Comparison of prescribing and adherence patterns of anti-osteoporotic medications post-admission for fragility type fracture in an urban teaching hospital and a rural teaching hospital in Ireland between 2005 and 2008

Irish Journal of Medical Science

Volumn 182, Issue 4, 2013, Pages 601-608

  McGowan, B ^a   Bennett, K ^b   Casey, M C ^b   Doherty, J ^c   Silke, C ^a   Whelan, B ^a  

^a Our Lady's Hospital Manorhamilton   (Ireland)

^b ST JAMES S HOSPITAL   (Ireland)

^c SLIGO UNIVERSITY HOSPITAL   (Ireland)

Author keywords

Datasets; Fragility fractures; Linkage; Osteoporosis; Persistence; Prescribing

Indexed keywords

BISPHOSPHONIC ACID DERIVATIVE; BONE DENSITY CONSERVATION AGENT;

ADULT; AGED; ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; FEMALE; FRAGILITY FRACTURE; HIP FRACTURE; HOSPITAL ADMISSION; HUMAN; IRELAND; MAJOR CLINICAL STUDY; MALE; MEDICATION COMPLIANCE; MIDDLE AGED; OSTEOPOROSIS; PATIENT COMPLIANCE; PRESCRIPTION; SPINE FRACTURE; TEACHING HOSPITAL; VERY ELDERLY; CLINICAL PRACTICE; DRUG USE; ELECTRONIC MEDICAL RECORD; HOSPITAL; HOSPITAL DISCHARGE; HOSPITAL INFORMATION SYSTEM; TIME; TREATMENT OUTCOME;

AGED; AGED, 80 AND OVER; BONE DENSITY CONSERVATION AGENTS; DRUG UTILIZATION REVIEW; ELECTRONIC HEALTH RECORDS; FEMALE; HOSPITAL INFORMATION SYSTEMS; HOSPITALS, RURAL; HOSPITALS, TEACHING; HOSPITALS, URBAN; HUMANS; IRELAND; MALE; MEDICATION ADHERENCE; MIDDLE AGED; OSTEOPOROSIS; OSTEOPOROTIC FRACTURES; PATIENT DISCHARGE; PHYSICIAN'S PRACTICE PATTERNS; TIME FACTORS; TREATMENT OUTCOME;

EID: 85027951074     PISSN: 00211265     EISSN: 18634362     Source Type: Journal    
DOI: 10.1007/s11845-013-0935-9     Document Type: Article

References (32)

1. Kanis JA, Johnell O, Oden A et al (2000) Long-term risk of osteoporotic fracture in Malmo. Osteoporos Int 11(8):669–674
2. Johnell O, Kanis JA, Oden A et al (2004) Mortality after osteoporotic fractures. Osteoporos Int 15(1):38–42 (Epub 2003 Oct 30)
3. Lips P, Van Schoor NM (2005) Quality of life in patients with osteoporosis. Osteoporos Int 16(5):447–455 (Epub 2004 Dec 18)
4. McGowan B, Casey MC, Silke C et al (2012) Hospitalizations for fracture and associated costs between 2000 and 2009 in Ireland: a trend analysis. Osteoporos Int 24(3):849–857. doi:10.1007/s00198-012-2032-8 (Epub 2012 May 26)
5. Report of the National Steering Group on the Prevention of Falls in Older People and the Prevention and Management of Osteoporosis throughout Life (2008). Strategy to Prevent Falls and Fractures in Ireland’s Ageing Population. 2008 January. Available from URL: http://www.hse.ie/eng/services/Publications/services/Older/Strategy_to_Prevent_Falls_and_Fractures_in_Ireland %E2%80%99s_Ageing_Population_-_Full_report.pdf, Accessed 20 May 2012
6. Kanis JA, McCloskey EV, Johansson H et al (2013) European guidance for the diagnosis and management of osteoporosis in postmenopausal women. Osteoporos Int 24(1):23–57. doi: 10.1007/s00198-012-2074-y (Epub 2012 Oct 19)
7. Elliott-Gibson V, Bogoch ER, Jamal SA et al (2004) Practice patterns in the diagnosis and treatment of osteoporosis after a fragility fracture: a systematic review. Osteoporos Int 15(10):767–778 (Epub 2004 Jul 16)
8. Fleurence RL, Iglesias CP, Torgerson DJ (2006) Economic evaluations of interventions for the prevention and treatment of osteoporosis: a structured review of the literature. Osteoporos Int 17(1):29–40 (Epub 2005 Jun 25)
9. Rabenda V, Vanoverloop J, Fabri V et al (2008) Low incidence of anti-osteoporosis treatment after hip fracture. J Bone Joint Surg Am. 90(10):2142–2148. doi:10.2106/JBJS.G.00864
10. Zethraeus N, Borgstrom F, Strom O et al (2007) Cost-effectiveness of the treatment and prevention of osteoporosis-a review of the literature and a reference model. Osteoporos Int 38(6):922–928 (Epub 2005 Dec 5)
11. Huybrechts KF, Ishak KJ, Caro JJ (2006) Assessment of compliance with osteoporosis treatment and its consequences in a managed care population. Bone 38(6):922–928 (Epub 2005 Dec 5)
12. Imaz I, Zegarra P, Gonzalez-Enriquez J et al (2010) Poor bisphosphonate adherence for treatment of osteoporosis increases fracture risk: systematic review and meta-analysis. Osteoporos Int 21(11):1943–1951. doi:10.1007/s00198-009-1134-4 (Epub 2009 Dec 5)
13. Rabenda V, Hiligsmann M, Reginster J-Y (2009) Poor adherence to oral bisphosphonate treatment and its consequences: a review of the evidence. Expert Opin Pharmacother 10(14):2303–2315. doi:10.1517/14656560903140533
14. Siris ES, Selby PL, Saag KG et al (2009) Impact of osteoporosis treatment adherence on fracture rates in North America and Europe. Am J Med 122(2 Suppl):S3–S13. doi:10.1016/j.amjmed. 2008.12.002
15. Danese MD, Badamgarav E, Bauer DC (2009) Effect of adherence on lifetime fractures in osteoporotic women treated with daily and weekly bisphosphonates. J Bone Miner Res 24(11):1819–1826. doi:10.1359/jbmr.090506
16. Hiligsmann M, Rabenda V, Bruyere O et al (2010) The clinical and economic burden of non-adherence with oral bisphosphonates in osteoporotic patients. Health Policy 96(2):170–177. doi: 10.1016/j.healthpol.2010.01.014 (Epub 2010 Feb 13)
17. Hiligsmann M, Rabenda V, Gathon HJ et al (2010) Potential clinical and economic impact of nonadherence with osteoporosis medications. Calcif Tissue Int 86(3):202–210
18. Landfeldt E, Lundkvist J, Strom O (2011) The societal burden of poor persistence to treatment of osteoporosis in Sweden. Bone 48(2):380–388. doi:10.1016/j.bone.2010.09.012 (Epub 2010 Sep 17)
19. Hiligsmann M, McGowan B, Bennett K et al (2012) The clinical and economic burden of poor adherence and persistence with osteoporosis medications in Ireland. Value Health 15(5):604–612. doi:10.1016/j.jval.2012.02.001 (Epub 2012 Apr 11)
20. Haynes RB, Ackloo E, Sahota N et al (2008) Interventions for enhancing medication adherence. Cochrane Database Syst Rev 16(2):CD000011. doi:10.1002/14651858.CD000011.pub3
21. McDonald HP, Garg AX, Haynes RB (2002) Interventions to enhance patient adherence to medication prescriptions: scientific review. JAMA 288(22):2868–2879
22. Hiligsmann M, Ravenda V, Bruyere O et al (2010) The clinical and economic burden of non-adherence with oral bisphosphonates in osteoporotic patients. Health Policy 96(2):170–177. doi: 10.1016/j.healthpol.2010.01.014 (Epub 2010 Feb 13)
23. Patrick AR, Schousboe JT, Losina E et al (2011) The economics of improving medication adherence in osteoporosis: validation and application of a simulation model. J Clin Endocrinol Metab 96(9):2762–2770. doi:10.1210/jc.2011-0575 (Epub 2011 Jul 6)
24. Copher C, Buzinec P, Zarotsky V et al (2010) Physician perception of patient adherence to osteoporosis medications from pharmacy claims. Curr Med Res Opin 26(4):777–785. doi: 10.1185/03007990903579171
25. Iversen MD, Vora RR, Servi A et al (2011) Factors affecting adherence to osteoporosis medications: a focus group approach examining viewpoints of patients and providers. J Geriatr Phys Ther 34(2):72–81. doi:10.1097/JPT.0b013e3181ff03b4
26. International Osteoporosis Foundation (2005) The adherence gap: why osteoporosis patients don’t continue with treatment. www.iofbonehealthorg/download/ostefound/filemanager/publications/ pdf/adherence:gap_reportpdf, Accessed 26 May 2012
27. Elwyn G, Edwards A, Britten N (2003) What information do patients need about medicines? ‘‘Doing prescribing’’: how doctors can be more effective. BMJ 327(7419):864–867
28. Lewis DK, Robinson J, Wilkinson E (2003) Factors involved in deciding to start preventive treatment: qualitative study of clini-cians’ and lay people’s attitudes. BMJ 327(7419):841
29. Louviere JJ, Islam T (2008) A comparison of importance weights and willingness-to-pay measures derived from choice-based conjoint, constant sum scales and best-worst scaling. J Bus Res 61(9):903–911
30. Elwyn G, O’Connor A, Stacey D et al (2006) Developing a quality criteria framework for patient decision aids: online international Delphi consensus process. BMJ 333(7565):417 (Epub 2006 Aug 14)
31. Elwyn G, Kreuwel I, Durand MA et al (2011) How to develop web-based decision support interventions for patients: a process map. Patient Educ Couns 82(2):260–265. doi:10.1016/j.pec.2010. 04.034 (Epub 2010 Jun 2)
32. McGowan B, Bennett K, Marry J, Walsh JB, Casey MC (2012) Patient profile in a bone health and osteoporosis prevention service in Ireland. IJMS 181(4):511–515. doi:10.1007/s11845-012-0806-9 (Epub 2012 Feb 29)