Fluoro-Hydroxyphenethylguanidines: Efficient Synthesis and Comparison of Two Structural Isomers as Radiotracers of Cardiac Sympathetic Innervation

ACS Chemical Neuroscience

Volumn 8, Issue 7, 2017, Pages 1530-1542

  Jung, Yong Woon ^a   Jang, Keun Sam ^a   Gu, Guie ^a   Koeppe, Robert A ^a   Sherman, Phillip S ^a   Quesada, Carole A ^a   Raffel, David M ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

3 18F Fluoro p hydroxyphenethylguanidine; 4 18F fluoro m hydroxyphenethylguanidine; norepinephrine transporter; sympathetic nervous system; 18F 3F PHPG; 18F 4F MHPG

Indexed keywords

(3 IODOBENZYL)GUANIDINE I 123; 3 FLUORO P HYDROXYPHENETHYLGUANIDINE F 18; 4 FLUORO M HYDROXYPHENETHYLGUANIDINE F 18; AMINE OXIDASE (FLAVIN CONTAINING); DIARYLIODONIUM SALT; GUANIDINE DERIVATIVE; INORGANIC SALT; M HYDROXYEPHEDRINE C 11; N GUANYL M OCTOPAMINE C 11; TRACER; UNCLASSIFIED DRUG; VESICULAR MONOAMINE TRANSPORTER 2; RADIOPHARMACEUTICAL AGENT;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CARDIAC MUSCLE; COMPARATIVE EFFECTIVENESS; CONTROLLED STUDY; DEPROTECTION REACTION; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG HALF LIFE; DRUG METABOLISM; DRUG SYNTHESIS; EVALUATION STUDY; FLUORINATION; GAMMA COUNTER; HEART INNERVATION; HEART NERVE; HEART TISSUE; IN VITRO STUDY; ISOMER; MALE; NERVOUS SYSTEM PARAMETERS; NEUROIMAGING; NONHUMAN; NUCLEOPHILICITY; PET SCANNER; PLASMA CONCENTRATION-TIME CURVE; POSITRON EMISSION TOMOGRAPHY; PRECLINICAL STUDY; PRIORITY JOURNAL; RADIOACTIVITY; RADIOCHEMISTRY; RAT; RETENTION TIME; SYMPATHETIC INNERVATION; SYMPATHETIC NERVE; SYMPATHETIC NERVE DENSITY; ADRENERGIC SYSTEM; ANIMAL; BLOOD; CHEMICAL STRUCTURE; CHEMISTRY; COMPARATIVE STUDY; DIAGNOSTIC IMAGING; HEART; INNERVATION; ISOMERISM; KINETICS; RHESUS MONKEY; SPRAGUE DAWLEY RAT; SYNTHESIS;

ANIMALS; DRUG EVALUATION, PRECLINICAL; GUANIDINES; HEART; IN VITRO TECHNIQUES; ISOMERISM; KINETICS; MACACA MULATTA; MALE; MOLECULAR STRUCTURE; POSITRON-EMISSION TOMOGRAPHY; RADIOPHARMACEUTICALS; RATS, SPRAGUE-DAWLEY; SYMPATHETIC NERVOUS SYSTEM;

EID: 85024892298     PISSN: None     EISSN: 19487193     Source Type: Journal    
DOI: 10.1021/acschemneuro.7b00051     Document Type: Article

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