Preoperative frailty assessment and outcomes at 6 months or later in older adults undergoing cardiac surgical procedures: A systematic review

Annals of Internal Medicine

Volumn 165, Issue 9, 2016, Pages 650-660

  Kim, Dae Hyun ^a   Kim, Caroline A ^a   Placide, Sebastian ^b   Lipsitz, Lewis A ^a   Marcantonio, Edward R ^a  

^a BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^b ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARDIOVASCULAR DISEASE; CARDIOVASCULAR MORTALITY; CEREBROVASCULAR DISEASE; CLINICAL EVALUATION; CLINICAL OUTCOME; COHORT ANALYSIS; COMPARATIVE STUDY; EMBASE; FUNCTIONAL STATUS; HEART SURGERY; HUMAN; MEDLINE; MINIMALLY INVASIVE PROCEDURE; NUTRITION; OUTCOME ASSESSMENT; PREOPERATIVE EVALUATION; PRIORITY JOURNAL; QUALITY CONTROL; REVIEW; SURGICAL RISK; SYSTEMATIC REVIEW; WALKING DIFFICULTY; ADVERSE EFFECTS; AGED; CASE REPORT; CAUSE OF DEATH; DISABILITY; FRAIL ELDERLY; MALE; MIDDLE AGED; MINIMALLY INVASIVE SURGERY; MORTALITY; NUTRITIONAL STATUS; POSTOPERATIVE COMPLICATION; RISK ASSESSMENT; VERY ELDERLY;

AGED; AGED, 80 AND OVER; CARDIAC SURGICAL PROCEDURES; CAUSE OF DEATH; DISABILITY EVALUATION; FRAIL ELDERLY; HUMANS; MALE; MIDDLE AGED; MINIMALLY INVASIVE SURGICAL PROCEDURES; MOBILITY LIMITATION; NUTRITIONAL STATUS; OUTCOME ASSESSMENT (HEALTH CARE); POSTOPERATIVE COMPLICATIONS; RISK ASSESSMENT;

EID: 84994462644     PISSN: 00034819     EISSN: 15393704     Source Type: Journal    
DOI: 10.7326/M16-0652     Document Type: Review

References (71)

1. Mozaffarian D, Benjamin EJ, Go AS, Arnett DK, Blaha MJ, Cush-man M, et al; American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Heart disease and stroke statistics-2015 update: a report from the American Heart Association. Circu-lation. 2015;131:e29-322. [PMID: 25520374] doi:10.1161/CIR.0000000000000152
2. Dodson JA, Maurer MS. Changing nature of cardiac interventions in older adults. Aging health. 2011;7:283-295. [PMID: 21743812]
3. Hassan A, Newman A, Ko DT, Rinfret S, Hirsch G, Ghali WA, et al. Increasing rates of angioplasty versus bypass surgery in Canada, 1994-2005. Am Heart J. 2010;160:958-65. [PMID: 21095286] doi:10.1016/j.ahj.2010.06.052
4. Brennan JM, Holmes DR, Sherwood MW, Edwards FH, Carroll JD, Grover FL, et al. The association of transcatheter aortic valve replace-ment availability and hospital aortic valve replacement volume and mortality in the United States. Ann Thorac Surg. 2014;98:2016-22. [PMID: 25443009] doi:10.1016/j.athoracsur.2014.07.051
5. Afilalo J, Karunananthan S, Eisenberg MJ, Alexander KP, Bergman H. Role of frailty in patients with cardiovascular disease. Am J Cardiol. 2009;103:1616-21. [PMID: 19463525] doi:10.1016/j.amjcard.2009.01.375
6. Afilalo J, Eisenberg MJ, Morin JF, Bergman H, Monette J, Noiseux N, et al. Gait speed as an incremental predictor of mortality and major morbidity in elderly patients undergoing cardiac surgery. J Am Coll Cardiol. 2010;56:1668-76. [PMID: 21050978] doi:10.1016/j.jacc.2010.06.039
7. Afilalo J, Kim S, O'Brien S, Brennan JM, Edwards FH, Mack MJ, et al. Gait speed and operative mortality in older adults following cardiac surgery. JAMA Cardiol. 2016;1:314-21.
8. Alfredsson J, Stebbins A, Brennan JM, Matsouaka R, Afilalo J, Peterson ED, et al. Gait speed predicts 30-day mortality after trans-catheter aortic valve replacement: results from the Society of Tho-racic Surgeons/American College of Cardiology Transcatheter Valve Therapy Registry. Circulation. 2016;133:1351-9. [PMID: 26920495] doi:10.1161/CIRCULATIONAHA.115.020279
9. Sündermann S, Dademasch A, Praetorius J, Kempfert J, Dewey T, Falk V, et al. Comprehensive assessment of frailty for elderly high-risk patients undergoing cardiac surgery. Eur J Cardiothorac Surg. 2011;39:33-7. [PMID: 20627611] doi:10.1016/j.ejcts.2010.04.013
10. Afilalo J, Kim S, O'Brien S, Brennan JM, Edwards FH, Mack MJ, et al. Gait speed and operative mortality in older adults following cardiac surgery. JAMA Cardiol. 2016;1:314-21. doi:10.1001/jama cardio.2016.0316.
11. Schoenenberger AW, Stortecky S, Neumann S, Moser A, Jüni P, Carrel T, et al. Predictors of functional decline in elderly patients undergoing transcatheter aortic valve implantation (TAVI). Eur Heart J. 2013;34:684-92. [PMID: 23008508] doi:10.1093/eurheartj/ehs304
12. Mok M, Nombela-Franco L, Dumont E, Urena M, DeLarochellière R, Doyle D, et al. Chronic obstructive pulmonary disease in patients undergoing transcatheter aortic valve implantation: insights on clin-ical outcomes, prognostic markers, and functional status changes. JACC Cardiovasc Interv. 2013;6:1072-84. [PMID: 24156967] doi:10.1016/j.jcin.2013.06.008
13. Arnold SV, Reynolds MR, Lei Y, Magnuson EA, Kirtane AJ, Kodali SK, et al; PARTNER Investigators. Predictors of poor outcomes after transcatheter aortic valve replacement: results from the PARTNER (Placement of Aortic Transcatheter Valve) trial. Circulation. 2014;129: 2682-90. [PMID: 24958751] doi:10.1161/CIRCULATIONAHA.113.007477
14. Green P, Arnold SV, Cohen DJ, Kirtane AJ, Kodali SK, Brown DL, et al. Relation of frailty to outcomes after transcatheter aortic valve replacement (from the PARTNER trial). Am J Cardiol. 2015;116: 264-9. [PMID: 25963221] doi:10.1016/j.amjcard.2015.03.061
15. Osnabrugge RL, Arnold SV, Reynolds MR, Magnuson EA, Wang K, Gaudiani VA, et al; CoreValve U.S. Trial Investigators. Health status after transcatheter aortic valve replacement in patients at extreme surgical risk: results from the CoreValve U.S. trial. JACC Cardiovasc Interv. 2015;8:315-23. [PMID: 25700755] doi:10.1016/j.jcin.2014.08.016
16. Clegg A, Young J, Iliffe S, Rikkert MO, Rockwood K. Frailty in elderly people. Lancet. 2013;381:752-62. [PMID: 23395245] doi:10.1016/S0140-6736(12)62167-9
17. Fried LP, Tangen CM, Walston J, Newman AB, Hirsch C, Gott-diener J, et al; Cardiovascular Health Study Collaborative Research Group. Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Sci Med Sci. 2001;56:M146-56. [PMID: 11253156]
18. Rockwood K, Mitnitski A. Frailty in relation to the accumulation of deficits. J Gerontol A Biol Sci Med Sci. 2007;62:722-7. [PMID: 17634318]
19. Saliba D, Elliott M, Rubenstein LZ, Solomon DH, Young RT, Kam-berg CJ, et al. The Vulnerable Elders Survey: a tool for identifying vulnerable older people in the community. J Am Geriatr Soc. 2001; 49:1691-9. [PMID: 11844005]
20. Ensrud KE, Ewing SK, Taylor BC, Fink HA, Cawthon PM, Stone KL, et al. Comparison of 2 frailty indexes for prediction of falls, dis-ability, fractures, and death in older women. Arch Intern Med. 2008; 168:382-9. [PMID: 18299493] doi:10.1001/archinternmed.2007.113
21. Rockwood K, Abeysundera MJ, Mitnitski A. How should we grade frailty in nursing home patients? J Am Med Dir Assoc. 2007; 8:595-603. [PMID: 17998116]
22. Peters LL, Boter H, Buskens E, Slaets JP. Measurement properties of the Groningen Frailty Indicator in home-dwelling and institutionalized elderly people. J Am Med Dir Assoc. 2012;13:546-51. [PMID: 22579590] doi:10.1016/j.jamda.2012.04.007
23. Howlett SE, Rockwood MR, Mitnitski A, Rockwood K. Standard laboratory tests to identify older adults at increased risk of death. BMC Med. 2014;12:171. [PMID: 25288274] doi:10.1186/s12916-014-0171-9
24. Morley JE, Vellas B, van Kan GA, Anker SD, Bauer JM, Bernabei R, et al. Frailty consensus: a call to action. J Am Med Dir Assoc. 2013;14:392-7. [PMID: 23764209] doi:10.1016/j.jamda.2013.03.022
25. Abellan van Kan G, Rolland Y, Bergman H, Morley JE, Kritchevsky SB, Vellas B. The I.A.N.A Task Force on frailty assessment of older people in clinical practice. J Nutr Health Aging. 2008;12:29-37. [PMID: 18165842]
26. Edwards FH, Cohen DJ, O'Brien SM, Peterson ED, Mack MJ, Shahian DM, et al. Development and validation of a risk prediction model for in-hospital mortality after transcatheter aortic valve re-placement. JAMA Cardiol. 2016;1:46-52. doi:10.1001/jamacardio.2015.0326
27. The Society of Thoracic Surgeons. Online STS adult cardiac surgery risk calculator. 2016. Accessed at http://riskcalc.sts.org/stswe briskcalc on 10 December 2015.
28. euroSCORE. euroScore cardiac surgery scoring system. 2011. Accessed at http://euroscore.org/index.htm on 10 December 2015.
29. American College of Cardiology; The Society of Thoracic Sur-geons. TAVR in-hospital mortality risk calculator. 2016. Accessed at http://tools.acc.org/TAVRRisk/content/evaluate on 19 June 2016.
30. Rowe R, Iqbal J, Murali-Krishnan R, Sultan A, Orme R, Briffa N, et al. Role of frailty assessment in patients undergoing cardiac inter-ventions. Open Heart. 2014;1:e000033. [PMID: 25332792] doi:10.1136/openhrt-2013-000033
31. Bagnall NM, Faiz O, Darzi A, Athanasiou T. What is the utility of preoperative frailty assessment for risk stratification in cardiac surgery? Interact Cardiovasc Thorac Surg. 2013;17:398-402. [PMID: 23667068] doi:10.1093/icvts/ivt197
32. Afilalo J, Alexander KP, Mack MJ, Maurer MS, Green P, Allen LA, et al. Frailty assessment in the cardiovascular care of older adults. J Am Coll Cardiol. 2014;63:747-62. [PMID: 24291279] doi:10.1016/j.jacc.2013.09.070
33. Sepehri A, Beggs T, Hassan A, Rigatto C, Shaw-Daigle C, Tangri N, et al. The impact of frailty on outcomes after cardiac surgery: a systematic review. J Thorac Cardiovasc Surg. 2014;148:3110-7. [PMID: 25199821] doi:10.1016/j.jtcvs.2014.07.087
34. Oresanya LB, Lyons WL, Finlayson E. Preoperative assessment of the older patient: a narrative review. JAMA. 2014;311:2110-20. [PMID: 24867014] doi:10.1001/jama.2014.4573
35. Furukawa H, Tanemoto K. Frailty in cardiothoracic surgery: sys-tematic review of the literature. Gen Thorac Cardiovasc Surg. 2015; 63:425-33. [PMID: 25916404] doi:10.1007/s11748-015-0553-8
36. Moher D, Liberati A, Tetzlaff J, Altman DG; PRISMA Group. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. Ann Intern Med. 2009;151:264-9. [PMID: 19622511]
37. DePew ZS, Karpman C, Novotny PJ, Benzo RP. Correlations be-tween gait speed, 6-minute walk distance, physical activity, and self-efficacy in patients with severe chronic lung disease. Respir Care. 2013;58:2113-9. [PMID: 23696689] doi:10.4187/respcare.02471
38. Harada ND, Chiu V, Stewart AL. Mobility-related function in older adults: assessment with a 6-minute walk test. Arch Phys Med Rehabil. 1999;80:837-41. [PMID: 10414771]
39. Hlatky MA, Boineau RE, Higginbotham MB, Lee KL, Mark DB, Califf RM, et al. A brief self-administered questionnaire to determine functional capacity (the Duke Activity Status Index). Am J Cardiol. 1989;64:651-4. [PMID: 2782256]
40. Green CP, Porter CB, Bresnahan DR, Spertus JA. Development and evaluation of the Kansas City Cardiomyopathy Questionnaire: a new health status measure for heart failure. J Am Coll Cardiol. 2000; 35:1245-55. [PMID: 10758967]
41. Sündermann SH, Dademasch A, Seifert B, Rodriguez Cetina Biefer H, Emmert MY, Walther T, et al. Frailty is a predictor of short-and mid-term mortality after elective cardiac surgery independently of age. Interact Cardiovasc Thorac Surg. 2014;18:580-5. [PMID: 24497604] doi:10.1093/icvts/ivu006
42. Robinson TN, Wu DS, Sauaia A, Dunn CL, Stevens-Lapsley JE, Moss M, et al. Slower walking speed forecasts increased postoperative morbidity and 1-year mortality across surgical specialties. Ann Surg. 2013;258:582-8. [PMID: 23979272] doi:10.1097/SLA.0b013 e3182a4e96c
43. de Arenaza DP, Pepper J, Lees B, Rubinstein F, Nugara F, Roughton M, et al; ASSERT (Aortic Stentless versus Stented valve assessed by Echocardiography Randomised Trial) Investigators. Pre-operative 6-minute walk test adds prognostic information to Euro-score in patients undergoing aortic valve replacement. Heart. 2010; 96:113-7. [PMID: 19561363] doi:10.1136/hrt.2008.161174
44. Rapp-Kesek D, Ståhle E, Karlsson TT. Body mass index and albu-min in the preoperative evaluation of cardiac surgery patients. Clin Nutr. 2004;23:1398-404. [PMID: 15556262]
45. Gardner SC, Grunwald GK, Rumsfeld JS, Mackenzie T, Gao D, Perlin JB, et al. Risk factors for intermediate-term survival after coronary artery bypass grafting. Ann Thorac Surg. 2001;72:2033-7. [PMID: 11789789]
46. Lee DH, Buth KJ, Martin BJ, Yip AM, Hirsch GM. Frail patients are at increased risk for mortality and prolonged institutional care after cardiac surgery. Circulation. 2010;121:973-8. [PMID: 20159833] doi: 10.1161/CIRCULATIONAHA.108.841437
47. Cervera R, Bakaeen FG, Cornwell LD, Wang XL, Coselli JS, Le-Maire SA, et al. Impact of functional status on survival after coronary artery bypass grafting in a veteran population. Ann Thorac Surg. 2012;93:1950-4.[PMID:22560262]doi:10.1016/j.athoracsur.2012.02.071
48. Sündermann S, Dademasch A, Rastan A, Praetorius J, Rodriguez H, Walther T, et al. One-year follow-up of patients undergoing elec-tive cardiac surgery assessed with the Comprehensive Assessment of Frailty test and its simplified form. Interact Cardiovasc Thorac Surg. 2011;13:119-23. [PMID: 21378017] doi:10.1510/icvts.2010.251884
49. Ad N, Holmes SD, Halpin L, Shuman DJ, Miller CE, Lamont D. The effects of frailty in patients undergoing elective cardiac surgery. J Card Surg. 2016;31:187-94. [PMID: 26833390] doi:10.1111/jocs.12699
50. Cockburn J, Singh MS, Rafi NH, Dooley M, Hutchinson N, Hill A, et al. Poor mobility predicts adverse outcome better than other frailty indices in patients undergoing transcatheter aortic valve implanta-tion. Catheter Cardiovasc Interv. 2015;86:1271-7. [PMID: 26119601] doi:10.1002/ccd.25991
51. Dvir D, Waksman R, Barbash IM, Kodali SK, Svensson LG, Tuzcu EM, et al. Outcomes of patients with chronic lung disease and severe aortic stenosis treated with transcatheter versus surgical aortic valve replacement or standard therapy: insights from the PARTNER tria (placement of AoRTic TraNscathetER Valve). J Am Coll Cardiol. 2014;63:269-79. [PMID: 24140659] doi:10.1016/j.jacc.2013.09.024
52. Green P, Cohen DJ, Genereux P, McAndrewT, Arnold SV, Alu M, et al. Relation between six-minute walk test performance and outcomes after transcatheter aortic valve implantation (from the PARTNER trial). Am J Cardiol. 2013;112:700-6. [PMID: 23725996] doi:10.1016/j.amjcard.2013.04.046
53. MokM, Nombela-Franco L, Urena M, Delarochelliere R, Doyle D, Ribeiro HB, et al. Prognostic value of exercise capacity as evaluated by the 6-minute walk test in patients undergoing transcatheter aortic valve implantation [Letter]. J Am Coll Cardiol. 2013;61:897-8. [PMID: 23428221] doi:10.1016/j.jacc.2012.10.050
54. Munoz-García AJ, Hernandez-García JM, Jimenez-Navarro MF, Alonso-Briales JH, Domínguez-Franco AJ, Rodríguez-Bailon I, et al. Survival and predictive factors of mortality after 30 days in patients treated with percutaneous implantation of the CoreValve aortic pros-thesis. Am Heart J. 2012;163:288-94. [PMID: 22305849] doi:10.1016/j.ahj.2011.11.013
55. Puls M, Sobisiak B, Bleckmann A, Jacobshagen C, Danner BC, Hunlich M, et al. Impact of frailty on short-and long-term morbidity and mortality after transcatheter aortic valve implantation: risk as-sessment by Katz Index of activities of daily living. EuroIntervention. 2014;10:609-19. [PMID: 25136880] doi:10.4244/EIJY14M08-03
56. Rodes-Cabau J, Webb JG, Cheung A, Ye J, Dumont E, Feindel CM, et al. Transcatheter aortic valve implantation for the treatment of severe symptomatic aortic stenosis in patients at very high or prohib-itive surgical risk: acute and late outcomes of the multicenter Cana-dian experience. J Am Coll Cardiol. 2010;55:1080-90. [PMID: 20096533] doi:10.1016/j.jacc.2009.12.014
57. Rodes-Cabau J, Webb JG, Cheung A, Ye J, Dumont E, Osten M, et al. Long-term outcomes after transcatheter aortic valve implanta-tion: insights on prognostic factors and valve durability from the Ca-nadian multicenter experience. J Am Coll Cardiol. 2012;60:1864-75. [PMID: 23062535] doi:10.1016/j.jacc.2012.08.960
58. Stortecky S, Schoenenberger AW, Moser A, Kalesan B, Juni P, Carrel T, et al. Evaluation of multidimensional geriatric assessment as a predictor of mortality and cardiovascular events after transcatheter aortic valve implantation. JACC Cardiovasc Interv. 2012;5:489-96. [PMID: 22625186] doi:10.1016/j.jcin.2012.02.012
59. Ewe SH, Ajmone Marsan N, Pepi M, Delgado V, Tamborini G, Muratori M, et al. Impact of left ventricular systolic function on clinica and echocardiographic outcomes following transcatheter aortic valve implantation for severe aortic stenosis. Am Heart J. 2010;160: 1113-20. [PMID: 21146666] doi:10.1016/j.ahj.2010.09.003
60. Seiffert M, Sinning JM, Meyer A, Wilde S, Conradi L, Vasa-Nicotera M, et al. Development of a risk score for outcome after transcatheter aortic valve implantation. Clin Res Cardiol. 2014;103: 631-40. [PMID: 24643728] doi:10.1007/s00392-014-0692-4
61. Codner P, Orvin K, Assali A, Sharony R, Vaknin-Assa H, Shapira Y, et al. Long-term outcomes for patients with severe symptomatic aortic stenosis treated with transcatheter aortic valve implantation. Am J Cardiol. 2015;116:1391-8. [PMID: 26342515] doi:10.1016/j.amjcard.2015.08.004
62. Rubenstein LZ, Harker JO, Salvà A, Guigoz Y, Vellas B. Screening for undernutrition in geriatric practice: developing the short-form mini-nutritional assessment (MNA-SF). J Gerontol A Biol Sci Med Sci. 2001;56:M366-72. [PMID: 11382797]
63. Castell MV, Sánchez M, Julián R, Queipo R, Martín S, Otero Á. Frailty prevalence and slow walking speed in persons age 65 and older: implications for primary care. BMC Fam Pract. 2013;14:86. [PMID: 23782891] doi:10.1186/1471-2296-14-86
64. Savva GM, Donoghue OA, Horgan F, O'Regan C, Cronin H, Kenny RA. Using timed up-and-go to identify frail members of the older population. J Gerontol A Biol Sci Med Sci. 2013;68:441-6. [PMID: 22987796] doi:10.1093/gerona/gls190
65. Abellan van Kan G, Rolland Y, Andrieu S, Bauer J, Beauchet O, Bonnefoy M, et al. Gait speed at usual pace as a predictor of adverse outcomes in community-dwelling older people an International Academy on Nutrition and Aging (IANA) Task Force. J Nutr Health Aging. 2009;13:881-9. [PMID: 19924348]
66. Rodés-Cabau J, Mok M. Working toward a frailty index in trans-catheter aortic valve replacement: a major move away from the "eyeball test" [Editorial]. JACC Cardiovasc Interv. 2012;5:982-3. [PMID: 22995886] doi:10.1016/j.jcin.2012.07.002
67. Evans SJ, Sayers M, Mitnitski A, Rockwood K. The risk of adverse outcomes in hospitalized older patients in relation to a frailty index based on a comprehensive geriatric assessment. Age Ageing. 2014; 43:127-32. [PMID: 24171946] doi:10.1093/ageing/aft156
68. Schwarze ML, Brasel KJ, Mosenthal AC. Beyond 30-day mortal-ity: aligning surgical quality with outcomes that patients value. JAMA Surg.2014;149:631-2.[PMID:24897945]doi:10.1001/jamasurg.2013.5143
69. Guiding principles for the care of older adults with multimorbid-ity: an approach for clinicians. Guiding principles for the care of older adults with multimorbidity: an approach for clinicians: Ameri-can Geriatrics Society Expert Panel on the Care of Older Adults with Multimorbidity. J Am Geriatr Soc. 2012;60:E1-25. [PMID: 22994865] doi:10.1111/j.1532-5415.2012.04188.x
70. Nishimura RA, Otto CM, Bonow RO, Carabello BA, Erwin JP 3rd, Guyton RA, et al; American College of Cardiology/American Heart Association Task Force on Practice Guidelines. 2014 AHA/ACC guideline for the management of patients with valvular heart dis-ease: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. J Am Coll Car-diol. 2014;63:e57-185. [PMID: 24603191] doi:10.1016/j.jacc.2014.02.536
71. Reuben DB, Rosen S. Principles of geriatric assessment. In: Halter JB, Ouslander JG, Tinetti ME, Studenski S, High KP, Asthana S, eds. Hazzard's Geriatric Medicine and Gerontology. 6th ed. New York: McGraw-Hill; 2009.