Frailty in Older Adults Undergoing Aortic Valve Replacement: The FRAILTY-AVR Study

Journal of the American College of Cardiology

Volumn 70, Issue 6, 2017, Pages 689-700

  Afilalo, Jonathan ^a,b   Lauck, Sandra ^c   Kim, Dae H ^d   Lefèvre, Thierry ^e   Piazza, Nicolo ^f   Lachapelle, Kevin ^f   Martucci, Giuseppe ^f   Lamy, Andre ^g   Labinaz, Marino ^h   Peterson, Mark D ⁱ   Arora, Rakesh C ^j   Noiseux, Nicolas ^k   Rassi, Andrew ^d   Palacios, Igor F ^d   Généreux, Philippe ^l   Lindman, Brian R ^m   Asgar, Anita W ⁿ   Kim, Caroline A ^d   Trnkus, Amanda ^b   Morais, José A ^o   Langlois, Yves ^a   Rudski, Lawrence G ^a   Morin, Jean Francois ^a   Popma, Jeffrey J ^d   Webb, John G ^c   Perrault, Louis P ⁿ   more..

^a MCGILL UNIVERSITY   (Canada)

^b MCGILL UNIVERSITY   (Canada)

^c ST PAUL S HOSPITAL   (Canada)

^d HARVARD UNIVERSITY   (United States)

^e INSTITUT CARDIOVASCULAIRE PARIS SUD   (France)

^f MCGILL UNIVERSITY HEALTH CENTRE   (Canada)

^g MCMASTER UNIVERSITY   (Canada)

^h UNIVERSITY OF OTTAWA HEART INSTITUTE   (Canada)

ⁱ ST MICHAEL'S HOSPITAL   (Canada)

^j UNIVERSITY OF MANITOBA   (Canada)

^k CENTRE HOSPITALIER DE L UNIVERSITÉ DE MONTRÉAL   (Canada)

^l HÔPITAL DU SACRÉ COEUR DE MONTRÉAL   (Canada)

^m WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

ⁿ MONTREAL HEART INSTITUTE   (Canada)

^o MCGILL UNIVERSITY   (Canada)

more..

Author keywords

aortic stenosis; disability; frailty; outcomes; surgical aortic valve replacement; survival; transcatheter aortic valve replacement

Indexed keywords

AGED; ANEMIA; AORTIC VALVE REPLACEMENT; ARTICLE; COGNITIVE DEFECT; COHORT ANALYSIS; CONTROLLED STUDY; DISABILITY; DISEASE EXACERBATION; FEMALE; FRAILTY; HUMAN; HYPOALBUMINEMIA; INTERMETHOD COMPARISON; MAJOR CLINICAL STUDY; MALE; MORTALITY; OUTCOME ASSESSMENT; PREDICTIVE VALUE; PRIORITY JOURNAL; PROSPECTIVE STUDY; RISK FACTOR; SURGICAL AORTIC VALVE REPLACEMENT; TRANSCATHETER AORTIC VALVE IMPLANTATION; WEAKNESS; AORTIC VALVE; AORTIC VALVE STENOSIS; CANADA; CLINICAL TRIAL; EPIDEMIOLOGY; FOLLOW UP; FRAIL ELDERLY; FRANCE; HEART VALVE PROSTHESIS; MULTICENTER STUDY; ODDS RATIO; PROCEDURES; RISK ASSESSMENT; SEVERITY OF ILLNESS INDEX; SURVIVAL RATE; TREATMENT OUTCOME; TRENDS; UNITED STATES; VERY ELDERLY;

AGED; AGED, 80 AND OVER; AORTIC VALVE; AORTIC VALVE STENOSIS; CANADA; FEMALE; FOLLOW-UP STUDIES; FRAIL ELDERLY; FRANCE; HEART VALVE PROSTHESIS; HUMANS; MALE; ODDS RATIO; PROSPECTIVE STUDIES; RISK ASSESSMENT; RISK FACTORS; SEVERITY OF ILLNESS INDEX; SURVIVAL RATE; TRANSCATHETER AORTIC VALVE REPLACEMENT; TREATMENT OUTCOME; UNITED STATES;

EID: 85021866942     PISSN: 07351097     EISSN: 15583597     Source Type: Journal    
DOI: 10.1016/j.jacc.2017.06.024     Document Type: Article

References (45)

1. Rodríguez-Mañas, L., Féart, C., Mann, G., et al., for the FOD-CC Group. Searching for an operational definition of frailty: a Delphi method based consensus statement: the frailty operative definition-consensus conference project. J Gerontol A Biol Sci Med Sci 68 (2013), 62–67.
2. Kim, D.H., Kim, C.A., Placide, S., Lipsitz, L.A., Marcantonio, E.R., Preoperative frailty assessment and outcomes at 6 months or later in older adults undergoing cardiac surgical procedures: a systematic review. Ann Intern Med 165 (2016), 650–660.
3. Talbot-Hamon, C., Afilalo, J., Transcatheter aortic valve replacement in the care of older persons with aortic stenosis. J Am Geriatr Soc 65 (2017), 693–698.
4. Holmes, D.R. Jr., Brennan, J.M., Rumsfeld, J.S., et al., for the STS/ACC TVT Registry. Clinical outcomes at 1 year following transcatheter aortic valve replacement. JAMA 313 (2015), 1019–1028.
5. Lindman, B.R., Alexander, K.P., O'Gara, P.T., Afilalo, J., Futility, benefit, and transcatheter aortic valve replacement. J Am Coll Cardiol Intv 7 (2014), 707–716.
6. Webb, J., Rodés-Cabau, J., Fremes, S., et al. Transcatheter aortic valve implantation: a Canadian Cardiovascular Society position statement. Can J Cardiol 28 (2012), 520–528.
7. Otto, C.M., Kumbhani, D.J., Alexander, K.P., et al. 2017 ACC expert consensus decision pathway for transcatheter aortic valve replacement in the management of adults with aortic stenosis: a report of the American College of Cardiology Task Force on Clinical Expert Consensus Documents. J Am Coll Cardiol 69 (2017), 1313–1346.
8. Nishimura, R.A., Otto, C.M., Bonow, R.O., et al. 2017 AHA/ACC focused update of the 2014 AHA/ACC guideline for the management of patients with valvular heart disease: a report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. J Am Coll Cardiol 70 (2017), 252–289.
9. Van Mieghem, N.M., Dumonteil, N., Chieffo, A., et al. Current decision making and short-term outcome in patients with degenerative aortic stenosis: the Pooled-RotterdAm-Milano-Toulouse In Collaboration Aortic Stenosis survey. EuroIntervention 11 (2016), e1305–e1313.
10. Afilalo, J., Alexander, K.P., Mack, M.J., et al. Frailty assessment in the cardiovascular care of older adults. J Am Coll Cardiol 63 (2014), 747–762.
11. Afilalo, J., Kim, S., O'Brien, S., et al. Gait speed and operative mortality in older adults following cardiac surgery. JAMA Cardiol 1 (2016), 314–321.
12. Alfredsson, J., Stebbins, A., Brennan, J.M., et al. Gait speed predicts 30-day mortality after transcatheter aortic valve replacement: results from the Society of Thoracic Surgeons/American College of Cardiology Transcatheter Valve Therapy Registry. Circulation 133 (2016), 1351–1359.
13. Arnold, S.V., Afilalo, J., Spertus, J.A., et al., for the U.S. CoreValve Investigators. Prediction of poor outcome after transcatheter aortic valve replacement. J Am Coll Cardiol 68 (2016), 1868–1877.
14. Afilalo, J., Mottillo, S., Eisenberg, M.J., et al. Addition of frailty and disability to cardiac surgery risk scores identifies elderly patients at high risk of mortality or major morbidity. Circ Cardiovasc Qual Outcomes 5 (2012), 222–228.
15. Shimura, T., Yamamoto, M., Kano, S., et al., for the OCEAN-TAVI Investigators. Impact of the Clinical Frailty Scale on outcomes after transcatheter aortic valve replacement. Circulation 135 (2017), 2013–2024.
16. Guralnik, J.M., Ferrucci, L., Simonsick, E.M., Salive, M.E., Wallace, R.B., Lower-extremity function in persons over the age of 70 years as a predictor of subsequent disability. N Engl J Med 332 (1995), 556–561.
17. Stortecky, S., Schoenenberger, A.W., Moser, A., et al. Evaluation of multidimensional geriatric assessment as a predictor of mortality and cardiovascular events after transcatheter aortic valve implantation. J Am Coll Cardiol Intv 5 (2012), 489–496.
18. Schoenenberger, A.W., Stortecky, S., Neumann, S., et al. Predictors of functional decline in elderly patients undergoing transcatheter aortic valve implantation (TAVI). Eur Heart J 34 (2013), 684–692.
19. Green, P., Arnold, S.V., Cohen, D.J., et al. Relation of frailty to outcomes after transcatheter aortic valve replacement (from the PARTNER Trial). Am J Cardiol 116 (2015), 264–269.
20. von Elm, E., Altman, D.G., Egger, M., et al., for the STROBE Initiative. The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies. Ann Intern Med 147 (2007), 573–577.
21. Fried, L.P., Tangen, C.M., Walston, J., et al., for the Cardiovascular Health Study Collaborative Research Group. Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Sci Med Sci 56 (2001), M146–M156.
22. Folstein, M.F., Folstein, S.E., McHugh, P.R., “Mini-mental state.” A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 12 (1975), 189–198.
23. Hoyl, M.T., Alessi, C.A., Harker, J.O., et al. Development and testing of a five-item version of the Geriatric Depression Scale. J Am Geriatr Soc 47 (1999), 873–878.
24. Rockwood, K., Song, X., MacKnight, C., et al. A global clinical measure of fitness and frailty in elderly people. CMAJ 173 (2005), 489–495.
25. Guralnik, J.M., Simonsick, E.M., Ferrucci, L., et al. A short physical performance battery assessing lower extremity function: association with self-reported disability and prediction of mortality and nursing home admission. J Gerontol 49 (1994), M85–M94.
26. Kaiser, M.J., Bauer, J.M., Ramsch, C., et al., for the MNA-International Group. Validation of the Mini Nutritional Assessment short-form (MNA-SF): a practical tool for identification of nutritional status. J Nutr Health Aging 13 (2009), 782–788.
27. Paffenbarger, R.S. Jr., Hyde, R.T., Wing, A.L., Lee, I.M., Jung, D.L., Kampert, J.B., The association of changes in physical-activity level and other lifestyle characteristics with mortality among men. N Engl J Med 328 (1993), 538–545.
28. Kappetein, A.P., Head, S.J., Généreux, P., et al. Updated standardized endpoint definitions for transcatheter aortic valve implantation: the Valve Academic Research Consortium-2 consensus document. J Am Coll Cardiol 60 (2012), 1438–1454.
29. Fillenbaum, G.G., Smyer, M.A., The development, validity, and reliability of the OARS multidimensional functional assessment questionnaire. J Gerontol 36 (1981), 428–434.
30. Pencina, M.J., D'Agostino, R.B. Sr., D'Agostino, R.B. Jr., Vasan, R.S., Evaluating the added predictive ability of a new marker: from area under the ROC curve to reclassification and beyond. Stat Med 27 (2008), 157–172.
31. Raftery, A.E., Bayesian model selection in social research. Sociological Methodology 25 (1995), 111–163.
32. Harris, P.A., Taylor, R., Thielke, R., Payne, J., Gonzalez, N., Conde, J.G., Research electronic data capture (REDCap)—a metadata-driven methodology and workflow process for providing translational research informatics support. J Biomed Inform 42 (2009), 377–381.
33. Huded, C.P., Huded, J.M., Friedman, J.L., et al. Frailty status and outcomes after transcatheter aortic valve implantation. Am J Cardiol 117 (2016), 1966–1971.
34. Puri, R., Iung, B., Cohen, D.J., Rodés-Cabau, J., TAVI or no TAVI: identifying patients unlikely to benefit from transcatheter aortic valve implantation. Eur Heart J 37 (2016), 2217–2225.
35. Medina-Mirapeix, F., Bernabeu-Mora, R., Llamazares-Herrán, E., Sánchez-Martínez, M.P., García-Vidal, J.A., Escolar-Reina, P., Interobserver reliability of peripheral muscle strength tests and short physical performance battery in patients with chronic obstructive pulmonary disease: a prospective observational study. Arch Phys Med Rehabil 97 (2016), 2002–2005.
36. Bibas, L., Levi, M., Bendayan, M., Mullie, L., Forman, D.E., Afilalo, J., Therapeutic interventions for frail elderly patients: part I. Published randomized trials. Prog Cardiovasc Dis 57 (2014), 134–143.
37. Gill, T.M., Baker, D.I., Gottschalk, M., Peduzzi, P.N., Allore, H., Byers, A., A program to prevent functional decline in physically frail, elderly persons who live at home. N Engl J Med 347 (2002), 1068–1074.
38. Bauer, J.M., Verlaan, S., Bautmans, I., et al. Effects of a vitamin D and leucine-enriched whey protein nutritional supplement on measures of sarcopenia in older adults, the PROVIDE study: a randomized, double-blind, placebo-controlled trial. J Am Med Dir Assoc 16 (2015), 740–747.
39. Ströhle, A., Schmidt, D.K., Schultz, F., et al. Drug and exercise treatment of Alzheimer disease and mild cognitive impairment: a systematic review and meta-analysis of effects on cognition in randomized controlled trials. Am J Geriatr Psychiatry 23 (2015), 1234–1249.
40. Mueller, C., Compher, C., Ellen, D.M., for the American Society for Parenteral and Enteral Nutrition (A.S.P.E.N.) Board of Directors. A.S.P.E.N. clinical guidelines: nutrition screening, assessment, and intervention in adults. JPEN J Parenter Enteral Nutr 35 (2011), 16–24.
41. Milne, A.C., Potter, J., Vivanti, A., Avenell, A., Protein and energy supplementation in elderly people at risk from malnutrition. Cochrane Database Syst Rev, 2009, CD003288.
42. Cesari, M., Penninx, B.W.J.H., Pahor, M., et al. Inflammatory markers and physical performance in older persons: the InCHIANTI study. J Gerontol A Biol Sci Med Sci 59 (2004), 242–248.
43. Sousa, A.C.P.A., Zunzunegui, M.V., Li, A., Phillips, S.P., Guralnik, J.M., Guerra, R.O., Association between C-reactive protein and physical performance in older populations: results from the International Mobility in Aging Study (IMIAS). Age Ageing 45 (2016), 274–280.
44. Sannino, A., Schiattarella, G.G., Toscano, E., et al. Meta-analysis of effect of body mass index on outcomes after transcatheter aortic valve implantation. Am J Cardiol 119 (2017), 308–316.
45. Borson, S., Scanlan, J.M., Watanabe, J., Tu, S.P., Lessig, M., Simplifying detection of cognitive impairment: comparison of the Mini-Cog and Mini-Mental State Examination in a multiethnic sample. J Am Geriatr Soc 53 (2005), 871–874.