Adenosine analog NITD008 is a potent inhibitor of zika virus

Open Forum Infectious Diseases

Volumn 3, Issue 4, 2016, Pages

  Deng, Yong Qiang ^a   Zhang, Na Na ^a,b   Li, Chun Feng ^c,d   Tian, Min ^e   Hao, Jia Nan ^a,f   Xie, Xu Ping ^g   Shi, Pei Yong ^g   Qin, Cheng Feng ^a,b,f  

^a BEIJING INSTITUTE OF MICROBIOLOGY AND EPIDEMIOLOGY   (China)

^b GUANGXI MEDICAL UNIVERSITY   (China)

^c INSTITUTE OF BASIC MEDICAL SCIENCES   (China)

^d SUZHOU INSTITUTE OF SYSTEMS MEDICINE   (China)

^e CAPITAL MEDICAL UNIVERSITY   (China)

^f ANHUI MEDICAL UNIVERSITY   (China)

^g University of Texas Medical Branch School of Medicine   (United States)

Author keywords

Adenosine analog; Antiviral; Mouse model; Zika virus

Indexed keywords

ADENOSINE DERIVATIVE; ANTIVIRUS AGENT; NITD008; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ANTIVIRAL ACTIVITY; ARTICLE; CELL CULTURE; CONTROLLED STUDY; EC50; MORTALITY; MOUSE; NEUROLOGIC DISEASE; NONHUMAN; NUCLEOTIDE SEQUENCE; PLAQUE FORMING CELL ASSAY; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; ZIKA FEVER;

EID: 84996504031     PISSN: None     EISSN: 23288957     Source Type: Journal    
DOI: 10.1093/ofid/ofw175     Document Type: Article

References (16)

1. Faria NR, Azevedo Rdo S, Kraemer MU, et al. Zika virus in the Americas: early epidemiological and genetic findings. Science 2016; 352:345-9
2. Li C, Xu D, Ye Q, et al. Zika virus disrupts neural progenitor development and leads to microcephaly in mice. Cell Stem Cell 2016; 19:120-6
3. Messina JP, Kraemer MU, Brady OJ, et al. Mapping global environmental suitability for Zika virus. ELife 2016; pii:e15272
4. Dejnirattisai W, Supasa P, WongwiwatW, et al. Dengue virus sero-cross-reactivity drives antibody-dependent enhancement of infection with Zika virus. Nat Immunol 2016; 17:1102-8
5. Yin Z, Chen YL, SchulW, et al. An adenosine nucleoside inhibitor of dengue virus. Proc Natl Acad Sci U S A 2009; 106:20435-9
6. Deng CL, Yeo H, Ye HQ, et al. Inhibition of enterovirus 71 by adenosine analog NITD008. J Virol 2014; 88:11915-23
7. Lo MK, Shi PY, Chen YL, et al. In vitro antiviral activity of adenosine analog NITD008 against tick-borne flaviviruses. Antiviral Res 2016; 130:46-9
8. Qing J, Luo R,Wang Y, et al. Resistance analysis and characterization of NITD008 as an adenosine analog inhibitor against hepatitis C virus. Antiviral Res 2016; 126:43-54
9. Zhang FC, Li XF, Deng YQ, et al. Excretion of infectious Zika virus in urine. Lancet Infect Dis 2016; 16:641-2
10. Shan C, Xie X, Muruato AE, et al. An Infectious cDNA clone of Zika virus to study viral virulence, mosquito transmission, and antiviral inhibitors. Cell Host Microbe 2016; 19:891-900
11. Ye Q, Liu ZY, Han JF, et al. Genomic characterization and phylogenetic analysis of Zika virus circulating in the Americas. Infect Genet Evol 2016; 43:43-9
12. Dai L, Song J, Lu X, et al. Structures of the Zika virus envelope protein and its complex with a Flavivirus broadly protective antibody. Cell Host Microbe 2016; 19:696-704
13. Lazear HM, Govero J, Smith AM, et al. A mouse model of Zika virus pathogenesis. Cell Host Microbe 2016; 19:720-30
14. Zmurko J, Marques RE, Schols D, et al. The viral polymerase inhibitor 7-deaza-2'- C-methyladenosine is a potent inhibitor of in vitro Zika virus replication and delays disease progression in a robust mouse infection model. PLoS Negl Trop Dis 2016; 10:e0004695
15. Eyer L, Nencka R, Huvarova I, et al. Nucleoside inhibitors of Zika virus. J Infect Dis 2016; 214:704-11
16. Weaver SC, Costa F, Garcia-Blanco MA, et al. Zika virus: History, emergence, biology, and prospects for control. Antiviral Res 2016; 130:69-80