메뉴 건너뛰기




Volumn 8, Issue JUL, 2017, Pages

The Staphylococcus aureus α-acetolactate synthase ALS confers resistance to nitrosative stress

Author keywords

A acetolactate synthase (ALS); Bacterial metabolism; Nitrosative stress; Nuclear magnetic resonance (NMR); Staphylococcus aureus

Indexed keywords

ACETOLACTATE SYNTHASE; METICILLIN; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; NITRATE REDUCTASE (NADPH); OXACILLIN; REACTIVE NITROGEN SPECIES;

EID: 85024120755     PISSN: None     EISSN: 1664302X     Source Type: Journal    
DOI: 10.3389/fmicb.2017.01273     Document Type: Article
Times cited : (27)

References (44)
  • 1
    • 84994365019 scopus 로고    scopus 로고
    • Neuraminidase A-exposed galactose promotes Streptococcus pneumoniae biofilm formation during colonization
    • Blanchette, K. A., Shenoy, A. T., Milner, J., Gilley, R. P., McClure, E., Hinojosa, C. A., et al. (2016). Neuraminidase A-exposed galactose promotes Streptococcus pneumoniae biofilm formation during colonization. Infect. Immun. 84, 2922-2932. doi: 10.1128/IAI.00277-16
    • (2016) Infect. Immun , vol.84 , pp. 2922-2932
    • Blanchette, K.A.1    Shenoy, A.T.2    Milner, J.3    Gilley, R.P.4    McClure, E.5    Hinojosa, C.A.6
  • 2
    • 80054830887 scopus 로고    scopus 로고
    • CcpA ensures optimal metabolic fitness of Streptococcus pneumoniae
    • Carvalho, S. M., Kloosterman, T. G., Kuipers, O. P., and Neves, A. R. (2011). CcpA ensures optimal metabolic fitness of Streptococcus pneumoniae. PLoS ONE 6:e26707. doi: 10.1371/journal.pone.0026707
    • (2011) PLoS ONE , vol.6
    • Carvalho, S.M.1    Kloosterman, T.G.2    Kuipers, O.P.3    Neves, A.R.4
  • 3
  • 4
    • 84872346304 scopus 로고    scopus 로고
    • CcpA-independent glucose regulation of lactate dehydrogenase 1 in Staphylococcus aureus
    • Crooke, A. K., Fuller, J. R., Obrist, M. W., Tomkovich, S. E., Vitko, N. P., and Richardson, A. R. (2013). CcpA-independent glucose regulation of lactate dehydrogenase 1 in Staphylococcus aureus. PLoS ONE 8:e54293. doi: 10.1371/journal.pone.0054293
    • (2013) PLoS ONE , vol.8
    • Crooke, A.K.1    Fuller, J.R.2    Obrist, M.W.3    Tomkovich, S.E.4    Vitko, N.P.5    Richardson, A.R.6
  • 5
    • 84940530890 scopus 로고    scopus 로고
    • T-REx: transcriptome analysis webserver for RNA-Seq expression data
    • de Jong, A., van der Meulen, S., Kuipers, O. P., and Kok, J. (2015). T-REx: transcriptome analysis webserver for RNA-Seq expression data. BMC Genomics 16, 663. doi: 10.1186/s12864-015-1834-4
    • (2015) BMC Genomics , vol.16 , pp. 663
    • de Jong, A.1    van der Meulen, S.2    Kuipers, O.P.3    Kok, J.4
  • 6
    • 84903386086 scopus 로고    scopus 로고
    • Steady-state hydrogen peroxide induces glycolysis in Staphylococcus aureus and Pseudomonas aeruginosa
    • Deng, X., Liang, H., Ulanovskaya, O. A., Ji, Q., Zhou, T., Sun, F., et al. (2014). Steady-state hydrogen peroxide induces glycolysis in Staphylococcus aureus and Pseudomonas aeruginosa. J. Bacteriol. 196, 2499-2513. doi: 10.1128/JB.01538-14
    • (2014) J. Bacteriol , vol.196 , pp. 2499-2513
    • Deng, X.1    Liang, H.2    Ulanovskaya, O.A.3    Ji, Q.4    Zhou, T.5    Sun, F.6
  • 7
    • 84855743230 scopus 로고    scopus 로고
    • Molecular mechanisms of Staphylococcus aureus nasopharyngeal colonization
    • Edwards, A. M., Massey, R. C., and Clarke, S. R. (2012). Molecular mechanisms of Staphylococcus aureus nasopharyngeal colonization. Mol. Oral Microbiol. 27, 1-10. doi: 10.1111/j.2041-1014.2011.00628.x
    • (2012) Mol. Oral Microbiol , vol.27 , pp. 1-10
    • Edwards, A.M.1    Massey, R.C.2    Clarke, S.R.3
  • 8
    • 84874639044 scopus 로고    scopus 로고
    • Effect of oxygen on glucose metabolism: utilization of lactate in Staphylococcus aureus as revealed by in vivo NMR studies
    • Ferreira, M. T., Manso, A. S., Gaspar, P., Pinho, M. G., and Neves, A. R. (2013). Effect of oxygen on glucose metabolism: utilization of lactate in Staphylococcus aureus as revealed by in vivo NMR studies. PLoS ONE 8:e58277. doi: 10.1371/journal.pone.0058277
    • (2013) PLoS ONE , vol.8
    • Ferreira, M.T.1    Manso, A.S.2    Gaspar, P.3    Pinho, M.G.4    Neves, A.R.5
  • 9
    • 30544444128 scopus 로고    scopus 로고
    • Immune evasion by staphylococci
    • Foster, T. J. (2005). Immune evasion by staphylococci. Nat. Rev. Microbiol. 3, 948-958. doi: 10.1038/nrmicro1289
    • (2005) Nat. Rev. Microbiol , vol.3 , pp. 948-958
    • Foster, T.J.1
  • 10
    • 34249822802 scopus 로고    scopus 로고
    • Anaerobic gene expression in Staphylococcus aureus
    • Fuchs, S., Pané-Farré, J., Kohler, C., Hecker, M., and Engelmann, S. (2007). Anaerobic gene expression in Staphylococcus aureus. J. Bacteriol. 189, 4275-4289. doi: 10.1128/JB.00081-07
    • (2007) J. Bacteriol , vol.189 , pp. 4275-4289
    • Fuchs, S.1    Pané-Farré, J.2    Kohler, C.3    Hecker, M.4    Engelmann, S.5
  • 11
    • 84872361683 scopus 로고    scopus 로고
    • Identification of a lactate-quinone oxidoreductase in Staphylococcus aureus that is essential for virulence
    • Fuller, J. R., Vitko, N. P., Perkowski, E. F., Scott, E., Khatri, D., Spontak, J. S., et al. (2011). Identification of a lactate-quinone oxidoreductase in Staphylococcus aureus that is essential for virulence. Front. Cell. Infect. Microbiol. 1:19. doi: 10.3389/fcimb.2011.00019
    • (2011) Front. Cell. Infect. Microbiol , vol.1 , pp. 19
    • Fuller, J.R.1    Vitko, N.P.2    Perkowski, E.F.3    Scott, E.4    Khatri, D.5    Spontak, J.S.6
  • 12
    • 33644895690 scopus 로고    scopus 로고
    • Flavohemoglobin requires microaerophilic conditions for nitrosative protection of Staphylococcus aureus
    • Gonçalves, V. L., Nobre, L. S., Vicente, J. B., Teixeira, M., and Saraiva, L. M. (2006). Flavohemoglobin requires microaerophilic conditions for nitrosative protection of Staphylococcus aureus. FEBS Lett. 580, 1817-1821. doi: 10.1016/j.febslet.2006.02.039
    • (2006) FEBS Lett , vol.580 , pp. 1817-1821
    • Gonçalves, V.L.1    Nobre, L.S.2    Vicente, J.B.3    Teixeira, M.4    Saraiva, L.M.5
  • 14
    • 84981351723 scopus 로고    scopus 로고
    • Regulatory requirements for Staphylococcus aureus nitric oxide resistance
    • Grosser, M. R., Weiss, A., Shaw, L. N., and Richardson, A. R. (2016). Regulatory requirements for Staphylococcus aureus nitric oxide resistance. J. Bacteriol. 198, JB.229-JB.216. doi: 10.1128/JB.00229-16
    • (2016) J. Bacteriol , vol.198
    • Grosser, M.R.1    Weiss, A.2    Shaw, L.N.3    Richardson, A.R.4
  • 15
    • 85014754736 scopus 로고    scopus 로고
    • Amino acid catabolism in Staphylococcus aureus and the function of carbon catabolite repression
    • Halsey, C. R., Lei, S., Wax, J. K., Lehman, M. K., Nuxoll, A. S., Steinke, L., et al. (2017). Amino acid catabolism in Staphylococcus aureus and the function of carbon catabolite repression. MBio 8:e1434-16. doi: 10.1128/MBIO.01434-16
    • (2017) MBio , vol.8
    • Halsey, C.R.1    Lei, S.2    Wax, J.K.3    Lehman, M.K.4    Nuxoll, A.S.5    Steinke, L.6
  • 16
    • 47249088762 scopus 로고    scopus 로고
    • Nitric oxide stress induces different responses but mediates comparable protein thiol protection in Bacillus subtilis and Staphylococcus aureus
    • Hochgräfe, F., Wolf, C., Fuchs, S., Liebeke, M., Lalk, M., Engelmann, S., et al. (2008). Nitric oxide stress induces different responses but mediates comparable protein thiol protection in Bacillus subtilis and Staphylococcus aureus. J. Bacteriol. 190, 4997-5008. doi: 10.1128/JB.01846-07
    • (2008) J. Bacteriol , vol.190 , pp. 4997-5008
    • Hochgräfe, F.1    Wolf, C.2    Fuchs, S.3    Liebeke, M.4    Lalk, M.5    Engelmann, S.6
  • 17
    • 34347250494 scopus 로고    scopus 로고
    • Integrated network analysis identifies nitric oxide response networks and dihydroxyacid dehydratase as a crucial target in Escherichia coli
    • Hyduke, D. R., Jarboe, L. R., Tran, L. M., Chou, K. J. Y., and Liao, J. C. (2007). Integrated network analysis identifies nitric oxide response networks and dihydroxyacid dehydratase as a crucial target in Escherichia coli. Proc. Natl. Acad. Sci. U.S.A. 104, 8484-8489. doi: 10.1073/pnas.0610888104
    • (2007) Proc. Natl. Acad. Sci. U.S.A , vol.104 , pp. 8484-8489
    • Hyduke, D.R.1    Jarboe, L.R.2    Tran, L.M.3    Chou, K.J.Y.4    Liao, J.C.5
  • 18
    • 84989360879 scopus 로고    scopus 로고
    • The role of two branched-chain amino acid transporters in Staphylococcus aureus growth, membrane fatty acid composition and virulence
    • Kaiser, J. C., Sen, S., Sinha, A., Wilkinson, B. J., and Heinrichs, D. E. (2016). The role of two branched-chain amino acid transporters in Staphylococcus aureus growth, membrane fatty acid composition and virulence. Mol. Microbiol. 102, 850-864. doi: 10.1111/mmi.13495
    • (2016) Mol. Microbiol , vol.102 , pp. 850-864
    • Kaiser, J.C.1    Sen, S.2    Sinha, A.3    Wilkinson, B.J.4    Heinrichs, D.E.5
  • 19
    • 76149123543 scopus 로고    scopus 로고
    • Pneumococcal modification of host sugars: a major contributor to colonization of the human airway?
    • King, S. J. (2010). Pneumococcal modification of host sugars: a major contributor to colonization of the human airway? Mol. Oral Microbiol. 25, 15-24. doi: 10.1111/j.2041-1014.2009.00564.x
    • (2010) Mol. Oral Microbiol , vol.25 , pp. 15-24
    • King, S.J.1
  • 20
    • 84893793314 scopus 로고    scopus 로고
    • Nutrient limitation governs Staphylococcus aureus metabolism and niche adaptation in the human nose
    • Krismer, B., Liebeke, M., Janek, D., Nega, M., Rautenberg, M., Hornig, G., et al. (2014). Nutrient limitation governs Staphylococcus aureus metabolism and niche adaptation in the human nose. PLoS Pathog. 10:e1003862. doi: 10.1371/journal.ppat.1003862
    • (2014) PLoS Pathog , vol.10
    • Krismer, B.1    Liebeke, M.2    Janek, D.3    Nega, M.4    Rautenberg, M.5    Hornig, G.6
  • 21
    • 38949165147 scopus 로고    scopus 로고
    • Nasal nitric oxide as a noninvasive marker in the antibiotic treatment of acute bacterial sinusitis
    • Lanz, M. J., Prendes, S., Peyrou, N., Toledo, G., and Ferrer, C. M. (2008). Nasal nitric oxide as a noninvasive marker in the antibiotic treatment of acute bacterial sinusitis. J. Allergy Clin. Immunol. 121, 530-531. doi: 10.1016/j.jaci.2007.09.014
    • (2008) J. Allergy Clin. Immunol , vol.121 , pp. 530-531
    • Lanz, M.J.1    Prendes, S.2    Peyrou, N.3    Toledo, G.4    Ferrer, C.M.5
  • 22
    • 0018570558 scopus 로고
    • Quantitative extraction and estimation of intracellular nicotinamide nucleotides of Escherichia coli
    • Lilius, E. M., Multanen, V. M., and Toivonen, V. (1979). Quantitative extraction and estimation of intracellular nicotinamide nucleotides of Escherichia coli. Anal. Biochem. 99, 22-27. doi: 10.1016/0003-2697(79)90039-3
    • (1979) Anal. Biochem , vol.99 , pp. 22-27
    • Lilius, E.M.1    Multanen, V.M.2    Toivonen, V.3
  • 24
    • 0032952196 scopus 로고    scopus 로고
    • Glucose 6-phosphate dehydrogenase is required for Salmonella typhimurium virulence and resistance to reactive oxygen and nitrogen intermediates
    • Lundberg, B. E., Wolf, R. E., Dinauer, M. C., Xu, Y., and Fang, F. C. (1999). Glucose 6-phosphate dehydrogenase is required for Salmonella typhimurium virulence and resistance to reactive oxygen and nitrogen intermediates. Infect. Immun. 67, 436-438
    • (1999) Infect. Immun , vol.67 , pp. 436-438
    • Lundberg, B.E.1    Wolf, R.E.2    Dinauer, M.C.3    Xu, Y.4    Fang, F.C.5
  • 26
    • 79955527630 scopus 로고    scopus 로고
    • Nitric oxide protects bacteria from aminoglycosides by blocking the energy-dependent phases of drug uptake
    • McCollister, B. D., Hoffman, M., Husain, M., and Vázquez-Torres, A. (2011). Nitric oxide protects bacteria from aminoglycosides by blocking the energy-dependent phases of drug uptake. Antimicrob. Agents Chemother. 55, 2189-2196. doi: 10.1128/AAC.01203-10
    • (2011) Antimicrob. Agents Chemother , vol.55 , pp. 2189-2196
    • McCollister, B.D.1    Hoffman, M.2    Husain, M.3    Vázquez-Torres, A.4
  • 27
    • 34547123127 scopus 로고    scopus 로고
    • Structures of Staphylococcus aureus D-tagatose-6-phosphate kinase implicate domain motions in specificity and mechanism
    • Miallau, L., Hunter, W. N., McSweeney, S. M., and Leonard, G. A. (2007). Structures of Staphylococcus aureus D-tagatose-6-phosphate kinase implicate domain motions in specificity and mechanism. J. Biol. Chem. 282, 19948-19957. doi: 10.1074/jbc.M701480200
    • (2007) J. Biol. Chem , vol.282 , pp. 19948-19957
    • Miallau, L.1    Hunter, W.N.2    McSweeney, S.M.3    Leonard, G.A.4
  • 29
    • 84878846133 scopus 로고    scopus 로고
    • Effect of combined oxidative and nitrosative stresses on Staphylococcus aureus transcriptome
    • Nobre, L. S., and Saraiva, L. M. (2013). Effect of combined oxidative and nitrosative stresses on Staphylococcus aureus transcriptome. Appl. Microbiol. Biotechnol. 97, 2563-2573. doi: 10.1007/s00253-013-4730-3
    • (2013) Appl. Microbiol. Biotechnol , vol.97 , pp. 2563-2573
    • Nobre, L.S.1    Saraiva, L.M.2
  • 30
    • 84904014972 scopus 로고    scopus 로고
    • Role of the siderophore transporter SirABC in the Staphylococcus aureus resistance to oxidative stress
    • Nobre, L. S., and Saraiva, L. M. (2014). Role of the siderophore transporter SirABC in the Staphylococcus aureus resistance to oxidative stress. Curr. Microbiol. 69, 164-168. doi: 10.1007/s00284-014-0567-y
    • (2014) Curr. Microbiol , vol.69 , pp. 164-168
    • Nobre, L.S.1    Saraiva, L.M.2
  • 31
    • 33746482772 scopus 로고    scopus 로고
    • The nitrosative stress response of Staphylococcus aureus is required for resistance to innate immunity
    • Richardson, A. R., Dunman, P. M., and Fang, F. C. (2006). The nitrosative stress response of Staphylococcus aureus is required for resistance to innate immunity. Mol. Microbiol. 61, 927-939. doi: 10.1111/j.1365-2958.2006.05290.x
    • (2006) Mol. Microbiol , vol.61 , pp. 927-939
    • Richardson, A.R.1    Dunman, P.M.2    Fang, F.C.3
  • 32
    • 41149096672 scopus 로고    scopus 로고
    • A nitric oxide-inducible lactate dehydrogenase enables Staphylococcus aureus to resist innate immunity
    • Richardson, A. R., Libby, S. J., and Fang, F. C. (2008). A nitric oxide-inducible lactate dehydrogenase enables Staphylococcus aureus to resist innate immunity. Science 319, 1672-1676. doi: 10.1126/science.1155207
    • (2008) Science , vol.319 , pp. 1672-1676
    • Richardson, A.R.1    Libby, S.J.2    Fang, F.C.3
  • 33
    • 79960549151 scopus 로고    scopus 로고
    • Multiple targets of nitric oxide in the tricarboxylic acid cycle of Salmonella enterica serovar typhimurium
    • Richardson, A. R., Payne, E. C., Younger, N., Karlinsey, J. E., Thomas, V. C., Becker, L. A., et al. (2011). Multiple targets of nitric oxide in the tricarboxylic acid cycle of Salmonella enterica serovar typhimurium. Cell Host Microbe 10, 33-43. doi: 10.1016/j.chom.2011.06.004
    • (2011) Cell Host Microbe , vol.10 , pp. 33-43
    • Richardson, A.R.1    Payne, E.C.2    Younger, N.3    Karlinsey, J.E.4    Thomas, V.C.5    Becker, L.A.6
  • 34
    • 84903552294 scopus 로고    scopus 로고
    • Deciphering nitric oxide stress in bacteria with quantitative modeling
    • Robinson, J. L., Adolfsen, K. J., and Brynildsen, M. P. (2014). Deciphering nitric oxide stress in bacteria with quantitative modeling. Curr. Opin. Microbiol. 19, 16-24. doi: 10.1016/j.mib.2014.05.018
    • (2014) Curr. Opin. Microbiol , vol.19 , pp. 16-24
    • Robinson, J.L.1    Adolfsen, K.J.2    Brynildsen, M.P.3
  • 35
    • 84880013364 scopus 로고    scopus 로고
    • Inactivation of the Pta-AckA pathway causes cell death in Staphylococcus aureus
    • Sadykov, M. R., Thomas, V. C., Marshall, D. D., Wenstrom, C. J., Moormeier, D. E., Widhelm, T. J., et al. (2013). Inactivation of the Pta-AckA pathway causes cell death in Staphylococcus aureus. J. Bacteriol. 195, 3035-3044. doi: 10.1128/JB.00042-13
    • (2013) J. Bacteriol , vol.195 , pp. 3035-3044
    • Sadykov, M.R.1    Thomas, V.C.2    Marshall, D.D.3    Wenstrom, C.J.4    Moormeier, D.E.5    Widhelm, T.J.6
  • 36
    • 77949412129 scopus 로고    scopus 로고
    • Effect of pharynx epithelial cells surface desialylation on receptor-mediated adherence of Staphylococcus aureus
    • Sakarya, S., Ertugrul, M. B., öztürk, T., and Gökbulut, C. (2010). Effect of pharynx epithelial cells surface desialylation on receptor-mediated adherence of Staphylococcus aureus. J. Appl. Microbiol. 108, 1313-1322. doi: 10.1111/j.1365-2672.2009.04525.x
    • (2010) J. Appl. Microbiol , vol.108 , pp. 1313-1322
    • Sakarya, S.1    Ertugrul, M.B.2    Öztürk, T.3    Gökbulut, C.4
  • 37
    • 0030052451 scopus 로고    scopus 로고
    • Staphylococcus aureus binding to human nasal mucin
    • Shuter, J., Hatcher, V. B., and Lowy, F. D. (1996). Staphylococcus aureus binding to human nasal mucin. Infect. Immun. 64, 310-318
    • (1996) Infect. Immun , vol.64 , pp. 310-318
    • Shuter, J.1    Hatcher, V.B.2    Lowy, F.D.3
  • 38
    • 84959492775 scopus 로고    scopus 로고
    • Staphylococcus aureus lactate-and malate-quinone oxidoreductases contribute to nitric oxide resistance and virulence
    • Spahich, N. A., Vitko, N. P., Thurlow, L. R., Temple, B., and Richardson, A. R. (2016). Staphylococcus aureus lactate-and malate-quinone oxidoreductases contribute to nitric oxide resistance and virulence. Mol. Microbiol. 100, 759-773. doi: 10.1111/mmi.13347
    • (2016) Mol. Microbiol , vol.100 , pp. 759-773
    • Spahich, N.A.1    Vitko, N.P.2    Thurlow, L.R.3    Temple, B.4    Richardson, A.R.5
  • 39
    • 65549146791 scopus 로고    scopus 로고
    • A novel nitroreductase of Staphylococcus aureus with S-nitrosoglutathione reductase activity
    • Tavares, A. F. N., Nobre, L. S., Melo, A. M. P., and Saraiva, L. M. (2009). A novel nitroreductase of Staphylococcus aureus with S-nitrosoglutathione reductase activity. J. Bacteriol. 191, 3403-3406. doi: 10.1128/JB.00022-09
    • (2009) J. Bacteriol , vol.191 , pp. 3403-3406
    • Tavares, A.F.N.1    Nobre, L.S.2    Melo, A.M.P.3    Saraiva, L.M.4
  • 40
  • 41
    • 84903484862 scopus 로고    scopus 로고
    • A central role for carbon-overflow pathways in the modulation of bacterial cell death
    • Thomas, V. C., Sadykov, M. R., Chaudhari, S. S., Jones, J., Endres, J. L., Widhelm, T. J., et al. (2014). A central role for carbon-overflow pathways in the modulation of bacterial cell death. PLoS Pathog. 10:e1004205. doi: 10.1371/journal.ppat.1004205
    • (2014) PLoS Pathog , vol.10
    • Thomas, V.C.1    Sadykov, M.R.2    Chaudhari, S.S.3    Jones, J.4    Endres, J.L.5    Widhelm, T.J.6
  • 42
    • 0033107539 scopus 로고    scopus 로고
    • In vivo dynamics of the pentose phosphate pathway in Saccharomyces cerevisiae
    • Vaseghi, S., Baumeister, A., Rizzi, M., and Reuss, M. (1999). In vivo dynamics of the pentose phosphate pathway in Saccharomyces cerevisiae. Metab. Eng. 1, 128-140. doi: 10.1006/mben.1998.0110
    • (1999) Metab. Eng , vol.1 , pp. 128-140
    • Vaseghi, S.1    Baumeister, A.2    Rizzi, M.3    Reuss, M.4
  • 43
    • 84929494191 scopus 로고    scopus 로고
    • Glycolytic dependency of high-level nitric oxide resistance and virulence in Staphylococcus aureus
    • Vitko, N. P., Spahich, N. A., and Richardson, A. R. (2015). Glycolytic dependency of high-level nitric oxide resistance and virulence in Staphylococcus aureus. MBio 6:e45-15. doi: 10.1128/mBio.00045-15
    • (2015) MBio , vol.6
    • Vitko, N.P.1    Spahich, N.A.2    Richardson, A.R.3
  • 44
    • 84860593366 scopus 로고    scopus 로고
    • Staphylococcus aureus determinants for nasal colonization
    • Weidenmaier, C., Goerke, C., and Wolz, C. (2012). Staphylococcus aureus determinants for nasal colonization. Trends Microbiol. 20, 243-250. doi: 10.1016/j.tim.2012.03.004
    • (2012) Trends Microbiol , vol.20 , pp. 243-250
    • Weidenmaier, C.1    Goerke, C.2    Wolz, C.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.