Bovine milk-derived exosomes from colostrum are enriched with proteins implicated in immune response and growth

Scientific Reports

Volumn 7, Issue 1, 2017, Pages

  Samuel, Monisha ^a   Chisanga, David ^a   Liem, Michael ^a   Keerthikumar, Shivakumar ^a   Anand, Sushma ^a   Ang, Ching Seng ^b   Adda, Christopher G ^a   Versteegen, Ellen ^a   Jois, Markandeya ^a   Mathivanan, Suresh ^a  

^a LA TROBE UNIVERSITY   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; MILK PROTEIN;

ANIMAL; BIOPHYSICS; BOVINE; COLOSTRUM; EXOSOME; GROWTH, DEVELOPMENT AND AGING; IMMUNOLOGY; METABOLISM; MILK; PROTEOMICS; ULTRASTRUCTURE;

ANIMALS; BIOMARKERS; BIOPHYSICAL PHENOMENA; CATTLE; COLOSTRUM; EXOSOMES; MILK; MILK PROTEINS; PROTEOMICS;

EID: 85025114025     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/s41598-017-06288-8     Document Type: Article

References (29)

1. Kalra, H., Drummen, G. P. & Mathivanan, S. Focus on Extracellular Vesicles: Introducing the Next Small Big Thing. International journal of molecular sciences 17, 170, doi:10.3390/ijms17020170 (2016).
2. Théry, C. Exosomes: secreted vesicles and intercellular communications. F1000 Biol Rep 3, 130 (2011).
3. Gangoda, L., Boukouris, S., Liem, M., Kalra, H. & Mathivanan, S. Extracellular vesicles including exosomes are mediators of signal transduction: are they protective or pathogenic? Proteomics 15, 260-271, doi:10.1002/pmic.201400234 (2015).
4. Reinhardt, T. A., Lippolis, J. D., Nonnecke, B. J. & Sacco, R. E. Bovine milk exosome proteome. J Proteomics 75, 1486-1492 (2012).
5. Melnik, B. C., John, S. M. & Schmitz, G. Milk is not just food but most likely a genetic transfection system activating mTORC1 signaling for postnatal growth. Nutrition journal 12, 1 (2013).
6. Le, A., Barton, L. D., Sanders, J. T. & Zhang, Q. Exploration of bovine milk proteome in colostral and mature whey using an ionexchange approach. J Proteome Res. 10, 692-704 (2010).
7. Uruakpa, F., Ismond, M. & Akobundu, E. Colostrum and its benefits: a review. Nutr. Res. 22, 755-767 (2002).
8. Zhang, L. et al. Bovine milk proteome in the first 9 days: protein interactions in maturation of the immune and digestive system of the newborn. PLoS One 10, e0116710 (2015).
9. Wheeler, T. T., Hodgkinson, A. J., Prosser, C. G. & Davis, S. R. Immune components of colostrum and milk-a historical perspective. J. Mammary Gland Biol. Neoplasia 12, 237-247 (2007).
10. Mathivanan, S., Ji, H. & Simpson, R. J. Exosomes: Extracellular organelles important in intercellular communication. J Proteomics 73, 1907-1920 (2010).
11. Hata, T. et al. Isolation of bovine milk-derived microvesicles carrying mRNAs and microRNAs. Biochem. Biophys. Res. Commun. 396, 528-533 (2010).
12. Muroya, S., Ogasawara, H. & Hojito, M. Grazing Affects Exosomal Circulating MicroRNAs in Cattle. PLoS One 10, doi:10.1371/ journal.pone.0136475 (2015).
13. Reinhardt, T. A., Sacco, R. E., Nonnecke, B. J. & Lippolis, J. D. Bovine milk proteome: quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis. Journal of proteomics 82, 141-154 (2013).
14. Keerthikumar, S. et al. Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes. Oncotarget 6, 15375-15396, doi:10.18632/oncotarget.3801 (2015).
15. Kalra, H. et al. Comparative proteomics evaluation of plasma exosome isolation techniques and assessment of the stability of exosomes in normal human blood plasma. Proteomics 13, 3354-3364, doi:10.1002/pmic.201300282 (2013).
16. Keerthikumar, S. et al. ExoCarta: A Web-Based Compendium of Exosomal Cargo. J. Mol. Biol. 428, 688-692, doi:10.1016/j. jmb.2015.09.019 (2016).
17. Kalra, H. et al. Vesiclepedia: a compendium for extracellular vesicles with continuous community annotation. PLoS Biol. 10, e1001450, doi:10.1371/journal.pbio.1001450 (2012).
18. Hsu, C. et al. Regulation of exosome secretion by Rab35 and its GTPase-activating proteins TBC1D10A-C. J. Cell Biol. 189, 223-232, doi:10.1083/jcb.200911018 (2010).
19. Hoshino, A. et al. Tumour exosome integrins determine organotropic metastasis. Nature 527, 329-335 (2015).
20. Pathan, M. et al. FunRich: An open access standalone functional enrichment and interaction network analysis tool. Proteomics 15, 2597-2601 (2015).
21. Senda, A., Fukuda, K., Ishii, T. & Urashima, T. Changes in the bovine whey proteome during the early lactation period. Anim. Sci. J. 82, 698-706 (2011).
22. Zhang, L.-y. et al. Comparative proteomic analysis of changes in the bovine whey proteome during the transition from colostrum to milk. Asian-Australas. J. Anim. Sci. 24, 272-278 (2011).
23. Admyre, C. et al. Exosomes with immune modulatory features are present in human breast milk. J. Immunol. 179, 1969-1978 (2007).
24. Pathan, M. et al. A novel community driven software for functional enrichment analysis of extracellular vesicles data. J Extracell Vesicles 6, 1321455, doi:10.1080/20013078.2017.1321455 (2017).
25. Gruys, E., Toussaint, M., Niewold, T. & Koopmans, S. Acute phase reaction and acute phase proteins. J Zhejiang Univ Sci B 6, 1045-1056 (2005).
26. D'Alessandro, A., Scaloni, A. & Zolla, L. Human milk proteins: an interactomics and updated functional overview. J Proteome Res. 9, 3339-3373 (2010).
27. Mathivanan, S. et al. Proteomics analysis of A33 immunoaffinity-purified exosomes released from the human colon tumor cell line LIM1215 reveals a tissue-specific protein signature. Mol. Cell. Proteomics 9, 197-208 (2010).
28. Pruitt, K. D., Tatusova, T. & Maglott, D. R. NCBI reference sequences (RefSeq): a curated non-redundant sequence database of genomes, transcripts and proteins. Nucleic Acids Res 35, D61-65 (2007).
29. Gangoda, L. et al. Inhibition of cathepsin proteases attenuates migration and sensitizes aggressive N-Myc amplified human neuroblastoma cells to doxorubicin. Oncotarget 6, 11175-11190 (2015).