Synthesis and molecular modeling studies of 3-chloro-4-substituted-1-(8- hydroxy-quinolin-5-yl)-azetidin-2-ones as novel anti-filarial agents

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 12, 2010, Pages 3640-3644

  Chhajed, Santosh S ^a   Manisha, Puranik ^b   Bastikar, Virupaksha A ^c   Animeshchandra, Haldar ^d   Ingle, V N ^d   Upasani, Chandrashekhar D ^e   Wazalwar, Sachin S ^f  

^a SMBT College of Pharmacy   (India)

^b INSTITUTE OF PHARMACEUTICAL EDUCATION AND RESEARCH   (India)

^c CBD Belapur   (India)

^d RTM NAGPUR UNIVERSITY   (India)

^e SSDJ College of Pharmacy   (India)

^f Rajiv Gandhi College of Engineering   (India)

Author keywords

Azetidin 2 ones; In vitro anti filarial; MDS; Molecular docking; Synthesis

Indexed keywords

5 AMINO 8 HYDROXYQUINOLINE; 5 NITROSO 8 HYDROXYQUINOLINE; 8 QUINOLINOL DERIVATIVE; ANTIFILARIAL AGENT; AZETIDINE DERIVATIVE; GLUTATHIONE TRANSFERASE; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ANTIFILARIAL ACTIVITY; ARTICLE; BINDING COMPETITION; BRUGIA MALAYI; DRUG ACTIVITY; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVE SITE; IN VITRO STUDY; MOLECULAR DOCKING; MOLECULAR MODEL; NONHUMAN; RECEPTOR AFFINITY;

ANIMALS; ANTHELMINTICS; AZETIDINES; COMPUTER SIMULATION; FILARIASIS; FILARIOIDEA; GLUTATHIONE TRANSFERASE; MODELS, MOLECULAR; PROTEIN BINDING; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 77954214113     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.04.106     Document Type: Article

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