Methylation of the oxytocin receptor gene and oxytocin blood levels in the development of psychopathy

Development and Psychopathology

Volumn 26, Issue 1, 2014, Pages 33-40

  Dadds, Mark R ^a   Moul, Caroline ^a   Cauchi, Avril ^a   Dobson Stone, Carol ^a,b   Hawes, David J ^c   Brennan, John ^d   Ebstein, Richard E ^e  

^a UNIVERSITY OF NEW SOUTH WALES   (Australia)

^b NEUROSCIENCE RESEARCH AUSTRALIA   (Australia)

^c UNIVERSITY OF SYDNEY   (Australia)

^d SYDNEY CHILDREN'S HOSPITAL   (Australia)

^e NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

OXYTOCIN; OXYTOCIN RECEPTOR;

ADOLESCENT; AGE; ANTISOCIAL PERSONALITY DISORDER; ARTICLE; BLOOD; CHILD; CONDUCT DISORDER; DNA METHYLATION; EMPATHY; FAMILY; GENETIC EPIGENESIS; GENETICS; HUMAN; MALE; PSYCHOLOGICAL ASPECT; SOCIAL ENVIRONMENT;

ADOLESCENT; AGE FACTORS; ANTISOCIAL PERSONALITY DISORDER; CHILD; CONDUCT DISORDER; DNA METHYLATION; EMPATHY; EPIGENESIS, GENETIC; FAMILY; HUMANS; MALE; OXYTOCIN; RECEPTORS, OXYTOCIN; SOCIAL ENVIRONMENT;

EID: 84896454578     PISSN: 09545794     EISSN: 14692198     Source Type: Journal    
DOI: 10.1017/S0954579413000497     Document Type: Article

References (61)

1. Arsenijevic, Y., & Tribollet, E. (1998). Region-specific effect of testosterone on oxytocin receptor binding in the brain of the aged rat. Brain Research, 785, 167-170. doi:10.1016/S0006-8993(97)01429-7
2. Beitchman, J. H., Zai, C. C., Muir, K., Berall, L., Nowrouzi, B., Choi, E., et al. (2012). Childhood aggression, callous-unemotional traits and oxytocin genes. European Child and Adolescent Psychiatry, 21, 125-132.
3. Blair, R. J. R. (2008). Fine cuts of empathy and the amygdala: Dissociable deficits in psychopathy and autism. Quarterly Journal of Experimental Psychology, 61, 157-170.
4. Blair, R. J. R., Morris, J. S., Frith, C. D., Perrett, D. I., & Dolan, R. J. (1999). Dissociable neural responses to facial expressions of sadness and anger. Brain, 122, 883-893.
5. Bora, E., Yucel, M., & Allen, N. B. (2009). Neurobiology of human affiliative behaviour: Implications for psychiatric disorders. Current Opinion in Psychiatry, 22, 320-325.
6. Carter, C. S. (2007). Sex differences in oxytocin and vasopressin: Implications for autism spectrum disorders? Behavioural Brain Research, 176, 170-186.
7. Copeland, W., Shanahan, L., Costello, E., & Angold, A. (2009). Childhood and adolescent psychiatric disorders as predictors of young adult disorders. Archives of General Psychiatry, 66, 764-772. doi:10.1001/archgen psychiatry.2009.85
8. Dadds, M. R. (2013). Polymorphisms in the oxytocin receptor gene are associated with the development of psychopathy. Manuscript submitted for publication.
9. Dadds, M. R., Allen, J. L., Oliver, B. R., Faulkner, N., Legge, K., Moul, C., et al. (2012). Love, eye contact and the developmental origins of empathy v. psychopathy. British Journal of Psychiatry, 200, 191-196.
10. Dadds, M. R., Frost, A., Fraser, J., & Hawes, D. J. (2005). Disentangling the underlying dimensions of psychopathy and conduct problems in childhood: A community study. Journal of Consulting and Clinical Psychology, 73, 400-410.
11. Dadds, M. R., & Hawes, D. J. (2006). Integrative Family Intervention for Child Conduct Disorders. Brisbane: Australian Academic Press.
12. Dadds, M. R., Hawes, D. J., Frost, A. D., Vassallo, S., Bunn, P., Hunter, K., et al. (2009). Learning to "talk the talk": the relationship of psychopathic traits to deficits in empathy across childhood. Journal of Child Psychology and Psychiatry and Allied Disciplines, 50, 599-606.
13. Dadds, M. R., Perry, Y., Hawes, D. J., Merz, S., Riddell, A. C., Haines, D. J., et al. (2006). Attention to the eyes and fear-recognition deficits in child psychopathy. British Journal of Psychiatry, 189, 280-281.
14. Dadds, M. R., & Rhodes, T. (2008). Aggression in young children with concurrent callous-unemotional traits: Can the neurosciences inform progress and innovation in treatment approaches? Philosophical Transactions of the Royal Society, 363B, 2567-2576.
15. De Brito, S. A., McCrory, E. J., Mechelli, A., Wilke, M., Jones, A. P., Hodgins, S., et al. (2011). Small, but not perfectly formed: Decreased white matter concentration in boys with psychopathic tendencies. Molecular Psychiatry, 16, 476-477.
16. Deeley, Q., Daly, E., Surguladze, S., Tunstall, N., Mezey, G., Beer, D. G., et al. (2006). Facial emotion processing in criminal psychopathy: Preliminary functional magnetic resonance imaging study. British Journal of Psychiatry, 189, 533-539.
17. Dulac, C. (2010).Brain function and chromatin plasticity.Nature, 465, 728-735.
18. Ebstein, R. P., Knafo, A., Mankuta, D., Chew, S. H., & Lai, P. S. (2012). The contributions of oxytocin and vasopressin pathway genes to human behavior. Hormones and Behavior, 61, 359-379.
19. Feldman, R., Zagoory-Sharon, O., Weisman, O., Schneiderman, I., Gordon, I., Maoz, R., et al. (2012). Sensitive parenting is associated with plasma oxytocin and polymorphisms in the OXTR and CD38 genes. Biological Psychiatry, 72, 175-181.
20. Frick, P. J., & Hare, R. D. (2001). Antisocial Process Screening Device: APSD. Toronto: Multi-Health Systems.
21. Frick, P. J., Lilienfeld, S. O., Ellis, M., Loney, B., & Silverthorn, P. (1999). The association between anxiety and psychopathy dimensions in children. Journal of Abnormal Child Psychology, 27, 383-392.
22. Frick, P. J., & Moffitt, T. E. (2010). A proposal to the DSM-V childhood disorders and ADHD and disruptive behavior disorders work groups to include a specifier to the diagnosis of conduct disorder based on the presence of callous-unemotional traits.Washington, DC: American Psychiatric Association.
23. Frick, P. J.,&White, S.F. (2008).The importance of callous-unemotional traits for developmental models of aggressive and antisocial behavior. Journal of Child Psychology and Psychiatry and Allied Disciplines, 49, 359-375.
24. Goodman, R. (1997). The Strengths and Difficulties Questionnaire: A research note. Journal of Child Psychology and Psychiatry and Allied Disciplines, 38, 581-586.
25. Gopal Rao, V. V. N., Loffler, C., Battey, J., & Hansmann, I. (1992). The human gene for oxytocin-neurophysin I (OXT) is physically mapped to chromosome 20p13 by in situ hybridization. Cytogenetics and Cell Genetics, 61, 271-273.
26. Gregory, S. G., Connelly, J. J., Towers, A. J., Johnson, J., Biscocho, D., Markunas, C. A., et al. (2009). Genomic and epigenetic evidence for oxytocin receptor deficiency in autism. BMC Medicine, 7, 62.
27. Hoge, E. A., Pollack, M. H., Kaufman, R. E., Zak, P. J., & Simon, N. M. (2008). Oxytocin levels in social anxiety disorder. CNS Neuroscience and Therapeutics, 14, 165-170.
28. Holland, D., & Dadds, M. R. (1997). The Diagnostic Interview Schedule for Children, Adolescents, and Parents. Unpublished manuscript, Griffith University, Brisbane.
29. Insel, T. R., Young, L., Witt, D. M., & Crews, D. (1993). Gonadal steroids have paradoxical effects on brain oxytocin receptors. Journal of Neuroendocrinology, 5, 619-628.
30. Jack, A., Connelly, J. J., & Morris, J. P. (2012). DNA methylation of the oxytocin receptor gene predicts neural response to ambiguous social stimuli. Frontiers in Human Neuroscience, 6, 280. doi:10.3389/fnhum.2012. 00280
31. Jansen, L. M. C., Gispen-De Wied, C. C., Wiegant, V. M., Westenberg, H. G. M., Lahuis, B. E.,&Van Engeland, H. (2006). Autonomic and neuroendocrine responses to a psychosocial stressor in adults with autistic spectrum disorder. Journal of Autism and Developmental Disorders, 36, 891-899.
32. Jones, A. P., Happé, F. G., Gilbert, F., Burnett, S., & Viding, E. (2010). Feeling, caring, knowing: Different types of empathy deficit in boys with psychopathic tendencies and autism spectrum disorder. Journal of Child Psychology and Psychiatry and Allied Disciplines, 51, 1188-1197.
33. Jones, A. P., Laurens, K. R., Herba, C. M., Barker, G. J.,& Viding, E. (2009). Amygdala hypoactivity to fearful faces in boys with conduct problems and callous-unemotional traits. American Journal of Psychiatry, 166, 95-102.
34. Kaminsky, Z., Wang, S. C., & Petronis, A. (2006). Complex disease, gender and epigenetics. Annals of Medicine, 38, 530-544.
35. Kim-Cohen, J., Caspi, A., Moffitt, T. E., Harrington, H.,Milne, B. J., & Poulton, R. (2003). Prior juvenile diagnoses in adults with mental disorder: Developmental follow-back of a prospective-longitudinal cohort. Archives of General Psychiatry, 60, 709-717. doi:10.1001/archpsyc.60.7.709
36. Kroneman, L. M., Hipwell, A. E., Loeber, R., Koot, H. M., & Pardini, D. A. (2011). Contextual risk factors as predictors of disruptive behavior disorder trajectories in girls: The moderating effect of callous-unemotional features. Journal of Child Psychology and Psychiatry and Allied Disciplines, 52, 167-175.
37. Kumsta, R., Hummel, E., Chen, F. S., & Heinrichs, M. (in press). Epigenetic regulation of the oxytocin receptor gene: Implications for behavioral neuroscience. Frontiers in Endocrine Science.
38. Kusui, C., Kimura, T., Ogita, K., Nakamura, H., Matsumura, Y., Koyama, M., et al. (2001). DNA methylation of the human oxytocin receptor gene promoter regulates tissue-specific gene suppression. Biochemical and Biophysical Research Communications, 289, 681-686.
39. Liu, J. C. J., McErlean, R. A., & Dadds, M. R. (2012). Are we there yet? The clinical potential of intranasal oxytocin in psychiatry. Current Psychiatry Reviews, 8, 37-48.
40. Malik, A. I., Zai, C. C., Abu, Z., Nowrouzi, B., & Beitchman, J. H. (2012). The role of oxytocin and oxytocin receptor gene variants in childhoodonset aggression. Genes, Brain and Behavior, 11, 545-551.
41. Meaney, M. J., & Ferguson-Smith, A. C. (2010). Epigenetic regulation of the neural transcriptome: The meaning of the marks. Nature Neuroscience, 13, 1313-1318.
42. Meaney, M. J., & Szyf, M. (2005). Environmental programming of stress responses through DNA methylation: Life at the interface between a dynamic environment and a fixed genome. Dialogues in Clinical Neuroscience, 7, 103-123.
43. Meyer-Lindenberg, A., Domes, G., Kirsch, P., & Heinrichs, M. (2011). Oxytocin and vasopressin in the human brain: Social neuropeptides for translational medicine. Nature Reviews Neuroscience, 12, 524-538.
44. Meyer-Lindenberg, A., Polin, J. B., Kohn, P. D., Holt, J. L., Egan, M. F., Weinberger, D. R., et al. (2001). Evidence for abnormal cortical functional connectivity during working memory in schizophrenia. American Journal of Psychiatry, 158, 1809-1817.
45. Mitchell, I. J., Smid,W., Troelstra, J.,Wever, E., Ziegler, T. E.,& Beech, A. R. (2012). Psychopathy is related to high basal urinary oxytocin levels in male forensic patients. Paper presented at the 31st Annual Research Treatment Conference,Association for the Treatment of SexualAbusers,Denver, CO.
46. Moffitt, T. E. (1993). Adolescence-limited and life-course-persistent antisocial behavior: A developmental taxonomy. Psychological Review, 100, 674-701.
47. Moul, C., Killcross, S., & Dadds, M. R. (2012). A model of differential amygdala activation in psychopathy. Psychological Review, 119, 789-806. doi:10.1037/a0029342
48. Oxford, M., Cavell, T. A.,&Hughes, J. N. (2003). Callous/unemotional traits moderate the relation between ineffective parenting and child externalizing problems: A partial replication and extension. Journal of Clinical Child and Adolescent Psychology, 32, 577-585.
49. Pasalich, D. S., Dadds, M. R., Hawes, D. J., & Brennan, J. (2011). Do callous- unemotional traits moderate the relative importance of parental coercion versus warmth in child conduct problems? An observational study. Journal of Child Psychology and Psychiatry and Allied Disciplines, 52, 1308-1315.
50. Petersen, A. C., Crockett, L., Richards, M., & Boxer, A. (1988). A self-report measure of pubertal status: Reliability, validity, and initial norms. Journal of Youth and Adolescence, 17, 117-133.
51. Rey, J. M., Singh, M., Hung, S. F., Dossetor, D. R., Newman, L., Plapp, J. M., et al. (1997). A global scale to measure the quality of the family environment. Archives of General Psychiatry, 54, 817-822.
52. Sakai, J. T., Crowley, T. J., Stallings, M. C., McQueen, M., Hewitt, J. K., Hopfer, C., et al. (2012). Test of association between 10 single nucleotide polymorphisms in the oxytocin receptor gene and conduct disorder. Psychiatric Genetics, 22, 99-102.
53. Sisk, C. L., & Foster, D. L. (2004). The neural basis of puberty and adolescence. Nature Neuroscience, 7, 1040-1047.
54. Szyf, M., & Bick, J. (2013). DNA methylation: A mechanism for embedding early life experiences in the genome. Child Development, 84, 49-57.
55. van IJzendoorn, M.H.,Bakermans-Kranenburg, M. J.,&Ebstein, R. P. (2011). Methylation matters in child development: Toward developmental behavioral epigenetics. Child Development Perspectives, 5, 305-310.
56. Viding, E., Blair, R. J. R., Moffitt, T. E., & Plomin, R. (2005). Evidence for substantial genetic risk for psychopathy in 7-year-olds. Journal of Child Psychology and Psychiatry and Allied Disciplines, 46, 592-597.
57. Viding, E., Frick, P. J., & Plomin, R. (2007). Aetiology of the relationship between callous-unemotional traits and conduct problems in childhood. British Journal of Psychiatry, 190(Suppl. 49), s33-s38.
58. Viding, E., Hanscombe, K. B., Curtis, C. J. C., Davis, O. S. P., Meaburn, E. L., & Plomin, R. (2010). In search of genes associated with risk for psychopathic tendencies in children: A two-stage genome-wide association study of pooled DNA. Journal of Child Psychology and Psychiatry and Allied Disciplines, 51, 780-788.
59. Viding, E., Sebastian, C. L., Dadds, M. R., Lockwood, P. L., Cecil, C. A. M., De Brito, S. A., et al. (in press). Fast and fearless: Amygdala response to pre-attentive masked fear is associated with callous-unemotional traits in children with conduct problems. American Journal of Psychiatry.
60. Wootton, J. M., Frick, P. J., Shelton, K. K., & Silverthorn, P. (1997). Ineffective parenting and childhood conduct problems: The moderating role of callous-unemotional traits. Journal of Consulting and Clinical Psychology, 65, 301-308.
61. Zoccolillo,M. (1993). Gender and the development of conduct disorder. Development and Psychopathology, 5, 65-78. doi:10.1017/S09545794 00004260