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1
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70349569569
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Tumor antigen-specific CD8T cells infiltrating the tumor express high levels of PD-1 and are functionally impaired
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This study showed that the majority of tumor-infiltrating T lymphocytes that express PD-1, are functionally impaired.
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Ahmadzadeh, M., Johnson, L.A., Heemskerk, B., Wunderlich, J.R., Dudley, M.E., White, D.E., Rosenberg, S.A., Tumor antigen-specific CD8T cells infiltrating the tumor express high levels of PD-1 and are functionally impaired. Blood 114 (2009), 1537–1544 This study showed that the majority of tumor-infiltrating T lymphocytes that express PD-1, are functionally impaired.
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This study demonstrated that adoptively transferred T lymphocytes effectively diminished tumor growth in humans.
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Andersen, R., Donia, M., Ellebaek, E., Borch, T.H., Kongsted, P., Iversen, T.Z., Holmich, L.R., Hendel, H.W., Met, O., Andersen, M.H., et al. Long-lasting complete responses in patients with metastatic melanoma after adoptive cell therapy with tumor-infiltrating lymphocytes and an attenuated IL2 regimen. Clin Cancer Res 22 (2016), 3734–3745 This study demonstrated that adoptively transferred T lymphocytes effectively diminished tumor growth in humans.
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Sharma, P., Retz, M., Siefker-Radtke, A., Baron, A., Necchi, A., Bedke, J., Plimack, E.R., Vaena, D., Grimm, M.O., Bracarda, S., et al. Nivolumab in metastatic urothelial carcinoma after platinum therapy (CheckMate 275): a multicentre, single-arm, phase 2 trial. Lancet Oncol, 2017.
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Sharma, P.1
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Akbay, E.A., Koyama, S., Carretero, J., Altabef, A., Tchaicha, J.H., Christensen, C.L., Mikse, O.R., Cherniack, A.D., Beauchamp, E.M., Pugh, T.J., et al. Activation of the PD-1 pathway contributes to immune escape in EGFR-driven lung tumors. Cancer Discov 3 (2013), 1355–1363.
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Classic work and accomplishments by one of the pioneers in tumor immunology vaccination.
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Klein, G., Tumor-specific transplantation antigens: G.H.A. Clowes memorial lecture. Cancer Res 28 (1968), 625–635 Classic work and accomplishments by one of the pioneers in tumor immunology vaccination.
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Klein, G.1
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This paper describes how not all modes of tumor cell death are immunogenic.
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Scheffer, S.R., Nave, H., Korangy, F., Schlote, K., Pabst, R., Jaffee, E.M., Manns, M.P., Greten, T.F., Apoptotic, but not necrotic, tumor cell vaccines induce a potent immune response in vivo. Int J Cancer 103 (2003), 205–211 This paper describes how not all modes of tumor cell death are immunogenic.
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Scheffer, S.R.1
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Preclinical data that resulted in the development of GVAX vaccines (Refs. [9–12]).
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A phase III trial of GVAX immunotherapy for prostate cancer in combination with docetaxel vs. docetaxel plus prednisone in symptomatic, castration-resistant prostate cancer (CRPC)
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Small, E., Demkow, T., Gerritson, W., Rolland, R., Hoskin, P., Smith, D., Parker, C., Chondros, D., Ma, J., Hege, K., A phase III trial of GVAX immunotherapy for prostate cancer in combination with docetaxel vs. docetaxel plus prednisone in symptomatic, castration-resistant prostate cancer (CRPC). ASCO GU, 2009.
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Small, E.1
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Higano, C., Saad, F., Somer, B., Curti, B., Petrylak, D., Drake, C., Schnell, F., Redfern, D., Schrijvers, D., Sacks, N., A phase III trial of GVAX immunotherapy for prostate cancer vs. docetaxel plus prednisone in asymptomatic castration-resistant prostate cancer (CRPC). ASCO GU, 2009.
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Vaccination with irradiated autologous tumor cells engineered to secrete granulocyte-macrophage colony-stimulating factor augments antitumor immunity in some patients with metastatic non-small-cell lung carcinoma
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Salgia, R., Lynch, T., Skarin, A., Lucca, J., Lynch, C., Jung, K., Hodi, F.S., Jaklitsch, M., Mentzer, S., Swanson, S., et al. Vaccination with irradiated autologous tumor cells engineered to secrete granulocyte-macrophage colony-stimulating factor augments antitumor immunity in some patients with metastatic non-small-cell lung carcinoma. J Clin Oncol 21 (2003), 624–630.
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This paper identified somatic point mutations in B16 mouse melanoma and showed induction of anti-tumor T cell responses after epitope vaccination.
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Castle, J.C., Kreiter, S., Diekmann, J., Lower, M., van de Roemer, N., de Graaf, J., Selmi, A., Diken, M., Boegel, S., Paret, C., et al. Exploiting the mutanome for tumor vaccination. Cancer Res 72 (2012), 1081–1091 This paper identified somatic point mutations in B16 mouse melanoma and showed induction of anti-tumor T cell responses after epitope vaccination.
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Castle, J.C.1
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Karosiene, E., Lundegaard, C., Lund, O., Nielsen, M., NetMHCcons: a consensus method for the major histocompatibility complex class I predictions. Immunogenetics 64 (2012), 177–186.
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17
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84920956731
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Predicting immunogenic tumour mutations by combining mass spectrometry and exome sequencing
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Very powerful approach to demonstrate the presence of mutated peptides bound to the tumor MHC molecules.
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Yadav, M., Jhunjhunwala, S., Phung, Q.T., Lupardus, P., Tanguay, J., Bumbaca, S., Franci, C., Cheung, T.K., Fritsche, J., Weinschenk, T., et al. Predicting immunogenic tumour mutations by combining mass spectrometry and exome sequencing. Nature 515 (2014), 572–576 Very powerful approach to demonstrate the presence of mutated peptides bound to the tumor MHC molecules.
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Yadav, M.1
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Identification of HLA-A3-restricted cytotoxic T lymphocyte epitopes from carcinoembryonic antigen and HER-2/neu by primary in vitro immunization with peptide-pulsed dendritic cells
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Example of the predictive approach to identify and validate T cell epitopes for CTLs.
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Kawashima, I., Tsai, V., Southwood, S., Takesako, K., Sette, A., Celis, E., Identification of HLA-A3-restricted cytotoxic T lymphocyte epitopes from carcinoembryonic antigen and HER-2/neu by primary in vitro immunization with peptide-pulsed dendritic cells. Cancer Res 59 (1999), 431–435 Example of the predictive approach to identify and validate T cell epitopes for CTLs.
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Kawashima, I.1
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19
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Review describing predictive approach for identifying HTL epitopes and correlates the presence of proximal or imbedded CTL epitopes.
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Kobayashi, H., Celis, E., Peptide epitope identification for tumor-reactive CD4T cells. Curr Opin Immunol 20 (2008), 221–227 Review describing predictive approach for identifying HTL epitopes and correlates the presence of proximal or imbedded CTL epitopes.
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Description of the TriVax approach to generate vast CTL responses using peptide, poly-IC and anti-CD40 antibodies.
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Cho, H.I., Celis, E., Optimized peptide vaccines eliciting extensive CD8 T-cell responses with therapeutic antitumor effects. Cancer Res 69 (2009), 9012–9019 Description of the TriVax approach to generate vast CTL responses using peptide, poly-IC and anti-CD40 antibodies.
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Cho, H.I.1
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Optimization of peptide vaccines to induce robust antitumor CD4 T-cell responses
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This study demonstrated that the combination of synthetic peptide, TLR7 ligand, CD40 agonist, and OX40 agonist elicits a huge number of antitumor CD4T lymphocytes with cytotoxic activity.
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Kumai, T., Lee, S., Cho, H.I., Sultan, H., Kobayashi, H., Harabuchi, Y., Celis, E., Optimization of peptide vaccines to induce robust antitumor CD4 T-cell responses. Cancer Immunol Res, 2016 This study demonstrated that the combination of synthetic peptide, TLR7 ligand, CD40 agonist, and OX40 agonist elicits a huge number of antitumor CD4T lymphocytes with cytotoxic activity.
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Kumai, T.1
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22
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Schurich, A., Pallett, L.J., Lubowiecki, M., Singh, H.D., Gill, U.S., Kennedy, P.T., Nastouli, E., Tanwar, S., Rosenberg, W., Maini, M.K., The third signal cytokine IL-12 rescues the anti-viral function of exhausted HBV-specific CD8T cells. PLoS Pathog, 9, 2013, e1003208.
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Schurich, A.1
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Curtsinger, J.M., Lins, D.C., Mescher, M.F., Signal 3 determines tolerance versus full activation of naive CD8T cells: dissociating proliferation and development of effector function. J Exp Med 197 (2003), 1141–1151.
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T-cell help for cytotoxic T lymphocytes is mediated by CD40-CD40L interactions
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Classic paper demonstrating the importance of CD40 ligation in the generation of effective CTL responses.
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Schoenberger, S.P., Toes, R.E., van der Voort, E.I., Offringa, R., Melief, C.J., T-cell help for cytotoxic T lymphocytes is mediated by CD40-CD40L interactions. Nature 393 (1998), 480–483 Classic paper demonstrating the importance of CD40 ligation in the generation of effective CTL responses.
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Schoenberger, S.P.1
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First report of a peptide vaccine producing a substantial T cell response by combining the antigen with TLR ligand and anti-CD40 antibodies.
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Ahonen, C.L., Doxsee, C.L., McGurran, S.M., Riter, T.R., Wade, W.F., Barth, R.J., Vasilakos, J.P., Noelle, R.J., Kedl, R.M., Combined TLR and CD40 triggering induces potent CD8+ T cell expansion with variable dependence on type I IFN. J Exp Med 199 (2004), 775–784 First report of a peptide vaccine producing a substantial T cell response by combining the antigen with TLR ligand and anti-CD40 antibodies.
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Ahonen, C.L.1
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Curtsinger, J.M., Valenzuela, J.O., Agarwal, P., Lins, D., Mescher, M.F., Type I IFNs provide a third signal to CD8T cells to stimulate clonal expansion and differentiation. J Immunol 174 (2005), 4465–4469.
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28
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77954939630
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Kohlmeier, J.E., Cookenham, T., Roberts, A.D., Miller, S.C., Woodland, D.L., Type I interferons regulate cytolytic activity of memory CD8(+) T cells in the lung airways during respiratory virus challenge. Immunity 33 (2010), 96–105.
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This controversial paper discusses and questions whether cancer vaccines will work against established tumors.
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Rosenberg, S.A., Yang, J.C., Restifo, N.P., Cancer immunotherapy: moving beyond current vaccines. Nat Med 10 (2004), 909–915 This controversial paper discusses and questions whether cancer vaccines will work against established tumors.
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Rosenberg, S.A.1
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Markovic, S.N., Suman, V.J., Ingle, J.N., Kaur, J.S., Pitot, H.C., Loprinzi, C.L., Rao, R.D., Creagan, E.T., Pittelkow, M.R., Allred, J.B., et al. Peptide vaccination of patients with metastatic melanoma: improved clinical outcome in patients demonstrating effective immunization. Am J Clin Oncol 29 (2006), 352–360.
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Markovic, S.N.1
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31
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84962326872
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Vaccination with LAG-3Ig (IMP321) and peptides induces specific CD4 and CD8 T-cell responses in metastatic melanoma patients – report of a phase I/IIa clinical trial
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Legat, A., Maby-El Hajjami, H., Baumgaertner, P., Cagnon, L., Abed Maillard, S., Geldhof, C., Iancu, E.M., Lebon, L., Guillaume, P., Dojcinovic, D., et al. Vaccination with LAG-3Ig (IMP321) and peptides induces specific CD4 and CD8 T-cell responses in metastatic melanoma patients – report of a phase I/IIa clinical trial. Clin Cancer Res 22 (2016), 1330–1340.
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TriVax-HPV: an improved peptide-based therapeutic vaccination strategy against human papillomavirus-induced cancers
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Barrios, K., Celis, E., TriVax-HPV: an improved peptide-based therapeutic vaccination strategy against human papillomavirus-induced cancers. Cancer Immunol Immunother 61 (2012), 1307–1317.
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84877825063
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BiVax: a peptide/poly-IC subunit vaccine that mimics an acute infection elicits vast and effective anti-tumor CD8 T-cell responses
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In this paper we showed that poly-IC is a unique adjuvant for peptide vaccines because it stimulates both TLR3 and MDA5.
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Cho, H.I., Barrios, K., Lee, Y.R., Linowski, A.K., Celis, E., BiVax: a peptide/poly-IC subunit vaccine that mimics an acute infection elicits vast and effective anti-tumor CD8 T-cell responses. Cancer Immunol Immunother 62 (2013), 787–799 In this paper we showed that poly-IC is a unique adjuvant for peptide vaccines because it stimulates both TLR3 and MDA5.
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Cho, H.I.1
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38449106129
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CD8+ CTL priming by exact peptide epitopes in incomplete Freund's adjuvant induces a vanishing CTL response, whereas long peptides induce sustained CTL reactivity
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