BITC and S-Carvone Restrain High-Fat Diet-Induced Obesity and Ameliorate Hepatic Steatosis and Insulin Resistance

Pharmaceutical Research

Volumn 34, Issue 11, 2017, Pages 2241-2249

  Alsanea, Sary ^a   Liu, Dexi ^a  

^a UNIVERSITY OF GEORGIA   (United States)

Author keywords

Antioxidant; BITC; Inflammation; Obesity; S carvone

Indexed keywords

BENZYL ISOTHIOCYANATE; CARVONE; CD11B ANTIGEN; CD36 ANTIGEN; GLYCOPROTEIN P 15095; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; TUMOR NECROSIS FACTOR; ANTIOXIDANT; ISOTHIOCYANIC ACID DERIVATIVE; TERPENE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY COMPOSITION; BODY WEIGHT; CONTROLLED STUDY; DIET INDUCED OBESITY; FATTY LIVER; FOOD INTAKE; GENE EXPRESSION; GLUCOSE METABOLISM; GLUCOSE TOLERANCE; INFLAMMATION; INSULIN RESISTANCE; INSULIN TOLERANCE TEST; LIPID DIET; LIPID METABOLISM; LIPID STORAGE; LIPID TRANSPORT; LIPOGENESIS; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; WEIGHT GAIN; WHITE ADIPOSE TISSUE; ANIMAL; BODY WEIGHT GAIN; C57BL MOUSE; CHEMISTRY; DRUG EFFECT; GLUCOSE TOLERANCE TEST; HUMAN; LIVER; MACROPHAGE; METABOLISM; OBESITY; PATHOLOGY; PATHOPHYSIOLOGY;

ADIPOSE TISSUE, WHITE; ANIMALS; ANTIOXIDANTS; BODY WEIGHT; DIET, HIGH-FAT; FATTY LIVER; GENE EXPRESSION; GLUCOSE TOLERANCE TEST; HUMANS; INSULIN RESISTANCE; ISOTHIOCYANATES; LIPID METABOLISM; LIVER; MACROPHAGES; MALE; MICE, INBRED C57BL; MONOTERPENES; OBESITY; WEIGHT GAIN;

EID: 85025431706     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-017-2230-3     Document Type: Article

References (35)

1. Ogden CL, Carroll MD, Fryar CD, Flegal KM. Prevalence of obesity among adults and youth: United States. NCHS Data Brief. 2011-2014;2015:1–8.
2. Pi-Sunyer X. The medical risks of obesity. Postgrad Med. 2009;121:21–33.
3. Hammond RA, Levine R. The economic impact of obesity in the United States. Diabetes Metab Syndr Obes. 2010;3:285–95.
4. Monteiro R, Azevedo I. Chronic inflammation in obesity and the metabolic syndrome. Mediat Inflamm. 2010;2010
5. Choe SS, Huh JY, Hwang IJ, Kim JI, Kim JB. Adipose tissue remodeling: its role in energy metabolism and metabolic disorders. Front Endocrinol (Lausanne). 2016;7:30.
6. Furukawa S, Fujita T, Shimabukuro M, Iwaki M, Yamada Y, Nakajima Y, et al. Increased oxidative stress in obesity and its impact on metabolic syndrome. J Clin Invest. 2004;114:1752–61.
7. Le Lay S, Simard G, Martinez MC, Andriantsitohaina R. Oxidative stress and metabolic pathologies: from an adipocentric point of view. Oxidative Med Cell Longev. 2014;2014:908539.
8. Cui R, Gao M, Qu S, Liu D. Overexpression of superoxide dismutase 3 gene blocks high-fat diet-induced obesity, fatty liver and insulin resistance. Gene Ther. 2014;21:840–8.
9. Ma Y, Gao M, Liu D. Chlorogenic acid improves high fat diet-induced hepatic steatosis and insulin resistance in mice. Pharm Res. 2015;32:1200–9.
10. Higdon JV, Delage B, Williams DE, Dashwood RH. Cruciferous vegetables and human cancer risk: epidemiologic evidence and mechanistic basis. Pharmacol Res. 2007;55:224–36.
11. Miyoshi N, Takabayashi S, Osawa T, Nakamura Y. Benzyl isothiocyanate inhibits excessive superoxide generation in inflammatory leukocytes: implication for prevention against inflammation-related carcinogenesis. Carcinogenesis. 2004;25:567–75.
12. Hecht SS. Inhibition of carcinogenesis by isothiocyanates. Drug Metab Rev. 2000;32:395–411.
13. Lee YM, Seon MR, Cho HJ, Kim JS, Park JH. Benzyl isothiocyanate exhibits anti-inflammatory effects in murine macrophages and in mouse skin. J Mol Med (Berl). 2009;87:1251–61.
14. Wu X, Zhou QH, Xu K. Are isothiocyanates potential anti-cancer drugs? Acta Pharmacol Sin. 2009;30:501–12.
15. de Carvalho CC, da Fonseca MMR. Carvone: why and how should one bother to produce this terpene. Food Chem. 2006;95:413–22.
16. Elmastaş M, Dermirtas I, Isildak O, Aboul-Enein HY. Antioxidant activity of S-Carvone isolated from spearmint (Mentha spicata L. fam Lamiaceae). J Liq Chromatogr Relat Technol. 2006;29:1465–75.
17. Rajeshwari T, Raja B. Antioxidant and free radical scavenging effect of D-carvone in hypertensive rats. In vivo and in vitro study. Int Lett Nat Sci. 2015;35:6–12.
18. Sabir S, Singh D, Rocha J. In vitro antioxidant activity of S-Carvone isolated from zanthoxylum alatum. Pharm Chem J. 2015;49:187–91.
19. Vinothkumar R, Sudha M, Viswanathan P, Kabalimoorthy J, Balasubramanian T, Nalini N. Modulating effect of d-carvone on 1,2-dimethylhydrazine-induced pre-neoplastic lesions, oxidative stress and biotransforming enzymes, in an experimental model of rat colon carcinogenesis. Cell Prolif. 2013;46:705–20.
20. Raphael T, Kuttan G. Immunomodulatory activity of naturally occurring monoterpenes carvone, limonene, and perillic acid. Immunopharm Immunot. 2003;25:285–94.
21. de Cassia da Silveira e Sa R, Andrade LN, de Sousa DP. A review on anti-inflammatory activity of monoterpenes. Molecules. 2013; 18: 1227–54.
22. Zheng G-q, Kenney PM, Lam LK. Effects of carvone compounds on glutathione S-transferase activity in a/J mice. J Agr Food Chem. 1992;40:751–5.
23. Noeman SA, Hamooda HE, Baalash AA. Biochemical study of oxidative stress markers in the liver, kidney and heart of high fat diet induced obesity in rats. Diabetol Metab Syndr. 2011;3:17.
24. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia. 1985;28:412–9.
25. Festi D, Colecchia A, Sacco T, Bondi M, Roda E, Marchesini G. Hepatic steatosis in obese patients: clinical aspects and prognostic significance. Obes Rev. 2004;5:27–42.
26. Kahn SE, Hull RL, Utzschneider KM. Mechanisms linking obesity to insulin resistance and type 2 diabetes. Nature. 2006;444:840–6.
27. Bu L, Gao M, Qu S, Liu D. Intraperitoneal injection of clodronate liposomes eliminates visceral adipose macrophages and blocks high-fat diet-induced weight gain and development of insulin resistance. AAPS J. 2013;15:1001–11.
28. Darkhal P, Gao M, Ma Y, Liu D. Blocking high-fat diet-induced obesity, insulin resistance and fatty liver by overexpression of Il-13 gene in mice. Int J Obes (Lond). 2015;39:1292–9.
29. Yan L, Song K, Gao M, Qu S, Liu D. Modulation of cell-mediated immunity to suppress high fat diet-induced obesity and insulin resistance. Pharm Res. 2016;33:395–403.
30. Alsanea S, Gao M, Liu D. Phloretin prevents high-fat diet-induced obesity and improves metabolic homeostasis. AAPS J. 2017;19:797–805.
31. Waterman C, Rojas-Silva P, Tumer TB, Kuhn P, Richard AJ, Wicks S, et al. Isothiocyanate-rich Moringa oleifera extract reduces weight gain, insulin resistance, and hepatic gluconeogenesis in mice. Mol Nutr Food Res. 2015;59:1013–24.
32. Inoue M, Ohtake T, Motomura W, Takahashi N, Hosoki Y, Miyoshi S, et al. Increased expression of PPARgamma in high fat diet-induced liver steatosis in mice. Biochem Biophys Res Commun. 2005;336:215–22.
33. Kotronen A, Seppanen-Laakso T, Westerbacka J, Kiviluoto T, Arola J, Ruskeepaa AL, et al. Hepatic stearoyl-CoA desaturase (SCD)-1 activity and diacylglycerol but not ceramide concentrations are increased in the nonalcoholic human fatty liver. Diabetes. 2009;58:203–8.
34. Samuel VT, Petersen KF, Shulman GI. Lipid-induced insulin resistance: unravelling the mechanism. Lancet. 2010;375:2267–77.
35. Chen L, Chen R, Wang H, Liang F. Mechanisms linking inflammation to insulin resistance. Int J Endocrinol. 2015;2015:508409.