Red blood cell transfusions are associated with lower mortality in patients with severe sepsis and septic shock: A propensity-matched analysis

Critical Care Medicine

Volumn 40, Issue 12, 2012, Pages 3140-3145

  Park, Dae Won ^a   Chun, Byung Chul ^b   Kwon, Soon Sun ^b   Yoon, Young Kyung ^c   Choi, Won Suk ^a   Sohn, Jang Wook ^c   Peck, Kyong Ran ^d   Kim, Yang Soo ^e   Choi, Young Hwa ^f   Choi, Jun Yong ^m   Kim, Sang Il ^h   Eom, Joong Sik ⁱ   Kim, Hyo Youl ^j   Cheong, Hee Jin ^g   Song, Young Goo ^g   Choi, Hee Jung ^k,l   Kim, June Myung ^g   Kim, Min Ja ^c  

^a Korea University College of Medicine   (South Korea)

^b Korea University College of Medicine   (South Korea)

^c Korea University College of Medicine   (South Korea)

^d Sungkyunkwan University School of Medicine   (South Korea)

^e University of Ulsan College of Medicine   (South Korea)

^f Ajou University School of Medicine   (South Korea)

^g Yonsei University College of Medicine   (South Korea)

^h The Catholic University of Korea   (South Korea)

ⁱ Hallym University Medical Center   (South Korea)

^j Yonsei University Wonju College of Medicine   (South Korea)

^k Korea University College of Medicine   (South Korea)

^l Ewha Womans University School of Medicine   (South Korea)

^m NONE

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Author keywords

blood transfusion; mortality; septic shock; severe sepsis

Indexed keywords

DOBUTAMINE; HEMOGLOBIN;

ABDOMINAL INFECTION; ACUTE PHYSIOLOGY AND CHRONIC HEALTH EVALUATION II SCORE; ADULT; AGED; ARTICLE; ASSISTED VENTILATION; BACTEREMIA; BONE INFECTION; CARDIOVASCULAR DISEASE; CARDIOVASCULAR INFECTION; CONTROLLED STUDY; CRITICALLY ILL PATIENT; DISEASE SEVERITY; ERYTHROCYTE TRANSFUSION; FEMALE; GASTROINTESTINAL DISEASE; HEAD AND NECK INFECTION; HEMATOLOGIC DISEASE; HEMOGLOBIN BLOOD LEVEL; HOSPITAL ADMISSION; HUMAN; INFECTIOUS ARTHRITIS; INTENSIVE CARE UNIT; KIDNEY DISEASE; LENGTH OF STAY; LIVER DISEASE; MAJOR CLINICAL STUDY; MALE; MORTALITY; OBSERVATIONAL STUDY; PRIORITY JOURNAL; PROPENSITY SCORE; PROSPECTIVE STUDY; RENAL REPLACEMENT THERAPY; RESPIRATORY TRACT DISEASE; RESPIRATORY TRACT INFECTION; RISK ASSESSMENT; SCORING SYSTEM; SEPSIS; SEPTIC SHOCK; SEQUENTIAL ORGAN FAILURE ASSESSMENT SCORE; SKIN INFECTION; SOFT TISSUE INFECTION; SYSTOLIC BLOOD PRESSURE; URINARY TRACT INFECTION;

AGED; COMMUNITY-ACQUIRED INFECTIONS; CONFIDENCE INTERVALS; ERYTHROCYTE TRANSFUSION; FEMALE; HOSPITALS, TEACHING; HUMANS; INTENSIVE CARE UNITS; MALE; MIDDLE AGED; ODDS RATIO; PROPENSITY SCORE; PROSPECTIVE STUDIES; REPUBLIC OF KOREA; RISK ASSESSMENT; SHOCK, SEPTIC;

EID: 84870244789     PISSN: 00903493     EISSN: 15300293     Source Type: Journal    
DOI: 10.1097/CCM.0b013e3182657b75     Document Type: Article

References (25)

1. von Ahsen N, Müller C, Serke S, et al: Important role of nondiagnostic blood loss and blunted erythropoietic response in the anemia of medical intensive care patients. Crit Care Med 1999; 27:2630-2639
2. Nelson AH, Fleisher LA, Rosenbaum SH: Relationship between postoperative anemia and cardiac morbidity in high-risk vascular patients in the intensive care unit. Crit Care Med 1993; 21:860-866
3. Hébert PC, Wells G, Tweeddale M, et al: Does transfusion practice affect mortality in critically ill patients? Transfusion Requirements in Critical Care (TRICC) Investigators and the Canadian Critical Care Trials Group. Am J Respir Crit Care Med 1997; 155:1618-1623
4. Hébert PC, Wells G, Blajchman MA, et al: A multicenter, randomized, controlled clinical trial of transfusion requirements in critical care. Transfusion Requirements in Critical Care Investigators, Canadian Critical Care Trials Group. N Engl J Med 1999; 340:409-417
5. Vincent JL, Baron JF, Reinhart K, et al; ABC (Anemia and Blood Transfusion in Critical Care) Investigators: Anemia and blood transfusion in critically ill patients. JAMA 2002; 288:1499-1507
6. Corwin HL, Gettinger A, Pearl RG, et al: The CRIT Study: Anemia and blood transfusion in the critically ill-current clinical practice in the United States. Crit Care Med 2004; 32:39-52
7. Rogiers P, Zhang H, Leeman M, et al: Erythropoietin response is blunted in critically ill patients. Intensive Care Med 1997; 23:159-162
8. Zimmerman JL: Use of blood products in sepsis: An evidence-based review. Crit Care Med 2004; 32(Suppl 11):S542-S547
9. Rivers E, Nguyen B, Havstad S, et al; Early Goal-Directed Therapy Collaborative Group: Early goal-directed therapy in the treatment of severe sepsis and septic shock. N Engl J Med 2001; 345:1368-1377
10. Garner JS, Jarvis WR, Emori TG, et al: CDC definitions for nosocomial infections, 1988. Am J Infect Control 1988; 16:128-140
11. American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference: Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. Crit Care Med 1992; 20:864-874
12. Munford RS: Severe sepsis and septic shock. In: Harrison's Principles of Internal Medicine. Sixteenth Edition. Kasper DL, Braunwald E, Fauci AS, et al (Eds). New York, McGraw-Hill, 2005, pp 1606-1612
13. Friedman ND, Kaye KS, Stout JE, et al: Health care-associated bloodstream infections in adults: A reason to change the accepted definition of community-acquired infections. Ann Intern Med 2002; 137:791-797
14. Deyo RA, Cherkin DC, Ciol MA: Adapting a clinical comorbidity index for use with ICD-9-CM administrative databases. J Clin Epidemiol 1992; 45:613-619
15. Knaus WA, Draper EA, Wagner DP, et al: APACHE II: A severity of disease classification system. Crit Care Med 1985; 13:818-829
16. Ferreira FL, Bota DP, Bross A, et al: Serial evaluation of the SOFA score to predict outcome in critically ill patients. JAMA 2001; 286:1754-1758
17. Hébert PC, Yetisir E, Martin C, et al; Transfusion Requirements in Critical Care Investigators for the Canadian Critical Care Trials Group: Is a low transfusion threshold safe in critically ill patients with cardiovascular diseases? Crit Care Med 2001; 29:227-234
18. Hébert PC, Blajchman MA, Cook DJ, et al; Transfusion Requirements in Critical Care Investigators for the Canadian Critical Care Trials Group: Do blood transfusions improve outcomes related to mechanical ventilation? Chest 2001; 119:1850-1857
19. Vincent JL, Sakr Y, Sprung C, et al; Sepsis Occurrence in Acutely Ill Patients (SOAP) Investigators: Are blood transfusions associated with greater mortality rates? Results of the Sepsis Occurrence in Acutely Ill Patients study. Anesthesiology 2008; 108:31-39
20. Sakr Y, Lobo S, Knuepfer S, et al: Anemia and blood transfusion in a surgical intensive care unit. Crit Care 2010; 14:R92
21. Vincent JL, Sakr Y, Sprung CL, et al; Sepsis Occurrence in Acutely Ill Patients Investigators: Sepsis in European intensive care units: Results of the SOAP study. Crit Care Med 2006; 34:344-353
22. Hollenberg SM, Ahrens TS, Annane D, et al: Practice parameters for hemodynamic support of sepsis in adult patients: 2004 update. Crit Care Med 2004; 32:1928-1948
23. Dellinger RP, Levy MM, Carlet JM, et al; International Surviving Sepsis Campaign Guidelines Committee; American Association of Critical-Care Nurses; American College of Chest Physicians; American College of Emergency Physicians; Canadian Critical Care Society; European Society of Clinical Microbiology and Infectious Diseases; European Society of Intensive Care Medicine; European Respiratory Society; International Sepsis Forum; Japanese Association for Acute Medicine; Japanese Society of Intensive Care Medicine; Society of Critical Care Medicine; Society of Hospital Medicine; Surgical Infection Society; World Federation of Societies of Intensive and Critical Care Medicine: Surviving Sepsis Campaign: International guidelines for management of severe sepsis and septic shock: 2008. Crit Care Med 2008; 36:296-327
24. Lelubre C, Piagnerelli M, Vincent JL: Association between duration of storage of transfused red blood cells and morbidity and mortality in adult patients: Myth or reality? Transfusion 2009; 49:1384-1394
25. Napolitano LM, Kurek S, Luchette FA, et al; American College of Critical Care Medicine of the Society of Critical Care Medicine; Eastern Association for the Surgery of Trauma Practice Management Workgroup: Clinical practice guideline: Red blood cell transfusion in adult trauma and critical care. Crit Care Med 2009; 37:3124-3157