-
1
-
-
84934323188
-
The economics of reproducibility in preclinical research
-
Freedman LP, Cockburn IM, Simcoe TS. The economics of reproducibility in preclinical research. PLoS Biol. 2015;13:e1002165.
-
(2015)
PLoS Biol
, vol.13
-
-
Freedman, L.P.1
Cockburn, I.M.2
Simcoe, T.S.3
-
2
-
-
80051837898
-
Evaluating preclinical efficacy
-
96cm22
-
Atkinson MA. Evaluating preclinical efficacy. Sci Transl Med. 2011;3:96cm22.
-
(2011)
Sci Transl Med
, vol.3
-
-
Atkinson, M.A.1
-
3
-
-
84860845827
-
The use of animal models in diabetes research
-
King AJF. The use of animal models in diabetes research. Br J Pharmacol. 2012;166:877-894.
-
(2012)
Br J Pharmacol
, vol.166
, pp. 877-894
-
-
King, A.J.F.1
-
4
-
-
84984684873
-
Experimental diabetes mellitus in different animal models
-
9051426
-
Al-Awar A, Kupai K, Veszelka M, et al. Experimental diabetes mellitus in different animal models. J Diabetes Res. 2016;2016:9051426.
-
(2016)
J Diabetes Res
, vol.2016
-
-
Al-Awar, A.1
Kupai, K.2
Veszelka, M.3
-
5
-
-
0018841766
-
Breeding of a non-obese, diabetic strain of mice
-
Makino S, Kunimoto K, Muraoka Y, Mizushima Y, Katagiri K, Tochino Y. Breeding of a non-obese, diabetic strain of mice. Jikken Dobutsu. 1980;29:1-13.
-
(1980)
Jikken Dobutsu
, vol.29
, pp. 1-13
-
-
Makino, S.1
Kunimoto, K.2
Muraoka, Y.3
Mizushima, Y.4
Katagiri, K.5
Tochino, Y.6
-
6
-
-
84930763863
-
The rise, fall, and resurgence of immunotherapy in type 1 diabetes
-
Ben Nasr M, D'Addio F, Usuelli V, Tezza S, Abdi R, Fiorina P. The rise, fall, and resurgence of immunotherapy in type 1 diabetes. Pharmacol Res. 2015;98:31-38.
-
(2015)
Pharmacol Res
, vol.98
, pp. 31-38
-
-
Ben Nasr, M.1
D'Addio, F.2
Usuelli, V.3
Tezza, S.4
Abdi, R.5
Fiorina, P.6
-
7
-
-
34249032122
-
Are insights gained from NOD mice sufficient to guide clinical translation? Another inconvenient truth
-
Roep BO. Are insights gained from NOD mice sufficient to guide clinical translation? Another inconvenient truth. Ann N Y Acad Sci. 2007;1103:1-10.
-
(2007)
Ann N Y Acad Sci
, vol.1103
, pp. 1-10
-
-
Roep, B.O.1
-
9
-
-
0033001488
-
The NOD mouse model of type 1 diabetes: as good as it gets?
-
Atkinson MA, Leiter EH. The NOD mouse model of type 1 diabetes: as good as it gets? Nat Med. 1999;5:601-604.
-
(1999)
Nat Med
, vol.5
, pp. 601-604
-
-
Atkinson, M.A.1
Leiter, E.H.2
-
10
-
-
0034909162
-
Translating data from animal models into methods for preventing human autoimmune diabetes mellitus: caveat emptor and primum non nocere
-
Greiner DL, Rossini AA, Mordes JP. Translating data from animal models into methods for preventing human autoimmune diabetes mellitus: caveat emptor and primum non nocere. Clin Immunol. 2001;100:134-143.
-
(2001)
Clin Immunol
, vol.100
, pp. 134-143
-
-
Greiner, D.L.1
Rossini, A.A.2
Mordes, J.P.3
-
11
-
-
10244226673
-
Animal models have little to teach us about type 1 diabetes: 1. In support of this proposal
-
Roep BO, Atkinson M. Animal models have little to teach us about type 1 diabetes: 1. In support of this proposal. Diabetologia. 2004;47:1650-1656.
-
(2004)
Diabetologia
, vol.47
, pp. 1650-1656
-
-
Roep, B.O.1
Atkinson, M.2
-
12
-
-
84894542402
-
Islet infiltration, cytokine expression and beta cell death in the NOD mouse, BB rat, Komeda rat, LEW.1AR1-iddm rat and humans with type 1 diabetes
-
Jörns A, Arndt T, Meyer zu Vilsendorf A, et al. Islet infiltration, cytokine expression and beta cell death in the NOD mouse, BB rat, Komeda rat, LEW.1AR1-iddm rat and humans with type 1 diabetes. Diabetologia. 2014;57:512-521.
-
(2014)
Diabetologia
, vol.57
, pp. 512-521
-
-
Jörns, A.1
Arndt, T.2
Meyer zu Vilsendorf, A.3
-
13
-
-
84958865564
-
Combination therapy reverses hyperglycemia in NOD mice with established type 1 diabetes
-
Xue S, Posgai A, Wasserfall C, et al. Combination therapy reverses hyperglycemia in NOD mice with established type 1 diabetes. Diabetes. 2015;64:3873-3884.
-
(2015)
Diabetes
, vol.64
, pp. 3873-3884
-
-
Xue, S.1
Posgai, A.2
Wasserfall, C.3
-
14
-
-
77950481729
-
Partial and transient modulation of the CD3-T-cell receptor complex, elicited by low-dose regimens of monoclonal anti-CD3, is sufficient to induce disease remission in non-obese diabetic mice
-
Mehta DS, Christmas RA, Waldmann H, Rosenzweig M. Partial and transient modulation of the CD3-T-cell receptor complex, elicited by low-dose regimens of monoclonal anti-CD3, is sufficient to induce disease remission in non-obese diabetic mice. Immunology. 2010;130:103-113.
-
(2010)
Immunology
, vol.130
, pp. 103-113
-
-
Mehta, D.S.1
Christmas, R.A.2
Waldmann, H.3
Rosenzweig, M.4
-
15
-
-
84887055430
-
Teplizumab preserves C-peptide in recent-onset type 1 diabetes: two-year results from the randomized, placebo-controlled Protege trial
-
Hagopian W, Ferry RJ Jr, Sherry N, et al. Teplizumab preserves C-peptide in recent-onset type 1 diabetes: two-year results from the randomized, placebo-controlled Protege trial. Diabetes. 2013;62:3901-3908.
-
(2013)
Diabetes
, vol.62
, pp. 3901-3908
-
-
Hagopian, W.1
Ferry, R.J.2
Sherry, N.3
-
16
-
-
84908218494
-
Low-dose otelixizumab anti-CD3 monoclonal antibody DEFEND-1 study: results of the randomized phase III study in recent-onset human type 1 diabetes
-
Aronson R, Gottlieb PA, Christiansen JS, et al. Low-dose otelixizumab anti-CD3 monoclonal antibody DEFEND-1 study: results of the randomized phase III study in recent-onset human type 1 diabetes. Diabetes Care. 2014;37:2746-2754.
-
(2014)
Diabetes Care
, vol.37
, pp. 2746-2754
-
-
Aronson, R.1
Gottlieb, P.A.2
Christiansen, J.S.3
-
17
-
-
77950649733
-
Developing combination immunotherapies for type 1 diabetes: recommendations from the ITN-JDRF Type 1 Diabetes Combination Therapy Assessment Group
-
Matthews JB, Staeva TP, Bernstein PL, Peakman M, von Herrath M, et al. Developing combination immunotherapies for type 1 diabetes: recommendations from the ITN-JDRF Type 1 Diabetes Combination Therapy Assessment Group. Clin Exp Immunol. 2010;160:176-184.
-
(2010)
Clin Exp Immunol
, vol.160
, pp. 176-184
-
-
Matthews, J.B.1
Staeva, T.P.2
Bernstein, P.L.3
Peakman, M.4
von Herrath, M.5
-
18
-
-
78649983200
-
Immunotherapy of type 1 diabetes—how to rationally prioritize combination therapies in T1D
-
Boettler T, von Herrath M. Immunotherapy of type 1 diabetes—how to rationally prioritize combination therapies in T1D. Int Immunopharmacol. 2010;10:1491-1495.
-
(2010)
Int Immunopharmacol
, vol.10
, pp. 1491-1495
-
-
Boettler, T.1
von Herrath, M.2
-
19
-
-
84896030882
-
Combination therapy for preservation of beta cell function in type 1 diabetes: new attitudes and strategies are needed!
-
Ludvigsson J. Combination therapy for preservation of beta cell function in type 1 diabetes: new attitudes and strategies are needed! Immunol Lett. 2014;159:30-35.
-
(2014)
Immunol Lett
, vol.159
, pp. 30-35
-
-
Ludvigsson, J.1
-
20
-
-
84929943190
-
Combination immunotherapies for type 1 diabetes mellitus
-
Pozzilli P, Maddaloni E, Buzzetti R. Combination immunotherapies for type 1 diabetes mellitus. Nat Rev Endocrinol. 2015;11:289-297.
-
(2015)
Nat Rev Endocrinol
, vol.11
, pp. 289-297
-
-
Pozzilli, P.1
Maddaloni, E.2
Buzzetti, R.3
-
21
-
-
0017353944
-
The spontaneously diabetic Wistar rat. Metabolic and morphologic studies
-
Nakhooda AF, Like AA, Chappel CI, Murray FT, Marliss EB. The spontaneously diabetic Wistar rat. Metabolic and morphologic studies. Diabetes. 1977;26:100-112.
-
(1977)
Diabetes
, vol.26
, pp. 100-112
-
-
Nakhooda, A.F.1
Like, A.A.2
Chappel, C.I.3
Murray, F.T.4
Marliss, E.B.5
-
22
-
-
15944398412
-
Rat models of type 1 diabetes: genetics, environment, and autoimmunity
-
Mordes JP, Bortell R, Blankenhorn EP, Rossini AA, Greiner DL. Rat models of type 1 diabetes: genetics, environment, and autoimmunity. ILAR J. 2004;45:278-291.
-
(2004)
ILAR J
, vol.45
, pp. 278-291
-
-
Mordes, J.P.1
Bortell, R.2
Blankenhorn, E.P.3
Rossini, A.A.4
Greiner, D.L.5
-
23
-
-
77953630580
-
Enhanced islet expansion by beta-cell proliferation in young diabetes-prone rats fed a protective diet
-
Wang GS, Kauri LM, Patrick C, Bareggi M, Rosenberg L, Scott FW. Enhanced islet expansion by beta-cell proliferation in young diabetes-prone rats fed a protective diet. J Cell Physiol. 2010;224:501-508.
-
(2010)
J Cell Physiol
, vol.224
, pp. 501-508
-
-
Wang, G.S.1
Kauri, L.M.2
Patrick, C.3
Bareggi, M.4
Rosenberg, L.5
Scott, F.W.6
-
24
-
-
0026052411
-
New inbred strain of Long-Evans Tokushima lean rats with IDDM without lymphopenia
-
Kawano K, Hirashima T, Mori S, Saitoh Y, Kurosumi M, Natori T. New inbred strain of Long-Evans Tokushima lean rats with IDDM without lymphopenia. Diabetes. 1991;40:1375-1381.
-
(1991)
Diabetes
, vol.40
, pp. 1375-1381
-
-
Kawano, K.1
Hirashima, T.2
Mori, S.3
Saitoh, Y.4
Kurosumi, M.5
Natori, T.6
-
25
-
-
0032469294
-
Establishment of two substrains, diabetes-prone and non-diabetic, from long-Evans Tokushima Lean (LETL) rats
-
Komeda K, Noda M, Terao K, Kuzuya N, Kanazawa M, Kanazawa Y. Establishment of two substrains, diabetes-prone and non-diabetic, from long-Evans Tokushima Lean (LETL) rats. Endocr J. 1998;45:737-744.
-
(1998)
Endocr J
, vol.45
, pp. 737-744
-
-
Komeda, K.1
Noda, M.2
Terao, K.3
Kuzuya, N.4
Kanazawa, M.5
Kanazawa, Y.6
-
26
-
-
17944372927
-
The LEW.1AR1/Ztm-iddm rat: a new model of spontaneous insulin-dependent diabetes mellitus
-
Lenzen S, Tiedge M, Elsner M, et al. The LEW.1AR1/Ztm-iddm rat: a new model of spontaneous insulin-dependent diabetes mellitus. Diabetologia. 2001;44:1189-1196.
-
(2001)
Diabetologia
, vol.44
, pp. 1189-1196
-
-
Lenzen, S.1
Tiedge, M.2
Elsner, M.3
-
27
-
-
21344471092
-
Immune cell infiltration, cytokine expression, and beta-cell apoptosis during the development of type 1 diabetes in the spontaneously diabetic LEW.1AR1/Ztm-iddm rat
-
Jörns A, Günther A, Hedrich HJ, Wedekind D, Tiedge M, Lenzen S. Immune cell infiltration, cytokine expression, and beta-cell apoptosis during the development of type 1 diabetes in the spontaneously diabetic LEW.1AR1/Ztm-iddm rat. Diabetes. 2005;54:2041-2052.
-
(2005)
Diabetes
, vol.54
, pp. 2041-2052
-
-
Jörns, A.1
Günther, A.2
Hedrich, H.J.3
Wedekind, D.4
Tiedge, M.5
Lenzen, S.6
-
28
-
-
84878094422
-
A variable CD3(+) T-cell frequency in peripheral blood lymphocytes associated with type 1 diabetes mellitus development in the LEW.1AR1-iddm rat
-
Arndt T, Jörns A, Weiss H, et al. A variable CD3(+) T-cell frequency in peripheral blood lymphocytes associated with type 1 diabetes mellitus development in the LEW.1AR1-iddm rat. PLoS One. 2013;8:e64305.
-
(2013)
PLoS One
, vol.8
-
-
Arndt, T.1
Jörns, A.2
Weiss, H.3
-
29
-
-
0036699521
-
Cblb is a major susceptibility gene for rat type 1 diabetes mellitus
-
Yokoi N, Komeda K, Wang HY, et al. Cblb is a major susceptibility gene for rat type 1 diabetes mellitus. Nat Genet. 2002;31:391-394.
-
(2002)
Nat Genet
, vol.31
, pp. 391-394
-
-
Yokoi, N.1
Komeda, K.2
Wang, H.Y.3
-
30
-
-
0036062788
-
Lymphopenia in the BB rat model of type 1 diabetes is due to a mutation in a novel immune-associated nucleotide (Ian)-related gene
-
MacMurray AJ, Moralejo DH, Kwitek AE, et al. Lymphopenia in the BB rat model of type 1 diabetes is due to a mutation in a novel immune-associated nucleotide (Ian)-related gene. Genome Res. 2002;12:1029-1039.
-
(2002)
Genome Res
, vol.12
, pp. 1029-1039
-
-
MacMurray, A.J.1
Moralejo, D.H.2
Kwitek, A.E.3
-
31
-
-
84946492391
-
A novel Dock8 gene mutation confers diabetogenic susceptibility in the LEW.1AR1/Ztm-iddm rat, an animal model of human type 1 diabetes
-
Arndt T, Wedekind D, Jörns A, et al. A novel Dock8 gene mutation confers diabetogenic susceptibility in the LEW.1AR1/Ztm-iddm rat, an animal model of human type 1 diabetes. Diabetologia. 2015;58:2800-2809.
-
(2015)
Diabetologia
, vol.58
, pp. 2800-2809
-
-
Arndt, T.1
Wedekind, D.2
Jörns, A.3
-
32
-
-
77949266510
-
Four-year metabolic outcome of a randomised controlled CD3-antibody trial in recent-onset type 1 diabetic patients depends on their age and baseline residual beta cell mass
-
Keymeulen B, Walter M, Mathieu C, et al. Four-year metabolic outcome of a randomised controlled CD3-antibody trial in recent-onset type 1 diabetic patients depends on their age and baseline residual beta cell mass. Diabetologia. 2010;53:614-623.
-
(2010)
Diabetologia
, vol.53
, pp. 614-623
-
-
Keymeulen, B.1
Walter, M.2
Mathieu, C.3
-
33
-
-
84943355943
-
TNF-alpha antibody therapy in combination with the T-cell-cpecific antibody anti-TCR reverses the diabetic metabolic state in the LEW.1AR1-iddm rat
-
Jörns A, Ertekin UG, Arndt T, Terbish T, Wedekind D, Lenzen S. TNF-alpha antibody therapy in combination with the T-cell-cpecific antibody anti-TCR reverses the diabetic metabolic state in the LEW.1AR1-iddm rat. Diabetes. 2015;64:2880-2891.
-
(2015)
Diabetes
, vol.64
, pp. 2880-2891
-
-
Jörns, A.1
Ertekin, U.G.2
Arndt, T.3
Terbish, T.4
Wedekind, D.5
Lenzen, S.6
-
34
-
-
84951022849
-
Predicting type 1 diabetes using biomarkers
-
Bonifacio E. Predicting type 1 diabetes using biomarkers. Diabetes Care. 2015;38:989-996.
-
(2015)
Diabetes Care
, vol.38
, pp. 989-996
-
-
Bonifacio, E.1
-
35
-
-
84903309761
-
Anti-TCR therapy combined with fingolimod for reversal of diabetic hyperglycemia by beta cell regeneration in the LEW.1AR1-iddm rat model of type 1 diabetes
-
Jörns A, Akin M, Arndt T, et al. Anti-TCR therapy combined with fingolimod for reversal of diabetic hyperglycemia by beta cell regeneration in the LEW.1AR1-iddm rat model of type 1 diabetes. J Mol Med (Berl). 2014;92:743-755.
-
(2014)
J Mol Med (Berl)
, vol.92
, pp. 743-755
-
-
Jörns, A.1
Akin, M.2
Arndt, T.3
|