Akt phosphorylates and activates HSF-1 independent of heat shock, leading to Slug overexpression and epithelial-mesenchymal transition (EMT) of HER2-overexpressing breast cancer cells

Oncogene

Volumn 34, Issue 5, 2015, Pages 546-557

  Carpenter, R L ^a   Paw, I ^a   Dewhirst, M W ^a,b   Lo, H W ^a,b  

^a DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b DUKE CANCER INSTITUTE   (United States)

Author keywords

Akt; EMT; HER2; HSF 1; phosphorylation; Slug

Indexed keywords

DNA BINDING PROTEIN; EPIDERMAL GROWTH FACTOR RECEPTOR 2; ERBB2 PROTEIN, HUMAN; HEAT SHOCK TRANSCRIPTION FACTOR; NEU DIFFERENTIATION FACTOR; ONCOPROTEIN; SMALL INTERFERING RNA; SNAIL FAMILY TRANSCRIPTION FACTORS; TRANSCRIPTION FACTOR;

ANIMAL; BIOSYNTHESIS; BREAST TUMOR; DRUG EFFECTS; EPITHELIAL MESENCHYMAL TRANSITION; FEMALE; GENE EXPRESSION REGULATION; GENETICS; HEAT SHOCK RESPONSE; HUMAN; MCF 7 CELL LINE; METABOLISM; PATHOLOGY; PHOSPHORYLATION; SIGNAL TRANSDUCTION;

ANIMALS; BREAST NEOPLASMS; DNA-BINDING PROTEINS; EPITHELIAL-MESENCHYMAL TRANSITION; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HEAT-SHOCK RESPONSE; HUMANS; MCF-7 CELLS; NEUREGULIN-1; ONCOGENE PROTEIN V-AKT; PHOSPHORYLATION; RECEPTOR, ERBB-2; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS;

EID: 85028268473     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2013.582     Document Type: Article

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