Centenarians maintain miRNA biogenesis pathway while it is impaired in octogenarians

Mechanisms of Ageing and Development

Volumn 168, Issue , 2017, Pages 54-57

  Borras C ^a,b   Serna, E ^a,b   Gambini, J ^a,b   Ingles M ^a,b   Vina, J ^a,b  

^a UNIVERSITY OF VALENCIA   (Spain)

^b Instituto de Investigación Biosanitaria Ibs   (Spain)

Author keywords

DICER; DROSHA; EXPORTIN 5; Health span; Longevity; RNA POL II

Indexed keywords

DICER; EXPORTIN 5; MICRORNA; RNA POLYMERASE II; DEAD BOX PROTEIN; DICER1 PROTEIN, HUMAN; DROSHA PROTEIN, HUMAN; KARYOPHERIN; RIBONUCLEASE III; TRANSCRIPTOME; XPO5 PROTEIN, HUMAN;

AGED; AGING; ARTICLE; BIOGENESIS; CONTROLLED STUDY; DICER GENE; DROSHA GENE; EXPORTIN 5 GENE; GENE; GENE EXPRESSION; GSK3B GENE; HDAC1 GENE; HNRNPA1 GENE; HUMAN; MICRORNA 16 GENE; MICRORNA 18A GENE; MICRORNA 21 GENE; PRIORITY JOURNAL; RNA POL II GENE; SIGNAL TRANSDUCTION; UPREGULATION; VERY ELDERLY; AGE; BIOSYNTHESIS; COMPARATIVE STUDY; GENETICS; METABOLISM;

AGE FACTORS; AGED, 80 AND OVER; AGING; DEAD-BOX RNA HELICASES; HUMANS; KARYOPHERINS; MICRORNAS; RIBONUCLEASE III; RNA POLYMERASE II; TRANSCRIPTOME; UP-REGULATION;

EID: 85026500178     PISSN: 00476374     EISSN: 18726216     Source Type: Journal    
DOI: 10.1016/j.mad.2017.07.003     Document Type: Article

References (11)

1. Borras, C., Abdelaziz, K.M., Gambini, J., Serna, E., Ingles, M., de la Fuente, M., Garcia, I., Matheu, A., Sanchis, P., Belenguer, A., Errigo, A., Avellana, J.A., Barettino, A., Lloret-Fernandez, C., Flames, N., Pes, G., Rodriguez-Manas, L., Vina, J., Human exceptional longevity: transcriptome from centenarians is distinct from septuagenarians and reveals a role of Bcl-xL in successful aging. Aging (Albany NY), 2016.
2. Conrad, C., Rauhut, R., Ribonuclease III: new sense from nuisance. Int. J. Biochem. Cell Biol. 34 (2002), 116–129.
3. Cullen, B.R., Transcription and processing of human microRNA precursors. Mol. Cell 16 (2004), 861–865.
4. ElSharawy, A., Keller, A., Flachsbart, F., Wendschlag, A., Jacobs, G., Kefer, N., Brefort, T., Leidinger, P., Backes, C., Meese, E., Schreiber, S., Rosenstiel, P., Franke, A., Nebel, A., Genome-wide miRNA signatures of human longevity. Aging Cell 11 (2012), 607–616.
5. Ha, M., Kim, V.N., Regulation of microRNA biogenesis. Nat. Rev. Mol. Cell Biol. 15 (2014), 509–524.
6. Han, J., Park, S.H., Kim, D.J., Kim, H., Choi, Y.H., Lee, J.H., Park, S.C., Chung, J., Antibodies to the DNA-directed RNA polymerase II subunit RPB1 occur with highest frequency in centenarians. Immun. Ageing, 13, 2016, 8.
7. Mori, M.A., Raghavan, P., Thomou, T., Boucher, J., Robida-Stubbs, S., Macotela, Y., Russell, S.J., Kirkland, J.L., Blackwell, T.K., Kahn, C.R., Role of microRNA processing in adipose tissue in stress defense and longevity. Cell Metab. 16 (2012), 336–347.
8. Mourelatos, Z., Small RNAs: the seeds of silence. Nature 455 (2008), 44–45.
9. Olivieri, F., Spazzafumo, L., Santini, G., Lazzarini, R., Albertini, M.C., Rippo, M.R., Galeazzi, R., Abbatecola, A.M., Marcheselli, F., Monti, D., Ostan, R., Cevenini, E., Antonicelli, R., Franceschi, C., Procopio, A.D., Age-related differences in the expression of circulating microRNAs: miR-21 as a new circulating marker of inflammaging. Mech. Ageing Dev. 133 (2012), 675–685.
10. Serna, E., Gambini, J., Borras, C., Mohammed, K., Belenguer, A., Sanchis, P., Avellana, J.A., Rodriguez-Manas, L., Vina, J., Centenarians, but not octogenarians, up-regulate the expression of microRNAs. Sci. Rep., 2, 2012, 961.
11. Ungvari, Z., Tucsek, Z., Sosnowska, D., Toth, P., Gautam, T., Podlutsky, A., Csiszar, A., Losonczy, G., Valcarcel-Ares, M.N., Sonntag, W.E., Csiszar, A., Aging-induced dysregulation of dicer1-dependent microRNA expression impairs angiogenic capacity of rat cerebromicrovascular endothelial cells. J. Gerontol. A Biol. Sci. Med. Sci. 68 (2013), 877–891.