Controlled release dexamethasone implants in the round window niche for salvage treatment of idiopathic sudden sensorineural hearing loss

Otology and Neurotology

Volumn 35, Issue 7, 2014, Pages 1168-1171

  Plontke, Stefan K ^a   Glien, Alexander ^a   Rahne, Torsten ^a   Mäder, Karsten ^a   Salt, Alec N ^b  

^a MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Controlled release; Dexamethasone; Intratympanic; Local drug delivery; Salvage treatment; Steroids; Sudden hearing loss

Indexed keywords

DELAYED RELEASE FORMULATION; DEXAMETHASONE; GLUCOCORTICOID;

ADMINISTRATION AND DOSAGE; AGED; COCHLEA FENESTRA; DELAYED RELEASE FORMULATION; DRUG DELIVERY SYSTEM; DRUG EFFECTS; EARDRUM; FEMALE; HEARING LOSS, SENSORINEURAL; HEARING LOSS, SUDDEN; HEARING TEST; HUMAN; MALE; MIDDLE AGED; PURE TONE AUDIOMETRY; THERAPEUTIC USE; TREATMENT OUTCOME;

AGED; AUDIOMETRY, PURE-TONE; DELAYED-ACTION PREPARATIONS; DEXAMETHASONE; DRUG DELIVERY SYSTEMS; FEMALE; GLUCOCORTICOIDS; HEARING LOSS, SENSORINEURAL; HEARING LOSS, SUDDEN; HEARING TESTS; HUMANS; MALE; MIDDLE AGED; ROUND WINDOW, EAR; TREATMENT OUTCOME; TYMPANIC MEMBRANE;

EID: 85027953051     PISSN: 15317129     EISSN: 15374505     Source Type: Journal    
DOI: 10.1097/MAO.0000000000000434     Document Type: Article

References (33)

1. Garavello W, Galluzzi F, Gaini RM, et al. Intratympanic steroid treatment for sudden deafness: a meta-analysis of randomized controlled trials. Otol Neurotol 2012;33:724-9.
2. Stachler RJ, Chandrasekhar SS, Archer SM, et al. Clinical practice guideline: sudden hearing loss. Otolaryngol Head Neck Surg 2012;146:S1-35.
3. Alzamil KS, Linthicum FH Jr. Extraneous round window membranes and plugs: possible effect on intratympanic therapy. Ann Otol Rhinol Laryngol 2000;109:30-2.
4. Plontke SK, Zimmermann R, Zenner HP, et al. Technical note on microcatheter implantation for local inner ear drug delivery: surgical technique and safety aspects. Otol Neurotol 2006;27:912-7.
5. Crane BT, Minor LB, Della Santina CC, et al. Middle ear exploration in patients with Meniere's disease who have failed outpatient intratympanic gentamicin therapy. Otol Neurotol 2009;30:619-24.
6. Plontke SK. Evaluation of the round window niche before local drug delivery to the inner ear using a new mini-otoscope. Otol Neurotol 2011;32:183-5.
7. Silverstein H, Choo D, Rosenberg SI, et al. Intratympanic steroid treatment of inner ear disease and tinnitus (preliminary report). Ear Nose Throat J 1996;75:468-71, 74, 76.
8. Kanzaki S, Saito H, Inoue Y, et al. A new device for delivering drugs into the inner ear: otoendoscope with microcatheter. Auris Nasus Larynx 2012;39:208-11.
9. Hiraumi H, Nakagawa T, Ito J. Efficiency of a transtympanic approach to the round window membrane using a microendoscope. Eur Arch Otorhinolaryngol 2009;266:367-71.
10. Plontke SK, Mikulec AA, Salt AN. Rapid clearance of methylprednisolone after intratympanic application in humans. Comment on: Bird PA, Begg EJ, Zhang M, et al. Intratympanic versus intravenous delivery of methylprednisolone to cochlear perilymph. Otol Neurotol 2007;28:1124-30. Otol Neurotol 2008;29:732-3.
11. Hahn H, Kammerer B, DiMauro A, et al. Cochlear microdialysis for quantification of dexamethasone and fluorescein entry into scala tympani during round window administration. Hear Res 2006;212:236-44.
12. Plontke SK, Salt AN. Simulation of application strategies for local drug delivery to the inner ear. ORL J Otorhinolaryngol Relat Spec 2006;68:386-92.
13. Salt AN, Plontke SK. Principles of local drug delivery to the inner ear. Audiol Neurootol 2009;14:350-60.
14. Kopke RD, Hoffer ME, Wester D, et al. Targeted topical steroid therapy in sudden sensorineural hearing loss. Otol Neurotol 2001;22: 475-9.
15. Plontke SK, Lowenheim H, Mertens J, et al. Randomized, double blind, placebo controlled trial on the safety and efficacy of continuous intratympanic dexamethasone delivered via a round window catheter for severe to profound sudden idiopathic sensorineural hearing loss after failure of systemic therapy. Laryngoscope 2009;119:359-69.
16. Schwab B, Lenarz T, Heermann R. [Use of the round window micro cath for inner ear therapy - results of a placebo-controlled, prospective study on chronic tinnitus]. Laryngorhinootologie 2004;83: 164-72.
17. Nakagawa T, Ito J. Local drug delivery to the inner ear using biodegradable materials. Ther Delivery 2011;2:807-14.
18. Roy S, Glueckert R, Johnston AH, et al. Strategies for drug delivery to the human inner ear by multifunctional nanoparticles. Nanomedicine (London, England) 2012;7:55-63.
19. Swan EE, Mescher MJ, Sewell WF, et al. Inner ear drug delivery for auditory applications. Adv Drug Deliv Rev 2008;60:1583-99.
20. Lambert PR, Nguyen S, Maxwell KS, et al. A randomized, double-blind, placebo-controlled clinical study to assess safety and clinical activity of OTO-104 given as a single intratympanic injection in patients with unilateral Meniere's disease. Otol Neurotol 2012;33:1257-65.
21. Lang J, Kothe W. [Measurements of the tympanic cavity]. Gegenbaurs morphologisches Jahrbuch 1987;133:469-505.
22. Chang-Lin JE, Attar M, Acheampong AA, et al. Pharmacokinetics and pharmacodynamics of a sustained-release dexamethasone intravitreal implant. Invest Ophthalmol Visual Sci 2011;52:80-6.
23. Haller JA, Bandello F, Belfort R Jr, et al. Randomized, sham-controlled trial of dexamethasone intravitreal implant in patients with macular edema due to retinal vein occlusion. Ophthalmology 2010;117:1134-46 e3.
24. Kuppermann BD, Blumenkranz MS, Haller JA, et al. Randomized controlled study of an intravitreous dexamethasone drug delivery system in patients with persistent macular edema. Arch Ophthalmol 2007;125:309-17.
25. Williams GA, Haller JA, Kuppermann BD, et al. Dexamethasone posterior-segment drug delivery system in the treatment of macular edema resulting from uveitis or Irvine-Gass syndrome. Am J Ophthalmol 2009;147:1048-54, 54 e1-2.
26. Salt AN, Gill RM, Plontke SK. Dependence of hearing changes on the dose of intratympanically applied gentamicin: a meta-analysis using mathematical simulations of clinical drug delivery protocols. Laryngoscope 2008;118:1793-800.
27. Salt AN, Hartsock J, Plontke S, et al. Distribution of dexamethasone and preservation of inner ear function following intratympanic delivery of a gel-based formulation. Audiol Neurootol 2011;16:323-35.
28. Chou YF, Chen PR, Kuo IJ, et al. Comparison of intermittent intratympanic steroid injection and near-continual transtympanic steroid perfusion as salvage treatments for sudden sensorineural hearing loss. Laryngoscope 2013;123:2264-9.
29. Li L, Ren J, Yin T, et al. Intratympanic dexamethasone perfusion versus injection for treatment of refractory sudden sensorineural hearing loss. Eur Arch Otorhinolaryngol 2013;270:861-7.
30. Salt AN, Hartsock JJ, Gill RM, et al. Perilymph pharmacokinetics of markers and dexamethasone applied and sampled at the lateral semicircular canal. J Assoc Res Otolaryngol 2012;13:771-83.
31. Plontke S, Lowenheim H, Preyer S, et al. Outcomes research analysis of continuous intratympanic glucocorticoid delivery in patients with acute severe to profound hearing loss: basis for planning randomized controlled trials. Acta Otolaryngol 2005;125:830-9.
32. Chen CY, Halpin C, Rauch SD. Oral steroid treatment of sudden sensorineural hearing loss: a ten year retrospective analysis. Otol Neurotol 2003;24:728-33.
33. Plontke SK, Bauer M, Meisner C. Comparison of pure-tone audiometry analysis in sudden hearing loss studies: lack of agreement for different outcome measures. Otol Neurotol 2007;28:753-63.