Impacts of amino acid substitutions in fungal cytochrome P450 monooxygenase (CYP57B3) on the effective production of 3'-hydroxygenistein

FEMS Microbiology Letters

Volumn 364, Issue 11, 2017, Pages

  Hatakeyama, Mayumi ^a   Kitaoka, Takuya ^a   Ichinose, Hirofumi ^a  

^a KYUSHU UNIVERSITY   (Japan)

Author keywords

3' hydroxygenistein; Aspergillus oryzae; Cytochrome P450; Genistein; Orobol; Random mutagenesis

Indexed keywords

3' HYDROXYGENISTEIN; CYTOCHROME P450; CYTOCHROME P450 57B3; GENISTEIN; UNCLASSIFIED DRUG; 3'-HYDROXY-GENISTEIN;

AMINO ACID SUBSTITUTION; BINDING AFFINITY; BIOCONVERSION REACTION; BIOSYNTHESIS; CATALYSIS; CHEMICAL REACTION; CONTROLLED STUDY; ERROR PRONE POLYMERASE CHAIN REACTION; FUNGUS MUTANT; GENETIC SCREENING; HYDROXYLATION; IN VITRO STUDY; KINETICS; LETTER; MOLECULAR LIBRARY; MUTAGENESIS; MUTATIONAL ANALYSIS; NONHUMAN; NUCLEIC ACID BASE SUBSTITUTION; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; RANDOM MUTAGENESIS; SACCHAROMYCES CEREVISIAE; ANALOGS AND DERIVATIVES; ASPERGILLUS ORYZAE; CHEMISTRY; CULTURE MEDIUM; ENZYME SPECIFICITY; ENZYMOLOGY; GENE LIBRARY; GENETICS; METABOLISM; MUTATION;

AMINO ACID SUBSTITUTION; ASPERGILLUS ORYZAE; CULTURE MEDIA; CYTOCHROME P-450 ENZYME SYSTEM; GENE LIBRARY; GENISTEIN; MUTAGENESIS; MUTATION; SACCHAROMYCES CEREVISIAE; SUBSTRATE SPECIFICITY;

EID: 85026822267     PISSN: 03781097     EISSN: 15746968     Source Type: Journal    
DOI: 10.1093/femsle/fnx107     Document Type: Letter

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