Isradipine attenuates MPTP-induced dopamine neuron degeneration by inhibiting up-regulation of L-type calcium channels and iron accumulation in the substantia nigra of mice

Oncotarget

Volumn 8, Issue 29, 2017, Pages 47284-47295

  Wang, Qi Min ^a   Xu, Yu Yu ^a   Liu, Shang ^a   Ma, Ze Gang ^a,b  

^a QINGDAO UNIVERSITY MEDICAL COLLEGE   (China)

^b QINGDAO UNIVERSITY   (China)

Author keywords

Dopamine neuron; Iron accumulation; Isradipine; L type calcium channel; Parkinson's disease

Indexed keywords

1,4 DIHYDRO 2,6 DIMETHYL 5 NITRO 4 [2 (TRIFLUOROMETHYL)PHENYL] 3 PYRIDINECARBOXYLIC ACID METHYL ESTER; CALCIUM CHANNEL CAV 1 2 ALPHA SUBUNIT; CALCIUM CHANNEL CAV 1 3 ALPHA SUBUNIT; CALCIUM CHANNEL L TYPE; DOPAMINE; IRON; ISRADIPINE; UNCLASSIFIED DRUG; 1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; BIOLOGICAL MARKER; CALCIUM CHANNEL BLOCKING AGENT; NEUROPROTECTIVE AGENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BIOACCUMULATION; CONTROLLED STUDY; CORPUS STRIATUM; DOPAMINERGIC NERVE CELL; DRUG MECHANISM; IRON TRANSPORT; MALE; MOTOR COORDINATION; MOUSE; NERVE DEGENERATION; NEUROPROTECTION; NONHUMAN; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; ROTAROD TEST; SUBSTANTIA NIGRA; UPREGULATION; WESTERN BLOTTING; ANIMAL; CELL LINE; DISEASE EXACERBATION; DISEASE MODEL; DRUG EFFECT; GENETICS; METABOLISM; PARKINSON DISEASE; PATHOLOGY;

1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE; ANIMALS; BIOMARKERS; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS, L-TYPE; CELL LINE; CORPUS STRIATUM; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; DOPAMINE; DOPAMINERGIC NEURONS; IRON; ISRADIPINE; MALE; MICE; NEUROPROTECTIVE AGENTS; PARKINSON DISEASE; SUBSTANTIA NIGRA;

EID: 85024403534     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.17618     Document Type: Article

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