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Volumn 20, Issue 2, 2008, Pages 221-227

Peptide epitope identification for tumor-reactive CD4 T cells

Author keywords

[No Author keywords available]

Indexed keywords

EPITOPE; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; PEPTIDE DERIVATIVE; TUMOR ANTIGEN;

EID: 44749086558     PISSN: 09527915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.coi.2008.04.011     Document Type: Review
Times cited : (42)

References (55)
  • 3
    • 2342551970 scopus 로고    scopus 로고
    • Towards a cellular definition of CD8+ T-cell memory: the role of CD4+ T-cell help in CD8+ T-cell responses
    • Rocha B., and Tanchot C. Towards a cellular definition of CD8+ T-cell memory: the role of CD4+ T-cell help in CD8+ T-cell responses. Curr Opin Immunol 16 (2004) 259-263
    • (2004) Curr Opin Immunol , vol.16 , pp. 259-263
    • Rocha, B.1    Tanchot, C.2
  • 5
    • 0037144612 scopus 로고    scopus 로고
    • A role for CD40 expression on CD8+ T cells in the generation of CD8+ T cell memory
    • Bourgeois C., Rocha B., and Tanchot C. A role for CD40 expression on CD8+ T cells in the generation of CD8+ T cell memory. Science 297 (2002) 2060-2063
    • (2002) Science , vol.297 , pp. 2060-2063
    • Bourgeois, C.1    Rocha, B.2    Tanchot, C.3
  • 7
    • 0036301486 scopus 로고    scopus 로고
    • Direct costimulation of tumor-reactive CTL by helper T cells potentiate their proliferation, survival, and effector function
    • Giuntoli II R.L., Lu J., Kobayashi H., Kennedy R., and Celis E. Direct costimulation of tumor-reactive CTL by helper T cells potentiate their proliferation, survival, and effector function. Clin Cancer Res 8 (2002) 922-931
    • (2002) Clin Cancer Res , vol.8 , pp. 922-931
    • Giuntoli II, R.L.1    Lu, J.2    Kobayashi, H.3    Kennedy, R.4    Celis, E.5
  • 8
    • 15444374364 scopus 로고    scopus 로고
    • Direct cross-priming by Th lymphocytes generates memory cytotoxic T cell responses
    • Kennedy R., Undale A.H., Kieper W.C., Block M.S., Pease L.R., and Celis E. Direct cross-priming by Th lymphocytes generates memory cytotoxic T cell responses. J Immunol 174 (2005) 3967-3977
    • (2005) J Immunol , vol.174 , pp. 3967-3977
    • Kennedy, R.1    Undale, A.H.2    Kieper, W.C.3    Block, M.S.4    Pease, L.R.5    Celis, E.6
  • 9
    • 33747772051 scopus 로고    scopus 로고
    • T helper lymphocytes rescue CTL from activation-induced cell death
    • This paper provides direct evidence that CD4 T cells can prevent apoptosis induced by activation in CD8 T cells acting as 'true helper lymphocytes' and allowing the survival and persistence of memory T cells. Interestingly, rescue from apoptosis required direct interaction between CD4 and CD8 T cells and appeared to be mediated through costimulatory molecules.
    • Kennedy R., and Celis E. T helper lymphocytes rescue CTL from activation-induced cell death. J Immunol 177 (2006) 2862-2872. This paper provides direct evidence that CD4 T cells can prevent apoptosis induced by activation in CD8 T cells acting as 'true helper lymphocytes' and allowing the survival and persistence of memory T cells. Interestingly, rescue from apoptosis required direct interaction between CD4 and CD8 T cells and appeared to be mediated through costimulatory molecules.
    • (2006) J Immunol , vol.177 , pp. 2862-2872
    • Kennedy, R.1    Celis, E.2
  • 10
    • 0028990666 scopus 로고
    • Mechanism and biological significance of CD4-mediated cytotoxicity
    • Hahn S., Gehri R., and Erb P. Mechanism and biological significance of CD4-mediated cytotoxicity. Immunol Rev 146 (1995) 57-79
    • (1995) Immunol Rev , vol.146 , pp. 57-79
    • Hahn, S.1    Gehri, R.2    Erb, P.3
  • 11
    • 40749108604 scopus 로고    scopus 로고
    • EBV latent membrane proteins (LMPs) 1 and 2 as immunotherapeutic targets: LMP-specific CD4+ cytotoxic T cell recognition of EBV-transformed B cell lines
    • Haigh T.A., Lin X., Jia H., Hui E.P., Chan A.T., Rickinson A.B., and Taylor G.S. EBV latent membrane proteins (LMPs) 1 and 2 as immunotherapeutic targets: LMP-specific CD4+ cytotoxic T cell recognition of EBV-transformed B cell lines. J Immunol 180 (2008) 1643-1654
    • (2008) J Immunol , vol.180 , pp. 1643-1654
    • Haigh, T.A.1    Lin, X.2    Jia, H.3    Hui, E.P.4    Chan, A.T.5    Rickinson, A.B.6    Taylor, G.S.7
  • 15
    • 12944325331 scopus 로고    scopus 로고
    • A listing of human tumor antigens recognized by T cells: March 2004 update
    • Novellino L., Castelli C., and Parmiani G. A listing of human tumor antigens recognized by T cells: March 2004 update. Cancer Immunol Immunother 54 (2005) 187-207
    • (2005) Cancer Immunol Immunother , vol.54 , pp. 187-207
    • Novellino, L.1    Castelli, C.2    Parmiani, G.3
  • 16
    • 0033591429 scopus 로고    scopus 로고
    • Cloning genes encoding MHC class II-restricted antigens: mutated CDC27 as a tumor antigen
    • Wang R.F., Wang X., Atwood A.C., Topalian S.L., and Rosenberg S.A. Cloning genes encoding MHC class II-restricted antigens: mutated CDC27 as a tumor antigen. Science 284 (1999) 1351-1354
    • (1999) Science , vol.284 , pp. 1351-1354
    • Wang, R.F.1    Wang, X.2    Atwood, A.C.3    Topalian, S.L.4    Rosenberg, S.A.5
  • 18
    • 2642683198 scopus 로고    scopus 로고
    • Simultaneous humoral and cellular immune response against cancer-testis antigen NY-ESO-1: definition of human histocompatibility leukocyte antigen (HLA)-A2-binding peptide epitopes
    • Jager E., Chen Y.T., Drijfhout J.W., Karbach J., Ringhoffer M., Jager D., Arand M., Wada H., Noguchi Y., Stockert E., et al. Simultaneous humoral and cellular immune response against cancer-testis antigen NY-ESO-1: definition of human histocompatibility leukocyte antigen (HLA)-A2-binding peptide epitopes. J Exp Med 187 (1998) 265-270
    • (1998) J Exp Med , vol.187 , pp. 265-270
    • Jager, E.1    Chen, Y.T.2    Drijfhout, J.W.3    Karbach, J.4    Ringhoffer, M.5    Jager, D.6    Arand, M.7    Wada, H.8    Noguchi, Y.9    Stockert, E.10
  • 20
    • 0034665130 scopus 로고    scopus 로고
    • Defining promiscuous MHC class II helper T-cell epitopes for the HER2/neu tumor antigen
    • Kobayashi H., Wood M., Song Y., Appella E., and Celis E. Defining promiscuous MHC class II helper T-cell epitopes for the HER2/neu tumor antigen. Cancer Res 60 (2000) 5228-5236
    • (2000) Cancer Res , vol.60 , pp. 5228-5236
    • Kobayashi, H.1    Wood, M.2    Song, Y.3    Appella, E.4    Celis, E.5
  • 21
    • 0037103364 scopus 로고    scopus 로고
    • Inhibition of EBV-induced lymphoproliferation by CD4(+) T cells specific for an MHC class II promiscuous epitope
    • Omiya R., Buteau C., Kobayashi H., Paya C.V., and Celis E. Inhibition of EBV-induced lymphoproliferation by CD4(+) T cells specific for an MHC class II promiscuous epitope. J Immunol 169 (2002) 2172-2179
    • (2002) J Immunol , vol.169 , pp. 2172-2179
    • Omiya, R.1    Buteau, C.2    Kobayashi, H.3    Paya, C.V.4    Celis, E.5
  • 22
    • 38849166751 scopus 로고    scopus 로고
    • Induction of EBV-latent membrane protein 1-specific MHC class II-restricted T-cell responses against natural killer lymphoma cells
    • Kobayashi H., Nagato T., Takahara M., Sato K., Kimura S., Aoki N., Azumi M., Tateno M., Harabuchi Y., and Celis E. Induction of EBV-latent membrane protein 1-specific MHC class II-restricted T-cell responses against natural killer lymphoma cells. Cancer Res 68 (2008) 901-908
    • (2008) Cancer Res , vol.68 , pp. 901-908
    • Kobayashi, H.1    Nagato, T.2    Takahara, M.3    Sato, K.4    Kimura, S.5    Aoki, N.6    Azumi, M.7    Tateno, M.8    Harabuchi, Y.9    Celis, E.10
  • 23
    • 6044233329 scopus 로고    scopus 로고
    • Recognition of adult T-cell leukemia/lymphoma cells by CD4+ helper T lymphocytes specific for human T-cell leukemia virus type I envelope protein
    • Kobayashi H., Nagato T., Yanai M., Oikawa K., Sato K., Kimura S., Tateno M., Omiya R., and Celis E. Recognition of adult T-cell leukemia/lymphoma cells by CD4+ helper T lymphocytes specific for human T-cell leukemia virus type I envelope protein. Clin Cancer Res 10 (2004) 7053-7062
    • (2004) Clin Cancer Res , vol.10 , pp. 7053-7062
    • Kobayashi, H.1    Nagato, T.2    Yanai, M.3    Oikawa, K.4    Sato, K.5    Kimura, S.6    Tateno, M.7    Omiya, R.8    Celis, E.9
  • 24
    • 33745697739 scopus 로고    scopus 로고
    • In vitro peptide immunization of target tax protein human T-cell leukemia virus type 1-specific CD4+ helper T lymphocytes
    • This paper describes 2 novel CD4 T cell epitopes from HTLV-I tax protein that lie proximal to CD8 T cell epitopes Notably, CD4 T cell clones specific for these epitopes could directly recognize HTLV-I tax-expressing T cell lymphoma lines.
    • Kobayashi H., Ngato T., Sato K., Aoki N., Kimura S., Tanaka Y., Aizawa H., Tateno M., and Celis E. In vitro peptide immunization of target tax protein human T-cell leukemia virus type 1-specific CD4+ helper T lymphocytes. Clin Cancer Res 12 (2006) 3814-3822. This paper describes 2 novel CD4 T cell epitopes from HTLV-I tax protein that lie proximal to CD8 T cell epitopes Notably, CD4 T cell clones specific for these epitopes could directly recognize HTLV-I tax-expressing T cell lymphoma lines.
    • (2006) Clin Cancer Res , vol.12 , pp. 3814-3822
    • Kobayashi, H.1    Ngato, T.2    Sato, K.3    Aoki, N.4    Kimura, S.5    Tanaka, Y.6    Aizawa, H.7    Tateno, M.8    Celis, E.9
  • 25
    • 0035887163 scopus 로고    scopus 로고
    • Identification of helper T-cell epitopes that encompass or lie proximal to cytotoxic T-cell epitopes in the gp100 melanoma tumor antigen
    • Kobayashi H., Lu J., and Celis E. Identification of helper T-cell epitopes that encompass or lie proximal to cytotoxic T-cell epitopes in the gp100 melanoma tumor antigen. Cancer Res 61 (2001) 7577-7584
    • (2001) Cancer Res , vol.61 , pp. 7577-7584
    • Kobayashi, H.1    Lu, J.2    Celis, E.3
  • 26
    • 0035874608 scopus 로고    scopus 로고
    • Tumor-reactive T helper lymphocytes recognize a promiscuous MAGE-A3 epitope presented by various major histocompatibility complex class II alleles
    • Kobayashi H., Song Y., Hoon D.S., Appella E., and Celis E. Tumor-reactive T helper lymphocytes recognize a promiscuous MAGE-A3 epitope presented by various major histocompatibility complex class II alleles. Cancer Res 61 (2001) 4773-4778
    • (2001) Cancer Res , vol.61 , pp. 4773-4778
    • Kobayashi, H.1    Song, Y.2    Hoon, D.S.3    Appella, E.4    Celis, E.5
  • 28
    • 10744224291 scopus 로고    scopus 로고
    • Identification of naturally processed helper T-cell epitopes from prostate-specific membrane antigen using peptide-based in vitro stimulation
    • Kobayashi H., Omiya R., Sodey B., Yanai M., Oikawa K., Sato K., Kimura S., Senju S., Nishimura Y., Tateno M., et al. Identification of naturally processed helper T-cell epitopes from prostate-specific membrane antigen using peptide-based in vitro stimulation. Clin Cancer Res 9 (2003) 5386-5393
    • (2003) Clin Cancer Res , vol.9 , pp. 5386-5393
    • Kobayashi, H.1    Omiya, R.2    Sodey, B.3    Yanai, M.4    Oikawa, K.5    Sato, K.6    Kimura, S.7    Senju, S.8    Nishimura, Y.9    Tateno, M.10
  • 30
    • 18844388681 scopus 로고    scopus 로고
    • Recognition of prostate and breast tumor cells by helper T lymphocytes specific for a prostate and breast tumor-associated antigen, TARP
    • Kobayashi H., Nagato T., Oikawa K., Sato K., Kimura S., Aoki N., Omiya R., Tateno M., and Celis E. Recognition of prostate and breast tumor cells by helper T lymphocytes specific for a prostate and breast tumor-associated antigen, TARP. Clin Cancer Res 11 (2005) 3869-3878
    • (2005) Clin Cancer Res , vol.11 , pp. 3869-3878
    • Kobayashi, H.1    Nagato, T.2    Oikawa, K.3    Sato, K.4    Kimura, S.5    Aoki, N.6    Omiya, R.7    Tateno, M.8    Celis, E.9
  • 33
    • 0028179993 scopus 로고
    • Circulating anti-Tax cytotoxic T lymphocytes from human T-cell leukemia virus type I-infected people, with and without tropical spastic paraparesis, recognize multiple epitopes simultaneously
    • Parker C.E., Nightingale S., Taylor G.P., Weber J., and Bangham C.R. Circulating anti-Tax cytotoxic T lymphocytes from human T-cell leukemia virus type I-infected people, with and without tropical spastic paraparesis, recognize multiple epitopes simultaneously. J Virol 68 (1994) 2860-2868
    • (1994) J Virol , vol.68 , pp. 2860-2868
    • Parker, C.E.1    Nightingale, S.2    Taylor, G.P.3    Weber, J.4    Bangham, C.R.5
  • 34
    • 0031568658 scopus 로고    scopus 로고
    • Identification of subdominant CTL epitopes of the GP100 melanoma-associated tumor antigen by primary in vitro immunization with peptide-pulsed dendritic cells
    • Tsai V., Southwood S., Sidney J., Sakaguchi K., Kawakami Y., Appella E., Sette A., and Celis E. Identification of subdominant CTL epitopes of the GP100 melanoma-associated tumor antigen by primary in vitro immunization with peptide-pulsed dendritic cells. J Immunol 158 (1997) 1796-1802
    • (1997) J Immunol , vol.158 , pp. 1796-1802
    • Tsai, V.1    Southwood, S.2    Sidney, J.3    Sakaguchi, K.4    Kawakami, Y.5    Appella, E.6    Sette, A.7    Celis, E.8
  • 35
    • 0031936036 scopus 로고    scopus 로고
    • Identification of cytotoxic T cell epitopes within Epstein-Barr virus (EBV) oncogene latent membrane protein 1 (LMP1): evidence for HLA A2 supertype-restricted immune recognition of EBV-infected cells by LMP1-specific cytotoxic T lymphocytes
    • Khanna R., Burrows S.R., Nicholls J., and Poulsen L.M. Identification of cytotoxic T cell epitopes within Epstein-Barr virus (EBV) oncogene latent membrane protein 1 (LMP1): evidence for HLA A2 supertype-restricted immune recognition of EBV-infected cells by LMP1-specific cytotoxic T lymphocytes. Eur J Immunol 28 (1998) 451-458
    • (1998) Eur J Immunol , vol.28 , pp. 451-458
    • Khanna, R.1    Burrows, S.R.2    Nicholls, J.3    Poulsen, L.M.4
  • 36
    • 0031755442 scopus 로고    scopus 로고
    • Identification of gp100-derived, melanoma-specific cytotoxic T-lymphocyte epitopes restricted by HLA-A3 supertype molecules by primary in vitro immunization with peptide-pulsed dendritic cells
    • Kawashima I., Tsai V., Southwood S., Takesako K., Celis E., and Sette A. Identification of gp100-derived, melanoma-specific cytotoxic T-lymphocyte epitopes restricted by HLA-A3 supertype molecules by primary in vitro immunization with peptide-pulsed dendritic cells. Int J Cancer 78 (1998) 518-524
    • (1998) Int J Cancer , vol.78 , pp. 518-524
    • Kawashima, I.1    Tsai, V.2    Southwood, S.3    Takesako, K.4    Celis, E.5    Sette, A.6
  • 38
    • 0033524378 scopus 로고    scopus 로고
    • Identification of HLA-A24 epitope peptides of carcinoembryonic antigen which induce tumor-reactive cytotoxic T lymphocyte
    • Nukaya I., Yasumoto M., Iwasaki T., Ideno M., Sette A., Celis E., Takesako K., and Kato I. Identification of HLA-A24 epitope peptides of carcinoembryonic antigen which induce tumor-reactive cytotoxic T lymphocyte. Int J Cancer 80 (1999) 92-97
    • (1999) Int J Cancer , vol.80 , pp. 92-97
    • Nukaya, I.1    Yasumoto, M.2    Iwasaki, T.3    Ideno, M.4    Sette, A.5    Celis, E.6    Takesako, K.7    Kato, I.8
  • 40
    • 0034176750 scopus 로고    scopus 로고
    • Selective elimination of leukemic CD34(+) progenitor cells by cytotoxic T lymphocytes specific for WT1
    • Gao L., Bellantuono I., Elsasser A., Marley S.B., Gordon M.Y., Goldman J.M., and Stauss H.J. Selective elimination of leukemic CD34(+) progenitor cells by cytotoxic T lymphocytes specific for WT1. Blood 95 (2000) 2198-2203
    • (2000) Blood , vol.95 , pp. 2198-2203
    • Gao, L.1    Bellantuono, I.2    Elsasser, A.3    Marley, S.B.4    Gordon, M.Y.5    Goldman, J.M.6    Stauss, H.J.7
  • 41
    • 0035879093 scopus 로고    scopus 로고
    • Identification of new epitopes from four different tumor-associated antigens: recognition of naturally processed epitopes correlates with HLA-A*0201-binding affinity
    • Keogh E., Fikes J., Southwood S., Celis E., Chesnut R., and Sette A. Identification of new epitopes from four different tumor-associated antigens: recognition of naturally processed epitopes correlates with HLA-A*0201-binding affinity. J Immunol 167 (2001) 787-796
    • (2001) J Immunol , vol.167 , pp. 787-796
    • Keogh, E.1    Fikes, J.2    Southwood, S.3    Celis, E.4    Chesnut, R.5    Sette, A.6
  • 42
    • 0034665127 scopus 로고    scopus 로고
    • Use of two predictive algorithms of the world wide web for the identification of tumor-reactive T-cell epitopes
    • Lu J., and Celis E. Use of two predictive algorithms of the world wide web for the identification of tumor-reactive T-cell epitopes. Cancer Res 60 (2000) 5223-5227
    • (2000) Cancer Res , vol.60 , pp. 5223-5227
    • Lu, J.1    Celis, E.2
  • 44
    • 4544273024 scopus 로고    scopus 로고
    • Generation of cytotoxic T lymphocytes specific for the prostate and breast tissue antigen TARP
    • Carlsson B., Totterman T.H., and Essand M. Generation of cytotoxic T lymphocytes specific for the prostate and breast tissue antigen TARP. Prostate 61 (2004) 161-170
    • (2004) Prostate , vol.61 , pp. 161-170
    • Carlsson, B.1    Totterman, T.H.2    Essand, M.3
  • 47
    • 34547660192 scopus 로고    scopus 로고
    • Peptide epitopes from the Wilms' tumor 1 oncoprotein stimulate CD4+ and CD8+ T cells that recognize and kill human malignant mesothelioma tumor cells
    • 122-140 contains within its sequence a previously defined CD8 T cell epitope. This MHC-II epitope may be the same one described in Ref. [31].
    • 122-140 contains within its sequence a previously defined CD8 T cell epitope. This MHC-II epitope may be the same one described in Ref. [31].
    • (2007) Clin Cancer Res
    • May, R.J.1    Dao, T.2    Pinilla-Ibarz, J.3    Korontsvit, T.4    Zakhaleva, V.5    Zhang, R.H.6    Maslak, P.7    Scheinberg, D.A.8
  • 48
    • 0035113705 scopus 로고    scopus 로고
    • Immunization with a HER-2/neu helper peptide vaccine generates HER-2/neu CD8 T-cell immunity in cancer patients
    • Knutson K.L., Schiffman K., and Disis M.L. Immunization with a HER-2/neu helper peptide vaccine generates HER-2/neu CD8 T-cell immunity in cancer patients. J Clin Invest 107 (2001) 477-484
    • (2001) J Clin Invest , vol.107 , pp. 477-484
    • Knutson, K.L.1    Schiffman, K.2    Disis, M.L.3
  • 49
    • 0028203840 scopus 로고
    • Helper-cytotoxic T lymphocyte (CTL) determinant linkage required for priming of anti-HIV CD8+ CTL in vivo with peptide vaccine constructs
    • Shirai M., Pendleton C.D., Ahlers J., Takeshita T., Newman M., and Berzofsky J.A. Helper-cytotoxic T lymphocyte (CTL) determinant linkage required for priming of anti-HIV CD8+ CTL in vivo with peptide vaccine constructs. J Immunol 152 (1994) 549-556
    • (1994) J Immunol , vol.152 , pp. 549-556
    • Shirai, M.1    Pendleton, C.D.2    Ahlers, J.3    Takeshita, T.4    Newman, M.5    Berzofsky, J.A.6
  • 50
    • 34547915603 scopus 로고    scopus 로고
    • Vaccination with an NY-ESO-1 peptide of HLA class I/II specificities induces integrated humoral and T cell responses in ovarian cancer
    • The authors describe a clinical trial in ovarian cancer using a peptide from the TAA NY-ESO-1 containing a CD4 and 2 CD8 T cell epitopes. T cell clones (CD4 and CD8) from vaccinated patients were able to recognize NY-ESO-1 expressing tumor cells.
    • Odunsi K., Qian F., Matsuzaki J., Mhawech-Fauceglia P., Andrews C., Hoffman E.W., Pan L., Ritter G., Villella J., Thomas B., et al. Vaccination with an NY-ESO-1 peptide of HLA class I/II specificities induces integrated humoral and T cell responses in ovarian cancer. Proc Natl Acad Sci U S A 104 (2007) 12837-12842. The authors describe a clinical trial in ovarian cancer using a peptide from the TAA NY-ESO-1 containing a CD4 and 2 CD8 T cell epitopes. T cell clones (CD4 and CD8) from vaccinated patients were able to recognize NY-ESO-1 expressing tumor cells.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 12837-12842
    • Odunsi, K.1    Qian, F.2    Matsuzaki, J.3    Mhawech-Fauceglia, P.4    Andrews, C.5    Hoffman, E.W.6    Pan, L.7    Ritter, G.8    Villella, J.9    Thomas, B.10
  • 51
    • 38449106129 scopus 로고    scopus 로고
    • CD8+ CTL priming by exact peptide epitopes in incomplete Freund's adjuvant induces a vanishing CTL response, whereas long peptides induce sustained CTL reactivity
    • This paper demonstrates that vaccines using long synthetic peptides induce far superior immune responses than vaccines composed of the minimal CD8 T cell epitopes. The authors hypothesize that long peptides can only be presented by professional APCs, while the short, minimal epitopes may be presented by non-professional APCs, resulting in T cell anergy.
    • Bijker M.S., van den Eeden S.J., Franken K.L., Melief C.J., Offringa R., and van der Burg S.H. CD8+ CTL priming by exact peptide epitopes in incomplete Freund's adjuvant induces a vanishing CTL response, whereas long peptides induce sustained CTL reactivity. J Immunol 179 (2007) 5033-5040. This paper demonstrates that vaccines using long synthetic peptides induce far superior immune responses than vaccines composed of the minimal CD8 T cell epitopes. The authors hypothesize that long peptides can only be presented by professional APCs, while the short, minimal epitopes may be presented by non-professional APCs, resulting in T cell anergy.
    • (2007) J Immunol , vol.179 , pp. 5033-5040
    • Bijker, M.S.1    van den Eeden, S.J.2    Franken, K.L.3    Melief, C.J.4    Offringa, R.5    van der Burg, S.H.6
  • 53
    • 33847075902 scopus 로고    scopus 로고
    • In vivo effects of vaccination with six-transmembrane epithelial antigen of the prostate: a candidate antigen for treating prostate cancer
    • This reports shows remarkable anti-tumor effects of vaccination with the STEAP antigen against prostate tumors using a mouse model system, where both CD4 and CD8 T cells play a critical role.
    • Garcia-Hernandez M.d.L., Gray A., Hubby B., and Kast W.M. In vivo effects of vaccination with six-transmembrane epithelial antigen of the prostate: a candidate antigen for treating prostate cancer. Cancer Res 67 (2007) 1344-1351. This reports shows remarkable anti-tumor effects of vaccination with the STEAP antigen against prostate tumors using a mouse model system, where both CD4 and CD8 T cells play a critical role.
    • (2007) Cancer Res , vol.67 , pp. 1344-1351
    • Garcia-Hernandez, M.d.L.1    Gray, A.2    Hubby, B.3    Kast, W.M.4
  • 54
    • 34250821064 scopus 로고    scopus 로고
    • Overlapping human leukocyte antigen class I/II binding peptide vaccine for the treatment of patients with stage IV melanoma: evidence of systemic immune dysfunction
    • Melanoma Study Group of the Mayo Clinic Cancer Center. This paper describes the first clinical study using a synthetic peptide vaccine containing a naturally occurring combination of a CD4 T cell epitope and a CD8 T cell epitope.
    • Melanoma Study Group of the Mayo Clinic Cancer Center, and Celis E. Overlapping human leukocyte antigen class I/II binding peptide vaccine for the treatment of patients with stage IV melanoma: evidence of systemic immune dysfunction. Cancer 110 (2007) 203-214. This paper describes the first clinical study using a synthetic peptide vaccine containing a naturally occurring combination of a CD4 T cell epitope and a CD8 T cell epitope.
    • (2007) Cancer , vol.110 , pp. 203-214
    • Celis, E.1
  • 55
    • 0037108840 scopus 로고    scopus 로고
    • Recognition of prostate tumor cells by cytotoxic T lymphocytes specific for prostate-specific membrane antigen
    • Lu J., and Celis E. Recognition of prostate tumor cells by cytotoxic T lymphocytes specific for prostate-specific membrane antigen. Cancer Res 62 (2002) 5807-5812
    • (2002) Cancer Res , vol.62 , pp. 5807-5812
    • Lu, J.1    Celis, E.2


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