Environmental risk, Oxytocin Receptor Gene (OXTR) methylation and youth callous-unemotional traits: a 13-year longitudinal study

Molecular Psychiatry

Volumn 19, Issue 10, 2014, Pages 1071-1077

  Cecil, C A M ^a   Lysenko, L J ^a   Jaffee, S R ^b   Pingault, J B ^a,c   Smith, R G ^a   Relton, C L ^d   Woodward, G ^d   McArdle, W ^e   Mill, J ^a,f   Barker, E D ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c UNIVERSITY COLLEGE LONDON   (United Kingdom)

^d UNIVERSITY OF BRISTOL   (United Kingdom)

^e UNIVERSITY OF BRISTOL   (United Kingdom)

^f UNIVERSITY OF EXETER MEDICAL SCHOOL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

OXTR PROTEIN, HUMAN; OXYTOCIN RECEPTOR;

CHILD; CONDUCT DISORDER; CRIME VICTIM; DNA METHYLATION; FAMILY; FEMALE; GENETICS; HUMAN; LONGITUDINAL STUDY; MALE; NEWBORN; PREGNANCY; PROSPECTIVE STUDY; PSYCHOLOGY; RISK; SOCIAL ENVIRONMENT;

CHILD; CONDUCT DISORDER; CRIME VICTIMS; DNA METHYLATION; FAMILY; FEMALE; HUMANS; INFANT, NEWBORN; LONGITUDINAL STUDIES; MALE; PREGNANCY; PROSPECTIVE STUDIES; RECEPTORS, OXYTOCIN; RISK; SOCIAL ENVIRONMENT;

EID: 85028254608     PISSN: 13594184     EISSN: 14765578     Source Type: Journal    
DOI: 10.1038/mp.2014.95     Document Type: Article

References (53)

1. Dandreaux DM, Frick PJ. Developmental pathways to conduct problems: a further test of the childhood and adolescent-onset distinction. J Abnorm Child Psychol 2009; 37: 375–385. DOI: 10.1007/s10802-008-9261-5
2. Rowe R, Maughan B, Moran P, Ford T, Briskman J, Goodman R. The role of callous and unemotional traits in the diagnosis of conduct disorder. J Child Psychol Psychiatry 2010; 51: 688–695. DOI: 10.1111/j.1469-7610.2009.02199.x
3. Frick PJ, Viding E. Antisocial behavior from a developmental psychopathology perspective. Dev Psychopathol 2009; 21(Special issue 04): 1111–1131. DOI: 10.1017/S0954579409990071
4. Kahn RE, Frick PJ, Youngstrom EA, Kogos Youngstrom J, Feeny NC, Findling RL. Distinguishing primary and secondary variants of callous-unemotional traits among adolescents in a clinic-referred sample. Psychol Assess 2013; 25: 966–978. DOI: 10.1037/a0032880
5. Kimonis ER, Frick PJ, Cauffman E, Goldweber A, Skeem J. Primary and secondary variants of juvenile psychopathy differ in emotional processing. Dev Psychopathol. 2012; 24: 1091–1103. DOI: 10.1017/S0954579412000557
6. Tatar JR, Cauffman E, Kimonis ER, Skeem JL. Victimization History and Posttraumatic Stress: An Analysis of Psychopathy Variants in Male Juvenile Offenders. J Child Adolesc Trauma 2012; 5: 102–113. DOI: 10.1080/19361521.2012.671794
7. Vaughn MG, Edens JF, Howard MO, Smith ST. An investigation of primary and secondary psychopathy in a statewide sample of incarcerated youth. Youth Violence and Juvenile Justice 2009; 7: 172–188. DOI: 10.1177/1541204009333792
8. Jaenisch R, Bird A. Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals. Nat Genet 2003; 33: 245–254. DOI: 10.1038/ng1089
9. Champagne FA. Epigenetic influence of social experiences across the lifespan. Dev Psychobiol 2010; 52: 299–311. DOI: 10.1002/dev.20436
10. Dadds MR, Moul C, Cauchi A, Dobson-Stone C, Hawes DJ, Brennan J et al. Methylation of the oxytocin receptor gene and oxytocin blood levels in the development of psychopathy. Dev Psychopathol 2014; 26: 33–40. DOI: 10.1017/S0954579413000497
11. Frick PJ, Ray JV, Thornton LC, Kahn RE. Annual research review: A developmental psychopathology approach to understanding callous-unemotional traits in children and adolescents with serious conduct problems. J Child Psychol Psychiatry 2013; 55: 532–548. DOI: 10.1111/jcpp.12152
12. Insel TR. The challenge of translation in social neuroscience: a review of oxytocin, vasopressin, and affiliative behavior. Neuron 2010; 65: 768–779. DOI: 10.1016/j.neuron.2010.03.005
13. Kumsta R, Hummel E, Chen FS, Heinrichs M. Epigenetic regulation of the oxytocin receptor gene: implications for behavioral neuroscience. Front Neurosci 2013; 7: 83. DOI: 10.3389/fnins.2013.00083
14. Barker ED, Oliver BR, Maughan B. Co-occurring problems of early onset persistent, childhood limited, and adolescent onset conduct problem youth. J Child Psychol Psychiatry 2010; 51: 1217–1226. DOI: 10.1111/j.1469-7610.2010.02240.x
15. Barker ED, Oliver BR, Viding E, Salekin RT, Maughan B. The impact of prenatal maternal risk, fearless temperament and early parenting on adolescent callous-unemotional traits: a 14-year longitudinal investigation. J Child Psychol Psychiatry 2011; 52: 878–888. DOI: 10.1111/j.1469-7610.2011.02397.x
16. Fraser A, Macdonald-Wallis C, Tilling K, Boyd A, Golding J, Davey Smith G et al. Cohort Profile: the Avon Longitudinal Study of Parents and Children: ALSPAC mothers cohort. Int J Epidemiol 2013; 42: 97–110. DOI: 10.1093/ije/dys066
17. Boyd A, Golding J, Macleod J, Lawlor DA, Fraser A, Henderson J et al. Cohort Profile: the 'children of the 90s'—the index offspring of the Avon Longitudinal Study of Parents and Children. Int J Epidemiol 2013; 42: 111–127. DOI: 10.1093/ije/dys064
18. Barker ED, Maughan B. Differentiating early-onset persistent versus childhood-limited conduct problem youth. Am J Psychiatry 2009; 166: 900–908. DOI: 10.1176/appi.ajp.2009.08121770
19. Pidsley R, YW CC, Volta M, Lunnon K, Mill J, Schalkwyk LC. A data-driven approach to preprocessing Illumina 450K methylation array data. BMC Genomics 2013; 14: 293. DOI: 10.1186/1471-2164-14-293
20. Johnson WE, Li C, Rabinovic A. Adjusting batch effects in microarray expression data using empirical Bayes methods. Biostatistics 2007; 8: 118–127. DOI: 10.1093/biostatistics/kxj037
21. Gregory SG, Connelly JJ, Towers AJ, Johnson J, Biscocho D, Markunas CA et al. Genomic and epigenetic evidence for oxytocin receptor deficiency in autism. BMC Med 2009; 7: 62. DOI: 10.1186/1741-7015-7-62
22. Jack A, Connelly JJ, Morris JP. DNA methylation of the oxytocin receptor gene predicts neural response to ambiguous social stimuli. Front Hum Neurosci 2012; 6: 280. DOI: 10.3389/fnhum.2012.00280
23. Kusui C, Kimura T, Ogita K, Nakamura H, Matsumura Y, Koyama M et al. DNA methylation of the human oxytocin receptor gene promoter regulates tissue-specific gene suppression. Biochem Biophys Res Commun 2001; 289: 681–686. DOI: 10.1006/bbrc.2001.6024
24. Thompson B. Exploratory and Confirmatory Factor Analysis: Understanding Concepts and Applications. American Psychological Association: Washington, DC, USA, 2004. DOI: 10.1037/10694-000
25. Goodman A, Heiervang E, Collishaw S, Goodman R. The 'DAWBA bands' as an ordered-categorical measure of child mental health: description and validation in British and Norwegian samples. Soci Psychiatry Psychiatri Epidemiol 2011; 46: 521–532. DOI: 10.1007/s00127-010-0219-x
26. Moran P, Ford T, Butler G, Goodman R. Callous and unemotional traits in children and adolescents living in Great Britain. Brit J Psychiatry 2008; 192: 65–66. DOI: 10.1192/bjp.bp.106.034876
27. Moran P, Rowe R, Flach C, Briskman J, Ford T, Maughan B et al. Predictive value of callous-unemotional traits in a large community sample. J Am Acad Child Adolesc Psychiatry 2009; 48: 1079–1084. DOI: 10.1097/CHI.0b013e3181b766ab
28. Muthen LK, Muthen BO. MPLUS User’s Guide, 1998-2010, 6th edn. Muthen & Muthen: Los Angeles, CA, USA, 2011.
29. Kline RB. Principles and Practice of Structural Equation Modeling, 3rd edn. The Guildford Press: New York, NY, USA, 2010.
30. Hu Lt, Bentler PM. Cutoff criteria for fit indexes in covariance structure analysis: Conventional criteria versus new alternatives. Struct Equation Model 1999; 6: 1–55. DOI: 10.1080/10705519909540118
31. Satorra A. Scaled and adjusted restricted tests in multi-sample analysis of moment structures. In: Heijmans DDH, Pollock DSG, Satorra A (eds). Innovations in Multivariate Statistical Analysis. A festschrift for Heinz Neudecker. Kluwer Academic Publishers: Dordrecht, Netherlands, 2000, pp 233–247. DOI: 10.1007/978-1-4615-4603-0_17
32. Sheskin D. The Handbook Of Parametric And Nonparametric Statistical Procedures. CRC Press: Boca Raton, FL, 2003. DOI: 10.1201/9781420036268
33. Meaburn EL, Schalkwyk LC, Mill J. Allele-specific methylation in the human genome: implications for genetic studies of complex disease. Epigenetics 2010; 5: 578–582. DOI: 10.4161/epi.5.7.12960
34. Schalkwyk LC, Meaburn EL, Smith R, Dempster EL, Jeffries AR, Davies MN et al. Allelic skewing of DNA methylation is widespread across the genome. Am J Hum Genet 2010; 86: 196–212. DOI: 10.1016/j.ajhg.2010.01.014
35. Eicher JD, Powers NR, Miller LL, Akshoomoff N, Amaral DG, Bloss CS et al. Genome-wide association study of shared components of reading disability and language impairment. Genes Brain Behav 2013; 12: 792–801. DOI: 10.1111/gbb.12085
36. Johansson A, Westberg L, Sandnabba K, Jern P, Salo B, Santtila P. Associations between oxytocin receptor gene (OXTR) polymorphisms and self-reported aggressive behavior and anger: Interactions with alcohol consumption. Psychoneuroendocrinology 2012; 37: 1546–1556. DOI: 10.1016/j.psyneuen.2012.02.009
37. Nyffeler J, Walitza S, Bobrowski E, Gundelfinger R, Grunblatt E. Association study in siblings and case-controls of serotonin- and oxytocin-related genes with high functioning autism. J Mol Psychiatry 2014; 2: 1. DOI: 10.1186/2049-9256-2-1
38. Loth E, Poline JB, Thyreau B, Jia T, Tao C, Lourdusamy A et al. Oxytocin receptor genotype modulates ventral striatal activity to social cues and response to stressful life events. Biol Psychiatry 2014; 76: 367–376. DOI: 10.1016/j.biopsych.2013.07.043
39. Wu N, Li Z, Su Y. The association between oxytocin receptor gene polymorphism (OXTR) and trait empathy. J Affect Disord 2012; 138: 468–472. DOI: 10.1016/j.jad.2012.01.009
40. Button TM, Corley RP, Rhee SH, Hewitt JK, Young SE, Stallings MC. Delinquent peer affiliation and conduct problems: a twin study. J Abnorm Psychol 2007; 116: 554–564. DOI: 10.1037/0021-843X.116.3.554
41. Jaffee SR, Price TS. Gene-environment correlations: a review of the evidence and implications for prevention of mental illness. Mol Psychiatry 2007; 12: 432–442. DOI: 10.1038/sj.mp.4001950
42. Kendler KS, Jacobson KC, Gardner CO, Gillespie N, Aggen SA, Prescott CA. Creating a social world: a developmental twin study of peer-group deviance. Arch Gen Psychiatry 2007; 64: 958–965. DOI: 10.1001/archpsyc.64.8.958
43. McAdams TA, Gregory AM, Eley TC. Genes of experience: explaining the heritability of putative environmental variables through their association with behavioural and emotional traits. Behav Genet 2013; 43: 314–328. DOI: 10.1007/s10519-013-9591-0
44. Barker ED, Arseneault L, Brendgen M, Fontaine N, Maughan B. Joint development of bullying and victimization in adolescence: relations to delinquency and self-harm. J Am Acad Child Adolesc Psychiatry 2008; 47: 1030–1038.
45. Barker ED, Salekin RT. Irritable oppositional defiance and callous unemotional traits: is the association partially explained by peer victimization? J Child Psychol Psychiatry 2012; 53: 1167–1175. DOI: 10.1111/j.1469-7610.2012.02579.x
46. Reijntjes A, Kamphuis JH, Prinzie P, Telch MJ. Peer victimization and internalizing problems in children: a meta-analysis of longitudinal studies. Child Abuse Neglect 2010; 34: 244–252. DOI: 10.1016/j.chiabu.2009.07.009
47. Meaney MJ, Szyf M, Seckl JR. Epigenetic mechanisms of perinatal programming of hypothalamic-pituitary-adrenal function and health. Trends Mol Med 2007; 13: 269–277. DOI: 10.1016/j.molmed.2007.05.003
48. Johannes F, Porcher E, Teixeira FK, Saliba-Colombani V, Simon M, Agier N et al. Assessing the Impact of Transgenerational Epigenetic Variation on Complex Traits. PLoS Genet 2009; 5: e1000530. DOI: 10.1371/journal.pgen.1000530
49. Richards EJ. Inherited epigenetic variation—revisiting soft inheritance. Nat Rev Genet 2006; 7: 395–401. DOI: 10.1038/nrg1834
50. Skeem JL, Poythress N, Edens JF, Lilienfeld SO, Cale EM. Psychopathic personality or personalities? Exploring potential variants of psychopathy and their implications for risk assessment. Aggress Violent Behav 2003; 8: 513–546. DOI: 10.1016/S1359-1789(02)00098-8
51. O'Connor TG, Heron J, Golding J, Beveridge M, Glover V. Maternal antenatal anxiety and children's behavioural/emotional problems at 4 years. Report from the Avon Longitudinal Study of Parents and Children. Brit J Psychiatry 2002; 180: 502–508. DOI: 10.1192/bjp.180.6.502
52. Sadeh N, Javdani S, Jackson JJ, Reynolds EK, Potenza MN, Gelernter J et al. Serotonin transporter gene associations with psychopathic traits in youth vary as a function of socioeconomic resources. J Abnorm Psychol 2010; 119: 604–609. DOI: 10.1037/a0019709
53. Craig IW, Halton KE. Genetics of human aggressive behaviour. Hum Genet 2009; 126: 101–113. DOI: 10.1007/s00439-009-0695-9