-
1
-
-
0035928391
-
Type 1 diabetes: New perspectives on disease pathogenesis and treatment
-
Atkinson MA, Eisenbarth GS. Type 1 diabetes: new perspectives on disease pathogenesis and treatment. Lancet 2001;358:221-229
-
(2001)
Lancet
, vol.358
, pp. 221-229
-
-
Atkinson, M.A.1
Eisenbarth, G.S.2
-
2
-
-
17644361955
-
The NOD mouse: A model of immune dysregulation
-
Anderson MS, Bluestone JA. The NOD mouse: a model of immune dysregulation. Annu Rev Immunol 2005;23:447-485
-
(2005)
Annu Rev Immunol
, vol.23
, pp. 447-485
-
-
Anderson, M.S.1
Bluestone, J.A.2
-
3
-
-
80051837898
-
Evaluating preclinical efficacy
-
Atkinson MA. Evaluating preclinical efficacy. Sci Transl Med 2011;3:96cm22
-
(2011)
Sci Transl Med
, vol.3
, pp. 96cm22
-
-
Atkinson, M.A.1
-
4
-
-
80051744661
-
Type 1 diabetes immunotherapy: Is the glass half empty or half full?
-
Herold KC, Bluestone JA. Type 1 diabetes immunotherapy: is the glass half empty or half full? Sci Transl Med 2011;3:95fs1
-
(2011)
Sci Transl Med
, vol.3
, pp. 95fs1
-
-
Herold, K.C.1
Bluestone, J.A.2
-
5
-
-
70349646680
-
Immune depletion with cellular mobilization imparts immunoregulation and reverses autoimmune diabetes in nonobese diabetic mice
-
Parker MJ, Xue S, Alexander JJ, et al. Immune depletion with cellular mobilization imparts immunoregulation and reverses autoimmune diabetes in nonobese diabetic mice. Diabetes 2009;58:2277-2284
-
(2009)
Diabetes
, vol.58
, pp. 2277-2284
-
-
Parker, M.J.1
Xue, S.2
Alexander, J.J.3
-
6
-
-
65249149784
-
Rabbit polyclonal mouse antithymocyte globulin administration alters dendritic cell profile and function in NOD mice to suppress diabetogenic responses
-
Huang Y, Parker M, Xia C, et al. Rabbit polyclonal mouse antithymocyte globulin administration alters dendritic cell profile and function in NOD mice to suppress diabetogenic responses. J Immunol 2009;182:4608-4615
-
(2009)
J Immunol
, vol.182
, pp. 4608-4615
-
-
Huang, Y.1
Parker, M.2
Xia, C.3
-
7
-
-
84920413163
-
Anti-thymocyte globulin/G-CSF treatment preserves b cell function in patients with established type 1 diabetes
-
Haller MJ, Gitelman SE, Gottlieb PA, et al. Anti-thymocyte globulin/G-CSF treatment preserves b cell function in patients with established type 1 diabetes. J Clin Invest 2015;125:448-455
-
(2015)
J Clin Invest
, vol.125
, pp. 448-455
-
-
Haller, M.J.1
Gitelman, S.E.2
Gottlieb, P.A.3
-
8
-
-
67650685905
-
Combination therapy with a dipeptidyl peptidase-4 inhibitor and a proton pump inhibitor restores normoglycaemia in non-obese diabetic mice
-
Suarez-Pinzon WL, Cembrowski GS, Rabinovitch A. Combination therapy with a dipeptidyl peptidase-4 inhibitor and a proton pump inhibitor restores normoglycaemia in non-obese diabetic mice. Diabetologia 2009;52:1680-1682
-
(2009)
Diabetologia
, vol.52
, pp. 1680-1682
-
-
Suarez-Pinzon, W.L.1
Cembrowski, G.S.2
Rabinovitch, A.3
-
9
-
-
33748331194
-
Chronic inhibition of dipeptidyl peptidase-4 with a sitagliptin analog preserves pancreatic beta-cell mass and function in a rodent model of type 2 diabetes
-
Mu J, Woods J, Zhou YP, et al. Chronic inhibition of dipeptidyl peptidase-4 with a sitagliptin analog preserves pancreatic beta-cell mass and function in a rodent model of type 2 diabetes. Diabetes 2006;55:1695-1704
-
(2006)
Diabetes
, vol.55
, pp. 1695-1704
-
-
Mu, J.1
Woods, J.2
Zhou, Y.P.3
-
10
-
-
0037342614
-
Dipeptidyl peptidase IV inhibitor treatment stimulates beta-cell survival and islet neogenesis in streptozotocininduced diabetic rats
-
Pospisilik JA, Martin J, Doty T, et al. Dipeptidyl peptidase IV inhibitor treatment stimulates beta-cell survival and islet neogenesis in streptozotocininduced diabetic rats. Diabetes 2003;52:741-750
-
(2003)
Diabetes
, vol.52
, pp. 741-750
-
-
Pospisilik, J.A.1
Martin, J.2
Doty, T.3
-
11
-
-
58149357117
-
Combination therapy with glucagon-like peptide-1 and gastrin restores normoglycemia in diabetic NOD mice
-
Suarez-Pinzon WL, Power RF, Yan Y, Wasserfall C, Atkinson M, Rabinovitch A. Combination therapy with glucagon-like peptide-1 and gastrin restores normoglycemia in diabetic NOD mice. Diabetes 2008;57:3281-3288
-
(2008)
Diabetes
, vol.57
, pp. 3281-3288
-
-
Suarez-Pinzon, W.L.1
Power, R.F.2
Yan, Y.3
Wasserfall, C.4
Atkinson, M.5
Rabinovitch, A.6
-
12
-
-
0027194337
-
Pancreatic gastrin stimulates islet differentiation of transforming growth factor alpha-induced ductular precursor cells
-
Wang TC, Bonner-Weir S, Oates PS, et al. Pancreatic gastrin stimulates islet differentiation of transforming growth factor alpha-induced ductular precursor cells. J Clin Invest 1993;92:1349-1356
-
(1993)
J Clin Invest
, vol.92
, pp. 1349-1356
-
-
Wang, T.C.1
Bonner-Weir, S.2
Oates, P.S.3
-
13
-
-
0036310118
-
Gastrin stimulates beta-cell neogenesis and increases islet mass from transdifferentiated but not from normal exocrine pancreas tissue
-
Rooman I, Lardon J, Bouwens L. Gastrin stimulates beta-cell neogenesis and increases islet mass from transdifferentiated but not from normal exocrine pancreas tissue. Diabetes 2002;51:686-690
-
(2002)
Diabetes
, vol.51
, pp. 686-690
-
-
Rooman, I.1
Lardon, J.2
Bouwens, L.3
-
14
-
-
0038652047
-
Randomized prospective trial of the effect of induced hypergastrinemia on the prevention of pancreatic atrophy after pancreatoduodenectomy in humans
-
Jang JY, Kim SW, Han JK, et al. Randomized prospective trial of the effect of induced hypergastrinemia on the prevention of pancreatic atrophy after pancreatoduodenectomy in humans. Ann Surg 2003;237:522-529
-
(2003)
Ann Surg
, vol.237
, pp. 522-529
-
-
Jang, J.Y.1
Kim, S.W.2
Han, J.K.3
-
15
-
-
84872018209
-
Recent lessons learned from prevention and recent-onset type 1 diabetes immunotherapy trials
-
Staeva TP, Chatenoud L, Insel R, Atkinson MA. Recent lessons learned from prevention and recent-onset type 1 diabetes immunotherapy trials. Diabetes 2013;62:9-17
-
(2013)
Diabetes
, vol.62
, pp. 9-17
-
-
Staeva, T.P.1
Chatenoud, L.2
Insel, R.3
Atkinson, M.A.4
-
16
-
-
84861868291
-
Through the fog: Recent clinical trials to preserve b-cell function in type 1 diabetes
-
Greenbaum CJ, Schatz DA, Haller MJ, Sanda S. Through the fog: recent clinical trials to preserve b-cell function in type 1 diabetes. Diabetes 2012;61:1323-1330
-
(2012)
Diabetes
, vol.61
, pp. 1323-1330
-
-
Greenbaum, C.J.1
Schatz, D.A.2
Haller, M.J.3
Sanda, S.4
-
17
-
-
84940105815
-
Distinct roles of b-cell mass and function during type 1 diabetes onset and remission
-
Chmelova H, Cohrs CM, Chouinard JA, et al. Distinct roles of b-cell mass and function during type 1 diabetes onset and remission. Diabetes 2015;64:2148-2160
-
(2015)
Diabetes
, vol.64
, pp. 2148-2160
-
-
Chmelova, H.1
Cohrs, C.M.2
Chouinard, J.A.3
-
18
-
-
58149280846
-
Regulatory T cells prevent transfer of type 1 diabetes in NOD mice only when their antigen is present in vivo
-
Tonkin DR, He J, Barbour G, Haskins K. Regulatory T cells prevent transfer of type 1 diabetes in NOD mice only when their antigen is present in vivo. J Immunol 2008;181:4516-4522
-
(2008)
J Immunol
, vol.181
, pp. 4516-4522
-
-
Tonkin, D.R.1
He, J.2
Barbour, G.3
Haskins, K.4
-
19
-
-
67650003971
-
Regulatory T cells enter the pancreas during suppression of type 1 diabetes and inhibit effector T cells and macrophages in a TGF-beta-dependent manner
-
Tonkin DR, Haskins K. Regulatory T cells enter the pancreas during suppression of type 1 diabetes and inhibit effector T cells and macrophages in a TGF-beta-dependent manner. Eur J Immunol 2009;39:1313-1322
-
(2009)
Eur J Immunol
, vol.39
, pp. 1313-1322
-
-
Tonkin, D.R.1
Haskins, K.2
-
20
-
-
84857073835
-
Immunomodulation of antigen presenting cells promotes natural regulatory T cells that prevent autoimmune diabetes in NOD mice
-
Richer MJ, Lavallée DJ, Shanina I, Horwitz MS. Immunomodulation of antigen presenting cells promotes natural regulatory T cells that prevent autoimmune diabetes in NOD mice. PLoS One 2012;7:e31153
-
(2012)
PLoS One
, vol.7
, pp. e31153
-
-
Richer, M.J.1
Lavallée, D.J.2
Shanina, I.3
Horwitz, M.S.4
-
21
-
-
49649095420
-
Polyclonal adaptive regulatory CD4 cells that can reverse type I diabetes become oligoclonal long-term protective memory cells
-
Godebu E, Summers-Torres D, Lin MM, Baaten BJ, Bradley LM. Polyclonal adaptive regulatory CD4 cells that can reverse type I diabetes become oligoclonal long-term protective memory cells. J Immunol 2008;181:1798-1805
-
(2008)
J Immunol
, vol.181
, pp. 1798-1805
-
-
Godebu, E.1
Summers-Torres, D.2
Lin, M.M.3
Baaten, B.J.4
Bradley, L.M.5
-
22
-
-
33645786794
-
Adaptive islet-specific regulatory CD4 T cells control autoimmune diabetes and mediate the disappearance of pathogenic Th1 cells in vivo
-
Weber SE, Harbertson J, Godebu E, et al. Adaptive islet-specific regulatory CD4 T cells control autoimmune diabetes and mediate the disappearance of pathogenic Th1 cells in vivo. J Immunol 2006;176:4730-4739
-
(2006)
J Immunol
, vol.176
, pp. 4730-4739
-
-
Weber, S.E.1
Harbertson, J.2
Godebu, E.3
-
23
-
-
84863051225
-
Harnessing memory adaptive regulatory T cells to control autoimmunity in type 1 diabetes
-
Li CR, Baaten BJ, Bradley LM. Harnessing memory adaptive regulatory T cells to control autoimmunity in type 1 diabetes. J Mol Cell Biol 2012;4:38-47
-
(2012)
J Mol Cell Biol
, vol.4
, pp. 38-47
-
-
Li, C.R.1
Baaten, B.J.2
Bradley, L.M.3
-
24
-
-
84908632192
-
Blood and islet phenotypes indicate immunological heterogeneity in type 1 diabetes
-
Arif S, Leete P, Nguyen V, et al. Blood and islet phenotypes indicate immunological heterogeneity in type 1 diabetes. Diabetes 2014;63:3835-3845
-
(2014)
Diabetes
, vol.63
, pp. 3835-3845
-
-
Arif, S.1
Leete, P.2
Nguyen, V.3
-
25
-
-
84893708638
-
The Juvenile Diabetes Research Foundation Network for Pancreatic Organ Donors with Diabetes (nPOD) Program: Goals, operational model and emerging findings
-
Pugliese A, Yang M, Kusmarteva I, et al. The Juvenile Diabetes Research Foundation Network for Pancreatic Organ Donors with Diabetes (nPOD) Program: goals, operational model and emerging findings. Pediatr Diabetes 2014;15:1-9
-
(2014)
Pediatr Diabetes
, vol.15
, pp. 1-9
-
-
Pugliese, A.1
Yang, M.2
Kusmarteva, I.3
-
26
-
-
34247154341
-
Autologous nonmyeloablative hematopoietic stem cell transplantation in newly diagnosed type 1 diabetes mellitus
-
Voltarelli JC, Couri CE, Stracieri AB, et al. Autologous nonmyeloablative hematopoietic stem cell transplantation in newly diagnosed type 1 diabetes mellitus. JAMA 2007;297:1568-1576
-
(2007)
JAMA
, vol.297
, pp. 1568-1576
-
-
Voltarelli, J.C.1
Couri, C.E.2
Stracieri, A.B.3
-
27
-
-
64749084427
-
C-peptide levels and insulin independence following autologous nonmyeloablative hematopoietic stem cell transplantation in newly diagnosed type 1 diabetes mellitus
-
Couri CE, Oliveira MC, Stracieri AB, et al. C-peptide levels and insulin independence following autologous nonmyeloablative hematopoietic stem cell transplantation in newly diagnosed type 1 diabetes mellitus. JAMA 2009;301:1573-1579
-
(2009)
JAMA
, vol.301
, pp. 1573-1579
-
-
Couri, C.E.1
Oliveira, M.C.2
Stracieri, A.B.3
-
28
-
-
0344844384
-
Why can't we prevent type 1 diabetes?: Maybe it's time to try a different combination
-
Schatz D, Gale EA, Atkinson MA. Why can't we prevent type 1 diabetes?: maybe it's time to try a different combination. Diabetes Care 2003;26:3326-3328
-
(2003)
Diabetes Care
, vol.26
, pp. 3326-3328
-
-
Schatz, D.1
Gale, E.A.2
Atkinson, M.A.3
-
29
-
-
84908347082
-
Combination therapy with sitagliptin and lansoprazole in patients with recent-onset type 1 diabetes (REPAIR-T1D):12-month results of a multicentre, randomised, placebo-controlled, phase 2 trial
-
Griffin KJ, Thompson PA, Gottschalk M, Kyllo JH, Rabinovitch A. Combination therapy with sitagliptin and lansoprazole in patients with recent-onset type 1 diabetes (REPAIR-T1D):12-month results of a multicentre, randomised, placebo-controlled, phase 2 trial. Lancet Diabetes Endocrinol 2014;2:710-718
-
(2014)
Lancet Diabetes Endocrinol
, vol.2
, pp. 710-718
-
-
Griffin, K.J.1
Thompson, P.A.2
Gottschalk, M.3
Kyllo, J.H.4
Rabinovitch, A.5
|