A dual agonist of farnesoid X receptor (FXR) and the G protein– coupled receptor TGR5, INT-767, reverses age-related kidney disease in mice

Journal of Biological Chemistry

Volumn 292, Issue 29, 2017, Pages 12018-12024

  Wang, Xiaoxin X ^a   Luo, Yuhuan ^a   Wang, Dong ^a   Adorini, Luciano ^b   Pruzanski, Mark ^b   Dobrinskikh, Evgenia ^a   Levi, Moshe ^a  

^a UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^b INTERCEPT PHARMACEUTICALS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MITOCHONDRIA; PROTEINS;

CALORIC RESTRICTION; FARNESOID X RECEPTORS; HEALTHY INDIVIDUALS; MEMBRANE RECEPTORS; MITOCHONDRIAL BIOGENESIS; MITOCHONDRIAL FUNCTION; NUCLEAR HORMONE RECEPTOR; TOLL-LIKE RECEPTOR 2;

MAMMALS;

FARNESOID X RECEPTOR; FIBRONECTIN; G PROTEIN COUPLED RECEPTOR; G PROTEIN COUPLED RECEPTOR TGR5; INT 767; PROTEIN INHIBITOR; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG; 6-ETHYL-24-NORCHOLANE-3,7,23-TRIOL-23 SULFATE; ANTILIPEMIC AGENT; AUTACOID; BILE ACID; CELL RECEPTOR; FARNESOID X-ACTIVATED RECEPTOR; GPBAR1 PROTEIN, HUMAN; GPBAR1 PROTEIN, MOUSE; NONSTEROID ANTIINFLAMMATORY AGENT;

AGING; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOACCUMULATION; CALORIC RESTRICTION; CONTROLLED STUDY; DRUG RECEPTOR BINDING; HUMAN; HUMAN CELL; KIDNEY DISEASE; MITOCHONDRIAL BIOGENESIS; MITOCHONDRION; MOUSE; NONHUMAN; PODOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEINURIA; AGONISTS; ANIMAL; ANTAGONISTS AND INHIBITORS; C57BL MOUSE; CELL CULTURE; DRUG EFFECTS; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETICS; IMMUNOLOGY; KIDNEY; LONGEVITY; METABOLISM; MITOCHONDRIAL DYNAMICS; MUTANT MOUSE STRAIN; PATHOLOGY; RENAL INSUFFICIENCY;

AGING; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BILE ACIDS AND SALTS; CALORIC RESTRICTION; CELLS, CULTURED; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HUMANS; HYPOLIPIDEMIC AGENTS; INFLAMMATION MEDIATORS; KIDNEY; LONGEVITY; MICE, INBRED C57BL; MICE, MUTANT STRAINS; MITOCHONDRIA; MITOCHONDRIAL TURNOVER; PODOCYTES; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, G-PROTEIN-COUPLED; RENAL INSUFFICIENCY;

EID: 85025138799     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.C117.794982     Document Type: Article

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