메뉴 건너뛰기




Volumn 47, Issue , 2017, Pages 57-63

Cancer immunotherapy: moving forward with peptide T cell vaccines

Author keywords

[No Author keywords available]

Indexed keywords

ADJUVANT; ALUMINUM POTASSIUM SULFATE; ANTIGEN; BIVAX; CARBOXYMETHYLCELLULOSE; CD40 LIGAND MONOCLONAL ANTIBODY; DIPHTHERIA PERTUSSIS TETANUS VACCINE; EPITOPE; FREUND ADJUVANT; INTERFERON INDUCED HELICASE C DOMAIN CONTAINING PROTEIN 1; PEPTIDE; PEPTIDE VACCINE; POLYINOSINIC POLYCYTIDYLIC ACID; POLYLYSINE; PROTEIN; PROTEIN E7; T CELL VACCINE; UNCLASSIFIED DRUG; CANCER VACCINE; IMMUNOLOGICAL ADJUVANT; SUBUNIT VACCINE; T LYMPHOCYTE RECEPTOR; TUMOR ANTIGEN;

EID: 85024864255     PISSN: 09527915     EISSN: 18790372     Source Type: Journal    
DOI: 10.1016/j.coi.2017.07.003     Document Type: Review
Times cited : (54)

References (50)
  • 1
    • 70349569569 scopus 로고    scopus 로고
    • Tumor antigen-specific CD8T cells infiltrating the tumor express high levels of PD-1 and are functionally impaired
    • This study showed that the majority of tumor-infiltrating T lymphocytes that express PD-1, are functionally impaired.
    • Ahmadzadeh, M., Johnson, L.A., Heemskerk, B., Wunderlich, J.R., Dudley, M.E., White, D.E., Rosenberg, S.A., Tumor antigen-specific CD8T cells infiltrating the tumor express high levels of PD-1 and are functionally impaired. Blood 114 (2009), 1537–1544 This study showed that the majority of tumor-infiltrating T lymphocytes that express PD-1, are functionally impaired.
    • (2009) Blood , vol.114 , pp. 1537-1544
    • Ahmadzadeh, M.1    Johnson, L.A.2    Heemskerk, B.3    Wunderlich, J.R.4    Dudley, M.E.5    White, D.E.6    Rosenberg, S.A.7
  • 2
    • 84980009912 scopus 로고    scopus 로고
    • Long-lasting complete responses in patients with metastatic melanoma after adoptive cell therapy with tumor-infiltrating lymphocytes and an attenuated IL2 regimen
    • This study demonstrated that adoptively transferred T lymphocytes effectively diminished tumor growth in humans.
    • Andersen, R., Donia, M., Ellebaek, E., Borch, T.H., Kongsted, P., Iversen, T.Z., Holmich, L.R., Hendel, H.W., Met, O., Andersen, M.H., et al. Long-lasting complete responses in patients with metastatic melanoma after adoptive cell therapy with tumor-infiltrating lymphocytes and an attenuated IL2 regimen. Clin Cancer Res 22 (2016), 3734–3745 This study demonstrated that adoptively transferred T lymphocytes effectively diminished tumor growth in humans.
    • (2016) Clin Cancer Res , vol.22 , pp. 3734-3745
    • Andersen, R.1    Donia, M.2    Ellebaek, E.3    Borch, T.H.4    Kongsted, P.5    Iversen, T.Z.6    Holmich, L.R.7    Hendel, H.W.8    Met, O.9    Andersen, M.H.10
  • 3
    • 84938547904 scopus 로고    scopus 로고
    • Checkpoint blockade for cancer therapy: revitalizing a suppressed immune system
    • Pico de Coaña, Y., Choudhury, A., Kiessling, R., Checkpoint blockade for cancer therapy: revitalizing a suppressed immune system. Trends Mol Med 21 (2015), 482–491.
    • (2015) Trends Mol Med , vol.21 , pp. 482-491
    • Pico de Coaña, Y.1    Choudhury, A.2    Kiessling, R.3
  • 6
    • 0014277270 scopus 로고
    • Tumor-specific transplantation antigens: G.H.A. Clowes memorial lecture
    • Classic work and accomplishments by one of the pioneers in tumor immunology vaccination.
    • Klein, G., Tumor-specific transplantation antigens: G.H.A. Clowes memorial lecture. Cancer Res 28 (1968), 625–635 Classic work and accomplishments by one of the pioneers in tumor immunology vaccination.
    • (1968) Cancer Res , vol.28 , pp. 625-635
    • Klein, G.1
  • 7
    • 0037427785 scopus 로고    scopus 로고
    • Apoptotic, but not necrotic, tumor cell vaccines induce a potent immune response in vivo
    • This paper describes how not all modes of tumor cell death are immunogenic.
    • Scheffer, S.R., Nave, H., Korangy, F., Schlote, K., Pabst, R., Jaffee, E.M., Manns, M.P., Greten, T.F., Apoptotic, but not necrotic, tumor cell vaccines induce a potent immune response in vivo. Int J Cancer 103 (2003), 205–211 This paper describes how not all modes of tumor cell death are immunogenic.
    • (2003) Int J Cancer , vol.103 , pp. 205-211
    • Scheffer, S.R.1    Nave, H.2    Korangy, F.3    Schlote, K.4    Pabst, R.5    Jaffee, E.M.6    Manns, M.P.7    Greten, T.F.8
  • 8
    • 0027538181 scopus 로고
    • Vaccination with irradiated tumor cells engineered to secrete murine granulocyte-macrophage colony-stimulating factor stimulates potent, specific, and long-lasting anti-tumor immunity
    • Preclinical data that resulted in the development of GVAX vaccines (Refs. [9–12]).
    • Dranoff, G., Jaffee, E., Lazenby, A., Golumbek, P., Levitsky, H., Brose, K., Jackson, V., Hamada, H., Pardoll, D., Mulligan, R.C., Vaccination with irradiated tumor cells engineered to secrete murine granulocyte-macrophage colony-stimulating factor stimulates potent, specific, and long-lasting anti-tumor immunity. Proc Natl Acad Sci U S A 90 (1993), 3539–3543 Preclinical data that resulted in the development of GVAX vaccines (Refs. [9–12]).
    • (1993) Proc Natl Acad Sci U S A , vol.90 , pp. 3539-3543
    • Dranoff, G.1    Jaffee, E.2    Lazenby, A.3    Golumbek, P.4    Levitsky, H.5    Brose, K.6    Jackson, V.7    Hamada, H.8    Pardoll, D.9    Mulligan, R.C.10
  • 9
    • 84857221683 scopus 로고    scopus 로고
    • A phase III trial of GVAX immunotherapy for prostate cancer in combination with docetaxel vs. docetaxel plus prednisone in symptomatic, castration-resistant prostate cancer (CRPC)
    • Small, E., Demkow, T., Gerritson, W., Rolland, R., Hoskin, P., Smith, D., Parker, C., Chondros, D., Ma, J., Hege, K., A phase III trial of GVAX immunotherapy for prostate cancer in combination with docetaxel vs. docetaxel plus prednisone in symptomatic, castration-resistant prostate cancer (CRPC). ASCO GU, 2009.
    • (2009) ASCO GU
    • Small, E.1    Demkow, T.2    Gerritson, W.3    Rolland, R.4    Hoskin, P.5    Smith, D.6    Parker, C.7    Chondros, D.8    Ma, J.9    Hege, K.10
  • 10
    • 79151482353 scopus 로고    scopus 로고
    • GM-CSF-secreting vaccines for solid tumors: moving forward
    • Gupta, R., Emens, L.A., GM-CSF-secreting vaccines for solid tumors: moving forward. Discov Med 10 (2010), 52–60.
    • (2010) Discov Med , vol.10 , pp. 52-60
    • Gupta, R.1    Emens, L.A.2
  • 11
    • 85024889298 scopus 로고    scopus 로고
    • A phase III trial of GVAX immunotherapy for prostate cancer vs. docetaxel plus prednisone in asymptomatic castration-resistant prostate cancer (CRPC)
    • Higano, C., Saad, F., Somer, B., Curti, B., Petrylak, D., Drake, C., Schnell, F., Redfern, D., Schrijvers, D., Sacks, N., A phase III trial of GVAX immunotherapy for prostate cancer vs. docetaxel plus prednisone in asymptomatic castration-resistant prostate cancer (CRPC). ASCO GU, 2009.
    • (2009) ASCO GU
    • Higano, C.1    Saad, F.2    Somer, B.3    Curti, B.4    Petrylak, D.5    Drake, C.6    Schnell, F.7    Redfern, D.8    Schrijvers, D.9    Sacks, N.10
  • 12
    • 0037441842 scopus 로고    scopus 로고
    • Vaccination with irradiated autologous tumor cells engineered to secrete granulocyte-macrophage colony-stimulating factor augments antitumor immunity in some patients with metastatic non-small-cell lung carcinoma
    • Salgia, R., Lynch, T., Skarin, A., Lucca, J., Lynch, C., Jung, K., Hodi, F.S., Jaklitsch, M., Mentzer, S., Swanson, S., et al. Vaccination with irradiated autologous tumor cells engineered to secrete granulocyte-macrophage colony-stimulating factor augments antitumor immunity in some patients with metastatic non-small-cell lung carcinoma. J Clin Oncol 21 (2003), 624–630.
    • (2003) J Clin Oncol , vol.21 , pp. 624-630
    • Salgia, R.1    Lynch, T.2    Skarin, A.3    Lucca, J.4    Lynch, C.5    Jung, K.6    Hodi, F.S.7    Jaklitsch, M.8    Mentzer, S.9    Swanson, S.10
  • 13
    • 84857725402 scopus 로고    scopus 로고
    • Exploiting the mutanome for tumor vaccination
    • This paper identified somatic point mutations in B16 mouse melanoma and showed induction of anti-tumor T cell responses after epitope vaccination.
    • Castle, J.C., Kreiter, S., Diekmann, J., Lower, M., van de Roemer, N., de Graaf, J., Selmi, A., Diken, M., Boegel, S., Paret, C., et al. Exploiting the mutanome for tumor vaccination. Cancer Res 72 (2012), 1081–1091 This paper identified somatic point mutations in B16 mouse melanoma and showed induction of anti-tumor T cell responses after epitope vaccination.
    • (2012) Cancer Res , vol.72 , pp. 1081-1091
    • Castle, J.C.1    Kreiter, S.2    Diekmann, J.3    Lower, M.4    van de Roemer, N.5    de Graaf, J.6    Selmi, A.7    Diken, M.8    Boegel, S.9    Paret, C.10
  • 14
    • 84857362309 scopus 로고    scopus 로고
    • NetMHCcons: a consensus method for the major histocompatibility complex class I predictions
    • Karosiene, E., Lundegaard, C., Lund, O., Nielsen, M., NetMHCcons: a consensus method for the major histocompatibility complex class I predictions. Immunogenetics 64 (2012), 177–186.
    • (2012) Immunogenetics , vol.64 , pp. 177-186
    • Karosiene, E.1    Lundegaard, C.2    Lund, O.3    Nielsen, M.4
  • 15
    • 85029445972 scopus 로고    scopus 로고
    • TepiTool: a pipeline for computational prediction of T cell epitope candidates
    • 18.19.11–18.19.24
    • Paul, S., Sidney, J., Sette, A., Peters, B., TepiTool: a pipeline for computational prediction of T cell epitope candidates. Curr Protoc Immunol, 114, 2016 18.19.11–18.19.24.
    • (2016) Curr Protoc Immunol , vol.114
    • Paul, S.1    Sidney, J.2    Sette, A.3    Peters, B.4
  • 16
    • 0023115557 scopus 로고
    • The relation between major histocompatibility complex (MHC) restriction and the capacity of Ia to bind immunogenic peptides
    • Buus, S., Sette, A., Colon, S.M., Miles, C., Grey, H.M., The relation between major histocompatibility complex (MHC) restriction and the capacity of Ia to bind immunogenic peptides. Science 235 (1987), 1353–1358.
    • (1987) Science , vol.235 , pp. 1353-1358
    • Buus, S.1    Sette, A.2    Colon, S.M.3    Miles, C.4    Grey, H.M.5
  • 17
    • 84920956731 scopus 로고    scopus 로고
    • Predicting immunogenic tumour mutations by combining mass spectrometry and exome sequencing
    • Very powerful approach to demonstrate the presence of mutated peptides bound to the tumor MHC molecules.
    • Yadav, M., Jhunjhunwala, S., Phung, Q.T., Lupardus, P., Tanguay, J., Bumbaca, S., Franci, C., Cheung, T.K., Fritsche, J., Weinschenk, T., et al. Predicting immunogenic tumour mutations by combining mass spectrometry and exome sequencing. Nature 515 (2014), 572–576 Very powerful approach to demonstrate the presence of mutated peptides bound to the tumor MHC molecules.
    • (2014) Nature , vol.515 , pp. 572-576
    • Yadav, M.1    Jhunjhunwala, S.2    Phung, Q.T.3    Lupardus, P.4    Tanguay, J.5    Bumbaca, S.6    Franci, C.7    Cheung, T.K.8    Fritsche, J.9    Weinschenk, T.10
  • 18
    • 0033556012 scopus 로고    scopus 로고
    • Identification of HLA-A3-restricted cytotoxic T lymphocyte epitopes from carcinoembryonic antigen and HER-2/neu by primary in vitro immunization with peptide-pulsed dendritic cells
    • Example of the predictive approach to identify and validate T cell epitopes for CTLs.
    • Kawashima, I., Tsai, V., Southwood, S., Takesako, K., Sette, A., Celis, E., Identification of HLA-A3-restricted cytotoxic T lymphocyte epitopes from carcinoembryonic antigen and HER-2/neu by primary in vitro immunization with peptide-pulsed dendritic cells. Cancer Res 59 (1999), 431–435 Example of the predictive approach to identify and validate T cell epitopes for CTLs.
    • (1999) Cancer Res , vol.59 , pp. 431-435
    • Kawashima, I.1    Tsai, V.2    Southwood, S.3    Takesako, K.4    Sette, A.5    Celis, E.6
  • 19
    • 44749086558 scopus 로고    scopus 로고
    • Peptide epitope identification for tumor-reactive CD4T cells
    • Review describing predictive approach for identifying HTL epitopes and correlates the presence of proximal or imbedded CTL epitopes.
    • Kobayashi, H., Celis, E., Peptide epitope identification for tumor-reactive CD4T cells. Curr Opin Immunol 20 (2008), 221–227 Review describing predictive approach for identifying HTL epitopes and correlates the presence of proximal or imbedded CTL epitopes.
    • (2008) Curr Opin Immunol , vol.20 , pp. 221-227
    • Kobayashi, H.1    Celis, E.2
  • 20
    • 71549172516 scopus 로고    scopus 로고
    • Optimized peptide vaccines eliciting extensive CD8 T-cell responses with therapeutic antitumor effects
    • Description of the TriVax approach to generate vast CTL responses using peptide, poly-IC and anti-CD40 antibodies.
    • Cho, H.I., Celis, E., Optimized peptide vaccines eliciting extensive CD8 T-cell responses with therapeutic antitumor effects. Cancer Res 69 (2009), 9012–9019 Description of the TriVax approach to generate vast CTL responses using peptide, poly-IC and anti-CD40 antibodies.
    • (2009) Cancer Res , vol.69 , pp. 9012-9019
    • Cho, H.I.1    Celis, E.2
  • 21
    • 85024842810 scopus 로고    scopus 로고
    • Optimization of peptide vaccines to induce robust antitumor CD4 T-cell responses
    • This study demonstrated that the combination of synthetic peptide, TLR7 ligand, CD40 agonist, and OX40 agonist elicits a huge number of antitumor CD4T lymphocytes with cytotoxic activity.
    • Kumai, T., Lee, S., Cho, H.I., Sultan, H., Kobayashi, H., Harabuchi, Y., Celis, E., Optimization of peptide vaccines to induce robust antitumor CD4 T-cell responses. Cancer Immunol Res, 2016 This study demonstrated that the combination of synthetic peptide, TLR7 ligand, CD40 agonist, and OX40 agonist elicits a huge number of antitumor CD4T lymphocytes with cytotoxic activity.
    • (2016) Cancer Immunol Res
    • Kumai, T.1    Lee, S.2    Cho, H.I.3    Sultan, H.4    Kobayashi, H.5    Harabuchi, Y.6    Celis, E.7
  • 23
    • 0037544148 scopus 로고    scopus 로고
    • Signal 3 determines tolerance versus full activation of naive CD8T cells: dissociating proliferation and development of effector function
    • Curtsinger, J.M., Lins, D.C., Mescher, M.F., Signal 3 determines tolerance versus full activation of naive CD8T cells: dissociating proliferation and development of effector function. J Exp Med 197 (2003), 1141–1151.
    • (2003) J Exp Med , vol.197 , pp. 1141-1151
    • Curtsinger, J.M.1    Lins, D.C.2    Mescher, M.F.3
  • 24
    • 77951877953 scopus 로고    scopus 로고
    • Identification and functions of pattern-recognition receptors
    • Kumagai, Y., Akira, S., Identification and functions of pattern-recognition receptors. J Allergy Clin Immunol 125 (2010), 985–992.
    • (2010) J Allergy Clin Immunol , vol.125 , pp. 985-992
    • Kumagai, Y.1    Akira, S.2
  • 25
    • 0032482474 scopus 로고    scopus 로고
    • T-cell help for cytotoxic T lymphocytes is mediated by CD40-CD40L interactions
    • Classic paper demonstrating the importance of CD40 ligation in the generation of effective CTL responses.
    • Schoenberger, S.P., Toes, R.E., van der Voort, E.I., Offringa, R., Melief, C.J., T-cell help for cytotoxic T lymphocytes is mediated by CD40-CD40L interactions. Nature 393 (1998), 480–483 Classic paper demonstrating the importance of CD40 ligation in the generation of effective CTL responses.
    • (1998) Nature , vol.393 , pp. 480-483
    • Schoenberger, S.P.1    Toes, R.E.2    van der Voort, E.I.3    Offringa, R.4    Melief, C.J.5
  • 26
    • 1642362512 scopus 로고    scopus 로고
    • Combined TLR and CD40 triggering induces potent CD8+ T cell expansion with variable dependence on type I IFN
    • First report of a peptide vaccine producing a substantial T cell response by combining the antigen with TLR ligand and anti-CD40 antibodies.
    • Ahonen, C.L., Doxsee, C.L., McGurran, S.M., Riter, T.R., Wade, W.F., Barth, R.J., Vasilakos, J.P., Noelle, R.J., Kedl, R.M., Combined TLR and CD40 triggering induces potent CD8+ T cell expansion with variable dependence on type I IFN. J Exp Med 199 (2004), 775–784 First report of a peptide vaccine producing a substantial T cell response by combining the antigen with TLR ligand and anti-CD40 antibodies.
    • (2004) J Exp Med , vol.199 , pp. 775-784
    • Ahonen, C.L.1    Doxsee, C.L.2    McGurran, S.M.3    Riter, T.R.4    Wade, W.F.5    Barth, R.J.6    Vasilakos, J.P.7    Noelle, R.J.8    Kedl, R.M.9
  • 27
    • 18344362061 scopus 로고    scopus 로고
    • Type I IFNs provide a third signal to CD8T cells to stimulate clonal expansion and differentiation
    • Curtsinger, J.M., Valenzuela, J.O., Agarwal, P., Lins, D., Mescher, M.F., Type I IFNs provide a third signal to CD8T cells to stimulate clonal expansion and differentiation. J Immunol 174 (2005), 4465–4469.
    • (2005) J Immunol , vol.174 , pp. 4465-4469
    • Curtsinger, J.M.1    Valenzuela, J.O.2    Agarwal, P.3    Lins, D.4    Mescher, M.F.5
  • 28
    • 77954939630 scopus 로고    scopus 로고
    • Type I interferons regulate cytolytic activity of memory CD8(+) T cells in the lung airways during respiratory virus challenge
    • Kohlmeier, J.E., Cookenham, T., Roberts, A.D., Miller, S.C., Woodland, D.L., Type I interferons regulate cytolytic activity of memory CD8(+) T cells in the lung airways during respiratory virus challenge. Immunity 33 (2010), 96–105.
    • (2010) Immunity , vol.33 , pp. 96-105
    • Kohlmeier, J.E.1    Cookenham, T.2    Roberts, A.D.3    Miller, S.C.4    Woodland, D.L.5
  • 29
    • 4644324025 scopus 로고    scopus 로고
    • Cancer immunotherapy: moving beyond current vaccines
    • This controversial paper discusses and questions whether cancer vaccines will work against established tumors.
    • Rosenberg, S.A., Yang, J.C., Restifo, N.P., Cancer immunotherapy: moving beyond current vaccines. Nat Med 10 (2004), 909–915 This controversial paper discusses and questions whether cancer vaccines will work against established tumors.
    • (2004) Nat Med , vol.10 , pp. 909-915
    • Rosenberg, S.A.1    Yang, J.C.2    Restifo, N.P.3
  • 31
    • 84962326872 scopus 로고    scopus 로고
    • Vaccination with LAG-3Ig (IMP321) and peptides induces specific CD4 and CD8 T-cell responses in metastatic melanoma patients – report of a phase I/IIa clinical trial
    • Legat, A., Maby-El Hajjami, H., Baumgaertner, P., Cagnon, L., Abed Maillard, S., Geldhof, C., Iancu, E.M., Lebon, L., Guillaume, P., Dojcinovic, D., et al. Vaccination with LAG-3Ig (IMP321) and peptides induces specific CD4 and CD8 T-cell responses in metastatic melanoma patients – report of a phase I/IIa clinical trial. Clin Cancer Res 22 (2016), 1330–1340.
    • (2016) Clin Cancer Res , vol.22 , pp. 1330-1340
    • Legat, A.1    Maby-El Hajjami, H.2    Baumgaertner, P.3    Cagnon, L.4    Abed Maillard, S.5    Geldhof, C.6    Iancu, E.M.7    Lebon, L.8    Guillaume, P.9    Dojcinovic, D.10
  • 32
    • 84865748503 scopus 로고    scopus 로고
    • TriVax-HPV: an improved peptide-based therapeutic vaccination strategy against human papillomavirus-induced cancers
    • Barrios, K., Celis, E., TriVax-HPV: an improved peptide-based therapeutic vaccination strategy against human papillomavirus-induced cancers. Cancer Immunol Immunother 61 (2012), 1307–1317.
    • (2012) Cancer Immunol Immunother , vol.61 , pp. 1307-1317
    • Barrios, K.1    Celis, E.2
  • 33
    • 84877825063 scopus 로고    scopus 로고
    • BiVax: a peptide/poly-IC subunit vaccine that mimics an acute infection elicits vast and effective anti-tumor CD8 T-cell responses
    • In this paper we showed that poly-IC is a unique adjuvant for peptide vaccines because it stimulates both TLR3 and MDA5.
    • Cho, H.I., Barrios, K., Lee, Y.R., Linowski, A.K., Celis, E., BiVax: a peptide/poly-IC subunit vaccine that mimics an acute infection elicits vast and effective anti-tumor CD8 T-cell responses. Cancer Immunol Immunother 62 (2013), 787–799 In this paper we showed that poly-IC is a unique adjuvant for peptide vaccines because it stimulates both TLR3 and MDA5.
    • (2013) Cancer Immunol Immunother , vol.62 , pp. 787-799
    • Cho, H.I.1    Barrios, K.2    Lee, Y.R.3    Linowski, A.K.4    Celis, E.5
  • 34
    • 39149107423 scopus 로고    scopus 로고
    • MDA5/RIG-I and virus recognition
    • Takeuchi, O., Akira, S., MDA5/RIG-I and virus recognition. Curr Opin Immunol 20 (2008), 17–22.
    • (2008) Curr Opin Immunol , vol.20 , pp. 17-22
    • Takeuchi, O.1    Akira, S.2
  • 35
    • 38449106129 scopus 로고    scopus 로고
    • CD8+ CTL priming by exact peptide epitopes in incomplete Freund's adjuvant induces a vanishing CTL response, whereas long peptides induce sustained CTL reactivity
    • These authors are proponents of using elongated peptides and avoiding minimal peptide epitopes in vaccines.
    • Bijker, M.S., van den Eeden, S.J., Franken, K.L., Melief, C.J., Offringa, R., van der Burg, S.H., CD8+ CTL priming by exact peptide epitopes in incomplete Freund's adjuvant induces a vanishing CTL response, whereas long peptides induce sustained CTL reactivity. J Immunol 179 (2007), 5033–5040 These authors are proponents of using elongated peptides and avoiding minimal peptide epitopes in vaccines.
    • (2007) J Immunol , vol.179 , pp. 5033-5040
    • Bijker, M.S.1    van den Eeden, S.J.2    Franken, K.L.3    Melief, C.J.4    Offringa, R.5    van der Burg, S.H.6
  • 37
    • 0033587720 scopus 로고    scopus 로고
    • CD4(+) T cells eliminate MHC class II-negative cancer cells in vivo by indirect effects of IFN-gamma
    • Interesting and important report showing that HTL recognition of antigen in tumor-infiltrating stromal cells can lead to anti-tumor effects.
    • Mumberg, D., Monach, P.A., Wanderling, S., Philip, M., Toledano, A.Y., Schreiber, R.D., Schreiber, H., CD4(+) T cells eliminate MHC class II-negative cancer cells in vivo by indirect effects of IFN-gamma. Proc Natl Acad Sci U S A 96 (1999), 8633–8638 Interesting and important report showing that HTL recognition of antigen in tumor-infiltrating stromal cells can lead to anti-tumor effects.
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 8633-8638
    • Mumberg, D.1    Monach, P.A.2    Wanderling, S.3    Philip, M.4    Toledano, A.Y.5    Schreiber, R.D.6    Schreiber, H.7
  • 38
    • 0037496082 scopus 로고    scopus 로고
    • Melacine: an allogeneic melanoma tumor cell lysate vaccine
    • Sosman, J.A., Sondak, V.K., Melacine: an allogeneic melanoma tumor cell lysate vaccine. Expert Rev Vaccines 2 (2003), 353–368.
    • (2003) Expert Rev Vaccines , vol.2 , pp. 353-368
    • Sosman, J.A.1    Sondak, V.K.2
  • 39
    • 70349772954 scopus 로고    scopus 로고
    • Allogeneic GM-CSF-secreting tumor cell immunotherapies generate potent anti-tumor responses comparable to autologous tumor cell immunotherapies
    • Li, B., Simmons, A., Du, T., Lin, C., Moskalenko, M., Gonzalez-Edick, M., VanRoey, M., Jooss, K., Allogeneic GM-CSF-secreting tumor cell immunotherapies generate potent anti-tumor responses comparable to autologous tumor cell immunotherapies. Clin Immunol 133 (2009), 184–197.
    • (2009) Clin Immunol , vol.133 , pp. 184-197
    • Li, B.1    Simmons, A.2    Du, T.3    Lin, C.4    Moskalenko, M.5    Gonzalez-Edick, M.6    VanRoey, M.7    Jooss, K.8
  • 40
    • 68049111686 scopus 로고    scopus 로고
    • Targeted delivery of tumor antigens to activated dendritic cells via CD11c molecules induces potent antitumor immunity in mice
    • Wei, H., Wang, S., Zhang, D., Hou, S., Qian, W., Li, B., Guo, H., Kou, G., He, J., Wang, H., et al. Targeted delivery of tumor antigens to activated dendritic cells via CD11c molecules induces potent antitumor immunity in mice. Clin Cancer Res 15 (2009), 4612–4621.
    • (2009) Clin Cancer Res , vol.15 , pp. 4612-4621
    • Wei, H.1    Wang, S.2    Zhang, D.3    Hou, S.4    Qian, W.5    Li, B.6    Guo, H.7    Kou, G.8    He, J.9    Wang, H.10
  • 41
    • 70349286016 scopus 로고    scopus 로고
    • E1B-55kD-deleted oncolytic adenovirus armed with canstatin gene yields an enhanced anti-tumor efficacy on pancreatic cancer
    • He, X.P., Su, C.Q., Wang, X.H., Pan, X., Tu, Z.X., Gong, Y.F., Gao, J., Liao, Z., Jin, J., Wu, H.Y., et al. E1B-55kD-deleted oncolytic adenovirus armed with canstatin gene yields an enhanced anti-tumor efficacy on pancreatic cancer. Cancer Lett 285 (2009), 89–98.
    • (2009) Cancer Lett , vol.285 , pp. 89-98
    • He, X.P.1    Su, C.Q.2    Wang, X.H.3    Pan, X.4    Tu, Z.X.5    Gong, Y.F.6    Gao, J.7    Liao, Z.8    Jin, J.9    Wu, H.Y.10
  • 44
    • 0027959410 scopus 로고
    • Delivery of a viral antigen to the class I processing and presentation pathway by Listeria monocytogenes
    • Ikonomidis, G., Paterson, Y., Kos, F.J., Portnoy, D.A., Delivery of a viral antigen to the class I processing and presentation pathway by Listeria monocytogenes. J Exp Med 180 (1994), 2209–2218.
    • (1994) J Exp Med , vol.180 , pp. 2209-2218
    • Ikonomidis, G.1    Paterson, Y.2    Kos, F.J.3    Portnoy, D.A.4
  • 45
    • 42949106143 scopus 로고    scopus 로고
    • Intravaginal immunization of mice with recombinant Salmonella enterica serovar Typhimurium expressing human papillomavirus type 16 antigens as a potential route of vaccination against cervical cancer
    • Echchannaoui, H., Bianchi, M., Baud, D., Bobst, M., Stehle, J.C., Nardelli-Haefliger, D., Intravaginal immunization of mice with recombinant Salmonella enterica serovar Typhimurium expressing human papillomavirus type 16 antigens as a potential route of vaccination against cervical cancer. Infect Immun 76 (2008), 1940–1951.
    • (2008) Infect Immun , vol.76 , pp. 1940-1951
    • Echchannaoui, H.1    Bianchi, M.2    Baud, D.3    Bobst, M.4    Stehle, J.C.5    Nardelli-Haefliger, D.6
  • 46
    • 84930646474 scopus 로고    scopus 로고
    • Efficient delivery of antigen to DCs using yeast-derived microparticles
    • Pan, Y., Li, X., Kang, T., Meng, H., Chen, Z., Yang, L., Wu, Y., Wei, Y., Gou, M., Efficient delivery of antigen to DCs using yeast-derived microparticles. Sci Rep, 5, 2015, 10687.
    • (2015) Sci Rep , vol.5 , pp. 10687
    • Pan, Y.1    Li, X.2    Kang, T.3    Meng, H.4    Chen, Z.5    Yang, L.6    Wu, Y.7    Wei, Y.8    Gou, M.9
  • 47
    • 0032878254 scopus 로고    scopus 로고
    • A phase I trial of an HLA-A1 restricted MAGE-3 epitope peptide with incomplete Freund's adjuvant in patients with resected high-risk melanoma
    • Weber, J.S., Hua, F.L., Spears, L., Marty, V., Kuniyoshi, C., Celis, E., A phase I trial of an HLA-A1 restricted MAGE-3 epitope peptide with incomplete Freund's adjuvant in patients with resected high-risk melanoma. J Immunother 22 (1999), 431–440.
    • (1999) J Immunother , vol.22 , pp. 431-440
    • Weber, J.S.1    Hua, F.L.2    Spears, L.3    Marty, V.4    Kuniyoshi, C.5    Celis, E.6
  • 48
    • 84947869406 scopus 로고    scopus 로고
    • Safety, efficacy, and immunogenicity of VGX-3100, a therapeutic synthetic DNA vaccine targeting human papillomavirus 16 and 18 E6 and E7 proteins for cervical intraepithelial neoplasia 2/3: a randomised, double-blind, placebo-controlled phase 2b trial
    • Trimble, C.L., Morrow, M.P., Kraynyak, K.A., Shen, X., Dallas, M., Yan, J., Edwards, L., Parker, R.L., Denny, L., Giffear, M., et al. Safety, efficacy, and immunogenicity of VGX-3100, a therapeutic synthetic DNA vaccine targeting human papillomavirus 16 and 18 E6 and E7 proteins for cervical intraepithelial neoplasia 2/3: a randomised, double-blind, placebo-controlled phase 2b trial. Lancet 386 (2015), 2078–2088.
    • (2015) Lancet , vol.386 , pp. 2078-2088
    • Trimble, C.L.1    Morrow, M.P.2    Kraynyak, K.A.3    Shen, X.4    Dallas, M.5    Yan, J.6    Edwards, L.7    Parker, R.L.8    Denny, L.9    Giffear, M.10
  • 49
    • 84908060936 scopus 로고    scopus 로고
    • Phase Ib study evaluating a self-adjuvanted mRNA cancer vaccine (RNActive(R)) combined with local radiation as consolidation and maintenance treatment for patients with stage IV non-small cell lung cancer
    • Sebastian, M., Papachristofilou, A., Weiss, C., Fruh, M., Cathomas, R., Hilbe, W., Wehler, T., Rippin, G., Koch, S.D., Scheel, B., et al. Phase Ib study evaluating a self-adjuvanted mRNA cancer vaccine (RNActive(R)) combined with local radiation as consolidation and maintenance treatment for patients with stage IV non-small cell lung cancer. BMC Cancer, 14, 2014, 748.
    • (2014) BMC Cancer , vol.14 , pp. 748
    • Sebastian, M.1    Papachristofilou, A.2    Weiss, C.3    Fruh, M.4    Cathomas, R.5    Hilbe, W.6    Wehler, T.7    Rippin, G.8    Koch, S.D.9    Scheel, B.10
  • 50
    • 84966714463 scopus 로고    scopus 로고
    • Heat shock protein-peptide and HSP-based immunotherapies for the treatment of cancer
    • Shevtsov, M., Multhoff, G., Heat shock protein-peptide and HSP-based immunotherapies for the treatment of cancer. Front Immunol, 7, 2016, 171.
    • (2016) Front Immunol , vol.7 , pp. 171
    • Shevtsov, M.1    Multhoff, G.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.