Poor bisphosphonate adherence for treatment of osteoporosis increases fracture risk: Systematic review and meta-analysis

Osteoporosis International

Volumn 21, Issue 11, 2010, Pages 1943-1951

  Imaz, I ^a   Zegarra, P ^a   Gonzalez Enriquez J ^a   Rubio, B ^a   Alcazar, R ^a   Amate, J M ^a  

^a INSTITUTO DE SALUD CARLOS III   (Spain)

Author keywords

Adherence; Bisphosphonates; Bone fracture; Compliance; Osteoporosis; Systematic review

Indexed keywords

ALENDRONIC ACID; BISPHOSPHONIC ACID DERIVATIVE; ETIDRONIC ACID; IBANDRONIC ACID; RISEDRONIC ACID;

ARTICLE; FRACTURE; HIP FRACTURE; HORMONE SUBSTITUTION; HUMAN; META ANALYSIS; OSTEOPOROSIS; PATIENT COMPLIANCE; POSTMENOPAUSE; PRIORITY JOURNAL; SYSTEMATIC REVIEW; VERTEBRA FRACTURE;

AGED; BONE DENSITY CONSERVATION AGENTS; DIPHOSPHONATES; FEMALE; HUMANS; MALE; MEDICATION ADHERENCE; MIDDLE AGED; OSTEOPOROSIS; OSTEOPOROSIS, POSTMENOPAUSAL; OSTEOPOROTIC FRACTURES; RISK ASSESSMENT;

EID: 77953476723     PISSN: 0937941X     EISSN: 14332965     Source Type: Journal    
DOI: 10.1007/s00198-009-1134-4     Document Type: Article

References (33)

1. Wells GA, Cranney A, Peterson J, et al (2008) Alendronate for the primary and secondary prevention of osteoporotic fractures in postmenopausal women. Cochrane Database Syst Rev
2. Wells G, Cranney A, Peterson J, et al (2008) Risedronate for the primary and secondary prevention of osteoporotic fractures in postmenopausal women. Cochrane Database Syst Rev
3. Organización Mundial de la Salud (OMS-WHO) (2003) Adherencia a los tratamientos a largo plazo. Pruebas para la acción. Organización Panamericana de la Salud, Washington
4. JA Cramer D Gold S Silverman, et al. 2007 A systematic review of persistence and compliance with bisphosphonates for osteoporosis Osteoporosis Int 18 1023 1031 1:CAS:528:DC%2BD2sXntVOlsrY%3D 10.1007/s00198-006-0322-8 (Pubitemid 47019996)
5. P Kothawala E Badamgarav S Ryu, et al. 2007 Systematic review and meta-analysis of real-world adherence to drug therapy for osteoporosis Mayo Clin Proc 82 1493 1501 10.4065/82.12.1493 18053457
6. Haynes RB, Ackloo E, Sahota N, et al (2008) Interventions for enhancing medication adherence. Cochrane Database Syst Rev. Issue 2
7. CM Dezii 2001 Persistence with drug therapy: a practical approach using administrative claims data Manag Care 10 42 45 1:STN:280:DC%2BD3M7psFymsQ%3D%3D 11236643
8. DT Gold S Silverman 2006 Review of adherence to medications for the treatment of osteoporosis Curr Osteoporos Rep 4 21 27 10.1007/s11914-006-0011-8 16527004 (Pubitemid 44623944)
9. JA Cramer A Roy A Burrell, et al. 2008 Medication compliance and persistence: terminology and definitions Value Health 11 44 47 18237359
10. V Essebag RW Platt M Abrahamowicz, et al. 2005 Comparison of nested case-control and survival analysis methodologies for analysis of time-dependent exposure BMC Med Res Method 5 5 10.1186/1471-2288-5-5 (Pubitemid 40317980)
11. Wells GA, Shea B, O'Connell D, et al (2009) The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses [On line]. Ottawa Health Research Institute, http://www.ohri.ca/programs/clinical- epidemiology/oxford.htm. Accessed on 27 Apr 2009
12. M Egger G Davey Smith M Schneider, et al. 1997 Bias in meta-analysis detected by a simple, graphical test BMJ 315 629 634 1:STN:280: DyaK2svls1KjtA%3D%3D 9310563
13. MKB Parmar V Torri L Stewart 1998 Extracting summary statistics to perform meta-analyses of the published literature for survival endpoints Statist Med 17 2815 2834 1:STN:280:DyaK1M7itVWksA%3D%3D 10.1002/(SICI)1097- 0258(19981230)17:24<2815::AID-SIM110>3.0.CO;2-8 (Pubitemid 28562978)
14. JF Tierney LA Stewart D Ghersi, et al. 2007 Practical methods for incorporating summary time-to-event data into meta-analysis Trials 8 16 10.1186/1745-6215-8-16 17555582 (Pubitemid 47161711)
15. TA Furukawa C Barbui A Cipriani, et al. 2006 Imputing missing standard deviations in meta-analyses can provide accurate results J Clin Epidemiol 59 7 10 10.1016/j.jclinepi.2005.06.006 16360555 (Pubitemid 41797469)
16. J Blouin A Dragomir Y Moride, et al. 2008 Impact of noncompliance with alendronate and risedronate on the incidence of nonvertebral osteoporotic fractures in elderly women Br J Clin Pharmacol 66 117 127 1:CAS:528: DC%2BD1cXptVKis7c%3D 10.1111/j.1365-2125.2008.03178.x 18460036 (Pubitemid 351822168)
17. E Brankin M Walker N Lynch, et al. 2006 The impact of dosing frequency on compliance and persistence with bisphosphonates among postmenopausal women in the UK: evidence from three databases Curr Med Res Opin 22 1249 1256 1:CAS:528:DC%2BD28XotlKgtLw%3D 10.1185/030079906X112688 16834823 (Pubitemid 44085576)
18. JJ Caro KJ Ishak KF Huybrechts, et al. 2004 The impact of compliance with osteoporosis therapy on fracture rates in actual practice Osteoporosis Int 15 1003 1008 10.1007/s00198-004-1652-z (Pubitemid 40064656)
19. JA Cramer NO Lynch AF Gaudin, et al. 2006 The effect of dosing frequency on compliance and persistence with bisphosphonate therapy in postmenopausal women: a comparison of studies in the United States, the United Kingdom, and France Clin Ther 28 1686 1694 1:CAS:528:DC%2BD28XhtlartrvP 10.1016/j.clinthera. 2006.10.013 17157124 (Pubitemid 44838898)
20. JR Curtis AO Westfall H Cheng, et al. 2008 Benefit of adherence with bisphosphonates depends on age and fracture type: results from an analysis of 101,038 new bisphosphonate users J Bone Miner Res 23 1435 1441 10.1359/jbmr.080418 18442318
21. S de Lusignan J van Vlymen N Hague, et al. 2006 Using computers to identify non-compliant people at increased risk of osteoporotic fractures in general practice: a cross-sectional study Osteoporos Int 17 1808 1814 10.1007/s00198-006-0188-9 16932873 (Pubitemid 44607402)
22. AM Gallagher S Rietbrock M Olson, et al. 2008 Fracture outcomes related to persistence and compliance with oral bisphosphonates J Bone Miner Res 23 1569 1575 10.1359/jbmr.080510 18505366
23. KF Huybrechts KJ Ishak JJ Caro 2006 Assessment of compliance with osteoporosis treatment and its consequences in a managed care population Bone 38 922 928 10.1016/j.bone.2005.10.022 16330270 (Pubitemid 44498580)
24. J Kertes M Dushenat JL Vesterman, et al. 2008 Factors contributing to compliance with osteoporosis medication Isr Med Assoc J 10 207 213 18494234
25. FJ Penning-van Beest JA Erkens M Olson, et al. 2008 Loss of treatment benefit due to low compliance with bisphosphonate therapy Osteoporos Int 19 511 517 1:STN:280:DC%2BD1c7nvFWqtw%3D%3D 10.1007/s00198-007-0466-1 17874028
26. V Rabenda J Vanoverloop V Fabri, et al. 2008 Low incidence of anti-osteoporosis treatment after hip fracture J Bone Joint Surg Am 90 2142 2148 10.2106/JBJS.G.00864 18829912
27. RR Recker R Gallagher PE MacCosbe 2005 Effect of dosing frequency on bisphosphonate medication adherence in a large longitudinal cohort of women Mayo Clin Proc 80 856 861 10.4065/80.7.856 16007889
28. O Sheehy C Kindundu M Barbeau, et al. 2009 Adherence to weekly oral bisphosphonate therapy: cost of wasted drugs and fractures Osteoporos Int 20 1583 1594 1:CAS:528:DC%2BD1MXhtVSit7rP 10.1007/s00198-008-0829-2 19153677
29. ES Siris ST Harris CJ Rosen, et al. 2006 Adherence to bisphosphonate therapy and fracture rates in osteoporotic women: relationship to vertebral and nonvertebral fractures from 2 US claims databases Mayo Clin Proc 81 1013 1022 10.4065/81.8.1013 16901023
30. TW Weiss SC Henderson CA McHorney, et al. 2007 Persistence across weekly and monthly bisphosphonates: analysis of US retail pharmacy prescription refills Curr Med Res Opin 23 2193 2203 10.1185/030079907X226069 17686228 (Pubitemid 350246605)
31. Haynes RB, Taylor DW, Sackett DL et al (1979) Compliance in health care. Johns Hopkins University Press, Baltimore
32. BA Briesacher SE Andrade RA Yood, et al. 2007 Consequences of poor compliance with bisphosphonates Bone 41 882 887 1:CAS:528:DC%2BD2sXhtF2htb3N 10.1016/j.bone.2007.07.009 17707710 (Pubitemid 47593009)
33. D Weycker D Macarios J Edelsberg, et al. 2007 Compliance with osteoporosis drug therapy and risk of fracture Osteoporosis Int 18 271 277 1:STN:280:DC%2BD2s%2FoslKktg%3D%3D 10.1007/s00198-006-0230-y (Pubitemid 46233172)