Dual activation of the bile acid nuclear receptor FXR and G-Protein-Coupled receptor TGR5 protects mice against atherosclerosis

PLoS ONE

Volumn 9, Issue 9, 2014, Pages

  Miyazaki Anzai, Shinobu ^a   Masuda, Masashi ^a   Levi, Moshe ^a   Keenan, Audrey L ^a   Miyazaki, Makoto ^a  

^a UNIVERSITY OF COLORADO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

6ALPHA ETHYL 24 NOR 5BETA CHOLANE 3ALPHA,7ALPHA,23 TRIOL 23 SULFATE SODIUM SALT; ANTILIPEMIC AGENT; APOLIPOPROTEIN E; BILE ACID; CHEMOKINE; CHOLESTEROL; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYTOKINE; FARNESOID X RECEPTOR; G PROTEIN COUPLED RECEPTOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LOW DENSITY LIPOPROTEIN RECEPTOR; PROTEIN TGR5; UNCLASSIFIED DRUG; 6-ETHYL-24-NORCHOLANE-3,7,23-TRIOL-23 SULFATE; CELL RECEPTOR; FARNESOID X-ACTIVATED RECEPTOR; GPBAR1 PROTEIN, MOUSE; TRIACYLGLYCEROL;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; ATHEROSCLEROSIS; ATHEROSCLEROTIC PLAQUE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG MECHANISM; INFLAMMATION; MACROPHAGE; MALE; MOUSE; NONHUMAN; PROTEIN EXPRESSION; AGONISTS; ANIMAL; BLOOD; C57BL MOUSE; CELL LINE; DRUG EFFECTS; GENETICS; METABOLISM; PHYSIOLOGY; SIGNAL TRANSDUCTION;

MUS;

ANIMALS; ATHEROSCLEROSIS; BILE ACIDS AND SALTS; CELL LINE; CHOLESTEROL; MALE; MICE; MICE, INBRED C57BL; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, G-PROTEIN-COUPLED; SIGNAL TRANSDUCTION; TRIGLYCERIDES;

EID: 84907195331     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0108270     Document Type: Article

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