Fructose: Back to the future?

American Journal of Clinical Nutrition

Volumn 106, Issue 2, 2017, Pages 439-442

  Sievenpiper, John L ^a,b,c  

^a UNIVERSITY OF TORONTO   (Canada)

^b ST MICHAEL'S HOSPITAL   (Canada)

^c ST MICHAEL'S HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

FRUCTOSE; GLUCOSE; MALTOSE; STARCH; SUCROSE; SUGAR ALCOHOL; SWEETENING AGENT; INSULIN; TRIACYLGLYCEROL;

ADVERSE OUTCOME; CARDIOMETABOLIC RISK; HUMAN; IMPAIRED GLUCOSE TOLERANCE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONALCOHOLIC FATTY LIVER; REVIEW; SWEETNESS; SYSTEMATIC REVIEW (TOPIC); BEVERAGE;

BEVERAGES; FRUCTOSE; GLUCOSE; INSULIN; SUCROSE; TRIGLYCERIDES;

EID: 85026664807     PISSN: 00029165     EISSN: 19383207     Source Type: Journal    
DOI: 10.3945/ajcn.117.161539     Document Type: Review

References (48)

1. DiNicolantonio JJ, O'Keefe JH, Lucan SC. Added fructose: A principal driver of type 2 diabetes mellitus and its consequences. Mayo Clin Proc 2015;90:372-81.
2. Lustig RH. Sickeningly sweet: Does sugar cause type 2 diabetes? Yes. Can J Diabetes 2016;40:282-6.
3. Taubes G. The case against sugar. Toronto: Alfred A Knopf Canada, Random House of Canada; 2016.
4. Lustig RH. Fat chance: Beating the odds against sugar, processed food, obesity, and disease. Toronto: Hudson Street Press, Penguin Group (Canada); 2012.
5. Schaub EO. Year of no sugar a memoir. Naperville (IL): Sourcebooks Inc.; 2014.
6. Gillespie D. Sweet poison: why sugar makes us fat. Toronto: Viking, Penguin Group (Canada); 2008.
7. Gameau D. That sugar film [motion picture]. Victoria (Australia): Madman Production Company; 2015.
8. Hozier M. Sugar coated [motion picture]. Toronto: One Sweet Film Inc.; 2015.
9. Joslin EP. Carbohydrate utilization in diabetes based on studies of the respiration, urine and blood. Arch Intern Med (Chic) 1915;XVI: 693-732.
10. Külz E. Beitrage zur Pathologie und Therapie des Diabetes Mellitus. Marburg (Germany): Elwert Verlag; 1874. p. 130-46.
11. Minkowski O. Untersuchungen iiber den Diabetes Mellitus nach estirpation des Pankreas. Arch Exp Pathol Pharmakol 1893;31:85-189.
12. Joslin EP. The treatment of diabetes mellitus: with observations based upon three thousand cases. 3rd ed. Philadelphia: Lea & Febiger; 1923. p. 550.
13. Nuttall FQ, Brunzell JD. Principles of nutrition and dietary recommendations for individuals with diabetes mellitus: 1979. Report of the American Diabetes Association. Diabetes 1979;28:1027-30.
14. Brunzell JD. Use of fructose, sorbitol, or xylitol as a sweetener in diabetes mellitus. Diabetes Care 1978;1:223-30.
15. Kalkhoff RK, Levin ME. The saccharin controversy. Diabetes Care 1978;1:211-22.
16. Crapo PA, Kolterman OG, Olefsky JM. Effects of oral fructose in normal, diabetic, and impaired glucose tolerance subjects. Diabetes Care 1980;3:575-82.
17. Bantle JP, Laine DC, Castle GW, Thomas JW, Hoogwerf BJ, Goetz FC. Postprandial glucose and insulin responses to meals containing different carbohydrates in normal and diabetic subjects. N Engl J Med 1983;309:7-12.
18. Jenkins DJ, Wolever TM, Taylor RH, Barker H, Fielden H, Baldwin JM, Bowling AC, Newman HC, Jenkins AL, Goff DV. Glycemic index of foods: A physiological basis for carbohydrate exchange. Am J Clin Nutr 1981;34:362-6.
19. Bantle JP, Laine DC, Thomas JW. Metabolic effects of dietary fructose and sucrose in types I and II diabetic subjects. JAMA 1986;256:3241-6.
20. Osei K, Falko J, Bossetti BM, Holland GC. Metabolic effects of fructose as a natural sweetener in the physiologic meals of ambulatory obese patients with type II diabetes. Am J Med 1987;83:249-55.
21. American Diabetes Association. Nutritional recommendations and principles for individuals with diabetes mellitus: 1986. Diabetes Care 1987; 10:126-32.
22. American Diabetes Association. Nutrition recommendations and principles for people with diabetes mellitus. Diabetes Care 2001;21(Suppl 1): S44-7.
23. Franz MJ, Bantle JP, Beebe CA, Brunzell JD, Chiasson JL, Garg A, Holzmeister LA, Hoogwerf B, Mayer-Davis E, Mooradian AD, et al. Evidence-based nutrition principles and recommendations for the treatment and prevention of diabetes and related complications. Diabetes Care 2002;25:148-98.
24. Bray GA, Nielsen SJ, Popkin BM. Consumption of high-fructose corn syrup in beverages may play a role in the epidemic of obesity [review]. Am J Clin Nutr 2004;79:537-43. Erratum in: Am J Clin Nutr 2004;80 (4):1090.
25. Evans RA, Frese M, Romero J, Cunningham JH, Mills KE. Fructose replacement of glucose or sucrose in food or beverages lowers postprandial glucose and insulin without raising triglycerides: A systematic review and meta-analysis. Am J Clin Nutr 2017;106:506-18.
26. Evans RA, Frese M, Romero J, Cunningham JH, Mills KE. Chronic fructose substitution for glucose or sucrose in food or beverages has little effect on fasting blood glucose, insulin, or triglycerides: A systematic review and meta-analysis. Am J Clin Nutr 2017;106:519-29.
27. EFSA Panel on Dietetic Products. Nutrition and Allergies (NDA): Scientific Opinion on the substantiation of health claims related to fructose and reduction of post-prandial glycaemic responses (ID 558) pursuant to Article 13(1) of Regulation (EC) no 1924/2006. EFSA J 2011;9:2223. Available from: Http://onlinelibrary.wiley.com/doi/10.2903/j.efsa.2011.2223/epdf.
28. Livesey G, Taylor R. Fructose consumption and consequences for glycation, plasma triacylglycerol, and body weight: Meta-analyses and meta-regression models of intervention studies. Am J Clin Nutr 2008;88:1419-37.
29. Cozma AI, Sievenpiper JL, de Souza RJ, Chiavaroli L, Ha V, Wang DD, Mirrahimi A, Yu ME, Carleton AJ, DiBuono M, et al. Effect of fructose on glycemic control in diabetes: A meta-analysis of controlled feeding trials. Diabetes Care 2012;35:1611-20.
30. Sievenpiper JL, de Souza RJ, Mirrahim A, Yu ME, Carleton AJ, Chiavaroli L, DiBuono M, Jenkins AL, Leiter LA, Wolever TWS, et al. Effect of fructose feeding on body weight: Systematic review and meta-analyses of controlled feeding trials. Ann Intern Med 2012;156: 291-304.
31. Sievenpiper JL, Carleton AJ, Chatha S, Jiang HY, de Souza RJ, Beyene J, Kendall CW, Jenkins DJ. Heterogeneous effects of fructose on blood lipids in people with type 2 diabetes: Systematic review and metaanalyses of experimental trials in humans. Diabetes Care 2009;32: 1930-7.
32. Chiavaroli L, de Souza RJ, Ha V, Cozma AI, Mirrahimi A, Wang DD, Yu M, Carleton AJ, Di Buono M, Jenkins AL, et al. Effect of fructose on established lipid targets: A systematic review and meta-analysis of controlled feeding trials. J Am Heart Assoc 2015;4:e001700.
33. Wang DD, Sievenpiper JL, de Souza RJ, Cozma AI, Chiavaroli L, Ha V, Mirrahimi A, Carleton AJ, Di Buono M, Jenkins AL, et al. Effect of fructose on postprandial triglycerides: A systematic review and metaanalysis of controlled feeding trials. Atherosclerosis 2014;232:125-33.
34. Ha V, Sievenpiper JL, de Souza RJ, Chiavaroli L, Wang DD, Cozma AI, Mirrahimi A, Yu ME, Carleton AJ, DiBuono M, et al. Effect of fructose on blood pressure: A meta-analysis of controlled feeding trials. Hypertension 2012;59:787-95.
35. Wang DD, Sievenpiper JL, de Souza RJ, Chiavaroli L, Ha V, Cozma AI, Mirrahimi A, Yu ME, Carleton AJ, DiBuono M, et al. Effect of fructose on uric acid: A meta-analysis of controlled feeding trials. J Nutr 2012; 142:916-23.
36. Chiu S, Sievenpiper JL, de Souza RJ, Cozma AI, Mirrahimi A, Carleton AJ, Ha V, Di Buono M, Jenkins AL, Leiter LA, et al. Effect of fructose on markers of non-alcoholic fatty liver disease (NAFLD): A systematic review and meta-analysis of controlled feeding trials. Eur J Clin Nutr 2014;68:416-23.
37. Sievenpiper JL, Chiavaroli L, de Souza RJ, Mirrahimi A, Cozma AI, Ha V, Wang DD, Yu ME, Carleton AJ, Beyene J, et al. 'Catalytic' doses of fructose may benefit glycaemic control without harming cardiometabolic risk factors: A small meta-analysis of randomised controlled feeding trials. Br J Nutr 2012;108:418-23.
38. Sievenpiper JL, Tappy L, Brouns F. Fructose as a driver of diabetes: An incomplete view of the evidence. Mayo Clin Proc 2015;90:984-8.
39. Sievenpiper JL, de Souza RJ, Cozma AI, Chiavaroli L, Ha V, Mirrahimi A. Fructose vs. glucose and metabolism: Do the metabolic differences matter? Curr Opin Lipidol 2014;25:8-19.
40. Agius L, Peak M. Intracellular binding of glucokinase in hepatocytes and translocation by glucose, fructose and insulin. Biochem J 1993;296:785-96.
41. Van Schaftingen E, Detheux M, Veiga da Cunha M. Short-term control of glucokinase activity: Role of a regulatory protein. FASEB J 1994;8:414-9.
42. Detheux M, Vandercammen A, Van Schaftingen E. Effectors of the regulatory protein acting on liver glucokinase: A kinetic investigation. Eur J Biochem 1991;200:553-61.
43. Vandercammen A, Detheux M, Van Schaftingen E. Binding of sorbitol 6-phosphate and of fructose 1-phosphate to the regulatory protein of liver glucokinase. Biochem J 1992;286:253-6.
44. Petersen KF, Laurent D, Yu C, Cline GW, Shulman GI. Stimulating effects of low-dose fructose on insulin-stimulated hepatic glycogen synthesis in humans. Diabetes 2001;50:1263-8.
45. Hawkins M, Gabriely I, Wozniak R, Vilcu C, Shamoon H, Rossetti L. Fructose improves the ability of hyperglycemia per se to regulate glucose production in type 2 diabetes. Diabetes 2002;51:606-14.
46. Tsilas CS, de Souza RJ, Mejia SB, Mirrahimi A, Cozma AI, Jayalath VH, Ha V, Tawfik R, Di Buono M, Jenkins AL, et al. Relation of total sugars, fructose and sucrose with incident type 2 diabetes: A systematic review and meta-analysis of prospective cohort studies. CMAJ 2017; 189:E711-20.
47. Sievenpiper JL, de Souza RJ, Kendall CW, Jenkins DJ. Is fructose a story of mice but not men? J Am Diet Assoc 2011;111:219-20.
48. Bernstein JT, Schermel A, Mills CM, L'Abbé MR. Total and free sugar content of Canadian prepackaged foods and beverages. Nutrients 2016; 8:E582.