Refractory coeliac disease: One step closer to the origin of aberrant lymphocytes

Gut

Volumn 62, Issue 4, 2013, Pages 485-486

  Zevallos, Victor F ^a   Schuppan, Detlef ^a  

^a JOHANNES GUTENBERG UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CD103 ANTIGEN; CD3 ANTIGEN; CD34 ANTIGEN; CD4 ANTIGEN; CD7 ANTIGEN; CD8 ANTIGEN; GLUTEN; GRANZYME B; INTERLEUKIN 15; INTERLEUKIN 15 RECEPTOR; INTERLEUKIN 15 RECEPTOR BETA; INTERLEUKIN 2; INTERLEUKIN 21; INTERLEUKIN 7 RECEPTOR; KILLER CELL IMMUNOGLOBULIN LIKE RECEPTOR; NATURAL KILLER CELL RECEPTOR NKG2A; NATURAL KILLER CELL RECEPTOR NKG2D; PERFORIN; T LYMPHOCYTE RECEPTOR ALPHA CHAIN; T LYMPHOCYTE RECEPTOR BETA CHAIN; UNCLASSIFIED DRUG;

ADAPTIVE IMMUNITY; ANTIGEN EXPRESSION; CELIAC DISEASE; DUODENUM BIOPSY; HISTOPATHOLOGY; HUMAN; INNATE IMMUNITY; INTRAEPITHELIAL LYMPHOCYTE; LYMPHOCYTE; LYMPHOCYTE COUNT; LYMPHOCYTE DIFFERENTIATION; MALIGNANT TRANSFORMATION; MOLECULAR INTERACTION; NATURAL KILLER CELL; NOTE; PRE T LYMPHOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REFRACTORY CELIAC DISEASE; T CELL LYMPHOMA;

EID: 85027923627     PISSN: 00175749     EISSN: 14683288     Source Type: Journal    
DOI: 10.1136/gutjnl-2012-303030     Document Type: Note

References (16)

1. Schmitz F, Tjon JML, Lai Y, et al. Identification of a potential physiological precursor of aberrant cells in refractory coeliac disease type II. Gut Published Online First: 3 July 2012. doi:10.1136/gutjnl-2012-302265.
2. Li Y, Innocentin S, Withers DR, et al. Exogenous stimuli maintain intraepithelial lymphocytes via aryl hydrocarbon receptor activation. Cell 2011;147:629-40.
3. Daum S, Cellier C, Mulder JJC. Refractory coeliac disease. Best practice & research. Clin Gastroenterol 2005;19:413-24.
4. Leffler DA, Dennis M, Hyett B, et al. Etiologies and predictors of diagnosis in nonresponsive celiac disease. Clin Gastroenterol Hepatol 2007;5:445-50. (Pubitemid 46575362)
5. Patey-Mariaud de Serre N, Cellier C, Jabri B, et al. Distinction between coeliac disease and refractory sprue: a simple immunohistochemical method. Histopathology 2000;37:70-7. (Pubitemid 30496738)
6. Verbeek WHM, Goerres MS, von Blomberg BM, et al. Flow cytometric determination of aberrant intra-epithelial lymphocytes predicts T-cell lymphoma development more accurately than T-cell clonality analysis in Refractory Celiac Disease. Clin Immunol 2008;126:48-56. (Pubitemid 350266454)
7. Tack GJ, Verbeek WHM, Schreurs MWJ, et al. The spectrum of celiac disease: epidemiology, clinical aspects and treatment. Nat Rev Gastroenterol Hepatol 2010;7:204-13.
8. Cellier C, Delabesse E, Helmer C, et al. Refractory sprue, coeliac disease, and enteropathy-associated T-cell lymphoma. Lancet 2000;356:203-8. (Pubitemid 30446975)
9. Leon FF, Roldan E FAU, Sanchez L, et al. Human small-intestinal epithelium contains functional natural killer lymphocytes. Gastroenterology 2003;125:345-56. (Pubitemid 36929414)
10. Eiras PF, Leon FF, Camarero CF, et al. Intestinal intraepithelial lymphocytes contain a CD3- CD7+ subset expressing natural killer markers and a singular pattern of adhesion molecules. Scand J Immunol 2000;52:1-6.
11. Gunther U, Holloway JA, Gordon JN, et al. Phenotypic characterization of CD3-7+ cells in developing human intestine and an analysis of their ability to differentiate into T cells. J Immunol 2005;174:5414-22. (Pubitemid 40593181)
12. Tjon J, van Bergen J, Koning F. Celiac disease: how complicated can it get? Immunogenetics 2010;62:641-51.
13. Bas AF, Forsberg GF, Sjoberg VF, et al. Aberrant extrathymic T cell receptor gene rearrangement in the small intestinal mucosa: a risk factor for coeliac disease? Gut 2009;58:189-95.
14. Malamut GF, El Machhour RF, Montcuquet NF, et al. IL-15 triggers an antiapoptotic pathway in human intraepithelial lymphocytes that is a potential new target in celiac disease-associated inflammation and lymphomagenesis. J Clin Invest 2010;120:2131-43.
15. Meresse B, Curran SA, Ciszewski C, et al. Reprogramming of CTLs into natural killer-like cells in celiac disease. J Exp Med 2006;203:1343-55. (Pubitemid 43736602)
16. Ebert EC. Interleukin 21 up-regulates perforinmediated cytotoxic activity of human intra-epithelial lymphocytes. Immunology 2009;127:206-15.