Oral tranexamic acid reduces blood loss in total knee replacement arthroplasty

Current Orthopaedic Practice

Volumn 23, Issue 3, 2012, Pages 209-212

  Bradshaw, Anthony R ^a   Monoghan, Jennifer ^a   Campbell, David ^a  

^a REPATRIATION GENERAL HOSPITAL   (Australia)

Author keywords

Arthroplasty; Knee; Total knee replacement arthroplasty; Tranexamic acid

Indexed keywords

HEMOGLOBIN; TRANEXAMIC ACID;

AGED; ARTICLE; BLEEDING; BLOOD SAMPLING; CLINICAL ARTICLE; CONTROLLED STUDY; DEEP VEIN THROMBOSIS; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; FEMALE; FOLLOW UP; HEMATOCRIT; HUMAN; KNEE ARTHROPLASTY; MALE; OSTEOARTHRITIS; PATIENT SELECTION; PREOPERATIVE PERIOD; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SAFETY; THROMBOEMBOLISM; TOTAL KNEE REPLACEMENT;

EID: 84863637573     PISSN: 19407041     EISSN: 19417551     Source Type: Journal    
DOI: 10.1097/BCO.0b013e318247f1d5     Document Type: Article

References (33)

1. Bombeli T, Spahn D. Updates in perioperative coagulation: physiology and management of thromboembolism and haemorrhage. Br J Anaesth. 2004; 93:275-287. (Pubitemid 39117404)
2. De Bonis M, Cavaliere F, Alessandrini F, et al. Topical use of tranexamic acid in coronary artery bypass operations: a doubleblind, prospective, randomised, placebo-controlled study. J Thorac Cardiovasc Surg. 2000; 119:575-580. (Pubitemid 30146538)
3. Keating M, Meding J. Perioperative blood management practices in elective orthopaedic surgery. J Am Acad Orthop Surg. 2002; 10:393-400.
4. Longstaff C. Studies on the mechanisms of action of aprotinin and transexamic acid as plasmin inhibitors and antifibrinolytic agents. Blood Coagul Fibrinolysis. 1994; 5:537-542. (Pubitemid 24301574)
5. Murkin J, Shannon N, Bourne R, et al. Aprotinin decreases blood loss in patients undergoing revision or bilateral total hip arthroplasty. Anesth Analg. 1995; 80:343-348.
6. Thorpe C, Murphy W, Logan M. Use of aprotinin in knee replacement surgery. Br J Anaesth. 1994; 73:408-410. (Pubitemid 24267441)
7. Astedt B. Clinical pharmacology of tranexamic acid. Scand J Gastroenterol Suppl. 1987; 137:22-25.
8. Krohn C, Sorenses R, Lange J, et al. Tranexamic acid given in to the wound reduces postoperative blood loss by half in major orthopaedic surgery. Eur J Surg. 2003; 588:57-61. (Pubitemid 36918759)
9. Hippala S, Strid L, Wennerstrand M, et al. Tranexamic acid (Cyklokapron) reduces perioperative blood loss associated with total knee arthroplasty. Br J Anaesth. 1995; 74:534-537.
10. Benoni G, Fredin H, Knebel R, et al. Blood conservation with trenexamic acid in total hip arthroplasty: a randomised, doubleblind study in 40 primary operations. Acta Orthop Scand. 2001; 72:442-448. (Pubitemid 33043582)
11. Benoni G, Lethagen S, Nilsson P, et al. Tranexamic acid, given at the end of the operation, does not reduce postoperative blood loss in hip arthroplasty. Acta Orthop Scandi. 2000; 71:250-254. (Pubitemid 30648928)
12. Duquenne P, Lhoest L, HenkesW, et al. Tranexamic acid reduces postoperative blood losses associated with elective total hip replacement. J Bone Joint Surg. 1999; 81-B:233-234.
13. Veien M, Sorensen J, Madsen F, et al. Tranexamic acid given intraoperatively reduces blood loss after total knee replacement: a randomized, controlled study. Acta Anaesth Scand. 2002; 46:1206-1213.
14. Yamasaki S, Masuhara K, Fuji T. Tranexamic acid significantly reduces postoperative blood loss in patients undergoing cementless total hip arthroplasty. Int Orthop. 2004; 28:69-73. (Pubitemid 38543976)
15. Zohar E, Fredman B, Ellis M, et al. The postoperative bloodsparing efficacy of oral versus intravenous tranexamic acid after total knee replacement. Anesth Analg. 2004; 99:1679-1683. (Pubitemid 39551902)
16. Harrow J, Van Riper D, Strong M, et al. The dose-response relationship of tranexamic acid. Anaesthesiology. 1995; 82:383-392.
17. Sorin A, Cleays M, Jansen A, et al. Reduction of blood loss by tranexamic acid in total knee replacement. J Bone Joint Surg. 1999; 81-B:234.
18. Henry DA, Moxey AJ, Carless PA, et al. Anti-fibrinolytic use for minimising perioperative allogenic blood transfusion (Cochrane Review) The Cochrane Library, Issue 3, 2004. Chichester, UK: John Wiley & Sons, Ltd.
19. Ho KM, Ismail H. Use of intravenous tranexamic acid to reduce allogenic blood transfusion in total hip and knee arthroplasty: a meta-analysis. Anaesth Intensive Care. 2003; 31:529-537. (Pubitemid 37265248)
20. Coker N, Higgins D. Tranexamic acid applied topically to achieve haemostasis. Anaesthesia. 2000; 55:600-601. (Pubitemid 30345044)
21. Ruel M, Wang F, Bourke M, et al. Is tranexamic acid safe in patients undergoing coronary endarterectomy? Annals Throrac Surg. 2001; 71:1508-1511.
22. Akizuki S, Yasukawa Y, Takizawa T. A new method of haemostasis for cementless total knee arthroplasty. Bull Hosp Jt Dis. 1997; 56:222-224. (Pubitemid 28070568)
23. Benoni G, Fredin H. Fibrinolytic inhibition with tranexamic acid reduces blood loss and blood transfusion after knee arthroplasty: a prospective, randomised, double-blind study of 86 patients. J Bone Joint Surg. 1996; 38-B:434-440. (Pubitemid 26158834)
24. Ekback G, Axelsson K, Ryttberg L, et al. Tranexamic acid reduces blood loss in total hip replacement surgery. Anaesth Analg. 2000; 91:1124-1130.
25. Molloy D, Archbold H, Ogonda L, et al. Comparison of topical fibrin spray and tranexamic acid on blood loss after total knee replacement. J Bone Joint Surg. 2007; 89-B:306-309. (Pubitemid 46563903)
26. Benoni G, Lethagen S, Fredin H. The effect of tranexamic acid on local and plasma fibrinolysis during total knee arthroplasty. Thrombosis Res. 1997; 85:195-206. (Pubitemid 27145456)
27. Yamasaki S, Masuhara K, Fuji T. Tranexamic acid reduces postoperative blood loss in cementless total hip arthroplasty. J Bone Joint Surg. 2005; 87-A:766-770. (Pubitemid 40489352)
28. MIMS Australia. Cyclokapron Abbreviated Prescribing Information. 2004.
29. Benoni G. Tranexamic acid reduces the blood loss in knee arthroplasty-if it's administered at the right time. Lakartidningen. 1999; 96:2967-2969.
30. Hippala T, Seppo M, Strid L, et al. Trenexamic acid radically decreases blood loss and transfusions associated with total knee arthroplasty. Anaesth Analg. 1997; 84:839-844. (Pubitemid 27147712)
31. Zohar E, Fredman B, Ellis M, et al. A comparative study of the postoperative allogenic blood sparing effect of tranexamic acid versus acute normovolaemic haemodilution after total knee replacement. Anesth Analg. 1999; 89:1382.
32. Engel J, Hohaus T, Ruwoldt R, et al. Regional heamostatic status and blood requirements after total knee arthroplasty with and without tranexamic acid or aprotinin. Anaesth Analg. 2001; 92:775-780. (Pubitemid 32185127)
33. Tanaka N, Sakahashi H, Sata E, et al. Timing of the administration of tranexamic acid for maximum reduction in blood loss in arthroplasty of the knee. J Bone Joint Surg. 2001; 83-B:702-705. (Pubitemid 32700674)