Antibody-based assay discriminates Zika virus infection from other flaviviruses

Proceedings of the National Academy of Sciences of the United States of America

Volumn 114, Issue 31, 2017, Pages 8384-8389

  Balmaseda, Angel ^a,b   Stettler, Karin ^c   Medialdea Carrera, Raquel ^d   Collado, Damaris ^b   Jin, Xia ^c   Zambrana, José Victor ^b   Jaconi, Stefano ^c   Cameroni, Elisabetta ^c   Saborio, Saira ^a,b   Rovida, Francesca ^e   Percivalle, Elena ^e   Ijaz, Samreen ^f   Dicks, Steve ^f   Ushiro Lumb, Ines ^g   Barzon, Luisa ^h   Siqueira, Patricia ⁱ   Brown, David W G ⁱ   Baldanti, Fausto ^e,j   Tedder, Richard ^f   Zambon, Maria ^f   Bispo de Filippis, A M ⁱ   Harris, Eva ^k   Corti, Davide ^c   more..

^a Ministry of Health   (Nicaragua)

^b Sustainable Sciences Institute   (Nicaragua)

^c Humabs BioMed SA ^*  (Switzerland)

^d UNIVERSITY OF LIVERPOOL   (United Kingdom)

^e FONDAZIONE IRCCS POLICLINICO SAN MATTEO   (Italy)

^f PUBLIC HEALTH ENGLAND   (United Kingdom)

^g NHS BLOOD AND TRANSPLANT   (United Kingdom)

^h UNIVERSITY OF PADOVA   (Italy)

ⁱ INSTITUTO OSWALDO CRUZ   (Brazil)

^j UNIVERSITY OF PAVIA   (Italy)

^k UNIVERSITY OF CALIFORNIA   (United States)

more..

Author keywords

dengue; ELISA; flaviviruses; serology; Zika

Indexed keywords

MONOCLONAL ANTIBODY; NONSTRUCTURAL PROTEIN 1; BLOCKING ANTIBODY; NS1 PROTEIN, ZIKA VIRUS; VIRAL PROTEIN; VIRUS ANTIBODY;

ADOLESCENT; ADULT; AGED; ARTICLE; BRAZIL; CHIKUNGUNYA; CHIKUNGUNYA VIRUS; CHILD; CONTROLLED STUDY; CROSS REACTION; DENGUE; DENGUE VIRUS; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; INFANT; INTERVENTION STUDY; ITALY; MAJOR CLINICAL STUDY; MALE; NEWBORN; NICARAGUA; NONHUMAN; PRIORITY JOURNAL; PROSPECTIVE STUDY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SENSITIVITY AND SPECIFICITY; SEROPREVALENCE; SWITZERLAND; UNITED KINGDOM; VACCINATION; WEST NILE FEVER; WEST NILE VIRUS; ZIKA FEVER; ZIKA VIRUS; DIFFERENTIAL DIAGNOSIS; FLAVIVIRUS INFECTION; IMMUNOLOGY; PRESCHOOL CHILD; PROCEDURES; VIROLOGY;

ADOLESCENT; ANTIBODIES, BLOCKING; ANTIBODIES, MONOCLONAL; ANTIBODIES, VIRAL; CHILD; CHILD, PRESCHOOL; CROSS REACTIONS; DENGUE; DIAGNOSIS, DIFFERENTIAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLAVIVIRUS INFECTIONS; HUMANS; PROSPECTIVE STUDIES; SENSITIVITY AND SPECIFICITY; VIRAL NONSTRUCTURAL PROTEINS; ZIKA VIRUS; ZIKA VIRUS INFECTION;

EID: 85026758218     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1704984114     Document Type: Article

References (34)

1. Oliveira Melo AS, et al. (2016) Zika virus intrauterine infection causes fetal brain abnormality and microcephaly: Tip of the iceberg? Ultrasound Obstet Gynecol 47:6–7.
2. Moore CA, et al. (2017) Characterizing the pattern of anomalies in congenital Zika syndrome for pediatric clinicians. JAMA Pediatr 171:288–295.
3. Parra B, et al. (2016) Guillain–Barré syndrome associated with Zika virus infection in Colombia. N Engl J Med 20;375:1513–1523.
4. Muller DA, Young PR (2013) The flavivirus NS1 protein: Molecular and structural biology, immunology, role in pathogenesis and application as a diagnostic biomarker. Antiviral Res 98:192–208.
5. Katzelnick LC, Coloma J, Harris E (2017) Dengue: Knowledge gaps, unmet needs, and research priorities. Lancet Infect Dis 17:e88–e100.
6. Bingham AM, et al. (2016) Comparison of test results for Zika virus RNA in urine, serum, and saliva specimens from persons with travel-associated Zika virus disease - Florida, 2016. MMWR Morb Mortal Wkly Rep 65:475–478.
7. Gourinat A-C, O’Connor O, Calvez E, Goarant C, Dupont-Rouzeyrol M (2015) Detection of Zika virus in urine. Emerg Infect Dis 21:84–86.
8. Lanciotti RS, et al. (2008) Genetic and serologic properties of Zika virus associated with an epidemic, Yap State, Micronesia, 2007. Emerg Infect Dis 14:1232–1239.
9. Priyamvada L, et al. (2016) Human antibody responses after dengue virus infection are highly cross-reactive to Zika virus. Proc Natl Acad Sci USA 113:7852–7857.
10. Stettler K, et al. (2016) Specificity, cross-reactivity, and function of antibodies elicited by Zika virus infection. Science 353:823–826.
11. Harrison SC (2016) Immunogenic cross-talk between dengue and Zika viruses. Nat Immunol 17:1010–1012.
12. Beltramello M, et al. (2010) The human immune response to Dengue virus is dominated by highly cross-reactive antibodies endowed with neutralizing and enhancing activity. Cell Host Microbe 8:271–283.
13. Kuan G, et al. (2009) The Nicaraguan pediatric dengue cohort study: Study design, methods, use of information technology, and extension to other infectious diseases. Am J Epidemiol 170:120–129.
14. Gordon A, et al. (2013) The Nicaraguan pediatric dengue cohort study: Incidence of inapparent and symptomatic dengue virus infections, 2004-2010. PLoS Negl Trop Dis 7:e2462.
15. Dejnirattisai W, et al. (2016) Dengue virus sero-cross-reactivity drives antibody-dependent enhancement of infection with zika virus. Nat Immunol 17:1102–1108.
16. Halstead SB, Rojanasuphot S, Sangkawibha N (1983) Original antigenic sin in dengue. Am J Trop Med Hyg 32:154–156.
17. Midgley CM, et al. (2011) An in-depth analysis of oringinal antigenic sin in dengue virus infection. J Virol 85:410–421.
18. Steinhagen K, et al. (2016) Serodiagnosis of Zika virus (ZIKV) infections by a novel NS1-based ELISA devoid of cross-reactivity with dengue virus antibodies: A multicohort study of assay performance, 2015 to 2016. Euro Surveill 21:30426.
19. Ginier M, Neumayr A, Günther S, Schmidt-Chanasit J, Blum J (2016) Zika without symptoms in returning travellers: What are the implications? Travel Med Infect Dis 14: 16–20.
20. Waggoner JJ, et al. (2016) Single-reaction multiplex reverse transcription PCR for detection of Zika, chikungunya, and dengue viruses. Emerg Infect Dis 22:1295–1297.
21. US Food and Drug Administration (2016) Zika virus emergency use authorization. Silver Spring, MD: US Department of Health and Human Services; 2016.
22. Waggoner JJ, et al. (2016) Clinical evaluation of a single-reaction real-time RT-PCR for pan-dengue and chikungunya virus detection. J Clin Virol 78:57–61.
23. Lanciotti RS, Calisher CH, Gubler DJ, Chang GJ, Vorndam AV (1992) Rapid detection and typing of dengue viruses from clinical samples by using reverse transcriptase-polymerase chain reaction. J Clin Microbiol 30:545–551.
24. Harris E, et al. (1998) Typing of dengue viruses in clinical specimens and mosquitoes by single-tube multiplex reverse transcriptase PCR. J Clin Microbiol 36:2634–2639.
25. Narvaez F, et al. (2011) Evaluation of the traditional and revised WHO classifications of Dengue disease severity. PLoS Negl Trop Dis 5:e1397.
26. Timiryasova TM, et al. (2013) Optimization and validation of a plaque reduction neutralization test for the detection of neutralizing antibodies to four serotypes of dengue virus used in support of dengue vaccine development. Am J Trop Med Hyg 88: 962–970.
27. Scaramozzino N, et al. (2001) Comparison of flavivirus universal primer pairs and development of a rapid, highly sensitive heminested reverse transcription-PCR assay for detection of flaviviruses targeted to a conserved region of the NS5 gene sequences. J Clin Microbiol 39:1922–1927.
28. Tiller T, et al. (2008) Efficient generation of monoclonal antibodies from single human B cells by single cell RT-PCR and expression vector cloning. J Immunol Methods 329: 112–124.
29. Fernández RJ, Vázquez S (1990) Serological diagnosis of dengue by an ELISA inhibition method (EIM). Mem Inst Oswaldo Cruz 85:347–351.
30. Balmaseda A, et al. (2006) High seroprevalence of antibodies against dengue virus in a prospective study of schoolchildren in Managua, Nicaragua. Trop Med Int Health 11: 935–942.
31. Gutiérrez G, et al. (2013) Evaluation of the diagnostic utility of the traditional and revised WHO dengue case definitions. PLoS Negl Trop Dis 7:e2385.
32. Huhtamo E, et al. (2010) Early diagnosis of dengue in travelers: Comparison of a novel real-time RT-PCR, NS1 antigen detection and serology. J Clin Virol 47:49–53.
33. Pastorino B, et al. (2005) Development of a TaqMan RT-PCR assay without RNA extraction step for the detection and quantification of African Chikungunya viruses. J Virol Methods 124:65–71.
34. Linke S, Ellerbrok H, Niedrig M, Nitsche A, Pauli G (2007) Detection of West Nile virus lineages 1 and 2 by real-time PCR. J Virol Methods 146:355–358.