S., Ross, N.A., A prediction-based approach to modelling temporal and spatial variability of traffic-related air pollution in Montreal, Canada. Atmos. Environ. 43:32 (2009), 5075–5084.
24. Cyrys, J., et al. Comparison between different traffic-related particle indicators: elemental carbon (EC), PM2. 5 mass, and absorbance. J. Expo. Sci. Environ. Epidemiol. 13:2 (2003), 134–143.
25. Davies, H.T.O., Crombie, I.K., Tavakoli, M., When can odds ratios mislead?. BMJ 316:7136 (1998), 989–991.
26. Deeks, J., Higgins, J., Altman, D., Chapter 9: Analysing data and undertaking meta-analyses. JPT, H., Green, S., (eds.) Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [Updated March 2011]. The Cochrane Collaboration, 2011, 2011 (Available from: http://handbook.cochrane.org/chapter_9/9_analysing_data_and_undertaking_meta_analyses.htm).
27. Dell, S.D., et al. Presence of other allergic disease modifies the effect of early childhood traffic-related air pollution exposure on asthma prevalence. Environ. Int. 65 (2014), 83–92.
28. Department for Environment Food and Rural Affairs, D.E.F.R.A, Conversion Factors Between ppb and μg m-3 and ppm and mgm-3. 2014 (August 2014 12th September 2016]; Available from: https://uk-air.defra.gov.uk/assets/documents/reports/cat06/0502160851_Conversion_Factors_Between_ppb_and.pdf).
29. Deng, Q., et al. Early life exposure to ambient air pollution and childhood asthma in China. Environ. Res. 143 (2015), 83–92.
30. Deng, Q., et al. Preconceptional, prenatal and postnatal exposure to outdoor and indoor environmental factors on allergic diseases/symptoms in preschool children. Chemosphere 152 (2016), 459–467.
31. Douwes, J., et al. Non-eosinophilic asthma: importance and possible mechanisms. Thorax 57:7 (2002), 643–648.
32. Eder, W., Ege, M.J., von Mutius, E., The asthma epidemic. N. Engl. J. Med. 355:21 (2006), 2226–2235.
33. Eeftens, M., et al. Development of land use regression models for PM2. 5, PM2. 5 absorbance, PM10 and PMcoarse in 20 European study areas; results of the ESCAPE project. Environ. Sci. Technol. 46:20 (2012), 11195–11205.
34. English, P., et al. Examining associations between childhood asthma and traffic flow using a geographic information system. Environ. Health Perspect., 107(9), 1999, 761.
35. European Study of Cohorts for Air Pollution Effects, E. ESCAPE - European Study of Cohorts for Air Pollution Effects. 2014 (30th March 2016 30th March 2016]; Available from: http://www.escapeproject.eu/).
36. Favarato, G., et al. Traffic-related pollution and asthma prevalence in children. Quantification of associations with nitrogen dioxide. Air Qual. Atmos. Health 7:4 (2014), 459–466.
37. Fischer, P., et al. Traffic-related differences in outdoor and indoor concentrations of particles and volatile organic compounds in Amsterdam. Atmos. Environ. 34:22 (2000), 3713–3722.
38. Fuertes, E., et al. A longitudinal analysis of associations between traffic-related air pollution with asthma, allergies and sensitization in the GINIplus and LISAplus birth cohorts. PeerJ, 1, 2013, e193.
39. Fuertes, E., et al. The influence of childhood traffic-related air pollution exposure on asthma, allergy and sensitization. Allergy 70:10 (2015), 1350–1352.
40. Gaffin, J.M., Kanchongkittiphon, W., Phipatanakul, W., Perinatal and early childhood environmental factors influencing allergic asthma immunopathogenesis. Int. Immunopharmacol. 22:1 (2014), 21–30.
41. Gasana, J., et al. Motor vehicle air pollution and asthma in children: a meta-analysis. Environ. Res. 117 (2012), 36–45.
42. Gauderman, W.J., et al. Childhood asthma and exposure to traffic and nitrogen dioxide. Epidemiology 16:6 (2005), 737–743.
43. Gehring, U., et al. Traffic-related air pollution and respiratory health during the first 2 yrs of life. Eur. Respir. J. 19:4 (2002), 690–698.
44. Gehring, U., et al. Traffic-related air pollution and the development of asthma and allergies during the first 8 years of life. Am. J. Respir. Crit. Care Med. 181:6 (2010), 596–603.
45. Gehring, U., et al. Exposure to air pollution and development of asthma and rhinoconjunctivitis throughout childhood and adolescence: a population-based birth cohort study. Lancet Respir. Med. 3:12 (2015), 933–942.
46. Gehring, U., et al. Particulate matter composition and respiratory health: the PIAMA birth cohort study. Epidemiology 26:3 (2015), 300–309.
47. Gilmour, M.I., et al. How exposure to environmental tobacco smoke, outdoor air pollutants, and increased pollen burdens influences the incidence of asthma. Environ. Health Perspect., 2006, 627–633.
48. Global Asthma Network, G, The Global Asthma Report. 2014, 2014 Auckland, New Zealand.
49. Gowers, A.M., et al. Does outdoor air pollution induce new cases of asthma? Biological plausibility and evidence; a review. Respirology 17:6 (2012), 887–898.
50. Gruzieva, O., et al. Traffic-related air pollution and development of allergic sensitization in children during the first 8 years of life. J. Allergy Clin. Immunol. 129:1 (2012), 240–246.
51. Gruzieva, O., et al. Exposure to air pollution from traffic and childhood asthma until 12 years of age. Epidemiology 24:1 (2013), 54–61.
52. Guarnieri, M., Balmes, J.R., Outdoor air pollution and asthma. Lancet 383:9928 (2014), 1581–1592.
53. Hansen, S., et al. A comparison of three methods to measure asthma in epidemiologic studies: results from the danish national birth cohort. PLoS One, 7(5), 2012, e36328.
54. Hasunuma, H., et al. Association between traffic-related air pollution and asthma in preschool children in a national Japanese nested case–control study. BMJ Open, 6(2), 2016, e010410.
55. Health Effects Institute, H.E.I, Traffic-related air pollution: a critical review of the literature on emissions, exposure, and health effects. Special Report 17. HEI Panel on the Health Effects of Traffic-Related Air Pollution, 2010, Health Effects Institute, Boston, Massachusetts (2010).
56. Heinrich, J., et al. Trends in prevalence of atopic diseases and allergic sensitization in children in Eastern Germany. Eur. Respir. J. 19:6 (2002), 1040–1046.
57. Henderson, S.B., et al. Application of land use regression to estimate long-term concentrations of traffic-related nitrogen oxides and fine particulate matter. Environ. Sci. Technol. 41:7 (2007), 2422–2428.
58. Higgins, J.P., et al. Measuring inconsistency in meta-analyses. BMJ [Br. Med. J.], 327(7414), 2003, 557.
59. Hochadel, M., et al. Predicting long-term average concentrations of traffic-related air pollutants using GIS-based information. Atmos. Environ. 40:3 (2006), 542–553.
60. Huang, C., et al. Updated prevalences of asthma, allergy, and airway symptoms, and a systematic review of trends over time for childhood asthma in Shanghai, China. PLoS One, 10(4), 2015, e0121577.
61. Jerrett, M., Does traffic-related air pollution contribute to respiratory disease formation in children?. Eur. Respir. J. 29:5 (2007), 825–826.
62. Jerrett, M., et al. A review and evaluation of intraurban air pollution exposure models. J. Expo. Sci. Environ. Epidemiol. 15:2 (2005), 185–204.
63. Jerrett, M., et al. Modeling the intraurban variability of ambient traffic pollution in Toronto, Canada. J. Toxic. Environ. Health A 70:3–4 (2007), 200–212.
64. Jerrett, M., et al. Traffic-related air pollution and asthma onset in children: a prospective cohort study with individual exposure measurement. Environ. Health Perspect. 116:10 (2008), 1433–1438.
65. Karimi, P., et al. Polycyclic aromatic hydrocarbons and childhood asthma. Eur. J. Epidemiol. 30:2 (2015), 91–101.
66. Kaur, S., Nieuwenhuijsen, M.J., Colvile, R.N., Fine particulate matter and carbon monoxide exposure concentrations in urban street transport microenvironments. Atmos. Environ. 41:23 (2007), 4781–4810.
67. Kerkhof, M., et al. Toll-like receptor 2 and 4 genes influence susceptibility to adverse effects of traffic-related air pollution on childhood asthma. Thorax 65:8 (2010), 690–697.
68. Khreis, H., et al. Exposure to Traffic-Related Air Pollution and the Development of Childhood Asthma. PROSPERO. 2016 (CRD42014015448. 2014 8th September 2016 [cited 2016 12th September 2016]; Available from: http://www.crd.york.ac.uk/PROSPERO/display_record.asp?ID=CRD42014015448).
69. Kim, J., et al. Association of carbon monoxide levels with allergic diseases in children. Allergy and Asthma Proceedings, 2016, OceanSide Publications, Inc.
70. Kirkwood, B., Sterne, J., Essential Medical Statistics. 2003, Blackwell, Malden, 268–270.
71. Koenig, J.Q., Air pollution and asthma. J. Allergy Clin. Immunol. 104:4 (1999), 717–722.
72. Krämer, U., et al. Eczema, respiratory allergies, and traffic-related air pollution in birth cohorts from small-town areas. J. Dermatol. Sci. 56:2 (2009), 99–105.
73. Krzyzanowski, M., Cohen, A., Update of WHO air quality guidelines. Air Qual. Atmos. Health 1:1 (2008), 7–13.
74. LeMasters, G., et al. Secondhand smoke and traffic exhaust confer opposing risks for asthma in normal and overweight children. Obesity 23:1 (2015), 32–36.
75. Li, N., et al. Particulate air pollutants and asthma: a paradigm for the role of oxidative stress in PM-induced adverse health effects. Clin. Immunol. 109:3 (2003), 250–265.
76. Li, N., et al. Ultrafine particulate pollutants induce oxidative stress and mitochondrial damage. Environ. Health Perspect., 111(4), 2003, 455.
77. Lindgren, A., et al. Asthma incidence in children growing up close to traffic: a registry-based birth cohort. Environ. Health, 12(1), 2013, 91.
78. Liu, W., et al. Associations of gestational and early life exposures to ambient air pollution with childhood respiratory diseases in Shanghai, China: a retrospective cohort study. Environ. Int. 92 (2016), 284–293.
79. Longley, I., et al. Exposure to ultrafine particles from traffic in city streets and the urban atmosphere. Tenth International Conference on Urban Transport and the Environment, 2004, Dresden, Germany.
80. MacIntyre, E.A., et al. Traffic, asthma and genetics: combining international birth cohort data to examine genetics as a mediator of traffic-related air pollution's impact on childhood asthma. Eur. J. Epidemiol. 28:7 (2013), 597–606.
81. MacIntyre, E.A., et al. GSTP1 and TNF gene variants and associations between air pollution and incident childhood asthma: the traffic, asthma and genetics (TAG) study. Environ. Health Perspect. 122:4 (2014), 418–424.
82. Martinez, F.D., et al. Asthma and wheezing in the first six years of life. N. Engl. J. Med. 332:3 (1995), 133–138.
83. McConnell, R., et al. Childhood incident asthma and traffic-related air pollution at home and school. Environ. Health Perspect., 118(7), 2010, 1021.
84. Mölter, A., et al. Effects of long-term exposure to PM10 and NO2 on asthma and wheeze in a prospective birth cohort. J. Epidemiol. Community Health 68:1 (2014), 21–28.
85. Mölter, A., et al. A multicentre study of air pollution exposure and childhood asthma prevalence: the ESCAPE project. Eur. Respir. J., 2014 (erj00836–2014).
86. Morgenstern, V., et al. Respiratory health and individual estimated exposure to traffic-related air pollutants in a cohort of young children. Occup. Environ. Med. 64:1 (2007), 8–16.
87. Morgenstern, V., et al. Atopic diseases, allergic sensitization, and exposure to traffic-related air pollution in children. Am. J. Respir. Crit. Care Med. 177:12 (2008), 1331–1337.
88. Nishimura, K.K., et al. Early-life air pollution and asthma risk in minority children. The GALA II and SAGE II studies. Am. J. Respir. Crit. Care Med. 188:3 (2013), 309–318.
89. Nordling, E., et al. Traffic-related air pollution and childhood respiratory symptoms, function and allergies. Epidemiology 19:3 (2008), 401–408.
90. Oftedal, B., et al. Modelling long-term averages of local ambient air pollution in Oslo, Norway: evaluation of nitrogen dioxide, PM10 and PM2. 5. Int. J. Environ. Pollut. 36:1–3 (2008), 110–126.
91. Oftedal, B., et al. Long-term traffic-related exposures and asthma onset in schoolchildren in Oslo, Norway. Environ. Health Perspect. 117:5 (2009), 839–844.
92. Patel, M.M., et al. Traffic density and stationary sources of air pollution associated with wheeze, asthma, and immunoglobulin E from birth to age 5 years among New York City children. Environ. Res. 111:8 (2011), 1222–1229.
93. Pearce, N., Pekkanen, J., Beasley, R., How much asthma is really attributable to atopy?. Thorax 54:3 (1999), 268–272.
94. Pearce, N., et al. Worldwide trends in the prevalence of asthma symptoms: phase III of the international study of asthma and allergies in childhood (ISAAC). Thorax 62:9 (2007), 758–766.
95. Piippo-Savolainen, E., Korppi, M., Wheezy babies—wheezy adults? Review on long-term outcome until adulthood after early childhood wheezing. Acta Paediatr. 97:1 (2008), 5–11.
96. Ranzi, A., et al. Exposure to air pollution and respiratory symptoms during the first 7 years of life in an Italian birth cohort. Occup. Environ. Med., 2014 (oemed-2013-101867).
97. Ryan, P.H., et al. A comparison of proximity and land use regression traffic exposure models and wheezing in infants. Environ. Health Perspect., 2007, 278–284.
98. Ryan, P.H., et al. A land-use regression model for estimating microenvironmental diesel exposure given multiple addresses from birth through childhood. Sci. Total Environ. 404:1 (2008), 139–147.
99. Salam, M.T., Islam, T., Gilliland, F.D., Recent evidence for adverse effects of residential proximity to traffic sources on asthma. Curr. Opin. Pulm. Med. 14:1 (2008), 3–8.
100. Salameh, P., et al. Asthme, pollutions intérieure et extérieure: étude pilote chez des adolescents libanais scolarisés. Rev. Mal. Respir. 32:7 (2015), 692–704.
101. Sarnat, J.A., Holguin, F., Asthma and air quality. Curr. Opin. Pulm. Med. 13:1 (2007), 63–66.
102. Sbihi, H., et al. Perinatal air pollution exposure and development of asthma from birth to age 10 years. Eur. Respir. J., 2016 (ERJ-00746-2015).
103. Schwartz, J., Air pollution and children's health. Pediatrics 113:Suppl. 3 (2004), 1037–1043.
104. Shima, M., Adachi, M., Effect of outdoor and indoor nitrogen dioxide on respiratory symptoms in schoolchildren. Int. J. Epidemiol. 29:5 (2000), 862–870.
105. Shima, M., et al. Effects of air pollution on the prevalence and incidence of asthma in children. Arch. Environ. Health: Int. J. 57:6 (2002), 529–535.
106. Shima, M., Nitta, Y., Adachi, M., Traffic-related air pollution and respiratory symptoms in children living along trunk roads in Chiba Prefecture, Japan. J. Epidemiol. 13:2 (2003), 108–119.
107. Sterne, J.A., Egger, M., Funnel plots for detecting bias in meta-analysis: guidelines on choice of axis. J. Clin. Epidemiol. 54:10 (2001), 1046–1055.
108. Stroh, E., et al. Measured and modeled personal and environmental NO2exposure. Popul. Health Metrics, 2012, 10(10).
109. Stroup, D.F., et al. Meta-analysis of observational studies in epidemiology: a proposal for reporting. JAMA 283:15 (2000), 2008–2012.
110. Tétreault, L.F., Doucet, M., Gamache, P., Fournier, M., Brand, A., Kosatsky, T., Smargiassi, A., Childhood exposure to ambient air pollutants and the onset of asthma: an administrative cohort study in Québec. Environ. Health Perspect. 124 (2016), 1276–1282.
111. Vardoulakis, S., et al. Modelling air quality in street canyons: a review. Atmos. Environ. 37:2 (2003), 155–182.
112. Veremchuk, L., et al. Methodology for the assessment of the impact of the atmospheric air pollution on the formation of the levels of overall morbidity rate of bronchial asthma. Gig. Sanit. 94:3 (2014), 119–122.
113. Vitnerova, N., Horstman, D., Hnizdova, E., Prevalence priznaku chorob dychaciho traktu u deti skolniho veku zijicich v oblastech s rozdilnym znecistenim ovzdusi. Hygie 44:Suppl. 2 (1999), 30–39.
114. Vrijheid, M., et al. Ambient air pollution and risk of congenital anomalies: a systematic review and meta-analysis. Environ. Health Perspect. 119:5 (2011), 598–606.
115. Wang, I.-J., et al. Allergens, air pollutants, and childhood allergic diseases. Int. J. Hyg. Environ. Health 219:1 (2016), 66–71.
116. Wenzel, S.E., Asthma phenotypes: the evolution from clinical to molecular approaches. Nat. Med. 18:5 (2012), 716–725.
117. Williams, M., et al. Review of Air Quality Modelling in DEFRA. 2011 (22 September 2014; Available from: http://uk-air.defra.gov.uk/assets/documents/reports/cat20/1106290858_DefraModellingReviewFinalReport.pdf).
118. Wong, G.W.K., Leung, T.F., The effects of air pollution on asthma in children. Clin. Pulm. Med. 12:1 (2005), 1–6.
119. World Health Organization, W.H.O, Maternal, Newborn, Child and Adolescent Health: Adolescent Development. 2014 (29th March 2016 29th March 2016]; Available from: http://www.who.int/maternal_child_adolescent/topics/adolescence/dev/en/).
120. Wright, R.J., Brunst, K.J., Programming of respiratory health in childhood: influence of outdoor air pollution. Curr. Opin. Pediatr. 25:2 (2013), 232–239.
121. Xie, M., Wenzel, S.E., A global perspective in asthma: from phenotype to endotype. Chin. Med. J. 126 (2013), 166–174.
122. Yamazaki, S., et al. Association between traffic-related air pollution and development of asthma in school children: cohort study in Japan. J. Expo. Sci. Environ. Epidemiol. 24:4 (2014), 372–379.
123. Yang, A., et al. Children's respiratory health and oxidative potential of PM2.5: the PIAMA birth cohort study. Occup. Environ. Med., 2016 (oemed-2015-103175).
124. Zhang, Y., et al. Ten cities cross-sectional questionnaire survey of children asthma and other allergies in China. Chin. Sci. Bull. 58:34 (2013), 4182–4189.
125. Zmirou, D., et al. Traffic related air pollution and incidence of childhood asthma: results of the Vesta case-control study. J. Epidemiol. Community Health 58:1 (2004), 18–23.