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Odunsi K., Qian F., Matsuzaki J., Mhawech-Fauceglia P., Andrews C., Hoffman E.W., Pan L., Ritter G., Villella J., Thomas B., et al. Vaccination with an NY-ESO-1 peptide of HLA class I/II specificities induces integrated humoral and T cell responses in ovarian cancer. Proc Natl Acad Sci U S A 104 (2007) 12837-12842. The authors describe a clinical trial in ovarian cancer using a peptide from the TAA NY-ESO-1 containing a CD4 and 2 CD8 T cell epitopes. T cell clones (CD4 and CD8) from vaccinated patients were able to recognize NY-ESO-1 expressing tumor cells.
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This paper demonstrates that vaccines using long synthetic peptides induce far superior immune responses than vaccines composed of the minimal CD8 T cell epitopes. The authors hypothesize that long peptides can only be presented by professional APCs, while the short, minimal epitopes may be presented by non-professional APCs, resulting in T cell anergy.
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Bijker M.S., van den Eeden S.J., Franken K.L., Melief C.J., Offringa R., and van der Burg S.H. CD8+ CTL priming by exact peptide epitopes in incomplete Freund's adjuvant induces a vanishing CTL response, whereas long peptides induce sustained CTL reactivity. J Immunol 179 (2007) 5033-5040. This paper demonstrates that vaccines using long synthetic peptides induce far superior immune responses than vaccines composed of the minimal CD8 T cell epitopes. The authors hypothesize that long peptides can only be presented by professional APCs, while the short, minimal epitopes may be presented by non-professional APCs, resulting in T cell anergy.
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This reports shows remarkable anti-tumor effects of vaccination with the STEAP antigen against prostate tumors using a mouse model system, where both CD4 and CD8 T cells play a critical role.
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Garcia-Hernandez M.d.L., Gray A., Hubby B., and Kast W.M. In vivo effects of vaccination with six-transmembrane epithelial antigen of the prostate: a candidate antigen for treating prostate cancer. Cancer Res 67 (2007) 1344-1351. This reports shows remarkable anti-tumor effects of vaccination with the STEAP antigen against prostate tumors using a mouse model system, where both CD4 and CD8 T cells play a critical role.
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Melanoma Study Group of the Mayo Clinic Cancer Center. This paper describes the first clinical study using a synthetic peptide vaccine containing a naturally occurring combination of a CD4 T cell epitope and a CD8 T cell epitope.
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Melanoma Study Group of the Mayo Clinic Cancer Center, and Celis E. Overlapping human leukocyte antigen class I/II binding peptide vaccine for the treatment of patients with stage IV melanoma: evidence of systemic immune dysfunction. Cancer 110 (2007) 203-214. This paper describes the first clinical study using a synthetic peptide vaccine containing a naturally occurring combination of a CD4 T cell epitope and a CD8 T cell epitope.
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