Innate immune responses in human hepatocyte-derived cell lines alter genotype 1 hepatitis e virus replication efficiencies

Scientific Reports

Volumn 6, Issue , 2016, Pages

  Devhare, Pradip B ^a   Desai, Swapnil ^a   Lole, Kavita S ^a  

^a NATIONAL INSTITUTE OF VIROLOGY   (India)

Author keywords

[No Author keywords available]

Indexed keywords

DDX58 PROTEIN, HUMAN; INTERFERON REGULATORY FACTOR; PATTERN RECOGNITION RECEPTOR; RETINOIC ACID INDUCIBLE PROTEIN I; TLR3 PROTEIN, HUMAN; TOLL LIKE RECEPTOR 3; TRANSCRIPTOME;

GENE EXPRESSION; HEPATITIS E VIRUS; HUMAN; IMMUNOLOGY; INNATE IMMUNITY; LIVER CELL; LIVER CELL CARCINOMA; LIVER TUMOR; METABOLISM; SIGNAL TRANSDUCTION; TUMOR CELL LINE; VIROLOGY; VIRUS REPLICATION;

CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; DEAD BOX PROTEIN 58; GENE EXPRESSION; HEPATITIS E VIRUS; HEPATOCYTES; HUMANS; IMMUNITY, INNATE; INTERFERON REGULATORY FACTORS; LIVER NEOPLASMS; RECEPTORS, PATTERN RECOGNITION; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 3; TRANSCRIPTOME; VIRUS REPLICATION;

EID: 84971349981     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep26827     Document Type: Article

References (33)

1. Smith, D. B. et al. Consensus proposals for classification of the family Hepeviridae. J Gen Virol 95, 2223-2232 (2014).
2. Ahmad, I., Holla, R. P., Jameel, S. Molecular virology of hepatitis E virus. Virus Res 161, 47-58 (2011).
3. Holla, R. P., Ahmad, I., Ahmad, Z., Jameel, S. Molecular virology of hepatitis E virus. Semin Liver Dis 33, 3-14 (2013).
4. Koonin, E. V. et al. Computer-assisted assignment of functional domains in the nonstructural polyprotein of hepatitis E virus: delineation of an additional group of positive-strand RNA plant and animal viruses. ProcNatlAcadSci USA 89, 8259-8263 (1992).
5. Perttila, J., Spuul, P., Ahola, T. Early secretory pathway localization and lack of processing for hepatitis E virus replication protein pORF1. J Gen Virol 94, 807-816 (2013).
6. Graff, J., Torian, U., Nguyen, H., Emerson, S. U. A bicistronicsubgenomic mRNA encodes both the ORF2 and ORF3 proteins of hepatitis E virus. J Virol 80, 5919-5926 (2006).
7. Shalimar, & Acharya, S. K. Hepatitis E and Acute Liver Failure in Pregnancy. J ClinExpHepatol 3(3), 213-224 (2013).
8. Kamar, N., Dalton, H. R., Abravanel, F., Izopet, J. Hepatitis E virus infection. Clinical microbiology reviews 27, 116-138 (2014).
9. Akira, S., Uematsu, S., Takeuchi, O. Pathogen recognition and Innate Immunity. Cell 124, 783-801 (2006).
10. Randall, R. E., Goodbourn, S. Interferons and viruses: an interplay between induction, signalling, antiviral responses and virus countermeasures. J Gen Virol 89, 1-47 (2008).
11. Thompson, M. R., Kaminski, J. J., Kurt-Jones, E. A., Fitzgerald, K. A. Pattern recognition receptors and the innate immune response to viral infection. Viruses 3, 920-940 (2011).
12. Jensen, S., Thomsen, A. R. Sensing of RNA viruses: a review of innate immune receptors involved in recognizing RNA virus invasion. J Virol 86, 2900-2910 (2012).
13. Devhare, P. B., Chatterjee, S. N., Arankalle, V. A., Lole, K. S. Analysis of antiviral response in human epithelial cells infected with hepatitis E virus. PLoS ONE 8(5), e63793 (2013).
14. Dong, C. et al. Suppression of interferon-? signaling by hepatitis E virus. HEPATOLOGY 55, 1324-1332 (2012).
15. Nan, Y. et al. Hepatitis E virus inhibits type I interferon induction by ORF1 products. J Virol 88, 11924-11932 (2014).
16. Panda, S. K., Ansari, I. H., Durgapal, H., Agrawal, S., Jameel, S. The in vitro synthesized RNA from a cDNA clone of hepatitis E virus is infectious. J Virol 74, 2430-2437 (2000).
17. Emerson, S. U. et al. In vitro replication of hepatitis E virus (HEV) genomes and of an HEV replicon expressing green fluorescent protein. J Virol 78, 4838-4846 (2004).
18. Graff, J. et al. In vitro and in vivo mutational analysis of the 3?-terminal regions of hepatitis E virus genomes and replicons. J virol 79, 1017-1026 (2005).
19. Cao, D., Huang, Y. W., Meng, X. J. The nucleotides on the stem-loop RNA structure in the junction region of the hepatitis E virus genome are critical for virus replication. J Virol 84, 13040-13044 (2010).
20. Devhare, P., Sharma, K., Mhaindarkar, V., Arankalle, V., Lole, K. Analysis of helicase domain mutations in the hepatitis E virus derived from patients with fulminant hepatic failure: Effects on enzymatic activities and virus replication. Virus Res 184, 103-110 (2014).
21. Honda, K., Taniguchi, T. IRFs: master regulators of signalling by Toll-like receptors and cytosolic pattern-recognition receptors. Nat Rev Immunol. 6(9), 644-658 (2006).
22. Li, K., Chen, Z., Kato, N., Gale, M. Jr., Lemon, S. M. Distinct Poly(I-C) and virus-activated signaling pathways leading to interferon production in Hepatocytes. J BiolChem 280, 16739-16747 (2005).
23. Sumpter, Jr. R. et al. Regulating intracellular antiviral defense and permissiveness to hepatitis C virus RNA replication through a cellular RNA helicase, RIG-I. J Virol 79, 2689-2699 (2005).
24. Clark, K., Plater, L., Peggie, M., Cohen, P. Use of the pharmacological inhibitor BX795 to study the regulation and physiological roles of TBK1 and IkappaB kinase epsilon: a distinct upstream kinase mediates Ser-172 phosphorylation and activation. J BiolChem 284, 14136-14146 (2009).
25. Okamoto, H. Culture systems for hepatitis E virus. Journal of Gastroenterol, 48(2), 147-158 (2013).
26. Lohmann, V. et al. Replication of subgenomic hepatitis C virus RNAs in a hepatoma cell line. Science 285, 110-113 (1999).
27. Yi, M., Lemon, S. M. Replication of subgenomic hepatitis A virus RNAs expressing firefly luciferase is enhanced by mutations associated with adaptation of virus to growth in cultured cells. J Virol 76, 1171-1180 (2002).
28. Rehman, S., Kapur, N., Durgapal, H., Panda, S. K. Subcellular localization of hepatitis E virus (HEV) replicase. Virology 370, 77-92 (2008).
29. Hiscott, J. Triggering the innate antiviral response through IRF-3 activation. J BiolChem 282, 15325-15329 (2007).
30. Sutlu, T. et al. Inhibition of intracellular antiviral defense mechanisms augments lentiviral transduction of human natural killer cells: implications for gene therapy. Human gene therapy. 23, 1090-1100 (2012).
31. Emerson, S. U. et al. Release of genotype 1 hepatitis E virus from cultured hepatoma and polarized intestinal cells depends on open reading frame 3 protein and requires an intact PXXP motif. J Virol 84, 9059-9069 (2010).
32. Tanaka, T., Takahashi, M., Kusano, E., Okamoto, H. Development and evaluation of an efficient cell-culture system for Hepatitis E virus. J Gen Virol 88, 903-911 (2007).
33. Takahashi, M. et al. Hepatitis E virus (HEV) strains in serum samples can replicate efficiently in cultured cells despite the coexistence of HEV antibodies: characterization of HEV virions in blood circulation. J ClinMicrobiol 48, 1112-1125 (2010).