Singlet oxygen as a signaling transducer for modulating artemisinin biosynthetic genes in Artemisia annua

Biologia Plantarum

Volumn 55, Issue 4, 2011, Pages 669-674

  Zeng, Q P ^a   Zeng, X M ^a   Yang, R Y ^a   Yang, X Q ^a  

^a GUANGZHOU UNIVERSITY OF CHINESE MEDICINE   (China)

Author keywords

fluridone; fosmidomycin; gene expression; reactive oxygen species; upregulation

Indexed keywords

ARTEMISIA ANNUA;

EID: 85027933250     PISSN: 00063134     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10535-011-0166-8     Document Type: Article

References (33)

1. Bartels, P. G., Watson, C. W.: Inhibition of carotenoid synthesis by fluridone and norflurazon. - Weed Sci. 26: 198-203, 1978.
2. Benderliev, K. M., Ivanova, N. I., Pilarski, P. S.: Singlet oxygen and other reactive oxygen species are involved in regulation of release of iron-binding chelators from Scenedesmus cells. - Biol. Plant. 47: 523-526, 2003.
3. Bertea, C. M., Freije, J. R., van der Woude, H., Verstappen, F. W., Perk, L., Marquez, V., De Kraker, J. W., Posthumus, M. A., Jansen, B. J., De Groot, A., Franssen, M. C., Bouwmeester, H. J.: Identification of intermediates and enzymes involved in the early steps of artemisinin biosynthesis in Artemisia annua. - Planta med. 71: 40-47, 2005.
4. Bertea, C. M., Voster, A., Verstappen, F. W., Maffei, M., Beekwilder, J., Bouwmeester, H. J.: Isoprenoid biosynthesis in Artemisia annua: cloning and heterologous expression of a germacrene A synthase from a glandular trichome cDNA library. - Arch. Biochem. Biophys. 448: 3-12, 2006.
5. Chappell, J.: The genetics and molecular genetics of terpene and sterol origami. - Curr. Opin. Plant Biol. 5: 151-157, 2002.
6. Covello, P. S.: Making artemisinin. - Phytochemistry 69: 2881-2885, 2008.
7. Covello, P. S., Teoh, K. H., Polichuk, D. R., Reed, D. W., Nowak, G.: Functional genomics and the biosynthesis of artemisinin. - Phytochemistry 68: 1864-1871, 2007.
8. Feng, L. L., Yang, R. Y., Yang, X. Q., Zeng, X. M., Lu, W. J., Zeng, Q. P.: Synergistic re-channeling of mevalonate pathway for artemisinin overproduction in transgenic Artemisia annua. - Plant Sci. 177: 57-67, 2009.
9. Guo, X. X., Yang, X. Q., Yang, R. Y., Zeng, Q. P.: Salicylic acid and methyl jasmonate but not Rose Bengal up-regulate artemisinin biosynthetic genes through invoking burst of endogenous singlet oxygen. - Plant Sci. 178: 390-397, 2010.
10. Hirayama, O., Nakamura, K., Hamada, S., Kobayashi, Y.: Singlet oxygen quenching ability of naturally occurring carotenoids. - Lipids 29: 149-150, 1994.
11. Kim, S. H., Chang, Y. J., Kim, S. U.: Tissue specificity and developmental pattern of amorpha-4, 11-diene synthase (ADS) proved by ADS promoter-driven GUS expression in the heterologous plant, Arabidopsis thaliana. - Planta med. 74: 188-193, 2008.
12. Laloi, C., Przybyla, D., Apel, K.: A genetic approach towards elucidating the biological activity of different reactive oxygen species in Arabidopsis thaliana.- J. exp. Bot. 57: 1719-1724, 2006.
13. Laloi, C., Stachowiak, M., Pers-Kamczyc, E., Warzych, I. M., Apel, K.: Cross-talk between singlet oxygen- and hydrogen peroxide-dependent signalling of stress responses in Arabidopsis thaliana. - Proc. nat. Acad. Sci. USA 104: 672-677, 2007.
14. Laule, O., Furholz, A., Chang, H. S., Zhu, T., Wang, X., Heifetz, P. B., Gruissem, W., Lange, M.: Crosstalk between cytosolic and plastidial pathways of isoprenoid biosynthesis in Arabidopsis thaliana. - Proc. nat. Acad. Sci. USA 100: 6866-6871, 2003.
15. Lee, K. P., Kim, C., Landgraf, F., Apel, K.: EXECUTER1- and EXECUTER2-dependent transfer of stress-related signals from the plastid to the nucleus of Arabidopsis thaliana. -Proc. nat. Acad. Sci. USA 104: 10270-10275, 2007.
16. Maeda, H., Sakuragi, Y., Bryant, D. A., Della Penna, D.: Tocopherols protect Synechocystis sp. strain PCC 6803 from lipid peroxidation. - Plant Physiol. 138: 1422-1435, 2005.
17. Ro, D. K., Paradise, E. M., Ouelle, t M., Fisher, K. J., Newman, K. L., Ndungu, J. M., Ho, K. A., Eachus, R. A., Ham, T. S., Kirby, J., Chang, M. C., Withers, S. T., Shiba, Y., Sarpong, R., Keasling, J. D.: Production of the antimalarial drug precursor artemisinic acid in engineered yeast. - Nature 440: 940-943, 2006.
18. Rodriguez-Concepcion, M., Fores, O., Martinez-Garcia, J. F., Gonzalez, V., Phillips, M. A., Ferrer, A., Boronat, A.: Distinct light-mediated pathways regulate the biosynthesis and exchange of isoprenoid precursors during Arabidopsis seedling development. - Plant Cell 16: 144-156, 2004.
19. Sy, L. K., Brown, G. D.: The mechanism of the spontaneous autoxidation of dihydroartemisinic acid. - Tetrahedron 58: 897-908, 2002.
20. Teoh, K. H., Polichuk, D. R., Reed, D. W., Nowak, G., Covello, P. S.: Artemisia annua L. (Asteraceae) trichome-specific cDNAs reveal CYP71AV1, a cytochrome P450 with a key role in the biosynthesis of the antimalarial sesquiterpene lactone artemisinin. - FEBS Lett. 580: 1411-1416, 2006.
21. Towler, M. J., Weathers, P. J.: Evidence of artemisinin production from IPP stemming from both the mevalonate and the nonmevalonate pathways. - Plant Cell Rep. 26: 2129-2136, 2007.
22. Triantaphylides, C., Havaux, M.: Singlet oxygen in plants: production, detoxification and signaling. - Trends Plant Sci. 14: 219-228, 2009.
23. Wallaart, T. E., van Uden, W., Lubberink, H. G. M., Woerdenbag, H. J., Pras, N., Quax, W. J.: Isolation and identification of dihydroartemisinic acid from Artemisia annua and its possible role in the biosynthesis of artemisinin. - J. natur. Prod. 62: 430-433, 1999.
24. Wu, S., Schalk, M., Clark, A., Miles, R. B., Coates, R., Chappell, J.: Redirection of cytosolic or plastidic isoprenoid precursors elevates terpene production in plants. - Nat. Biotechnol. 24: 1441-1447, 2006.
25. Xu, X., Hu, X., Neill, S. J., Fang, J., Cai, W.: Fungal elicitor induces singlet oxygen generation, ethylene release and saponin synthesis in cultured cells of Panax ginseng C. A. Meyer. - Plant Cell Physiol. 46: 947-954, 2005.
26. Yang, R. Y., Feng, L. L., Yang, X. Q., Yin, L. L., Xu, X. L., Zeng, Q. P.: Quantitative transcript profiling reveals downregulation of a steroid pathway relevant gene and overexpression of artemisinin biogenetic genes in transgenic Artemisia annua plants. - Planta med. 74: 1510-1516, 2008.
27. Yang, R. Y., Zeng, X. M., Lu, Y. Y., Lu, W. J., Feng, L. L., Yang, X. Q., Zeng, Q. P.: Senescent leaves of Artemisia annua are one of the most active organs for overexpression of artemisinin biosynthesis responsible genes upon burst of singlet oxygen. - Planta med. 76: 734-742, 2010.
28. Yin, L. L., Zhao, C., Huang, Y., Yang, R. Y.: Abiotic stressinduced expression of artemisinin biosynthesis genes in Artemisia annua L. - Chin. appl. environ. Biol. 14: 1-5, 2008.
29. Zeng, Q. P., Qiu, F., Yuan, L.: Production of artemisinin by genetically modified microbes. - Biotechnol. Lett. 30: 581-592, 2008a.
30. Zeng, Q. P., Yang, R. Y., Feng, L. L., Yang, X. Q.: Genetic and environmental regulation and artificial metabolic manipulation for artemisinin biosynthesis. - In: Richter, F. W. (ed.): Biotechnology: Research, Technology and Applications. Pp. 159-210. Nova Science Publishers, New York 2008b.
31. Zeng, Q. P., Zeng, X. M., Feng, L. L., Yin, L. L., Yang, X. Q., Yang, R. Y.: Quantification of three key enzymes involved in artemisinin biosynthesis in Artemisia annua by polyclonal antisera-based ELISA. - Plant mol. Biol. Rep. 27: 50-57, 2009.
32. Zeng, Q. P., Zhao, C., Yin, L. L., Yang, R. Y., Zeng, X. M., Huang, Y., Feng, L. L., Yang, X. Q.: Cloning of artemisinin biosynthetic cDNAs and novel ESTs and quantification of low temperature-induced gene overexpression. - Sci. China Ser. C 51: 232-244, 2008c.
33. 11 (13) reductase and its role in glandular trichome-dependent biosynthesis of artemisinin in Artemisia annua. - J. biol. Chem. 283: 21501-21508, 2008.