Blood-Sparing Efficacy of Oral Tranexamic Acid in Primary Total Hip Arthroplasty

Journal of Arthroplasty

Volumn 32, Issue 1, 2017, Pages 139-142

  Lee, Qunn Jid ^a   Chang, Wai Yee Esther ^a   Wong, Yiu Chung ^a  

^a YAN CHAI HOSPITAL   (Hong Kong)

Author keywords

hemoglobin drop; hidden blood loss; oral tranexamic acid; total blood loss; total hip arthroplasty

Indexed keywords

HEMOGLOBIN; TRANEXAMIC ACID; ANTIFIBRINOLYTIC AGENT;

ADULT; ARTICLE; BLOOD TRANSFUSION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFICACY; DRUG SAFETY; FEMALE; HEMOGLOBIN BLOOD LEVEL; HIP ARTHROPLASTY; HUMAN; MAJOR CLINICAL STUDY; MALE; MORTALITY; OPERATIVE BLOOD LOSS; OUTCOME ASSESSMENT; POSTOPERATIVE CARE; PREOPERATIVE CARE; AGED; HIP REPLACEMENT; MIDDLE AGED; ORAL DRUG ADMINISTRATION; POSTOPERATIVE PERIOD; STATISTICS AND NUMERICAL DATA;

ADMINISTRATION, ORAL; AGED; ANTIFIBRINOLYTIC AGENTS; ARTHROPLASTY, REPLACEMENT, HIP; BLOOD LOSS, SURGICAL; BLOOD TRANSFUSION; DRAINAGE; FEMALE; HEMOGLOBINS; HUMANS; MALE; MIDDLE AGED; OUTCOME ASSESSMENT (HEALTH CARE); POSTOPERATIVE PERIOD; TRANEXAMIC ACID;

EID: 84999752044     PISSN: 08835403     EISSN: 15328406     Source Type: Journal    
DOI: 10.1016/j.arth.2016.06.058     Document Type: Article

References (32)

1. 1 Huang, F., Wu, Y., Yin, Z., et al. A systematic review and meta-analysis of the use of antifibrinolytic agents in total hip arthroplasty. Hip Int, 25(6), 2014, 502.
2. 2 Alshryda, S., Sukeik, M., Sarda, P., et al. A systematic review and meta-analysis of the topical administration of tranexamic acid in total hip and knee replacement. Bone Joint J, 96-b(8), 2014, 1005.
3. 3 Zhou, X.D., Tao, L.J., Li, J., et al. Do we really need tranexamic acid in total hip arthroplasty? a meta-analysis of nineteen randomized controlled trials. Arch Orthop Trauma Surg, 133(7), 2013, 1017.
4. 4 Wang, C., Xu, G.J., Han, Z., et al. Topical application of tranexamic acid in primary total hip arthroplasty: a systemic review and meta-analysis. Int J Surg, 15, 2015, 134.
5. 5 Sukeik, M., Alshryda, S., Haddad, F.S., et al. Systematic review and meta-analysis of the use of tranexamic acid in total hip replacement. J Bone Joint Surg Br, 93(1), 2011, 39.
6. 6 Hsu, C.H., Lin, P.C., Kuo, F.C., et al. A regime of two intravenous injections of tranexamic acid reduces blood loss in minimally invasive total hip arthroplasty: a prospective randomised double-blind study. Bone Joint J, 97-B(7), 2015, 905.
7. 7 Martin, J.G., Cassatt, K.B., Kincaid-Cinnamon, K.A., et al. Topical administration of tranexamic acid in primary total hip and total knee arthroplasty. J Arthroplasty, 29(5), 2014, 889.
8. 8 Yue, C., Kang, P., Yang, P., et al. Topical application of tranexamic acid in primary total hip arthroplasty: a randomized double-blind controlled trial. J Arthroplasty, 29(12), 2014, 2452.
9. 9 Poeran, J., Rasul, R., Suzuki, S., et al. Tranexamic acid use and postoperative outcomes in patients undergoing total hip or knee arthroplasty in the United States: retrospective analysis of effectiveness and safety. BMJ, 349, 2014, g4829.
10. 10 Wind, T.C., Barfield, W.R., Moskal, J.T., The effect of tranexamic acid on transfusion rate in primary total hip arthroplasty. J Arthroplasty, 29(2), 2014, 387.
11. 11 Whiting, D.R., Gillette, B.P., Duncan, C., et al. Preliminary results suggest tranexamic acid is safe and effective in arthroplasty patients with severe comorbidities. Clin Orthop Relat Res, 472(1), 2014, 66.
12. 12 Alshryda, S., Mason, J., Sarda, P., et al. Topical (intra-articular) tranexamic acid reduces blood loss and transfusion rates following total hip replacement: a randomized controlled trial (TRANX-H). J Bone Joint Surg Am, 95(21), 2013, 1969.
13. 13 Chang, C.H., Chang, Y., Chen, D.W., et al. Topical tranexamic acid reduces blood loss and transfusion rates associated with primary total hip arthroplasty. Clin Orthop Relat Res, 472(5), 2014, 1552.
14. 14 Wei, W., Wei, B., Comparison of topical and intravenous tranexamic acid on blood loss and transfusion rates in total hip arthroplasty. J Arthroplasty, 29(11), 2014, 2113.
15. 15 Duncan, C.M., Gillette, B.P., Jacob, A.K., et al. Venous thromboembolism and mortality associated with tranexamic acid use during total hip and knee arthroplasty. J Arthroplasty, 30(2), 2015, 272.
16. 16 Gillette, B.P., DeSimone, L.J., Trousdale, R.T., et al. Low risk of thromboembolic complications with tranexamic acid after primary total hip and knee arthroplasty. Clin Orthop Relat Res, 471(1), 2013, 150.
17. 17 Nishihara, S., Hamada, M., Does tranexamic acid alter the risk of thromboembolism after total hip arthroplasty in the absence of routine chemical thromboprophylaxis?. Bone Joint J, 97-b(4), 2015, 458.
18. 18 Lucas-Polomeni, M.M., Delaval, Y., Menestret, P., et al. A case of anaphylactic shock with tranexamique acid (Exacyl). Ann Fr Anesth Reanim, 23(6), 2004, 607.
19. 19 Klak, M., Anakkala, N., Wang, W., et al. Tranexamic acid, an inhibitor of plasminogen activation, aggravates staphylococcal septic arthritis and sepsis. Scand J Infect Dis, 42(5), 2010, 351.
20. 20 Irwin, A., Khan, S.K., Jameson, S.S., et al. Oral versus intravenous tranexamic acid in enhanced-recovery primary total hip and knee replacement: results of 3000 procedures. Bone Joint J, 95–B(11), 2013, 1556.
21. 21 Bradshaw, A.R., Monoghan, J., Campbell, D., Oral tranexamic acid reduces blood loss in total knee replacement arthroplasty. Curr Orthop Pract, 23(3), 2012, 209.
22. 22 Charoencholvanich, K., Siriwattanasakul, P., Tranexamic acid reduces blood loss and blood transfusion after TKA: a prospective randomized controlled trial. Clin Orthop Relat Res, 469(10), 2011, 2874.
23. 23 Zohar, E., Ellis, M., Ifrach, N., et al. The postoperative blood-sparing efficacy of oral versus intravenous tranexamic acid after total knee replacement. Anesth Analg, 99(6), 2004, 1679.
24. 24 Nadler, S.B., Hidalgo, J.H., Bloch, T., Prediction of blood volume in normal human adults. Surgery, 51(2), 1962, 224.
25. 25 Gross, J.B., Estimating allowable blood loss: corrected for dilution. Anesthesiology, 58(3), 1983, 277.
26. 26 Liu, X., Zhang, X., Chen, Y., et al. Hidden blood loss after total hip arthroplasty. J Arthroplasty, 26(7), 2011, 1100.
27. 27 Lee, Q.J., Mak, W.P., Hau, W.S., et al. Short duration and low suction pressure drain versus no drain following total knee replacement. J Orthop Surg (Hong Kong), 23(3), 2015, 278.
28. 28 Cheung, K.W., Chiu, K.H., Effect of drain pressure in total knee arthroplasty. J Orthop Surg (Hong Kong), 14(2), 2006, 163.
29. 29 Pilbrant, A., Schannong, M., Vessman, J., Pharmacokinetics and bioavailability of tranexamic acid. Eur J Clin Pharmacol, 20(1), 1981, 65.
30. 30 Blanie, A., Bellamy, L., Rhayem, Y., et al. Duration of postoperative fibrinolysis after total hip or knee replacement: a laboratory follow-up study. Thromb Res, 131(1), 2013, e6.
31. 31 Kaku, Y., Ito, T., Kudo, K., et al. Generalized fixed drug eruption induced by tranexamic acid. Eur J Dermatol, 24(3), 2014, 408.
32. 32 Imbesi, S., Nettis, E., Minciullo, P.L., et al. Hypersensitivity to tranexamic acid: a wide spectrum of adverse reactions. Pharm World Sci, 32(4), 2010, 416.