Peripartum Antibiotics Promote Gut Dysbiosis, Loss of Immune Tolerance, and Inflammatory Bowel Disease in Genetically Prone Offspring

Cell Reports

Volumn 20, Issue 2, 2017, Pages 491-504

  Miyoshi, Jun ^a   Bobe, Alexandria M ^a   Miyoshi, Sawako ^a   Huang, Yong ^a   Hubert, Nathaniel ^a   Delmont, Tom O ^a   Eren, A Murat ^a   Leone, Vanessa ^a   Chang, Eugene B ^a  

^a UNIVERSITY OF CHICAGO   (United States)

Author keywords

complex immune disorders; dysbiosis; host microbe interactions; immune development; inflammatory bowel diseases; microbial assemblage; microbiome; microbiome intervention; vertical transmission

Indexed keywords

CEFOPERAZONE; RETINOID RELATED ORPHAN RECEPTOR GAMMA; T BOX TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR FOXP3; ANTIINFECTIVE AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COLITIS; CONTROLLED STUDY; DISEASE PREDISPOSITION; DRUG EXPOSURE; DYSBIOSIS; FEMALE; GENE AMPLIFICATION; GENETIC SUSCEPTIBILITY; GENOTYPE; IMMUNE SYSTEM; IMMUNOLOGICAL TOLERANCE; INFLAMMATORY BOWEL DISEASE; LYMPHOCYTE SUBPOPULATION; MALE; MICROBIAL COMMUNITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROGENY; PROTEIN FUNCTION; REGULATORY T LYMPHOCYTE; SURVIVAL RATE; TH1 CELL; TH17 CELL; TH2 CELL; ANIMAL; CHEMICALLY INDUCED; DRUG EFFECTS; IMMUNOLOGY; PERINATAL PERIOD;

ANIMALS; ANTI-BACTERIAL AGENTS; COLITIS; DYSBIOSIS; FEMALE; IMMUNE TOLERANCE; INFLAMMATORY BOWEL DISEASES; MALE; MICE; PERIPARTUM PERIOD;

EID: 85021945034     PISSN: None     EISSN: 22111247     Source Type: Journal    
DOI: 10.1016/j.celrep.2017.06.060     Document Type: Article

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