Lycium barbarum polysaccharides decrease hyperglycemia-aggravated ischemic brain injury through maintaining mitochondrial fission and fusion balance

International Journal of Biological Sciences

Volumn 13, Issue 7, 2017, Pages 901-910

  Liu, Wen Jing ^a   Jiang, Hai Feng ^a   Rehman, Faisal U L ^a   Zhang, Jing Wen ^a   Chang, Yue ^a   Jing, Li ^a   Zhang, Jian Zhong ^a  

^a NINGXIA MEDICAL UNIVERSITY   (China)

Author keywords

Cerebral ischemia and reperfusion; Dynamin related protein 1; Hyperglycemia; Lycium barbarum polysaccharides; Mitochondrial fission fusion; Neuroprotection; Optic atrophy 1

Indexed keywords

DEATH ASSOCIATED PROTEIN KINASE; GUANOSINE TRIPHOSPHATASE; OPA1 PROTEIN, RAT; POLYSACCHARIDE;

ANIMAL; BRAIN ISCHEMIA; CHEMISTRY; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; HYPERGLYCEMIA; LYCIUM; METABOLISM; MITOCHONDRIAL DYNAMICS; MITOCHONDRION; PATHOLOGY; RANDOMIZATION; RAT; REPERFUSION INJURY; SPRAGUE DAWLEY RAT;

ANIMALS; BRAIN ISCHEMIA; DEATH-ASSOCIATED PROTEIN KINASES; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GTP PHOSPHOHYDROLASES; HYPERGLYCEMIA; LYCIUM; MITOCHONDRIA; MITOCHONDRIAL DYNAMICS; POLYSACCHARIDES; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; REPERFUSION INJURY;

EID: 85025147010     PISSN: 14492288     EISSN: None     Source Type: Journal    
DOI: 10.7150/ijbs.18404     Document Type: Article

References (33)

1. Jiao R, Liu Y, Gao H, et al. The anti-oxidant and antitumor properties of plant polysaccharides. Am J Chin Med. 2016; 44(3):463-88.
2. Yang X, Bai H, Cai W,et al. Lycium barbarum polysaccharides reduce intestinal ischemia/reperfusion injuries in rats. Chem Biol Interact. 2013; 204(3):166-72.
3. Zhang R, Kang KA, Piao MJ, et al. Cytoprotective effect of the fruits of Lycium chinense Miller against oxidative stress-induced hepatotoxicity. J Ethnopharmacol. 2010; 130(2):299-306.
4. Li SY, Yang D, Yeung CM, et al. Lycium barbarum polysaccharides reduce neuronal damage, blood-retinal barrier disruption and oxidative stress in retinal ischemia/reperfusion injury. PLoS One. 2011; 6(1):e16380.
5. Yu MS, Lai CS, Ho YS, et al. Characterization of the effects of anti-aging medicine Fructus lycii on beta-amyloid peptide neurotoxicity. Int J Mol Med. 2007; 20(2):261-8.
6. Xing X, Liu F, Xiao J, et al. Neuro-protective mechanisms of Lycium barbarum. Neuromolecular Med. 2016; 18(3):253-63.
7. Wang T, Li Y, Wang Y, et al. Lycium barbarum polysaccharide prevents focal cerebral ischemic injury by inhibiting neuronal apoptosis in mice. PLoS One. 2014; 9(3):e90780.
8. Hafez S, Coucha M, Bruno A, et al. Hyperglycemia, acute ischemic stroke, and thrombolytic therapy. Transl Stroke Res. 2014; 5(4):442-53.
9. Ergul A, Kelly CA, Abdalla M, et al. Cerebrovascular complications of diabetes: focus on stroke. Endocr Metab Immune Disord Drug Targets. 2012; 12(2):148-58.
10. Li W, Qu Z, Prakash R, et al. Comparative analysis of the neurovascular injury and functional outcomes in experimental stroke models in diabetic Goto-Kakizaki rats. Brain Res. 2013; 1541:106-14.
11. Zhang Z, Yan J, Shi H. Hyperglycemia as a risk factor of ischemic stroke. J Drug Metab Toxicol. 2013; 4(4):153.
12. Ten V S, Starkov A. Hypoxic-ischemic injury in the developing brain: the role of reactive oxygen species originating in mitochondria. Neurol Res Int. 2012;2012:542976.
13. Rehni AK, Nautiyal N, Perez-Pinzon MA, et al. Hyperglycemia/hypoglycemia-induced mitochondrial dysfunction and cerebral ischemic damage in diabetics. Metab Brain Dis. 2015; 30(2):437-47.
14. Wu S, Zhou F, Zhang Z, et al. Mitochondrial oxidative stress causes mitochondrial fragmentation via differential modulation of mitochondrial fission–fusion proteins. FEBS J. 2011; 278(6):941-54.
15. Szkudelski T. Streptozotocin-nicotinamide-induced diabetes in the rat. Characteristics of the experimental model. Exp Biol Med (Maywood). 2012; 237(5):481-90.
16. Longa EZ, Weinstein PR, Carlson S, et al. Reversible middle cerebral artery occlusion without craniectomy in rats. Stroke. 1989; 20(1):84-91.
17. Ho YS, Yu MS, Yang XF, et al. Neuroprotective effects of polysaccharides from wolfberry, the fruits of Lycium barbarum, against homocysteine-induced toxicity in rat cortical neurons. J Alzheimers Dis. 2010; 19(3):813-27.
18. Yang M, Gao N, Zhao Y, et al. Protective effect of Lycium barbarum polysaccharide on retinal ganglion cells in vitro. Int J Ophthalmol. 2011; 4(4):377-9.
19. Zhu J, Liu W, Yu J, et al. Characterization and hypoglycemic effect of a polysaccharide extracted from the fruit of Lycium barbarum L. Carbohydr Polym. 2013; 98(1):8-16.
20. Chen R, Li YX, Hao YJ, et al. Protective effects of Lycium barbarum polysaccharide on neonatal rat primary cultured hippocampal neurons injured by oxygen-glucose deprivation and reperfusion. J Mol Histol. 2012; 43(5):535-42.
21. Zhao R, Qiu B, Li Q, et al. LBP-4a improves insulin resistance via translocation and activation of GLUT4 in OLETF rats. Food Funct. 2014; 5(4):811-20.
22. Tang L, Zhang Y, Jiang Y, et al. Dietary Wolfberry ameliorates retinal structure abnormalities in db/db mice at the early stage of diabetes. Exp Biol Med. 2011; 236(6):1051-63.
23. Cai H, Liu F, Zuo P, et al. Practical application of antidiabetic efficacy of Lycium barbarum polysaccharide in patients with type 2 diabetes. Med Chem. 2015; 11(4):383-90.
24. Sanderson TH, Raghunayakula S, Kumar R. Neuronal hypoxia disrupts mitochondrial fusion. Neuroscience. 2015; 301:71-8.
25. Varanita T, Soriano ME, Romanello V, et al. The OPA1-dependent mitochondrial cristae remodeling pathway controls atrophic, apoptotic, and ischemic tissue damage. Cell Metab. 2015; 21(6):834-44.
26. Sharp WW, Fang YH, Han M, et al. Dynamin-related protein 1 (Drp1)-mediated diastolic dysfunction in myocardial ischemia-reperfusion injury: therapeutic benefits of Drp1 inhibition to reduce mitochondrial fission. FASEB J. 2014; 28(1):316-26.
27. Huang S, Wang Y, Gan X, et al. Drp1-mediated mitochondrial abnormalities link to synaptic injury in diabetes model. Diabetes. 2015; 64(5):1728-42.
28. Baek SH, Noh AR, Kim KA, et al. Modulation of mitochondrial function and autophagy mediates carnosine neuroprotection against ischemic brain damage. Stroke. 2014; 45(8):2438-43.
29. Kumar R, Bukowski MJ, Wider JM, et al. Mitochondrial dynamics following global cerebral ischemia. Mol Cell Neurosci. 2016; 76:68-75.
30. Bhatti JS, Bhatti GK, Reddy PH. Mitochondrial dysfunction and oxidative stress in metabolic disorders - A step towards mitochondria based therapeutic strategies. Biochim Biophys Acta. 2016; pii: S0925-4439(16)30292-7.
31. Luitse MJ, Biessels GJ, Rutten GE, et al. Diabetes, hyperglycaemia, and acute ischemic stroke. Lancet Neurol. 2012; 11(3):261-71.
32. Kim H, Choi J, Ryu J, et al. Activation of autophagy during glutamate-induced HT22 cell death. Biochem Biophys Res Commun. 2009; 388(2):339-44.
33. Tang Y, Liu X, Zhao J, et al. Hypothermia-induced ischemic tolerance is associated with Drp1 inhibition in cerebral ischemia-reperfusion injury of mice. Brain Res. 2016; 1646:73-83.