Metformin attenuates myocardial Ischemia-reperfusion injury via Up-regulation of antioxidant enzymes

PLoS ONE

Volumn 12, Issue 8, 2017, Pages

  Wang, Xiaoling ^a   Yang, Lei ^a,b   Kang, Licheng ^a   Li, Jing ^a   Yang, Liang ^a   Zhang, Jincai ^a   Liu, Jie ^a   Zhu, Mengmeng ^a   Zhang, Qiong ^c   Shen, Yanna ^c   Qi, Zhi ^a,d  

^a NANKAI UNIVERSITY   (China)

^b TIANJIN NANKAI HOSPITAL   (China)

^c TIANJIN MEDICAL UNIVERSITY   (China)

^d National Clinical Research Centre for Respiratory Disease   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIOXIDANT; CATALASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; METFORMIN; PROTEIN SERINE THREONINE KINASE; REACTIVE OXYGEN METABOLITE; STK11 PROTEIN, RAT; SUPEROXIDE DISMUTASE;

ANIMAL; ANTAGONISTS AND INHIBITORS; APOPTOSIS; CARDIAC MUSCLE CELL; CELL LINE; DRUG EFFECTS; GENETICS; HEART VENTRICLE FUNCTION; MALE; METABOLISM; MYOCARDIAL REPERFUSION INJURY; RAT; SPRAGUE DAWLEY RAT;

AMP-ACTIVATED PROTEIN KINASES; ANIMALS; ANTIOXIDANTS; APOPTOSIS; CATALASE; CELL LINE; MALE; METFORMIN; MYOCARDIAL REPERFUSION INJURY; MYOCYTES, CARDIAC; PROTEIN-SERINE-THREONINE KINASES; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; SUPEROXIDE DISMUTASE; VENTRICULAR FUNCTION;

EID: 85027697110     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0182777     Document Type: Article

References (28)

1. Hausenloy DJ, Yellon DM. Time to take myocardial reperfusion injury seriously. N Engl J Med. 2008; 359(5): 518–520. https://doi.org/10.1056/NEJMe0803746 PMID: 18669431
2. Braunwald E, Kloner RA. Myocardial reperfusion: a double-edged sword? J Clin Invest. 1985; 76(5): 1713–1719. https://doi.org/10.1172/JCI112160 PMID: 4056048
3. Schilling JD, Mann DL. Diabetic Cardiomyopathy: Bench to Bedside. Heart Fail Clin. 2012; 8(4): 619–631. https://doi.org/10.1016/j.hfc.2012.06.007 PMID: 22999244
4. Ekeløf S, Jensen SE, Rosenberg J, Gögenur I. Reduced Oxidative Stress in STEMI Patients Treated by Primary Percutaneous Coronary Intervention and with Antioxidant Therapy: A Systematic Review. Cardiovasc Drugs Ther. 2014; 28(2): 173–181. https://doi.org/10.1007/s10557-014-6511-3 PMID: 24532094
5. Sugamura K, Keaney JF Jr. Reactive oxygen species in cardiovascular disease. Free Radic Biol Med. 2011; 51(5): 978–992. https://doi.org/10.1016/j.freeradbiomed.2011.05.004 PMID: 21627987
6. Murphy E, Steenbergen C. Mechanisms underlying acute protection from cardiac ischemia-reperfusion injury. Physiol Rev. 2008; 88(2): 581–609. https://doi.org/10.1152/physrev.00024.2007 PMID: 18391174
7. Pisarenko O, Shulzhenko V, Studneva I, Pelogeykina Y, Timoshin A, Anesia R, et al. Structural apelin analogues: mitochondrial ROS inhibition and cardiometabolic protection in myocardial ischaemia reperfusion injury. Br J Pharmacol. 2014; 172(12): 2933–2945. https://doi.org/10.1111/bph.13038 PMID: 25521429
8. Yan YF, Chen HP, Huang XS, Qiu LY, Liao ZP, Huang QR. DJ-1 mediates the delayed cardioprotection of hypoxic preconditioning via activation of Nrf2 and subsequent upregulation of antioxidative enzymes. J Cardiovasc Pharmacol. 2015; 66(2): 148–158. https://doi.org/10.1097/FJC.0000000000000257PMID: 25915512
9. Wang XX, Wang XL, Tong MM, Gan L, Chen H, Wu SS, et al. SIRT6 protects cardiomyocytes against ischemia/reperfusion injury by augmenting FoxO3α-dependent antioxidant defense mechanisms. Basic Res Cardiol 2016; 111(2): 1–13. https://doi.org/10.1007/s00395-016-0531-z PMID: 26786260
10. Paiva MA, Gonçalves LM, Providência LA, Davidson SM, Yellon DM, Mocanu MM. Transitory Activation of AMPK at Reperfusion Protects the Ischaemic-Reperfused Rat Myocardium Against Infarction. Cardiovasc Drugs Ther. 2010; 24(1): 25–32. https://doi.org/10.1007/s10557-010-6222-3 PMID: 20229055
11. Basnet S, Kozikowski A, Makaryus AN, Pekmezaris R, Zeltser R, Akerman M, et al. Metformin and Myocardial Injury in Patients With Diabetes and ST-Segment Elevation Myocardial Infarction: A Propensity Score Matched Analysis. J Am Heart Assoc. 2015; 4(10): e002314. https://doi.org/10.1161/JAHA.115. 002314 PMID: 26494519
12. Whittington HJ, Hall AR, McLaughlin CP, usenloy DJ, Yellon DM, Mocanu MM.Chronic metformin associated cardioprotection against infarction: not just a glucose lowering phenomenon. Cardiovasc Drugs Ther. 2013; 27(1): 5–16. https://doi.org/10.1007/s10557-012-6425-x PMID: 23192487
13. Group UPDS. Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). Lancet. 1998; 352(9131):854–865. PMID: 9742977
14. Gundewar S, Calvert JW, Jha S, Toedt-Pingel I, Ji SY, Nunez D, et al. Activation of AMP-activated protein kinase by metformin improves left ventricular function and survival in heart failure. Circ Res. 2009; 104(3): 403–411. https://doi.org/10.1161/CIRCRESAHA.108.190918 PMID: 19096023
15. Sasaki H, Asanuma H, Fujita M, Takahama H, Wakeno M, Ito S, et al. Metformin prevents progression of heart failure in dogs: role of AMP-activated protein kinase. Circulation. 2009; 119(19): 2568–2577. https://doi.org/10.1161/CIRCULATIONAHA.108.798561 PMID: 19414638
16. Xu X, Lu Z, Fassett J, Zhang P, Hu X, Liu X, et al. Metformin protects against systolic overload-induced heart failure independent of AMP-activated protein kinase α2. Hypertension. 2014; 63(4): 723–728. https://doi.org/10.1161/HYPERTENSIONAHA.113.02619 PMID: 24420540
17. Singh RK, Gupta B, Tripathi K, Singh SK. Anti oxidant potential of Metformin and Pioglitazone in Type 2 Diabetes Mellitus: Beyond their anti glycemic effect. Diabetes Metab Syndr. 2016; 10(2): 102–104. https://doi.org/10.1016/j.dsx.2015.08.016 PMID: 26341927
18. Cahova M, Palenickova E, Dankova H, Sticova E4, Burian M5, Drahota Z, et al. Metformin prevents ischemia reperfusion-induced oxidative stress in the fatty liver by attenuation of reactive oxygen species formation. Am J Physiol Gastrointest Liver Physiol. 2015; 309(2): 100–111. https://doi.org/10.1152/ajpgi.00329.2014 PMID: 26045616
19. Liu F, Tian W, Yang Y, Zhang Q, Zhu M, Yang L, et al. Optimal method for short-term or long-term islet preservation: comparison of islet culture, cold preservation and cryopreservation. J Artif Organs. 2014; 17(4): 337–343. https://doi.org/10.1007/s10047-014-0777-x PMID: 24944122
20. Yang L, Yang L, Tian W, Li J, Liu J, Zhu M, et al. Resveratrol plays dual roles in pancreatic cancer cells. J Cancer Res Clin Oncol. 2014; 140(5): 749–755. https://doi.org/10.1007/s00432-014-1624-4 PMID: 24604347
21. Zhou G, Myers R, Li Y, Chen Y, Shen X, Fenyk-Melody J, et al. Role of AMP-activated protein kinase in mechanism of metformin action. J Clin Invest. 2001; 108(8): 1167–1174. https://doi.org/10.1172/ JCI13505 PMID: 11602624
22. Shaw RJ, Lamia KA, Vasquez D, Koo SH, Bardeesy N, Depinho RA, et al. The Kinase LKB1 Mediates Glucose Homeostasis in Liver and Therapeutic Effects of Metformin. Science. 2006; 310(5754): 1642–1646. https://doi.org/10.1126/science.1120781 PMID: 16308421
23. Wang XF, Zhang JY, Li L, Zhao XY, Tao HL, Zhang L. Metformin improves cardiac function in rats via activation of AMP-activated protein kinase. Clin Exp Pharmacol Physiol. 2011; 38(2): 94–101. https://doi.org/10.1111/j.1440-1681.2010.05470.x PMID: 21143620
24. Shi WY, Xiao D, Wang L, Dong LH, Yan ZX, Shen ZX, et al. Therapeutic metformin/AMPK activation blocked lymphoma cell growth via inhibition of mTOR pathway and induction of autophagy. Cell Death Dis. 2012; 3: e257. https://doi.org/10.1038/cddis.2012.13 PMID: 22378068
25. Miller RA, Chu Q, Xie J, Foretz M, Viollet B, Birnbaum MJ. Biguanides suppress hepatic glucagon sig-nalling by decreasing production of cyclic AMP. Nature. 2013; 494(7436): 256–260. https://doi.org/10.1038/nature11808 PMID: 23292513
26. Liu X, Chhipa RR, Pooya S, Wortman M, Yachyshin S, Chow LM, et al. Discrete mechanisms of mTOR and cell cycle regulation by AMPK agonists independent of AMPK. Proc Natl Acad Sci USA. 2014; 111 (4): e435–444. https://doi.org/10.1073/pnas.1311121111 PMID: 24474794
27. Silambarasan T, Manivannan J, Priya MK, Suganya N, Chatterjee S, Raja B. Sinapic acid protects heart against ischemia/reperfusion injury and H9c2 cardiomyoblast cells against oxidative stress. Bio-chem Biophys Res Commun. 2015; 456(4): 853–859. https://doi.org/10.1016/j.bbrc.2014.12.022PMID: 25511706
28. Zheng Z, Chen H, Li J, Li T, Zheng B, Zheng Y, et al. Sirtuin 1–Mediated Cellular Metabolic Memory of High Glucose Via the LKB1/AMPK/ROS Pathway and Therapeutic Effects of Metformin. Diabetes. 2011; 61(1): 217–228. https://doi.org/10.2337/db11-0416 PMID: 22124463.