Blood sparing efficacy of oral tranexamic acid in primary total knee arthroplasty: A randomized controlled trial

Knee Surgery and Related Research

Volumn 29, Issue 1, 2017, Pages 57-62

  Lee, Qunn Jid ^a   Ching, Wai Yee ^a   Wong, Yiu Chung ^a  

^a YAN CHAI HOSPITAL   (Hong Kong)

Author keywords

Arthroplasty; Blood los; Knee; Oral; Tranexamic acid

Indexed keywords

EID: 85026384359     PISSN: 22340726     EISSN: 22342451     Source Type: Journal    
DOI: 10.5792/ksrr.16.074     Document Type: Article

References (30)

1. travenous tranexamic acid reduce blood loss compared to routine hemostasis in total knee arthroplasty: a multicenter, randomized, controlled trial. Arch Orthop Trauma Surg. 2015;135:1017-25.
2. Alshryda S, Sukeik M, Sarda P, Blenkinsopp J, Haddad FS, Mason JM. A systematic review and meta-analysis of the topical administration of tranexamic acid in total hip and knee replacement. Bone Joint J. 2014;96:1005-15
3. Zhang H, Chen J, Chen F, Que W. The effect of tranexamic acid on blood loss and use of blood products in total knee arthroplasty: a meta-analysis. Knee Surg Sports Traumatol Arthrosc. 2012;20:1742-52.
4. Poeran J, Rasul R, Suzuki S, Danninger T, Mazumdar M, Opperer M, Boettner F, Memtsoudis SG. Tranexamic acid use and postoperative outcomes in patients undergoing total hip or knee arthroplasty in the United States: retrospective analysis of effectiveness and safety. BMJ. 2014;349:g4829.
5. Panteli M, Papakostidis C, Dahabreh Z, Giannoudis PV. Topical tranexamic acid in total knee replacement: a systematic review and meta-analysis. Knee. 2013;20:300-9.
6. Good L, Peterson E, Lisander B. Tranexamic acid decreases external blood loss but not hidden blood loss in total knee replacement. Br J Anaesth. 2003;90:596-9.
7. Molloy DO, Archbold HA, Ogonda L, McConway J, Wilson RK, Beverland DE. Comparison of topical fibrin spray and tranexamic acid on blood loss after total knee replacement: a prospective, randomised controlled trial. J Bone Joint Surg Br. 2007;89:306-9.
8. Alvarez JC, Santiveri FX, Ramos I, Vela E, Puig L, Escolano F. Tranexamic acid reduces blood transfusion in total knee arthroplasty even when a blood conservation program is ap-plied. Transfusion. 2008;48:519-25.
9. Aguilera X, Martinez-Zapata MJ, Bosch A, Urrutia G, Gonzalez JC, Jordan M, Gich I, Maymo RM, Martínez N, Monl-lau JC, Celaya F, Fernandez JA. Efficacy and safety of fibrin glue and tranexamic acid to prevent postoperative blood loss in total knee arthroplasty: a randomized controlled clinical trial. J Bone Joint Surg Am. 2013;95:2001-7.
10. Wong J, Abrishami A, El Beheiry H, Mahomed NN, Roder-ick Davey J, Gandhi R, Syed KA, Muhammad Ovais Hasan S, De Silva Y, Chung F. Topical application of tranexamic acid reduces postoperative blood loss in total knee arthroplasty: a randomized, controlled trial. J Bone Joint Surg Am. 2010; 92:2503-13.
11. Roy SP, Tanki UF, Dutta A, Jain SK, Nagi ON. Efficacy of intra-articular tranexamic acid in blood loss reduction following primary unilateral total knee arthroplasty. Knee Surg Sports Traumatol Arthrosc. 2012;20:2494-501.
12. Konig G, Hamlin BR, Waters JH. Topical tranexamic acid reduces blood loss and transfusion rates in total hip and total knee arthroplasty. J Arthroplasty. 2013;28:1473-6.
13. Aguilera X, Martinez-Zapata MJ, Hinarejos P, Jordan M, Leal J, Gonzalez JC, Monllau JC, Celaya F, Rodriguez-Arias A, Fernandez JA, Pelfort X, Puig-Verdie L. Topical and in-
14. Gomez-Barrena E, Ortega-Andreu M, Padilla-Eguiluz NG, Perez-Chrzanowska H, Figueredo-Zalve R. Topical intra-articular compared with intravenous tranexamic acid to reduce blood loss in primary total knee replacement: a double-blind, randomized, controlled, noninferiority clinical trial. J Bone Joint Surg Am. 2014;96:1937-44.
15. Duncan CM, Gillette BP, Jacob AK, Sierra RJ, Sanchez-Sotelo J, Smith HM. Venous thromboembolism and mortality associated with tranexamic acid use during total hip and knee arthroplasty. J Arthroplasty. 2015;30:272-6.
16. Gillette BP, DeSimone LJ, Trousdale RT, Pagnano MW, Sierra RJ. Low risk of thromboembolic complications with tranexamic acid after primary total hip and knee arthro-plasty. Clin Orthop Relat Res. 2013;471:150-4.
17. Lucas-Polomeni MM, Delaval Y, Menestret P, Delaval P, Ecoffey C. A case of anaphylactic shock with tranexamique acid (Exacyl). Ann Fr Anesth Reanim. 2004;23:607-9.
18. Klak M, Anakkala N, Wang W, Lange S, Jonsson IM, Tar-kowski A, Jin T. Tranexamic acid, an inhibitor of plasmino-gen activation, aggravates staphylococcal septic arthritis and sepsis. Scand J Infect Dis. 2010;42:351-8.
19. Bradshaw AR, Monoghan J, Campbell D. Oral tranexamic acid reduces blood loss in total knee replacement arthro-plasty. Curr Orthop Prac. 2012;23:209-12.
20. Zohar E, Ellis M, Ifrach N, Stern A, Sapir O, Fredman B. The postoperative blood-sparing efficacy of oral versus intravenous tranexamic acid after total knee replacement. Anesth Analg. 2004;99:1679-83.
21. Fillingham YA, Kayupov E, Plummer DR, Moric M, Ger-linger TL, Della Valle CJ. The James A. Rand Young Inves- tigator’s Award: a randomized controlled trial of oral and intravenous tranexamic acid in total knee arthroplasty: the same efficacy at lower cost? J Arthroplasty. 2016;31(9 Sup-pl):26-30.
22. Al ipour M, Tabari M, Keramati M, Zarmehri AM, Makhmalbaf H. Effectiveness of oral tranexamic acid administration on blood loss after knee artroplasty: a randomized clinical trial. Transfus Apher Sci. 2013;49:574-7.
23. McGrath S, Yates P, Prosser G. Oral tranexamic acid in hip and knee arthroplasty: a prospective cohort study. Open J Orthop. 2014;4:215-20.
24. Lee QJ, Chang WY, Wong YC. Blood-sparing efficacy of oral tranexamic acid in primary total hip arthroplasty. J Arthro-plasty. 2017;32:139-42.
25. Irwin A, Khan SK, Jameson SS, Tate RC, Copeland C, Reed MR. Oral versus intravenous tranexamic acid in enhanced-recovery primary total hip and knee replacement: results of 3000 procedures. Bone Joint J. 2013;95:1556-61.
26. Nadler SB, Hidalgo JH, Bloch T. Prediction of blood volume in normal human adults. Surgery. 1962;51:224-32.
27. Pilbrant A, Schannong M, Vessman J. Pharmacokinetics and bioavailability of tranexamic acid. Eur J Clin Pharmacol. 1981;20:65-72.
28. Blanie A, Bellamy L, Rhayem Y, Flaujac C, Samama CM, Fontenay M, Rosencher N. Duration of postoperative fi-brinolysis after total hip or knee replacement: a laboratory follow-up study. Thromb Res. 2013;131:e6-11.
29. Kaku Y, Ito T, Kudo K, Kido-Nakahara M, Nakahara T, Mo-roi Y, Furue M. Generalized fixed drug eruption induced by tranexamic acid. Eur J Dermatol. 2014;24:408-9.
30. Imbesi S, Nettis E, Minciullo PL, Di Leo E, Saija A, Vacca A, Gangemi S. Hypersensitivity to tranexamic acid: a wide spec-trum of adverse reactions. Pharm World Sci. 2010;32:416-9.