Human cytomegalovirus triggers the assembly of AIM2 inflammasome in THP-1-derived macrophages

Journal of Medical Virology

Volumn 89, Issue 12, 2017, Pages 2188-2195

  Huang, Yuan ^a   Liu, Lingling ^a   Ma, Di ^b   Liao, Yi ^a   Lu, Yuanyuan ^a   Huang, Heyu ^a   Qin, Wenqing ^a   Liu, Xinglou ^a   Fang, Feng ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b NONE

Author keywords

human cytomegalovirus; innate immunity; interleukin; siRNA

Indexed keywords

ABSENT IN MELANOMA 2 INFLAMMASOME; DNA POLYMERASE; INFLAMMASOME; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; UNCLASSIFIED DRUG; VIRUS DNA; AIM2 PROTEIN, HUMAN; CYTOMEGALOVIRUS MATRIX PROTEIN 65KDA; DNA BINDING PROTEIN; DNA DIRECTED DNA POLYMERASE; MATRIX PROTEIN; PHOSPHOPROTEIN; SMALL INTERFERING RNA; UL54 PROTEIN, HUMAN HERPESVIRUS 5; VIRAL PROTEIN;

AIM2 GENE; ARTICLE; CELL DEATH; CONTROLLED STUDY; CYTOMEGALOVIRUS INFECTION; ENZYME ACTIVITY; GENE SILENCING; HUMAN; HUMAN CELL; HUMAN CYTOMEGALOVIRUS (STRAIN AD169); IMMUNE RESPONSE; LIFE CYCLE; MACROPHAGE; NONHUMAN; PROTEIN ASSEMBLY; PROTEIN DEFICIENCY; PROTEIN FUNCTION; THP 1 DERIVED MACROPHAGE; UL54 GENE; UL83 GENE; VIRUS GENE; VIRUS LIFE CYCLE; VIRUS TRANSCRIPTION; CYTOMEGALOVIRUS; DEFICIENCY; GENETICS; IMMUNOLOGY; INNATE IMMUNITY; METABOLISM; VIROLOGY;

CASPASE 1; CELL DEATH; CYTOMEGALOVIRUS; DNA-BINDING PROTEINS; DNA-DIRECTED DNA POLYMERASE; HUMANS; IMMUNITY, INNATE; INFLAMMASOMES; INTERLEUKIN-1BETA; MACROPHAGES; PHOSPHOPROTEINS; RNA, SMALL INTERFERING; VIRAL MATRIX PROTEINS; VIRAL PROTEINS;

EID: 85023752934     PISSN: 01466615     EISSN: 10969071     Source Type: Journal    
DOI: 10.1002/jmv.24846     Document Type: Article

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