Loss of a mammalian circular RNA locus causes miRNA deregulation and affects brain function

Science

Volumn 357, Issue 6357, 2017, Pages

  Piwecka, Monika ^a   Glažar, Petar ^a   Hernandez Miranda, Luis R ^a   Memczak, Sebastian ^a   Wolf, Susanne A ^a   Rybak Wolf, Agnieszka ^a   Filipchyk, Andrei ^a   Klironomos, Filippos ^a   Jara, Cledi Alicia Cerda ^a   Fenske, Pascal ^b   Trimbuch, Thorsten ^b   Zywitza, Vera ^a   Plass, Mireya ^a   Schreyer, Luisa ^a   Ayoub, Salah ^a   Kocks, Christine ^a   Kühn, Ralf ^a,c   Rosenmund, Christian ^b   Birchmeier, Carmen ^a   Rajewsky, Nikolaus ^a  

^a MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

^b CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^c BERLIN INSTITUTE OF HEALTH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CIRCULAR RNA; CIRCULAR RNA CDR1AS; MICRORNA; MICRORNA 671; MICRORNA 7; PROTEIN C FOS; RNA; UNCLASSIFIED DRUG; LONG NON-CODING RNA CDR1AS, HUMAN; LONG UNTRANSLATED RNA; MIRN671 MICRORNA, HUMAN; MIRN671 MICRORNA, MOUSE; MIRN7 MICRORNA, HUMAN; MIRN7 MICRORNA, MOUSE; RNA, CIRCULAR;

BRAIN; GENE EXPRESSION; NEUROLOGY; PHENOTYPE; RNA; RODENT;

ANIMAL TISSUE; ARTICLE; BINDING SITE; BRAIN FUNCTION; CELL VACUOLE; CONTROLLED STUDY; DOWN REGULATION; GENE EXPRESSION; GENE LOCUS; GENETIC REGULATION; IMMEDIATE EARLY GENE; MOUSE; NEURITE; NONHUMAN; PREPULSE INHIBITION; PRIORITY JOURNAL; RNA BINDING; STARTLE REFLEX; SYNAPTIC TRANSMISSION; UPREGULATION; ANIMAL; ANIMAL BEHAVIOR; BRAIN; CRISPR CAS SYSTEM; GENETICS; HUMAN; KNOCKOUT MOUSE; METABOLISM; PHYSIOLOGY; RNA PROCESSING; RNA STABILITY;

ANIMALIA; MAMMALIA;

ANIMALS; BEHAVIOR, ANIMAL; BRAIN; CRISPR-CAS SYSTEMS; GENETIC LOCI; HUMANS; MICE; MICE, KNOCKOUT; MICRORNAS; RNA; RNA PROCESSING, POST-TRANSCRIPTIONAL; RNA STABILITY; RNA, LONG NONCODING; UP-REGULATION;

EID: 85027310408     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.aam8526     Document Type: Article

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