메뉴 건너뛰기




Volumn 7, Issue 1, 2017, Pages

Interferon-alpha treatment rapidly clears Hepatitis e virus infection in humanized mice

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; ANTIVIRUS AGENT; BIOLOGICAL MARKER; GAMMA INTERFERON INDUCIBLE PROTEIN 10; MACROGOL; PEGINTERFERON ALPHA2A; RECOMBINANT PROTEIN;

EID: 85027523562     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/s41598-017-07434-y     Document Type: Article
Times cited : (36)

References (51)
  • 2
    • 84907211274 scopus 로고    scopus 로고
    • Consensus proposals for classification of the family Hepeviridae
    • Smith, D. B., et al. Consensus proposals for classification of the family Hepeviridae. The Journal of general virology 95, 2223-2232, doi: 10.1099/vir.0.068429-0 (2014).
    • (2014) The Journal of General Virology , vol.95 , pp. 2223-2232
    • Smith, D.B.1
  • 4
    • 0037280909 scopus 로고    scopus 로고
    • Aetiology clinical course and outcome of sporadic acute viral hepatitis in pregnancy
    • Khuroo, M. S., Kamili, S. Aetiology, clinical course and outcome of sporadic acute viral hepatitis in pregnancy. Journal of viral hepatitis 10, 61-69 (2003).
    • (2003) Journal of Viral Hepatitis , vol.10 , pp. 61-69
    • Khuroo, M.S.1    Kamili, S.2
  • 5
    • 84891712487 scopus 로고    scopus 로고
    • Host immune status and response to hepatitis E virus infection
    • Krain, L. J., Nelson, K. E., Labrique, A. B. Host immune status and response to hepatitis E virus infection. Clinical microbiology reviews 27, 139-165, doi: 10.1128/CMR.00062-13 (2014).
    • (2014) Clinical Microbiology Reviews , vol.27 , pp. 139-165
    • Krain, L.J.1    Nelson, K.E.2    Labrique, A.B.3
  • 6
    • 79955424791 scopus 로고    scopus 로고
    • Factors associated with chronic hepatitis in patients with hepatitis E virus infection who have received solid organ transplants
    • Kamar, N., et al. Factors associated with chronic hepatitis in patients with hepatitis E virus infection who have received solid organ transplants. Gastroenterology 140, 1481-1489, doi: 10.1053/j.gastro.2011.02.050 (2011).
    • (2011) Gastroenterology , vol.140 , pp. 1481-1489
    • Kamar, N.1
  • 7
    • 84859841971 scopus 로고    scopus 로고
    • Hepatitis E virus infection among solid organ transplant recipients, the Netherlands
    • Pas, S. D., et al. Hepatitis E virus infection among solid organ transplant recipients, the Netherlands. Emerging infectious diseases 18, 869-872, doi: 10.3201/eid1805.111712 (2012).
    • (2012) Emerging Infectious Diseases , vol.18 , pp. 869-872
    • Pas, S.D.1
  • 8
    • 84951850174 scopus 로고    scopus 로고
    • Hepatitis E virus genotype 3 infection in a tertiary referral center in the Netherlands: Clinical relevance and impact on patient morbidity
    • Nijskens, C. M., et al. Hepatitis E virus genotype 3 infection in a tertiary referral center in the Netherlands: Clinical relevance and impact on patient morbidity. Journal of clinical virology: The official publication of the Pan American Society for Clinical Virology 74, 82-87, doi: 10.1016/j.jcv.2015.11.038 (2016).
    • (2016) Journal of Clinical Virology: The Official Publication of the Pan American Society for Clinical Virology , vol.74 , pp. 82-87
    • Nijskens, C.M.1
  • 9
    • 84896480771 scopus 로고    scopus 로고
    • Ribavirin for chronic hepatitis E virus infection in transplant recipients
    • Kamar, N., et al. Ribavirin for chronic hepatitis E virus infection in transplant recipients. The New England journal of medicine 370, 1111-1120, doi: 10.1056/NEJMoa1215246 (2014).
    • (2014) The New England Journal of Medicine , vol.370 , pp. 1111-1120
    • Kamar, N.1
  • 10
    • 84945460286 scopus 로고    scopus 로고
    • Antiviral therapy in chronic hepatitis E: A systematic review
    • Peters van Ton, A. M., Gevers, T. J., Drenth, J. P. Antiviral therapy in chronic hepatitis E: A systematic review. Journal of viral hepatitis 22, 965-973, doi: 10.1111/jvh.12403 (2015).
    • (2015) Journal of Viral Hepatitis , vol.22 , pp. 965-973
    • Peters Van Ton, A.M.1    Gevers, T.J.2    Drenth, J.P.3
  • 11
    • 77955287303 scopus 로고    scopus 로고
    • Chronic hepatitis E virus infection: Successful virologic response to pegylated interferon-alpha therapy
    • Alric, L., Bonnet, D., Laurent, G., Kamar, N., Izopet, J. Chronic hepatitis E virus infection: Successful virologic response to pegylated interferon-alpha therapy. Annals of internal medicine 153, 135-136, doi: 10.7326/0003-4819-153-2-201007200-00256 (2010).
    • (2010) Annals of Internal Medicine , vol.153 , pp. 135-136
    • Alric, L.1    Bonnet, D.2    Laurent, G.3    Kamar, N.4    Izopet, J.5
  • 12
    • 84872679631 scopus 로고    scopus 로고
    • Replication of hepatitis E virus in three-dimensional cell culture
    • Berto, A., et al. Replication of hepatitis E virus in three-dimensional cell culture. Journal of virological methods 187, 327-332, doi: 10.1016/j.jviromet.2012.10.017 (2013).
    • (2013) Journal of Virological Methods , vol.187 , pp. 327-332
    • Berto, A.1
  • 13
    • 84891709777 scopus 로고    scopus 로고
    • Hepatitis E virus genotype 1 infection of swine kidney cells in vitro is inhibited at multiple levels
    • Nguyen, H. T., Shukla, P., Torian, U., Faulk, K., Emerson, S. U. Hepatitis E virus genotype 1 infection of swine kidney cells in vitro is inhibited at multiple levels. Journal of virology 88, 868-877, doi: 10.1128/JVI.02205-13 (2014).
    • (2014) Journal of Virology , vol.88 , pp. 868-877
    • Nguyen, H.T.1    Shukla, P.2    Torian, U.3    Faulk, K.4    Emerson, S.U.5
  • 14
    • 84857082426 scopus 로고    scopus 로고
    • A naturally occurring human/hepatitis E recombinant virus predominates in serum but not in faeces of a chronic hepatitis E patient and has a growth advantage in cell culture
    • Nguyen, H. T., et al. A naturally occurring human/hepatitis E recombinant virus predominates in serum but not in faeces of a chronic hepatitis E patient and has a growth advantage in cell culture. The Journal of general virology 93, 526-530, doi: 10.1099/vir.0.037259-0 (2012).
    • (2012) The Journal of General Virology , vol.93 , pp. 526-530
    • Nguyen, H.T.1
  • 15
    • 84964961858 scopus 로고    scopus 로고
    • Hepatitis E Virus (HEV) Genotype 3 Infection of Human Liver Chimeric Mice as a Model for Chronic HEV Infection
    • van de Garde, M. D., et al. Hepatitis E Virus (HEV) Genotype 3 Infection of Human Liver Chimeric Mice as a Model for Chronic HEV Infection. Journal of virology 90, 4394-4401, doi: 10.1128/JVI.00114-16 (2016).
    • (2016) Journal of Virology , vol.90 , pp. 4394-4401
    • Vande Garde, M.D.1
  • 16
    • 33847636172 scopus 로고    scopus 로고
    • Development and evaluation of an efficient cell-culture system for Hepatitis E virus
    • Tanaka, T., Takahashi, M., Kusano, E., Okamoto, H. Development and evaluation of an efficient cell-culture system for Hepatitis E virus. The Journal of general virology 88, 903-911, doi: 10.1099/vir.0.82535-0 (2007).
    • (2007) The Journal of General Virology , vol.88 , pp. 903-911
    • Tanaka, T.1    Takahashi, M.2    Kusano, E.3    Okamoto, H.4
  • 17
    • 84964863009 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress induced synthesis of a novel viral factor mediates efficient replication of Genotype-1 Hepatitis E Virus
    • Nair, V. P., et al. Endoplasmic Reticulum Stress Induced Synthesis of a Novel Viral Factor Mediates Efficient Replication of Genotype-1 Hepatitis E Virus. PLoS pathogens 12, e1005521, doi: 10.1371/journal.ppat.1005521 (2016).
    • (2016) PLoS Pathogens , vol.12 , pp. e1005521
    • Nair, V.P.1
  • 18
    • 84971349981 scopus 로고    scopus 로고
    • Innate immune responses in human hepatocyte-derived cell lines alter genotype 1 hepatitis E virus replication efficiencies
    • Devhare, P. B., Desai, S., Lole, K. S. Innate immune responses in human hepatocyte-derived cell lines alter genotype 1 hepatitis E virus replication efficiencies. Scientific reports 6, 26827, doi: 10.1038/srep26827 (2016).
    • (2016) Scientific Reports , vol.6 , pp. 26827
    • Devhare, P.B.1    Desai, S.2    Lole, K.S.3
  • 19
    • 84961771504 scopus 로고    scopus 로고
    • Antiviral activities of different interferon types and subtypes against hepatitis E virus replication
    • Todt, D., et al. Antiviral Activities of Different Interferon Types and Subtypes against Hepatitis E Virus Replication. Antimicrobial agents and chemotherapy 60, 2132-2139, doi: 10.1128/AAC.02427-15 (2016).
    • (2016) Antimicrobial Agents and Chemotherapy , vol.60 , pp. 2132-2139
    • Todt, D.1
  • 20
    • 84960127573 scopus 로고    scopus 로고
    • Disparity of basal and therapeutically activated interferon signalling in constraining hepatitis E virus infection
    • Zhou, X., et al. Disparity of basal and therapeutically activated interferon signalling in constraining hepatitis E virus infection. Journal of viral hepatitis 23, 294-304, doi: 10.1111/jvh.12491 (2016).
    • (2016) Journal of Viral Hepatitis , vol.23 , pp. 294-304
    • Zhou, X.1
  • 21
    • 84859983685 scopus 로고    scopus 로고
    • Suppression of interferon-alpha signaling by hepatitis E virus
    • Dong, C., et al. Suppression of interferon-alpha signaling by hepatitis E virus. Hepatology 55, 1324-1332, doi: 10.1002/hep.25530 (2012).
    • (2012) Hepatology , vol.55 , pp. 1324-1332
    • Dong, C.1
  • 22
    • 0033604281 scopus 로고    scopus 로고
    • Impaired antiviral response in human hepatoma cells
    • Keskinen, P., et al. Impaired antiviral response in human hepatoma cells. Virology 263, 364-375, doi: 10.1006/viro.1999.9983 (1999).
    • (1999) Virology , vol.263 , pp. 364-375
    • Keskinen, P.1
  • 23
    • 84977632229 scopus 로고    scopus 로고
    • Hepatitis E virus mutations associated with ribavirin treatment failure result in altered viral fitness and ribavirin sensitivity
    • Debing, Y., et al. Hepatitis E virus mutations associated with ribavirin treatment failure result in altered viral fitness and ribavirin sensitivity. Journal of hepatology 65, 499-508, doi: 10.1016/j.jhep.2016.05.002 (2016).
    • (2016) Journal of Hepatology , vol.65 , pp. 499-508
    • Debing, Y.1
  • 24
    • 85005769258 scopus 로고    scopus 로고
    • Sofosbuvir shows antiviral activity in a patient with chronic hepatitis E virus infection
    • van der Valk, M., Zaaijer, H. L., Kater, A. P., Schinkel, J. Sofosbuvir shows antiviral activity in a patient with chronic hepatitis E virus infection. Journal of hepatology. doi: 10.1016/j.jhep.2016.09.014 (2016).
    • (2016) Journal of Hepatology.
    • Vander Valk, M.1    Zaaijer, H.L.2    Kater, A.P.3    Schinkel, J.4
  • 25
    • 85006277752 scopus 로고    scopus 로고
    • Sofosbuvir and daclatasvir Anti-Viral therapy fails to clear HEV viremia and restore reactive T Cells in a HEV/HCV Co-Infected liver transplant recipient
    • Donnelly, M. C., et al. Sofosbuvir and Daclatasvir Anti-Viral Therapy Fails to Clear HEV Viremia and Restore Reactive T Cells in a HEV/HCV Co-Infected Liver Transplant Recipient. Gastroenterology. doi: 10.1053/j.gastro.2016.05.060 (2016).
    • (2016) Gastroenterology
    • Donnelly, M.C.1
  • 26
    • 84997112245 scopus 로고    scopus 로고
    • Distinct antiviral potency of sofosbuvir against hepatitis C and E Viruses
    • Wang, W., et al. Distinct Antiviral Potency of Sofosbuvir Against Hepatitis C and E Viruses. Gastroenterology 151, 1251-1253, doi: 10.1053/j.gastro.2016.09.061 (2016).
    • (2016) Gastroenterology , vol.151 , pp. 1251-1253
    • Wang, W.1
  • 27
    • 84952719793 scopus 로고    scopus 로고
    • Sofosbuvir inhibits hepatitis e virus replication in vitro and results in an additive effect when combined with ribavirin
    • Dao Thi, V. L., et al. Sofosbuvir Inhibits Hepatitis E Virus Replication In Vitro and Results in an Additive Effect When Combined With Ribavirin. Gastroenterology 150, 82-85 e84, doi: 10.1053/j.gastro.2015.09.011 (2016).
    • (2016) Gastroenterology , vol.150 , Issue.82-85 , pp. e84
    • Dao Thi, V.L.1
  • 28
    • 84962835809 scopus 로고    scopus 로고
    • Study of hepatitis E virus infection of genotype 1 and 3 in mice with humanised liver
    • Sayed, I. M., et al. Study of hepatitis E virus infection of genotype 1 and 3 in mice with humanised liver. Gut. doi: 10.1136/gutjnl-2015-311109 (2016).
    • (2016) Gut
    • Sayed, I.M.1
  • 29
    • 84962938618 scopus 로고    scopus 로고
    • Human liver chimeric mice as a new model of chronic hepatitis E virus infection and preclinical drug evaluation
    • Allweiss, L., et al. Human liver chimeric mice as a new model of chronic hepatitis E virus infection and preclinical drug evaluation. Journal of hepatology 64, 1033-1040, doi: 10.1016/j.jhep.2016.01.011 (2016).
    • (2016) Journal of Hepatology , vol.64 , pp. 1033-1040
    • Allweiss, L.1
  • 30
    • 19044361835 scopus 로고    scopus 로고
    • Hepatic gene expression discriminates responders and nonresponders in treatment of chronic hepatitis C viral infection
    • Chen, L., et al. Hepatic gene expression discriminates responders and nonresponders in treatment of chronic hepatitis C viral infection. Gastroenterology 128, 1437-1444 (2005).
    • (2005) Gastroenterology , vol.128 , pp. 1437-1444
    • Chen, L.1
  • 31
    • 84862777615 scopus 로고    scopus 로고
    • Hepatic cell-type specific gene expression better predicts HCV treatment outcome than IL28B genotype
    • McGilvray, I., et al. Hepatic cell-type specific gene expression better predicts HCV treatment outcome than IL28B genotype. Gastroenterology 142, 1122-1131 e1121, doi: 10.1053/j.gastro.2012.01.028 (2012).
    • (2012) Gastroenterology , vol.142 , pp. 1122-1131e1121
    • McGilvray, I.1
  • 32
    • 36348960622 scopus 로고    scopus 로고
    • Hepatic gene expression during treatment with peginterferon and ribavirin: Identifying molecular pathways for treatment response
    • Feld, J. J., et al. Hepatic gene expression during treatment with peginterferon and ribavirin: Identifying molecular pathways for treatment response. Hepatology 46, 1548-1563, doi: 10.1002/hep.21853 (2007).
    • (2007) Hepatology , vol.46 , pp. 1548-1563
    • Feld, J.J.1
  • 33
    • 84894064916 scopus 로고    scopus 로고
    • Immune cell responses are not required to induce substantial hepatitis B virus antigen decline during pegylated interferon-alpha administration
    • Allweiss, L., et al. Immune cell responses are not required to induce substantial hepatitis B virus antigen decline during pegylated interferon-alpha administration. Journal of hepatology 60, 500-507, doi: 10.1016/j.jhep.2013.10.021 (2014).
    • (2014) Journal of Hepatology , vol.60 , pp. 500-507
    • Allweiss, L.1
  • 34
    • 33745543683 scopus 로고    scopus 로고
    • Anti-HCV therapies in chimeric scid-Alb/uPA mice parallel outcomes in human clinical application
    • Kneteman, N. M., et al. Anti-HCV therapies in chimeric scid-Alb/uPA mice parallel outcomes in human clinical application. Hepatology 43, 1346-1353, doi: 10.1002/hep.21209 (2006).
    • (2006) Hepatology , vol.43 , pp. 1346-1353
    • Kneteman, N.M.1
  • 35
    • 84881544361 scopus 로고    scopus 로고
    • Hepatitis C virus kinetics by administration of pegylated interferon-alpha in human and chimeric mice carrying human hepatocytes with variants of the IL28B gene
    • Watanabe, T., et al. Hepatitis C virus kinetics by administration of pegylated interferon-alpha in human and chimeric mice carrying human hepatocytes with variants of the IL28B gene. Gut 62, 1340-1346, doi: 10.1136/gutjnl-2012-302553 (2013).
    • (2013) Gut , vol.62 , pp. 1340-1346
    • Watanabe, T.1
  • 36
    • 84943533132 scopus 로고    scopus 로고
    • Intrahepatic transcriptional signature associated with response to Interferon-alpha treatment in the woodchuck model of chronic hepatitis B
    • Fletcher, S. P., et al. Intrahepatic Transcriptional Signature Associated with Response to Interferon-alpha Treatment in the Woodchuck Model of Chronic Hepatitis B. PLoS pathogens 11, e1005103, doi: 10.1371/journal.ppat.1005103 (2015).
    • (2015) PLoS Pathogens , vol.11 , pp. e1005103
    • Fletcher, S.P.1
  • 38
    • 84907445220 scopus 로고    scopus 로고
    • Hepatitis E virus inhibits type I interferon induction by ORF1 products
    • Nan, Y., et al. Hepatitis E virus inhibits type I interferon induction by ORF1 products. Journal of virology 88, 11924-11932, doi: 10.1128/JVI.01935-14 (2014).
    • (2014) Journal of Virology , vol.88 , pp. 11924-11932
    • Nan, Y.1
  • 39
    • 84871789410 scopus 로고    scopus 로고
    • Morphological and microarray analyses of human hepatocytes from xenogeneic host livers
    • Tateno, C., et al. Morphological and microarray analyses of human hepatocytes from xenogeneic host livers. Laboratory investigation; a journal of technical methods and pathology 93, 54-71, doi: 10.1038/labinvest.2012.158 (2013).
    • (2013) Laboratory Investigation; a Journal of Technical Methods and Pathology , vol.93 , pp. 54-71
    • Tateno, C.1
  • 40
    • 0031704911 scopus 로고    scopus 로고
    • Murine IL-2 receptor beta chain blockade improves human leukocyte engraftment in SCID mice
    • Tournoy, K. G., Depraetere, S., Meuleman, P., Leroux-Roels, G., Pauwels, R. A. Murine IL-2 receptor beta chain blockade improves human leukocyte engraftment in SCID mice. European journal of immunology 28, 3221-3230, doi:10.1002/(SICI)1521-4141(199810)28:10&60;3221::AID-IMMU3221&62;3.0.CO;2-S (1998).
    • (1998) European Journal of Immunology , vol.28 , pp. 3221-3230
    • Tournoy, K.G.1    Depraetere, S.2    Meuleman, P.3    Leroux-Roels, G.4    Pauwels, R.A.5
  • 41
    • 77957943114 scopus 로고    scopus 로고
    • Pathogenesis of hepatitis E virus and hepatitis C virus in chimpanzees: Similarities and differences
    • Yu, C., et al. Pathogenesis of hepatitis E virus and hepatitis C virus in chimpanzees: Similarities and differences. Journal of virology 84, 11264-11278, doi: 10.1128/JVI.01205-10 (2010).
    • (2010) Journal of Virology , vol.84 , pp. 11264-11278
    • Yu, C.1
  • 42
    • 77956188831 scopus 로고    scopus 로고
    • BST-2/tetherin: A new component of the innate immune response to enveloped viruses
    • Evans, D. T., Serra-Moreno, R., Singh, R. K., Guatelli, J. C. BST-2/tetherin: A new component of the innate immune response to enveloped viruses. Trends in microbiology 18, 388-396, doi: 10.1016/j.tim.2010.06.010 (2010).
    • (2010) Trends in Microbiology , vol.18 , pp. 388-396
    • Evans, D.T.1    Serra-Moreno, R.2    Singh, R.K.3    Guatelli, J.C.4
  • 43
    • 84857391377 scopus 로고    scopus 로고
    • Hepatitis E virus (HEV)-specific T-cell responses are associated with control of HEV infection
    • Suneetha, P. V., et al. Hepatitis E virus (HEV)-specific T-cell responses are associated with control of HEV infection. Hepatology 55, 695-708, doi: 10.1002/hep.24738 (2012).
    • (2012) Hepatology , vol.55 , pp. 695-708
    • Suneetha, P.V.1
  • 44
    • 84995666082 scopus 로고    scopus 로고
    • Characterization of the specificity functionality and durability of host T-Cell responses against the Full-Length Hepatitis E Virus
    • Brown, A., et al. Characterization of the Specificity, Functionality, and Durability of Host T-Cell Responses Against the Full-Length Hepatitis E Virus. Hepatology 64, 1934-1950, doi: 10.1002/hep.28819 (2016).
    • (2016) Hepatology , vol.64 , pp. 1934-1950
    • Brown, A.1
  • 45
    • 84954358569 scopus 로고    scopus 로고
    • Establishment of a humanized model of liver using NOD/Shi-scid IL2Rgnull mice
    • Suemizu, H., et al. Establishment of a humanized model of liver using NOD/Shi-scid IL2Rgnull mice. Biochemical and biophysical research communications 377, 248-252, doi: 10.1016/j.bbrc.2008.09.124 (2008).
    • (2008) Biochemical and Biophysical Research Communications , vol.377 , pp. 248-252
    • Suemizu, H.1
  • 46
    • 77955853940 scopus 로고    scopus 로고
    • Factors determining successful engraftment of hepatocytes and susceptibility to hepatitis B and C virus infection in uPA-SCID mice
    • Vanwolleghem, T., et al. Factors determining successful engraftment of hepatocytes and susceptibility to hepatitis B and C virus infection in uPA-SCID mice. Journal of hepatology 53, 468-476, doi: 10.1016/j.jhep.2010.03.024 (2010).
    • (2010) Journal of Hepatology , vol.53 , pp. 468-476
    • Vanwolleghem, T.1
  • 48
    • 0033890782 scopus 로고    scopus 로고
    • Development of a quantitative real-time detection assay for hepatitis B virus DNA and comparison with two commercial assays
    • Pas, S. D., Fries, E., De Man, R. A., Osterhaus, A. D., Niesters, H. G. Development of a quantitative real-time detection assay for hepatitis B virus DNA and comparison with two commercial assays. J Clin Microbiol 38, 2897-2901 (2000).
    • (2000) J Clin Microbiol , vol.38 , pp. 2897-2901
    • Pas, S.D.1    Fries, E.2    De Man, R.A.3    Osterhaus, A.D.4    Niesters, H.G.5
  • 50
    • 84928563808 scopus 로고    scopus 로고
    • Inflammatory monocytes recruited to the liver within 24 hours after virus-induced inflammation resemble Kupffer cells but are functionally distinct
    • Movita, D., et al. Inflammatory monocytes recruited to the liver within 24 hours after virus-induced inflammation resemble Kupffer cells but are functionally distinct. Journal of virology 89, 4809-4817, doi: 10.1128/JVI.03733-14 (2015).
    • (2015) Journal of Virology , vol.89 , pp. 4809-4817
    • Movita, D.1
  • 51
    • 84994246871 scopus 로고    scopus 로고
    • Liver monocytes and kupffer cells remain transcriptionally distinct during chronic viral infection
    • Vande Garde, M. D., et al. Liver Monocytes and Kupffer Cells Remain Transcriptionally Distinct during Chronic Viral Infection. PloS one 11, e0166094, doi: 10.1371/journal.pone.0166094 (2016).
    • (2016) PloS One , vol.11 , pp. e0166094
    • Vande Garde, M.D.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.