Inhaled AP301 for treatment of pulmonary edema in mechanically ventilated patients with acute respiratory distress syndrome: A phase IIa randomized placebo-controlled trial

Critical Care

Volumn 21, Issue 1, 2017, Pages

  Krenn, Katharina ^a   Lucas, Rudolf ^b   Croizé, Adrien ^a   Boehme, Stefan ^a   Klein, Klaus Ulrich ^a   Hermann, Robert ^c   Markstaller, Klaus ^a   Ullrich, Roman ^a  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

^b MEDICAL COLLEGE OF GEORGIA   (United States)

^c Clinical Research Appliance   (Germany)

Author keywords

Acute respiratory distress syndrome; Alveolar fluid clearance; Clinical trial; ENaC; Pulmonary edema

Indexed keywords

PLACEBO; SOLNATIDE; AP301 PEPTIDE; CYCLOPEPTIDE;

ADULT; ADULT RESPIRATORY DISTRESS SYNDROME; ANEMIA; ARTICLE; ASPIRATION PNEUMONIA; ATRIAL FIBRILLATION; BLOOD OXYGEN TENSION; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; DOUBLE BLIND PROCEDURE; DRUG EFFECT; DRUG TOLERABILITY; FEMALE; FEVER; GENERAL CONDITION DETERIORATION; HEART ARREST; HEART ATRIUM FLUTTER; HUMAN; LEUKOCYTOSIS; LUNG EDEMA; LUNG EXTRAVASCULAR FLUID; LUNG VENTILATION; MALE; MORTALITY; PHASE 2 CLINICAL TRIAL; PILOT STUDY; PLEURA EFFUSION; PNEUMONIA; PRIORITY JOURNAL; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; SEQUENTIAL ORGAN FAILURE ASSESSMENT SCORE; SIDE EFFECT; THROMBOCYTOPENIA; TIDAL VOLUME; TRACHEOSTOMY; VENTILATED PATIENT; AGED; ARTIFICIAL VENTILATION; CLINICAL TRIAL; COMPLICATION; INHALATIONAL DRUG ADMINISTRATION; LUNG; MIDDLE AGED; ORGAN DYSFUNCTION SCORE; PROCEDURES;

ADMINISTRATION, INHALATION; ADULT; AGED; DOUBLE-BLIND METHOD; FEMALE; HUMANS; LUNG; MALE; MIDDLE AGED; ORGAN DYSFUNCTION SCORES; PEPTIDES, CYCLIC; PULMONARY EDEMA; RESPIRATION, ARTIFICIAL; RESPIRATORY DISTRESS SYNDROME, ADULT;

EID: 85026388403     PISSN: 13648535     EISSN: 1466609X     Source Type: Journal    
DOI: 10.1186/s13054-017-1795-x     Document Type: Article

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