Kinetics of the norepinephrine analog [76Br]-meta- bromobenzylguanidine in isolated working rat heart

Nuclear Medicine and Biology

Volumn 25, Issue 1, 1998, Pages 1-16

  Raffel, David M ^a,b   Loc'h, Christian ^a   Mardon, Karine ^a   Mazière, Bernard ^a   Syrota, André ^a  

^a SERVICE HOSPITALIER FRÉDÉRIC JOLIOT   (France)

^b UNIVERSITY OF MICHIGAN   (United States)

Author keywords

Bromine 76; Metabromobenzylguanidine; Metaiodobenzylguanidine; Michaelis Menten constants; Norepinephrine transporter; Sympathetic nervous system

Indexed keywords

(3 BROMOBENZYL)GUANIDINE BR 76; BROMINE 76; GUANIDINE DERIVATIVE; NORADRENALIN DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; COMPARTMENT MODEL; CONTROLLED STUDY; DRUG UPTAKE; HEART; HEART PERFUSION; ISOLATED HEART; MALE; MICHAELIS CONSTANT; NONHUMAN; RAT;

ANIMALS; BODY FLUID COMPARTMENTS; BROMINE RADIOISOTOPES; BROMOBENZENES; GUANIDINES; KINETICS; MALE; MODELS, BIOLOGICAL; MYOCARDIUM; RADIOPHARMACEUTICALS; RATS; RATS, WISTAR;

EID: 0031986199     PISSN: 09698051     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0969-8051(97)00141-8     Document Type: Article

References (61)

1. 1. Allman K. C., Stevens M. J., Wieland D. M., Hutchins G. D., Wolfe E. R., Greene D. A. and Schwaiger M. (1993) Noninvasive assessment of cardiac diabetic neuropathy by carbon-11 hydroxyephedrine and positron emission tomography. J. Am. Coll. Cardiol. 22, 1425-1432.
2. 2. Anversa P., Beghi C., Levicky V., McDonald S. L., Kikkawa Y. and Olivetti G. (1985) Effects of strenuous exercise on the quantitative morphology of left ventricular myocardium in the rat. J. Am. Coll. Cardiol. 17, 587-595.
3. 2). Heart Vessels 10, 151-153.
4. 4. Berry C. R., Garg P. K., Zalutsky M. R., Coleman R. E. and DeGrado T. R. (1996) Uptake and retention kinetics of para-fluorine-18-fluorobenzylguanidine in isolated rat heart. J. Nucl. Med. 37, 2011-2016.
5. 5. Bevington P. R. (1969) Data Reduction and Error Analysis for the Physical Sciences. McGraw-Hill, New York.
6. 6. Bönisch H., Uhlig W. and Trendelenburg U. (1974) Analysis of the compartments involved in the extraneuronal storage and metabolism of isoprenaline in the perfused rat heart. Naunyn-Schmiedeberg's Arch. Pharmacol. 283, 223-244.
7. 7. Bönisch H. (1978) Further studies on the extraneuronal uptake and metabolism of isoprenaline in the perfused rat heart. Naunyn-Schmiedeberg's Arch. Pharmacol. 303, 121-131.
8. 3H-noradrenline in isolated perfused rabbit heart. Naunyn-Schmiedeberg's Arch. Pharmacol. 323, 233-244.
9. 9. Bönisch H. and Trendelenburg U. (1988) The mechanism of action of indirectly acting sympathomimetic amines. In: Catecholamines I: Handbook of Experimental Pharmacology, Vol. 90/1 (Edited by Trendelenburg U. and Weiner N.), pp. 247-278. Springer-Verlag, Berlin.
10. 10. Dae M. W., De Marco T., Botvinick E. H., O'Connell J. W., Hattner, R. S., Huberty J. P. and Yuen-Green M. S. (1992) Scintigraphic assessment of MIBG uptake in globally denervated human and canine hearts - Implications for clinical studies. J. Nucl. Med. 33, 1444-1450.
11. 11. DeGrado T. R., Hutchins G. D., Toorongian S. A., Wieland D. M. and Schwaiger M. (1993) Myocardial kinetics of carbon-11-meta-hydroxyephedrine: Retention mechanisms and effects of norepinephrine. J. Nucl. Med. 34, 1287-1293.
12. 123I]iodobenzylguanidine in isolated rat heart. Nucl. Med. Biol. 22, 1-12.
13. 3H-(±)-noradrenaline in nerve-free rabbit aortic strips. Naunyn-Schmiedeberg's Arch. Pharmacol. 293, 115-127.
14. 14. Eisenhofer G., Smolich J. J. and Esler M. D. (1992) Disposition of endogenous adrenaline compared to noradrenaline released by cardiac sympathetic nerves in the anaesthetized dog. Naunyn-Schmiedeberg's Arch. Pharmacol. 345, 160-171.
15. 3H-(-)-noradrenaline in the perfused rat heart. Naunyn-Schmiedeberg's Arch. Pharmacol. 303, 37-45.
16. 16. Gao D. W., Stillson C. A., Botvinick E. H. and Dae M. W. (1996) Absence of MIBG uptake in the denervated rabbit heart [abstract]. J. Nucl. Med. 37, 106P.
17. 17. Glowniak J. V., Turner F. E., Gray L. L., Palac R. T., Lagunas-Solar M. C. and Woodward W. R. (1989) Iodine-123 metaiodobenzylguanidine imaging of the heart in idiopathic congestive cardiomyopathy and cardiac transplants. J. Nucl. Med. 30, 1182-1191.
18. 18. Glowniak J. V., Wilson R. A., Joyce M. E. and Turner F. E (1992) Evaluation of metaiodobenzylguanidine heart and lung extraction fraction by first-pass analysis in pigs. J. Nucl. Med. 33, 716-723.
19. 19. Glowniak J. V., Kilty J. E., Hoffman B. J. and Turner F. E. (1993) Evaluation of metaiodobenzylguanidine uptake by the norepinephrine, dopamine, and serotonin transporters. J. Nucl. Med. 34, 1140-1146.
20. 20. Glowniak J. V. (1995) Cardiac studies with metaiodobenzylguanidine: A critique of methods and interpretation of results. J. Nucl. Med. 36, 2133-2137.
21. 21. Graefe K.-H, Bönisch H. and Keller B. (1978) Saturation kinetics of the adrenergic neurone uptake system in the perfused rabbit heart: A new method for determination of initial rates of amine uptake. Naunyn-Schmiedeberg's Arch. Pharmacol. 302, 263-273.
22. 3H-(-)-noradrenaline in the perfused cat and rabbit heart. Naunyn-Schmiedeberg's Arch. Pharmacol. 318, 71-82.
23. 2 in the rat heart. Naunyn-Schmiedeberg's Arch. Pharmacol. 328, 164-173.
24. 24. Hamilton C. A., Dalrymple H. W., Reid J. L. and Sumner D. J. (1984) The recovery of α-adrenoceptor function and binding sites after phenoxybenzamine: An index of receptor turnover? Naunyn-Schmiedeberg's Arch. Pharmacol. 325, 34-41.
25. 25. Henderson E. B., Kahn J. K., Corbett J. R., Jansen D. E., Pippin J. J., Kulkarni P., Ugolini V., Akers M. S., Hansen C., Buja L. M., Parkey R. W. and Willerson J. T. (1988) Abnormal 1-123 metaiodobenzylguanidine myocardial washout and distribution may reflect adrenergic derangement in patients with congestive cardiomyopathy. Circulation 78, 1192-1199.
26. 26. Imamura Y., Ando H., Mitsuoka W., Egashira S., Masaki H., Ashihara T. and Fukuyama T. (1995) Iodine-123 metaiodobenzylguanidine images reflect intense myocardial adrenergic nervous activity in congestive heart failure independent of underlying cause. J. Am. Coll. Cardiol. 26, 1594-1599.
27. 27. Iversen L. L. (1963) The uptake of noradrenaline by the isolated perfused rat heart. Br. J. Pharmacol. 21, 523-537.
28. 28. Iversen L. L. (1965) The inhibition of noradrenaline uptake by drugs. Adv. Drug Res. 2, 5-23.
29. 29. Iversen L. L. and Langer S. Z. (1969) Effects of phenoxybenzamine on the uptake and metabolism of noradrenaline in the rat heart and vas deferens. Br. J. Pharmacol. 37, 627-637.
30. 2 by steroids in the isolated rat heart. Br. J. Pharmacol. Chemother. 40, 528-530.
31. 31. Iversen L. L. (1971) Role of transmitter uptake mechanisms in synaptic neurotransmission. Br. J. Pharmacol. 41, 571-591.
32. 32. Iversen L. L., Salt P. J. and Wilson H. A. (1972) Inhibition of catecholamine uptake in the isolated rat heart by haloalkylamines related to phenoxybenzamine. Br. J. Pharmacol. 46, 647-657.
33. 33. Knoll G. F. (1991) Radiation Detection and Measurement, 2nd edn. John Wiley & Sons, New York.
34. 34. Knoth J., Peabody J. O., Huettl P. and Njus D. (1984) Kinetics of tyramine transport and permeation across chromaffin-vesicle membranes. Biochemistry 23, 2011-2016.
35. 3H-noradrenaline. Naunyn-Schmiedeberg's Arch. Pharmacol. 336, 611-620.
36. 2 in the extraneuronal metabolism of catecholamines in the isolated rat heart. Br. J. Pharmacol. 37, 638-649.
37. 37. Lindmar R. and Löffelholz K. (1974) Neuronal and extraneuronal uptake and efflux of catecholamines in the isolated rabbit heart. Naunyn-Schmiedeberg's Arch. Pharmacol. 284, 63-92.
38. 76Br-MBBG). Nucl. Med. Biol 21, 49-55.
39. 39. Marquardt D. W. (1963) An algorithm for least-squares estimation of nonlinear parameters. J. Soc. Ind. Appl. Meth. 11, 431-441.
40. 40. Michalke W., Langer R. and Burger A. (1990) Ghosts of chromaffin granules accumulate biogenic amines according to a "pump and leak system" without contribution of carrier-mediated efflux, Naunyn-Schmiedeberg's Arch. Pharmacol. 342, 312-322.
41. 123l-meta-iodobenzylguanidine (MIBG) uptake in hypertrophic cardiomyopathy. Am. Heart. J. 119, 1329-1337.
42. 42. Ng C. K., Holden J. E., DeGrado T. R., Raffel D. M., Kornguth M. L. and Gatley S. J. (1991) Sensitivity of myocardial fluorodeoxyglucose lumped constant to glucose and insulin. Am. J. Physiol. 260, H593-H603.
43. 43. Patlak C. S., Blasberg R. G. and Fenstermacher J. D. (1983) Graphical evaluation of blood-to-brain transfer constants from multiple-time uptake data. J. Cereb. Blood Flow Metabol. 3, 1-7.
44. 44. Patlak C. S. and Blasberg R. G (1985) Graphical evaluation of blood-to-brain transfer constants from multiple-time uptake data: Generalizations. J. Cereb. Blood Flow Metabol. 5, 584-590.
45. 45. Rabinovitch M. A., Rose C. P., Schwab A. J., Fitchett D. H., Honos G. N., Stewart J. A., Chen L. F., Castilla E. P., Gomez A. A. and Abrahamowicz M. (1993) A method of dynamic analysis of iodine-123-metaiodobenzylguanidine scintigrams in cardiac mechanical overload hypertrophy and failure. J. Nucl. Med. 34, 589-600.
46. 3H-(-)-phenylephrine in the perfused rat heart. Naunyn-Schmiedeberg's Arch. Pharmacol. 314, 237-247.
47. 47. Sánchez-García P., García A. G., Martinez-Sierra R. and Velasco-Martín A. (1977) Inhibition of norepinephrine uptake by phenoxybenzamine and desmethylimipramine in the isolated guinea-pig atrium. J. Pharmacol. Exp. Ther. 201, 192-198.
48. 48. Schofer J., Spielmann R., Schubert A., Weber K. and Schluter M. (1988) Iodine-123 metaiodobenzylguanidine scintigraphy: A noninvasive method to demonstrate myocardial adrenergic system disintegrity in patients with idiopathic dilated cardiomyopathy. J. Am. Coll. Cardiol. 12, 1252-1258.
49. 49. Schömig A., Fischer S., Kurz T., Richardt G. and Schömig E. (1987) Nonexocytotic release of endogenous noradrenaline in the ischemic and anoxic rat heart: Mechanism and metabolic requirements. Circ. Res. 60, 194-205.
50. 201T1 in congestive heart failure. Nucl. Med. Commun. 17, 225-230.
51. 51. Sisson J. C., Shapiro B., Meyers L., Mallette S., Mangner T. J., Wieland D. M., Glowniak J. V., Sherman P. and Beierwaltes W. H. (1987) Metaiodobenzylguanidine to map scintigraphically the adrenergic nervous system in man. J. Nucl. Med. 28, 1625-1636.
52. 52. Starke K. (1987) Presynaptic α-autoreceptors. Rev. Physiol. Biochem. Pharmacol. 107, 73-146.
53. 53. Taegtmeyer H., Hems R. and Krebs H. A. (1980) Utilization of energy-providing substrates in the isolated working rat heart. Biochem. J. 186, 701-711.
54. 54. Trendelenburg U., Fleig H., Bryan L. J. and Bönisch, H. (1983) The extraneuronal compartments for the distribution of isoprenaline in the rat heart. Naunyn-Schmiedeberg's Arch. Pharmacol. 324, 169-179.
55. 2 of the rat heart. Naunyn-Schmiedeberg's Arch. Pharmacol. 330, 203-211.
56. 56. Trendelenburg U. (1988) The extraneuronal uptake and metabolism of catecholamines. In: Catecholamines I: Handbook of Experimental Pharmacology, Vol. 90/I (Edited by Trendelenburg U. and Weiner N.), pp. 279-319. Springer-Verlag, Berlin.
57. 57. Valette H., Loc'h C., Mardon K., Bendriem B., Merlet P., Fuseau C., Sabry S., Raffel D., Mazière B. and Syrota A. (1993) Bromine-76-metabromobenzylguanidine: A PET radiotracer for mapping sympathetic nerves of the heart. J. Nucl. Med. 34, 1739-1744.
58. 58. Wakade A. R. and Wakade T. D. (1981) Release of noradrenaline by one pulse: Modulation of such release by alpha-adrenoreceptor antagonists and uptake blockers. Naunyn-Schmiedeberg's Arch. Pharmacol. 317, 302-309.
59. 131I]iodobenzylguandidine. J. Nucl. Med. 21, 349-353.
60. 60. Wieland D. M., Brown L. E., Rogers W. L., Wu J. I., Clinthone N., Otto C., Swanson D. and Beierwaltes W. (1981) Myocardial imaging with a radioiodinated norepinephrine storage analog. J. Nucl. Med. 22, 22-31.
61. 61. Yamakodo K., Takaeda K., Kitano T., Nakagawa T., Futagami Y., Konishi T., Hamada M., Nakano T. and Ichihara T. (1992) Serial change of iodine-123 metaiodobenzylguanidine (MIBG) myocardial concentration in patients with dilated cardiomyopathy. Eur. J. Nucl. Med. 19, 265-270.