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Volumn 10, Issue , 2017, Pages

Regulation of microglia and macrophage polarization via apoptosis signal-regulating kinase 1 silencing after ischemic/hypoxic injury

Author keywords

Apoptosis signal regulating kinase 1 (ASK1); BV2 microglia cell line; Cerebral ischemia; Hypoxia; Ischemic stroke; Late inflammation; M1 M2 polarization; RAW264.7 macrophage cell line

Indexed keywords


EID: 85027895394     PISSN: 16625099     EISSN: None     Source Type: Journal    
DOI: 10.3389/fnmol.2017.00261     Document Type: Article
Times cited : (55)

References (50)
  • 1
    • 57649186797 scopus 로고    scopus 로고
    • Post-ischemic brain damage: Pathophysiology and role of inflammatory mediators
    • Amantea, D., Nappi, G., Bernardi, G., Bagetta, G., and Corasaniti, M. T. (2009). Post-ischemic brain damage: pathophysiology and role of inflammatory mediators. FEBS J. 276, 13–26. doi: 10.1111/j.1742-4658.2008.06766.x
    • (2009) FEBS J , vol.276 , pp. 13-26
    • Amantea, D.1    Nappi, G.2    Bernardi, G.3    Bagetta, G.4    Corasaniti, M.T.5
  • 2
    • 84991066526 scopus 로고    scopus 로고
    • Inflammation and stroke: An overview
    • Anrather, J., and Iadecola, C. (2016). Inflammation and stroke: an overview. Neurotherapeutics 13, 661–670. doi: 10.1007/s13311-016-0483-x
    • (2016) Neurotherapeutics , vol.13 , pp. 661-670
    • Anrather, J.1    Iadecola, C.2
  • 3
    • 70449529633 scopus 로고    scopus 로고
    • The blood-brain barrier and immune function and dysfunction
    • Banks, W. A., and Erickson, M. A. (2010). The blood-brain barrier and immune function and dysfunction. Neurobiol. Dis. 37, 26–32. doi: 10.1016/j.nbd.2009. 07.031
    • (2010) Neurobiol. Dis. , vol.37 , pp. 26-32
    • Banks, W.A.1    Erickson, M.A.2
  • 4
    • 84940054645 scopus 로고    scopus 로고
    • The role of activated microglia and resident macrophages in the neurovascular unit during cerebral ischemia: Is the jury still out?
    • Barakat, R., and Redzic, Z. (2016). The role of activated microglia and resident macrophages in the neurovascular unit during cerebral ischemia: Is the jury still out? Med. Princ. Pract. 25(Suppl. 1), 3–14. doi: 10.1159/000435858
    • (2016) Med. Princ. Pract , vol.25 , pp. 3-14
    • Barakat, R.1    Redzic, Z.2
  • 5
    • 64149090337 scopus 로고    scopus 로고
    • Inflammatory and neuroimmunomodulatory changes in acute cerebral ischemia
    • Brea, D., Sobrino, T., Ramos-Cabrer, P., and Castillo, J. (2009). Inflammatory and neuroimmunomodulatory changes in acute cerebral ischemia. Cerebrovasc. Dis. 27(Suppl. 1), 48–64. doi: 10.1159/000200441
    • (2009) Cerebrovasc. Dis , vol.27 , pp. 48-64
    • Brea, D.1    Sobrino, T.2    Ramos-Cabrer, P.3    Castillo, J.4
  • 6
    • 84988625059 scopus 로고    scopus 로고
    • Blockade of apoptosis signal-regulating kinase 1 attenuates matrix metalloproteinase 9 activity in brain endothelial cells and the subsequent apoptosis in neurons after ischemic injury
    • Cheon, S. Y., Cho, K. J., Kim, S. Y., Kam, E. H., Lee, J. E., and Koo, B. N. (2016a). Blockade of apoptosis signal-regulating kinase 1 attenuates matrix metalloproteinase 9 activity in brain endothelial cells and the subsequent apoptosis in neurons after ischemic injury. Front. Cell Neurosci. 10:213. doi: 10.3389/fncel.2016.00213
    • (2016) Front. Cell Neurosci. , vol.10 , pp. 213
    • Cheon, S.Y.1    Cho, K.J.2    Kim, S.Y.3    Kam, E.H.4    Lee, J.E.5    Koo, B.N.6
  • 7
    • 84875194097 scopus 로고    scopus 로고
    • Cerebroprotective effects of red ginseng extract pretreatment against ischemia-induced oxidative stress and apoptosis
    • Cheon, S. Y., Cho, K. J., Lee, J. E., Kim, H. W., Lee, S. K., Kim, H. J., et al. (2013). Cerebroprotective effects of red ginseng extract pretreatment against ischemia-induced oxidative stress and apoptosis. Int. J. Neurosci. 123, 269–277. doi: 10.3109/00207454.2012.758120
    • (2013) Int. J. Neurosci. , vol.123 , pp. 269-277
    • Cheon, S.Y.1    Cho, K.J.2    Lee, J.E.3    Kim, H.W.4    Lee, S.K.5    Kim, H.J.6
  • 8
    • 84958818497 scopus 로고    scopus 로고
    • Knockdown of apoptosis signal-regulating kinase 1 affects ischaemia-induced astrocyte activation and glial scar formation
    • Cheon, S. Y., Cho, K. J., Song, J., and Kim, G. W. (2016b). Knockdown of apoptosis signal-regulating kinase 1 affects ischaemia-induced astrocyte activation and glial scar formation. Eur. J. Neurosci. 43, 912–922. doi: 10.1111/ejn. 13175
    • (2016) Eur. J. Neurosci. , vol.43 , pp. 912-922
    • Cheon, S.Y.1    Cho, K.J.2    Song, J.3    Kim, G.W.4
  • 9
    • 84953311201 scopus 로고    scopus 로고
    • Apoptosis signal-regulating kinase 1 mediates striatal degeneration via the regulation of C1q
    • Cho, K. J., Cheon, S. Y., and Kim, G. W. (2016). Apoptosis signal-regulating kinase 1 mediates striatal degeneration via the regulation of C1q. Sci. Rep. 6:18840. doi: 10.1038/srep18840
    • (2016) Sci. Rep. , vol.6 , pp. 18840
    • Cho, K.J.1    Cheon, S.Y.2    Kim, G.W.3
  • 10
    • 56849129516 scopus 로고    scopus 로고
    • Interleukin-1beta and tumor necrosis factor-alpha are expressed by different subsets of microglia and macrophages after ischemic stroke in mice
    • Clausen, B. H., Lambertsen, K. L., Babcock, A. A., Holm, T. H., Dagnaes-Hansen, F., and Finsen, B. (2008). Interleukin-1beta and tumor necrosis factor-alpha are expressed by different subsets of microglia and macrophages after ischemic stroke in mice. J. Neuroinflammation 5:46. doi: 10.1186/1742-2094-5-46
    • (2008) J. Neuroinflammation , vol.5 , pp. 46
    • Clausen, B.H.1    Lambertsen, K.L.2    Babcock, A.A.3    Holm, T.H.4    Dagnaes-Hansen, F.5    Finsen, B.6
  • 11
    • 0037312886 scopus 로고    scopus 로고
    • Inflammatory mechanisms after ischemia and stroke
    • Danton, G. H., and Dietrich, W. D. (2003). Inflammatory mechanisms after ischemia and stroke. J. Neuropathol. Exp. Neurol. 62, 127–136.
    • (2003) J. Neuropathol. Exp. Neurol. , vol.62 , pp. 127-136
    • Danton, G.H.1    Dietrich, W.D.2
  • 12
    • 77953620336 scopus 로고    scopus 로고
    • Inflammation and brain injury: Acute cerebral ischaemia, peripheral and central inflammation
    • Denes, A., Thornton, P., Rothwell, N. J., and Allan, S. M. (2010). Inflammation and brain injury: acute cerebral ischaemia, peripheral and central inflammation. Brain Behav. Immun. 24, 708–723. doi: 10.1016/j.bbi.2009. 09.010
    • (2010) Brain Behav. Immun. , vol.24 , pp. 708-723
    • Denes, A.1    Thornton, P.2    Rothwell, N.J.3    Allan, S.M.4
  • 13
    • 84858072878 scopus 로고    scopus 로고
    • Comparison of polarization properties of human adult microglia and blood-derived macrophages
    • Durafourt, B. A., Moore, C. S., Zammit, D. A., Johnson, T. A., Zaguia, F., Guiot, M. C., et al. (2012). Comparison of polarization properties of human adult microglia and blood-derived macrophages. Glia 60, 717–727. doi: 10.1002/glia. 22298
    • (2012) Glia , vol.60 , pp. 717-727
    • Durafourt, B.A.1    Moore, C.S.2    Zammit, D.A.3    Johnson, T.A.4    Zaguia, F.5    Guiot, M.C.6
  • 14
    • 79451472879 scopus 로고    scopus 로고
    • Myeloid-specific deletion of the mineralocorticoid receptor reduces infarct volume and alters inflammation during cerebral ischemia
    • Frieler, R. A., Meng, H., Duan, S. Z., Berger, S., Schutz, G., He, Y., et al. (2011). Myeloid-specific deletion of the mineralocorticoid receptor reduces infarct volume and alters inflammation during cerebral ischemia. Stroke 42, 179–185. doi: 10.1161/STROKEAHA.110.598441
    • (2011) Stroke , vol.42 , pp. 179-185
    • Frieler, R.A.1    Meng, H.2    Duan, S.Z.3    Berger, S.4    Schutz, G.5    He, Y.6
  • 15
    • 84941025594 scopus 로고    scopus 로고
    • Immune interventions in stroke
    • Fu, Y., Liu, Q., Anrather, J., and Shi, F. D. (2015). Immune interventions in stroke. Nat. Rev. Neurol. 11, 524–535. doi: 10.1038/nrneurol.2015.144
    • (2015) Nat. Rev. Neurol. , vol.11 , pp. 524-535
    • Fu, Y.1    Liu, Q.2    Anrather, J.3    Shi, F.D.4
  • 16
    • 0033976487 scopus 로고    scopus 로고
    • Microglia and macrophages are the major source of tumor necrosis factor in permanent middle cerebral artery occlusion in mice
    • Gregersen, R., Lambertsen, K., and Finsen, B. (2000). Microglia and macrophages are the major source of tumor necrosis factor in permanent middle cerebral artery occlusion in mice. J. Cereb. Blood Flow Metab. 20, 53–65. doi: 10.1097/00004647-200001000-00009
    • (2000) J. Cereb. Blood Flow Metab. , vol.20 , pp. 53-65
    • Gregersen, R.1    Lambertsen, K.2    Finsen, B.3
  • 17
    • 78650303038 scopus 로고    scopus 로고
    • Regulation of the severity of neuroinflammation and demyelination by TLR-ASK1-p38 pathway
    • Guo, X., Harada, C., Namekata, K., Matsuzawa, A., Camps, M., Ji, H., et al. (2010). Regulation of the severity of neuroinflammation and demyelination by TLR-ASK1-p38 pathway. EMBO Mol. Med. 2, 504–515. doi: 10.1002/emmm. 201000103
    • (2010) EMBO Mol. Med , vol.2 , pp. 504-515
    • Guo, X.1    Harada, C.2    Namekata, K.3    Matsuzawa, A.4    Camps, M.5    Ji, H.6
  • 18
    • 33646143763 scopus 로고    scopus 로고
    • The ASK1-MAP kinase pathways in immune and stress responses
    • Hayakawa, T., Matsuzawa, A., Noguchi, T., Takeda, K., and Ichijo, H. (2006). The ASK1-MAP kinase pathways in immune and stress responses. Microbes Infect. 8, 1098–1107. doi: 10.1016/j.micinf.2005.12.001
    • (2006) Microbes Infect , vol.8 , pp. 1098-1107
    • Hayakawa, T.1    Matsuzawa, A.2    Noguchi, T.3    Takeda, K.4    Ichijo, H.5
  • 19
    • 84920717602 scopus 로고    scopus 로고
    • Microglial and macrophage polarization-new prospects for brain repair
    • Hu, X., Leak, R. K., Shi, Y., Suenaga, J., Gao, Y., Zheng, P., et al. (2015). Microglial and macrophage polarization-new prospects for brain repair. Nat. Rev. Neurol. 11, 56–64. doi: 10.1038/nrneurol.2014.207
    • (2015) Nat. Rev. Neurol , vol.11 , pp. 56-64
    • Hu, X.1    Leak, R.K.2    Shi, Y.3    Suenaga, J.4    Gao, Y.5    Zheng, P.6
  • 20
    • 84868209611 scopus 로고    scopus 로고
    • Microglia/macrophage polarization dynamics reveal novel mechanism of injury expansion after focal cerebral ischemia
    • Hu, X., Li, P., Guo, Y., Wang, H., Leak, R. K., Chen, S., et al. (2012). Microglia/macrophage polarization dynamics reveal novel mechanism of injury expansion after focal cerebral ischemia. Stroke 43, 3063–3070. doi: 10.1161/STROKEAHA.112.659656
    • (2012) Stroke , vol.43 , pp. 3063-3070
    • Hu, X.1    Li, P.2    Guo, Y.3    Wang, H.4    Leak, R.K.5    Chen, S.6
  • 21
    • 85027925743 scopus 로고    scopus 로고
    • Class A scavenger receptor attenuates myocardial infarction-induced cardiomyocyte necrosis through suppressing M1 macrophage subset polarization
    • Hu, Y., Zhang, H., Lu, Y., Bai, H., Xu, Y., Zhu, X., et al. (2011). Class A scavenger receptor attenuates myocardial infarction-induced cardiomyocyte necrosis through suppressing M1 macrophage subset polarization. Basic Res. Cardiol. 106, 1311–1328. doi: 10.1007/s00395-011-0204-x
    • (2011) Basic Res. Cardiol. , vol.106 , pp. 1311-1328
    • Hu, Y.1    Zhang, H.2    Lu, Y.3    Bai, H.4    Xu, Y.5    Zhu, X.6
  • 22
    • 79960141471 scopus 로고    scopus 로고
    • The immunology of stroke: From mechanisms to translation
    • Iadecola, C., and Anrather, J. (2011). The immunology of stroke: from mechanisms to translation. Nat. Med. 17, 796–808. doi: 10.1038/nm.2399
    • (2011) Nat. Med. , vol.17 , pp. 796-808
    • Iadecola, C.1    Anrather, J.2
  • 23
    • 84969257089 scopus 로고    scopus 로고
    • Epigenetic control of macrophage polarisation and soluble mediator gene expression during inflammation
    • Kapellos, T. S., and Iqbal, A. J. (2016). Epigenetic control of macrophage polarisation and soluble mediator gene expression during inflammation. Mediators Inflamm. 2016:6591703. doi: 10.1155/2016/6591703
    • (2016) Mediators Inflamm. , vol.2016
    • Kapellos, T.S.1    Iqbal, A.J.2
  • 24
    • 84872336510 scopus 로고    scopus 로고
    • Inhibition of ASK1-p38 pathway prevents neural cell death following optic nerve injury
    • Katome, T., Namekata, K., Guo, X., Semba, K., Kittaka, D., Kawamura, K., et al. (2013). Inhibition of ASK1-p38 pathway prevents neural cell death following optic nerve injury. Cell Death Differ. 20, 270–280. doi: 10.1038/cdd. 2012.122
    • (2013) Cell Death Differ , vol.20 , pp. 270-280
    • Katome, T.1    Namekata, K.2    Guo, X.3    Semba, K.4    Kittaka, D.5    Kawamura, K.6
  • 25
    • 70350558453 scopus 로고    scopus 로고
    • Identification of two distinct macrophage subsets with divergent effects causing either neurotoxicity or regeneration in the injured mouse spinal cord
    • Kigerl, K. A., Gensel, J. C., Ankeny, D. P., Alexander, J. K., Donnelly, D. J., and Popovich, P. G. (2009). Identification of two distinct macrophage subsets with divergent effects causing either neurotoxicity or regeneration in the injured mouse spinal cord. J. Neurosci. 29, 13435–13444. doi: 10.1523/JNEUROSCI. 3257-09.2009
    • (2009) J. Neurosci , vol.29 , pp. 13435-13444
    • Kigerl, K.A.1    Gensel, J.C.2    Ankeny, D.P.3    Alexander, J.K.4    Donnelly, D.J.5    Popovich, P.G.6
  • 26
    • 80052023031 scopus 로고    scopus 로고
    • Apoptosis signal-regulating kinase 1 (Ask1) targeted small interfering RNA on ischemic neuronal cell death
    • Kim, H. W., Cho, K. J., Lee, S. K., and Kim, G. W. (2011). Apoptosis signal-regulating kinase 1 (Ask1) targeted small interfering RNA on ischemic neuronal cell death. Brain Res. 1412, 73–78. doi: 10.1016/j.brainres.2011. 07.018
    • (2011) Brain Res , vol.1412 , pp. 73-78
    • Kim, H.W.1    Cho, K.J.2    Lee, S.K.3    Kim, G.W.4
  • 27
    • 7644231561 scopus 로고    scopus 로고
    • The chemokine system in diverse forms of macrophage activation and polarization
    • Mantovani, A., Sica, A., Sozzani, S., Allavena, P., Vecchi, A., and Locati, M. (2004). The chemokine system in diverse forms of macrophage activation and polarization. Trends Immunol. 25, 677–686. doi: 10.1016/j.it.2004. 09.015
    • (2004) Trends Immunol , vol.25 , pp. 677-686
    • Mantovani, A.1    Sica, A.2    Sozzani, S.3    Allavena, P.4    Vecchi, A.5    Locati, M.6
  • 29
    • 9144253936 scopus 로고    scopus 로고
    • The ASK1-MAP kinase cascades in mammalian stress response
    • Matsukawa, J., Matsuzawa, A., Takeda, K., and Ichijo, H. (2004). The ASK1-MAP kinase cascades in mammalian stress response. J. Biochem. 136, 261–265. doi: 10.1093/jb/mvh134
    • (2004) J. Biochem. , vol.136 , pp. 261-265
    • Matsukawa, J.1    Matsuzawa, A.2    Takeda, K.3    Ichijo, H.4
  • 30
    • 8844270954 scopus 로고    scopus 로고
    • Human cerebral infarct: A proposed histopathologic classification based on 137 cases
    • Mena, H., Cadavid, D., and Rushing, E. J. (2004). Human cerebral infarct: a proposed histopathologic classification based on 137 cases. Acta Neuropathol. 108, 524–530. doi: 10.1007/s00401-004-0918-z
    • (2004) Acta Neuropathol , vol.108 , pp. 524-530
    • Mena, H.1    Cadavid, D.2    Rushing, E.J.3
  • 31
    • 77957223838 scopus 로고    scopus 로고
    • Critical role for apoptosis signal-regulating kinase 1 in the development of inflammatory K/BxN serum-induced arthritis
    • Mnich, S. J., Blanner, P. M., Hu, L. G., Shaffer, A. F., Happa, F. A., O’Neil, S., et al. (2010). Critical role for apoptosis signal-regulating kinase 1 in the development of inflammatory K/BxN serum-induced arthritis. Int. Immunopharmacol. 10, 1170–1176. doi: 10.1016/j.intimp.2010.06.023
    • (2010) Int. Immunopharmacol. , vol.10 , pp. 1170-1176
    • Mnich, S.J.1    Blanner, P.M.2    Hu, L.G.3    Shaffer, A.F.4    Happa, F.A.5    O’Neil, S.6
  • 32
    • 84957436714 scopus 로고    scopus 로고
    • Microglial M1/M2 polarization and metabolic states
    • Orihuela, R., McPherson, C. A., and Harry, G. J. (2016). Microglial M1/M2 polarization and metabolic states. Br. J. Pharmacol. 173, 649–665. doi: 10.1111/bph.13139
    • (2016) Br. J. Pharmacol. , vol.173 , pp. 649-665
    • Orihuela, R.1    McPherson, C.A.2    Harry, G.J.3
  • 33
    • 84983616254 scopus 로고    scopus 로고
    • 1-Oleyl-lysophosphatidic acid (LPA) promotes polarization of BV-2 and primary murine microglia towards an M1-like phenotype
    • Plastira, I., Bernhart, E., Goeritzer, M., Reicher, H., Kumble, V. B., Kogelnik, N., et al. (2016). 1-Oleyl-lysophosphatidic acid (LPA) promotes polarization of BV-2 and primary murine microglia towards an M1-like phenotype. J. Neuroinflammation 13:205. doi: 10.1186/s12974-016-0701-9
    • (2016) J. Neuroinflammation , vol.13 , pp. 205
    • Plastira, I.1    Bernhart, E.2    Goeritzer, M.3    Reicher, H.4    Kumble, V.B.5    Kogelnik, N.6
  • 34
    • 84962765800 scopus 로고    scopus 로고
    • Lipopolysaccharide preconditioning induces an anti-inflammatory phenotype in BV2 microglia
    • Qin, Y., Sun, X., Shao, X., Hu, M. X., Feng, J., Chen, Z., et al. (2016). Lipopolysaccharide preconditioning induces an anti-inflammatory phenotype in BV2 microglia. Cell Mol. Neurobiol. 36, 1269–1277. doi: 10.1007/s10571-015-0324-1
    • (2016) Cell Mol. Neurobiol. , vol.36 , pp. 1269-1277
    • Qin, Y.1    Sun, X.2    Shao, X.3    Hu, M.X.4    Feng, J.5    Chen, Z.6
  • 35
    • 53749099515 scopus 로고    scopus 로고
    • Immune-to-brain signaling: How important are the blood-brain barrier-independent pathways?
    • Quan, N. (2008). Immune-to-brain signaling: How important are the blood-brain barrier-independent pathways? Mol. Neurobiol. 37, 142–152. doi: 10.1007/s12035-008-8026-z
    • (2008) Mol. Neurobiol. , vol.37 , pp. 142-152
    • Quan, N.1
  • 36
    • 34347268434 scopus 로고    scopus 로고
    • Brain-immune communication pathways
    • Quan, N., and Banks, W. A. (2007). Brain-immune communication pathways. Brain Behav. Immun. 21, 727–735. doi: 10.1016/j.bbi.2007.05.005
    • (2007) Brain Behav. Immun. , vol.21 , pp. 727-735
    • Quan, N.1    Banks, W.A.2
  • 37
    • 84979730436 scopus 로고    scopus 로고
    • A polarizing question: Do M1 and M2 microglia exist?
    • Ransohoff, R. M. (2016). A polarizing question: Do M1 and M2 microglia exist? Nat. Neurosci. 19, 987–991. doi: 10.1038/nn.4338
    • (2016) Nat. Neurosci. , vol.19 , pp. 987-991
    • Ransohoff, R.M.1
  • 38
    • 84874005088 scopus 로고    scopus 로고
    • Activation mechanisms of ASK1 in response to various stresses and its significance in intracellular signaling
    • Shiizaki, S., Naguro, I., and Ichijo, H. (2013). Activation mechanisms of ASK1 in response to various stresses and its significance in intracellular signaling. Adv. Biol. Regul. 53, 135–144. doi: 10.1016/j.jbior.2012.09.006
    • (2013) Adv. Biol. Regul. , vol.53 , pp. 135-144
    • Shiizaki, S.1    Naguro, I.2    Ichijo, H.3
  • 39
    • 84944170532 scopus 로고    scopus 로고
    • Macrophage polarization in pathology
    • Sica, A., Erreni, M., Allavena, P., and Porta, C. (2015). Macrophage polarization in pathology. Cell Mol. Life Sci. 72, 4111–4126. doi: 10.1007/s00018-015-1995-y
    • (2015) Cell Mol. Life Sci. , vol.72 , pp. 4111-4126
    • Sica, A.1    Erreni, M.2    Allavena, P.3    Porta, C.4
  • 40
    • 84862293673 scopus 로고    scopus 로고
    • Oxidative stress-induced diseases via the ASK1 signaling pathway
    • Soga, M., Matsuzawa, A., and Ichijo, H. (2012). Oxidative stress-induced diseases via the ASK1 signaling pathway. Int. J. Cell Biol. 2012:439587. doi: 10.1155/2012/439587
    • (2012) Int. J. Cell Biol. , vol.2012
    • Soga, M.1    Matsuzawa, A.2    Ichijo, H.3
  • 41
    • 84919883208 scopus 로고    scopus 로고
    • The effect of ASK1 on vascular permeability and edema formation in cerebral ischemia
    • Song, J., Cheon, S. Y., Lee, W. T., Park, K. A., and Lee, J. E. (2015). The effect of ASK1 on vascular permeability and edema formation in cerebral ischemia. Brain Res. 1595, 143–155. doi: 10.1016/j.brainres.2014.11.024
    • (2015) Brain Res , vol.1595 , pp. 143-155
    • Song, J.1    Cheon, S.Y.2    Lee, W.T.3    Park, K.A.4    Lee, J.E.5
  • 42
    • 84929590762 scopus 로고    scopus 로고
    • ASK1 modulates the expression of microRNA Let7A in microglia under high glucose in vitro condition
    • Song, J., and Lee, J. E. (2015). ASK1 modulates the expression of microRNA Let7A in microglia under high glucose in vitro condition. Front. Cell Neurosci. 9:198. doi: 10.3389/fncel.2015.00198
    • (2015) Front. Cell Neurosci. , vol.9 , pp. 198
    • Song, J.1    Lee, J.E.2
  • 43
    • 38049016363 scopus 로고    scopus 로고
    • LPS-induced Toll-like receptor 4 signalling triggers cross-talk of apoptosis signal-regulating kinase 1 (ASK1) and HIF-1alpha protein
    • Sumbayev, V. V. (2008). LPS-induced Toll-like receptor 4 signalling triggers cross-talk of apoptosis signal-regulating kinase 1 (ASK1) and HIF-1alpha protein. FEBS Lett. 582, 319–326. doi: 10.1016/j.febslet.2007.12.024
    • (2008) FEBS Lett , vol.582 , pp. 319-326
    • Sumbayev, V.V.1
  • 44
    • 41149097725 scopus 로고    scopus 로고
    • Apoptosis signal-regulating kinase 1 in stress and immune response
    • Takeda, K., Noguchi, T., Naguro, I., and Ichijo, H. (2008). Apoptosis signal-regulating kinase 1 in stress and immune response. Annu. Rev. Pharmacol. Toxicol. 48, 199–225. doi: 10.1146/annurev.pharmtox.48.113006.094606
    • (2008) Annu. Rev. Pharmacol. Toxicol. , vol.48 , pp. 199-225
    • Takeda, K.1    Noguchi, T.2    Naguro, I.3    Ichijo, H.4
  • 45
    • 84879108078 scopus 로고    scopus 로고
    • Transcriptional control of macrophage polarization
    • Tugal, D., Liao, X., and Jain, M. K. (2013). Transcriptional control of macrophage polarization. Arterioscler. Thromb. Vasc. Biol. 33, 1135–1144. doi: 10.1161/ATVBAHA.113.301453
    • (2013) Arterioscler. Thromb. Vasc. Biol. , vol.33 , pp. 1135-1144
    • Tugal, D.1    Liao, X.2    Jain, M.K.3
  • 46
    • 85014630540 scopus 로고    scopus 로고
    • Akt signaling pathway in macrophage activation and M1/M2 Polarization
    • Vergadi, E., Ieronymaki, E., Lyroni, K., Vaporidi, K., and Tsatsanis, C. (2017). Akt signaling pathway in macrophage activation and M1/M2 Polarization. J. Immunol. 198, 1006–1014. doi: 10.4049/jimmunol.1601515
    • (2017) J. Immunol. , vol.198 , pp. 1006-1014
    • Vergadi, E.1    Ieronymaki, E.2    Lyroni, K.3    Vaporidi, K.4    Tsatsanis, C.5
  • 47
    • 84888860506 scopus 로고    scopus 로고
    • Immunological consequences of ischemic stroke
    • Vogelgesang, A., Becker, K. J., and Dressel, A. (2014). Immunological consequences of ischemic stroke. Acta Neurol. Scand. 129, 1–12. doi: 10.1111/ane.12165
    • (2014) Acta Neurol. Scand , vol.129 , pp. 1-12
    • Vogelgesang, A.1    Becker, K.J.2    Dressel, A.3
  • 48
    • 84924530220 scopus 로고    scopus 로고
    • In vivo analysis of neuroinflammation in the late chronic phase after experimental stroke
    • Walter, H. L., Walberer, M., Rueger, M. A., Backes, H., Wiedermann, D., Hoehn, M., et al. (2015). In vivo analysis of neuroinflammation in the late chronic phase after experimental stroke. Neuroscience 292, 71–80. doi: 10.1016/j.neuroscience.2015.02.024
    • (2015) Neuroscience , vol.292 , pp. 71-80
    • Walter, H.L.1    Walberer, M.2    Rueger, M.A.3    Backes, H.4    Wiedermann, D.5    Hoehn, M.6
  • 49
    • 84925352058 scopus 로고    scopus 로고
    • Atorvastatin promotes human monocyte differentiation toward alternative M2 macrophages through p38 mitogen-activated protein kinase-dependent peroxisome proliferator-activated receptor gamma activation
    • Zhang, O., and Zhang, J. (2015). Atorvastatin promotes human monocyte differentiation toward alternative M2 macrophages through p38 mitogen-activated protein kinase-dependent peroxisome proliferator-activated receptor gamma activation. Int. Immunopharmacol. 26, 58–64. doi: 10.1016/j.intimp. 2015.03.005
    • (2015) Int. Immunopharmacol. , vol.26 , pp. 58-64
    • Zhang, O.1    Zhang, J.2
  • 50
    • 85020386938 scopus 로고    scopus 로고
    • Ubiquitylation of MFHAS1 by the ubiquitin ligase praja2 promotes M1 macrophage polarization by activating JNK and p38 pathways
    • Zhong, J., Wang, H., Chen, W., Sun, Z., Chen, J., Xu, Y., et al. (2017). Ubiquitylation of MFHAS1 by the ubiquitin ligase praja2 promotes M1 macrophage polarization by activating JNK and p38 pathways. Cell Death Dis. 8:e2763. doi: 10.1038/cddis.2017.102
    • (2017) Cell Death Dis , vol.8
    • Zhong, J.1    Wang, H.2    Chen, W.3    Sun, Z.4    Chen, J.5    Xu, Y.6


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