Coagulation factor XI improves host defence during murine Pneumonia-Derived sepsis independent of factor XII activation

Thrombosis and Haemostasis

Volumn 117, Issue 8, 2017, Pages 1601-1614

  Stroo, Ingrid ^a,b   Zeerleder, Sacha ^a,b   Ding, Chao ^a,c   Luken, Brenda M ^b   Roelofs, Joris J T H ^a   De Boer, Onno J ^a   Meijers, Joost C M ^a,b   Castellino, Francis J ^d   Van ’T Veer, Cornelis ^a   Van Der Poll, Tom ^a  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

^b SANQUIN RESEARCH   (Netherlands)

^c MEDICAL SCHOOL OF NANJING UNIVERSITY   (China)

^d UNIVERSITY OF NOTRE DAME   (United States)

Author keywords

Factor XI; Factor XII; Klebsiella pneumoniae; Pneumonia; Streptococcus pneumoniae

Indexed keywords

BLOOD CLOTTING FACTOR 11; BLOOD CLOTTING FACTOR 12; CD15 ANTIGEN; CXCL1 CHEMOKINE; CXCL2 CHEMOKINE; D DIMER; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; FIBRINOGEN; INTERLEUKIN 6; MYELOPEROXIDASE; TUMOR NECROSIS FACTOR; AUTACOID; BLOOD CLOTTING FACTOR 12A; CYTOKINE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BACTERIAL GROWTH; BLOOD CLOTTING; BLOOD SAMPLING; COLONY FORMING UNIT; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; HISTOPATHOLOGY; HOST RESISTANCE; INFLAMMATION; KLEBSIELLA PNEUMONIAE; MALE; MOUSE; NEUTROPHIL; NONHUMAN; PHAGOCYTOSIS; PNEUMONIA; PRIORITY JOURNAL; PROTEIN EXPRESSION; SEPSIS; SEROTYPE; STREPTOCOCCUS PNEUMONIAE; WESTERN BLOTTING; ANIMAL; BACTERIAL PNEUMONIA; BLOOD; C57BL MOUSE; CELL CULTURE; DISEASE MODEL; GENETIC PREDISPOSITION; GENETICS; HOST PATHOGEN INTERACTION; HUMAN; IMMUNOLOGY; KLEBSIELLA INFECTION; KNOCKOUT MOUSE; METABOLISM; MICROBIOLOGY; PATHOGENICITY; PHENOTYPE; PNEUMOCOCCAL INFECTION;

ANIMALS; BLOOD COAGULATION; CELLS, CULTURED; CYTOKINES; DISEASE MODELS, ANIMAL; FACTOR XI; FACTOR XII; FACTOR XIIA; GENETIC PREDISPOSITION TO DISEASE; HOST-PATHOGEN INTERACTIONS; HUMANS; INFLAMMATION MEDIATORS; KLEBSIELLA INFECTIONS; KLEBSIELLA PNEUMONIAE; MICE, INBRED C57BL; MICE, KNOCKOUT; NEUTROPHILS; PHAGOCYTOSIS; PHENOTYPE; PNEUMOCOCCAL INFECTIONS; PNEUMONIA, BACTERIAL; SEPSIS; STREPTOCOCCUS PNEUMONIAE;

EID: 85026845689     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1160/TH16-12-0920     Document Type: Article

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