Simulation of application strategies for local drug delivery to the inner ear

ORL

Volumn 68, Issue 6, 2006, Pages 386-392

  Plontke, Stefan K ^a,c   Salt, Alec N ^b  

^a UNIVERSITY HOSPITAL TÜBINGEN   (Germany)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

Computer simulations; Drug delivery; Inner ear; Pharmacokinetics; Round window membrane; Steroids

Indexed keywords

METHYLPREDNISOLONE;

ARTICLE; COCHLEA FENESTRA; COMPUTER SIMULATION; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; INNER EAR; PERILYMPH; PRIORITY JOURNAL;

EID: 33750378702     PISSN: 03011569     EISSN: None     Source Type: Journal    
DOI: 10.1159/000095284     Document Type: Article

References (30)

1. Lalwani AK, McGuire JF: Pharmacologic treatment of the cochlea and labyrinth; in Cummings CW (ed): Otolaryngology - Head and Neck Surgery. Philadelphia, Mosby Inc, 2005, vol 4, pp 2944-2976.
2. DeCeulaer G, Johnson S, Yperman M, Daemers K, Offeciers FE, O'Donoghue GM, Govaerts PJ: Long-term evaluation of the effect of intracochlear steroid deposition on electrode impedance in cochlear implant patients. Otol Neurotol 2003;24:769-774.
3. Schuknecht HF: Ablation therapy for the relief of Ménière's disease. Laryngoscope 1956;66:859-870.
4. Arriaga MA, Goldman S: Hearing results of intratympanic steroid treatment of endolymphatic hydrops. Laryngoscope 1998;108:1682-1685.
5. Gouveris H, Selivanova O, Mann W: Intratympanic dexamethasone with hyaluronic acid in the treatment of idiopathic sudden sensorineural hearing loss after failure of intravenous steroid and vasoactive therapy. Eur Arch Otorhinolaryngol 2005;262:131-134.
6. Kroath F: Transtympanale Injektion zur Behandlung des Ménièreschen Syndroms. Z Laryngol Rhinol Otol 1960;39:190-195.
7. Silverstein H, Arruda J, Rosenberg SI, Deems D, Hester TO: Direct round window membrane application of gentamicin in the treatment of Ménière's disease. Otolaryngol Head Neck Surg 1999;120:649-655.
8. Silverstein H: Use of a new device, the Micro-Wick, to deliver medication to the inner ear. Ear Nose Throat J 1999;78:595-598, 600.
9. Arnold W, Senn P, Hennig M, Michaelis C, Deingruber K, Scheler R, Steinhoff HJ, Riphagen F, Lamm K: Novel slow- and fast-type drug release round-window microimplants for local drug application to the cochlea: an experimental study in guinea pigs. Audiol Neurootol 2005;10:53-63.
10. Endo T, Nakagawa T, Kita T, Iguchi F, Kim TS, Tamura T, Iwai K, Tabata Y, Ito J: Novel strategy for treatment of inner ears using a biodegradable gel. Laryngoscope 2005;115:2016-2020.
11. Tamura T, Kita T, Nakagawa T, Endo T, Kim TS, Ishihara T, Mizushima Y, Higaki M, Ito J: Drug delivery to the cochlea using PLGA nanoparticles. Laryngoscope 2005;115:2000-2005.
12. Brown JN, Miller JM, Altschuler RA, Nuttall AL: Osmotic pump implant for chronic infusion of drugs into the inner ear. Hear Res 1993;70:167-172.
13. Chen Z, Kujawa SG, McKenna MJ, Fiering JO, Mescher MJ, Borenstein JT, Leary Swan EE, Sewell WF: Inner ear drug delivery via a reciprocating perfusion system in the guinea pig. J Control Release 2005;110:1-19.
14. Praetorius M, Limberger A, Muller M, Lehner R, Schick B, Zenner HP, Plinkert P, Knipper M: A novel microperfusion system for the long-term local supply of drugs to the inner ear: implantation and function in the rat model. Audiol Neurootol 2001;6:250-258.
15. Plontke S, Lowenheim H, Preyer S, Leins P, Dietz K, Koitschev A, Zimmermann R, Zenner HP: Outcomes research analysis of continuous intratympanic glucocorticoid delivery in patients with acute severe to profound hearing loss: basis for planning randomized controlled trials. Acta Otolaryngol 2005;125:830-839.
16. Thomsen J, Charabi S, Tos M: Preliminary results of a new delivery system for gentamicin to the inner ear in patients with Ménière's disease. Eur Arch Otorhinolaryngol 2000;257:362-365.
17. Salt AN, Plontke SK: Local inner ear drug delivery and pharmacokinetics. Drug Discov Today 2005;10:1299-1306.
18. Hahn H, Kammerer B, DiMauro A, Salt AN, Plontke SK: Cochlear microdialysis for quantification of dexamethasone and fluorescein entry into scala tympani during round window administration. Hear Res 2006;212:236-244.
19. Mynatt R, Hale S, Gill R, Plontke S, Salt AN: Demonstration of a longitudinal concentration gradient along scala tympani by sequential sampling of perilymph from the cochlear apex. J Assoc Res Otolaryngol 2006;7:182-193.
20. Plontke SK, Wood AW, Salt AN: Analysis of gentamicin kinetics in fluids of the inner ear with round window administration. Otol Neurotol 2002;23:967-974.
21. Salt AN: Simulation of methods for drug delivery to the cochlear fluids. Adv Otorhinolaryngol 2002;59:140-148.
22. Plontke SK, Salt AN: Quantitative interpretation of corticosteroid pharmacokinetics in inner ear fluids using computer simulations. Hear Res 2003;182:34-42.
23. Salt AN, Ma Y: Quantification of solute entry into cochlear perilymph through the round window membrane. Hear Res 2001;154:88-97.
24. Plontke SK, Mynatt R, Hale S, Salt AN: Gentamicin concentration gradient along scala tympani of the guinea pig cochlea after round window drug administration. Assoc Res Otolaryngol Abs 2006:29.
25. Stover T, Yagi M, Raphael Y: Cochlear gene transfer: round window versus cochleostomy inoculation. Hear Res 1999;136:124-130.
26. Kopke RD, Wassel RA, Mondalek F, Grady B, Chen K, Liu J, Gibson D, Dormer KJ: Magnetic nanoparticles: inner ear targeted molecule delivery and middle ear implant. Audiol Neurootol 2006;11:123-133.
27. Plontke SK, Plinkert PK, Plinkert B, Koitschev A, Zenner HP, Lowenheim H: Transtympanic endoscopy for drug delivery to the inner ear using a new microendoscope. Adv Otorhinolaryngol 2002;59:149-155.
28. Lehner R, Brugger H, Maassen MM, Zenner HP: A totally implantable drug delivery system for local therapy of the middle and inner ear. Ear Nose Throat J 1997;76:567-570.
29. Kopke RD, Hoffer ME, Wester D, O'Leary MJ, Jackson RL: Targeted topical steroid therapy in sudden sensorineural hearing loss. Otol Neurotol 2001;22:475-479.
30. Plontke SK, Zimmermann R, Zenner HP, Löwenheim H: Technical note on microcatheter implantation for local inner ear drug delivery: Surgical technique and safety aspects. Otol Neurotol 2006;27:912-917.