Synthetic rescue couples NADPH generation to metabolite overproduction in Saccharomyces cerevisiae

Metabolic Engineering

Volumn 43, Issue , 2017, Pages 64-70

  Partow, Siavash ^a   Hyland, Patrick B ^a   Mahadevan, Radhakrishnan ^a,b  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

Alphaketoglutarate; Metabolic engineering; Saccharomyces cerevisiae; Synthetic rescue

Indexed keywords

BIOCHEMISTRY; METABOLISM; METABOLITES; PHYSIOLOGY; YEAST;

ALPHAKETOGLUTARATE; CONSTITUTIVE EXPRESSIONS; GLUCOSE-6-PHOSPHATE DEHYDROGENASE; ISOCITRATE DEHYDROGENASE; METABOLITE PRODUCTION; SPECIFIC GROWTH RATE; SUCCINYL COA LIGASE; SYNTHETIC RESCUE;

METABOLIC ENGINEERING;

2 OXOGLUTARIC ACID; GLUCOSE 6 PHOSPHATE DEHYDROGENASE; ISOCITRATE DEHYDROGENASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; SUCCINYL COENZYME A; ALPHA-KETOGLUTARIC ACID; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; SACCHAROMYCES CEREVISIAE PROTEIN;

ARTICLE; CYTOSOL; GENE DISRUPTION; GENE TARGETING; GROWTH RATE; METABOLIC ENGINEERING; METABOLISM; METABOLITE; NONHUMAN; OXIDATION REDUCTION REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; SACCHAROMYCES CEREVISIAE; SYNTHESIS; BIOSYNTHESIS; GENETICS; MUTATION;

KETOGLUTARIC ACIDS; MUTATION; NADP; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS;

EID: 85028000268     PISSN: 10967176     EISSN: 10967184     Source Type: Journal    
DOI: 10.1016/j.ymben.2017.08.004     Document Type: Article

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